Suchergebnisse - "Multiomics"

Spatial Immunometabolism: Integrating Technologies to Decode Cellular Metabolism in Tissues.

Autoren: Hartmann FJ; German Cancer Research Center (DKFZ), Systems Immunology & Single-Cell Biology, Heidelberg, Germany.; German Cancer Consortium (DKTK), DKFZ Core Center, Heidelberg, Germany.

Quelle: European journal of immunology [Eur J Immunol] 2025 Nov; Vol. 55 (11), pp. e70094.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE

MeSH-Schlagworte: Mass Spectrometry* , Multiomics*/methods, Animals ; Humans ; Microscopy/methods ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Metabolomics

Integrating multi-omics proteomic approaches in deciphering the tumor microenvironment and therapeutic resistance mechanisms in prostate cancer.

Autoren: Wang Y Wang F Pan Q et al.

Quelle: Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2025 Oct; Vol. 1880 (5), pp. 189426. Date of Electronic Publication: 2025 Aug 20.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9806362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2561 (Electronic) Linking ISSN: 0304419X NLM ISO Abbreviation: Biochim Biophys Acta Rev Cancer Subsets: MEDLINE

MeSH-Schlagworte: Multiomics*/methods , Tumor Microenvironment*/genetics , Drug Resistance, Neoplasm*/genetics , Prostatic Neoplasms*/drug therapy , Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/immunology , Prostatic Neoplasms*/pathology, Humans ; Male ; Proteogenomics/methods ; Immune Evasion/genetics ; Single-Cell Analysis/methods

Multi-omic spatially resolved analysis of the neuroinflammatory response to intracortical microelectrode arrays.

Autoren: Druschel LN Song SS Kasthuri NM et al.

Quelle: Biomaterials [Biomaterials] 2026 Jan; Vol. 324, pp. 123477. Date of Electronic Publication: 2025 Jun 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE

MeSH-Schlagworte: Multiomics*/methods , Neuroinflammatory Diseases*/etiology , Neuroinflammatory Diseases*/genetics , Neuroinflammatory Diseases*/metabolism , Cerebral Cortex*/metabolism , Cerebral Cortex*/pathology , Electrodes, Implanted*/adverse effects, Microelectrodes ; Animals ; Mice ; Gene Expression Profiling/methods ; Proteomics/methods ; Male ; Mice, Inbred C57BL

Rationale and design of the Dog Aging Project precision cohort: a multi-omic resource for longitudinal research in geroscience.

Autoren: Prescott J Keyser AJ Litwin P et al.

Körperschaften: Prescott J Keyser AJ Litwin P et al.

Quelle: GeroScience [Geroscience] 2025 Aug; Vol. 47 (4), pp. 5725-5748. Date of Electronic Publication: 2025 Mar 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE

MeSH-Schlagworte: Dogs*/physiology , Aging*/physiology , Multiomics*/methods , Multiomics*/organization & administration , Multiomics*/standards , Geroscience*/methods, Animals ; Female ; Male ; Immunophenotyping ; Life Expectancy ; Pets/physiology ; Research Design ; Longitudinal Studies

Pan-cancer analysis shapes the understanding of cancer biology and medicine.

Autoren: Cen X Lan Y Zou J et al.

Quelle: Cancer communications (London, England) [Cancer Commun (Lond)] 2025 Jul; Vol. 45 (7), pp. 728-746. Date of Electronic Publication: 2025 Mar 22.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 101723675 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2523-3548 (Electronic) Linking ISSN: 25233548 NLM ISO Abbreviation: Cancer Commun (Lond) Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/diagnosis , Neoplasms*/genetics , Neoplasms*/pathology , Neoplasms*/therapy , Multiomics*/methods , Multiomics*/trends , Medical Oncology*/methods , Medical Oncology*/trends, Datasets as Topic ; Humans ; Biomedical Research/methods ; Biomedical Research/trends ; Precision Medicine/methods ; Precision Medicine/trends

Multi-omic assessment of mRNA translation dynamics in liver cancer cell lines.

Autoren: González A Pandey M Schlusser N et al.

Quelle: Scientific data [Sci Data] 2025 Aug 30; Vol. 12 (1), pp. 1520. Date of Electronic Publication: 2025 Aug 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101640192 Publication Model: Electronic Cited Medium: Internet ISSN: 2052-4463 (Electronic) Linking ISSN: 20524463 NLM ISO Abbreviation: Sci Data Subsets: MEDLINE

MeSH-Schlagworte: Liver Neoplasms*/genetics , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Multiomics*/methods , Protein Biosynthesis* , RNA, Messenger*/genetics, Humans ; Cell Line, Tumor ; Polyribosomes ; Ribosomes ; Datasets as Topic

Integrated multi-omics analysis identifies lipid metabolism biomarkers in ONFH and reveals therapeutic potential of retinoic acid.

Autoren: Wang C Cen C Su H et al.

Quelle: Scientific reports [Sci Rep] 2025 Aug 21; Vol. 15 (1), pp. 30716. Date of Electronic Publication: 2025 Aug 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Multiomics* , Lipid Metabolism*/physiology , Tretinoin*/metabolism , Tretinoin*/therapeutic use , Femur Head Necrosis*/genetics , Femur Head Necrosis*/metabolism, Biomarkers/metabolism ; Osteonecrosis ; Femur Head ; RNA, Messenger ; Humans ; Single-Cell Gene Expression Analysis ; Gene Expression Regulation ; Animals ; Rats ; Rats, Sprague-Dawley ; MicroRNAs/metabolism

Integrated multi-omics analysis reveals diagnostic biomarkers and therapeutic targets for systemic lupus erythematosus.

Autoren: Huang L Shi J Li H et al.

Quelle: Medicine [Medicine (Baltimore)] 2025 Aug 15; Vol. 104 (33), pp. e42290.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

MeSH-Schlagworte: Lupus Erythematosus, Systemic*/diagnosis , Lupus Erythematosus, Systemic*/drug therapy , Lupus Erythematosus, Systemic*/genetics , Lupus Erythematosus, Systemic*/immunology , Multiomics*/methods, Biomarkers/blood ; Mendelian Randomization Analysis ; Molecular Targeted Therapy/methods ; Protein Interaction Maps/drug effects ; Protein Interaction Maps/genetics ; Protein Interaction Maps/immunology ; Glycoproteins/metabolism ; Molecular Docking Simulation ; Nomograms ; Single-Cell Gene Expression Analysis ; Proteasome Endopeptidase Complex/blood ; Proteasome Endopeptidase Complex/genetics ; Proteasome Endopeptidase Complex/metabolism ; Apolipoprotein A-II/blood ; Apolipoprotein A-II/genetics ; Apolipoprotein A-II/metabolism ; Immunosuppressive Agents/pharmacology ; Immunosuppressive Agents/therapeutic use ; Humans ; Genome-Wide Association Study

Cells Keep Diverse Company in Diseased Tissues.

Autoren: Campbell KR Goeva A

Quelle: Cancer research [Cancer Res] 2025 Jul 02; Vol. 85 (13), pp. 2351-2352.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

MeSH-Schlagworte: Multiomics*/methods , Spatial Analysis* , Neoplasms*/mortality , Neoplasms*/pathology, Disease Progression ; Palatine Tonsil/cytology ; Palatine Tonsil/pathology ; Germinal Center/cytology ; Germinal Center/pathology ; Spleen/cytology ; Spleen/pathology ; Lupus Erythematosus, Systemic/pathology ; Disease Models, Animal ; Humans ; Animals ; Mice

Deconvolution of cell types and states in spatial multiomics utilizing TACIT.

Autoren: Huynh KLA Tyc KM Matuck BF et al.

Quelle: Nature communications [Nat Commun] 2025 Apr 21; Vol. 16 (1), pp. 3747. Date of Electronic Publication: 2025 Apr 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Multiomics* , Unsupervised Machine Learning*, Animals ; Humans ; Mice ; Brain/cytology ; Brain/metabolism ; Deep Learning ; Gene Expression Profiling ; Intestines/cytology ; Proteomics/methods ; Transcriptome

LEOPARD: missing view completion for multi-timepoint omics data via representation disentanglement and temporal knowledge transfer.

Autoren: Han S Yu S Shi M et al.

Quelle: Nature communications [Nat Commun] 2025 Apr 06; Vol. 16 (1), pp. 3278. Date of Electronic Publication: 2025 Apr 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Multiomics*/methods , Computational Biology*, Humans ; COVID-19/metabolism ; COVID-19/virology ; Longitudinal Studies

FactVAE: a factorized variational autoencoder for single-cell multi-omics data integration analysis.

Autoren: Wang L Zhang H Yi B et al.

Quelle: Briefings in bioinformatics [Brief Bioinform] 2025 Mar 04; Vol. 26 (2).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 100912837 Publication Model: Print Cited Medium: Internet ISSN: 1477-4054 (Electronic) Linking ISSN: 14675463 NLM ISO Abbreviation: Brief Bioinform Subsets: MEDLINE

MeSH-Schlagworte: Autoencoder* , Computational Biology*/methods , Multiomics*/methods , Single-Cell Analysis*/methods, Humans ; Algorithms ; Neural Networks, Computer ; Software

Multi-Omics Deep-Learning Prediction of Homologous Recombination Deficiency-Like Phenotype Improved Risk Stratification and Guided Therapeutic Decisions in Gynecological Cancers.

Autoren: Zhang Y Yan C Yang Z et al.

Quelle: IEEE journal of biomedical and health informatics [IEEE J Biomed Health Inform] 2025 Mar; Vol. 29 (3), pp. 1861-1871. Date of Electronic Publication: 2025 Mar 06.

Publikationsart: Journal Article; Multicenter Study; Validation Study; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Institute of Electrical and Electronics Engineers Country of Publication: United States NLM ID: 101604520 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2168-2208 (Electronic) Linking ISSN: 21682194 NLM ISO Abbreviation: IEEE J Biomed Health Inform Subsets: MEDLINE

MeSH-Schlagworte: Genital Neoplasms, Female*/genetics , Genital Neoplasms, Female*/mortality , Genital Neoplasms, Female*/pathology , Genital Neoplasms, Female*/therapy , Homologous Recombination*/genetics , Multiomics*/methods , Risk Assessment*/methods , Autoencoder*, Female ; Humans ; Biomarkers, Tumor/genetics ; DNA Methylation/genetics ; Genomics/methods ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/mortality ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/therapy ; Phenotype

Multiplexed spatial mapping of chromatin features, transcriptome and proteins in tissues.

Autoren: Guo P Mao L Chen Y et al.

Quelle: Nature methods [Nat Methods] 2025 Mar; Vol. 22 (3), pp. 520-529. Date of Electronic Publication: 2025 Jan 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101215604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1548-7105 (Electronic) Linking ISSN: 15487091 NLM ISO Abbreviation: Nat Methods Subsets: MEDLINE

MeSH-Schlagworte: Chromatin*/genetics , Chromatin*/metabolism , Histones*/analysis , Histones*/metabolism , Multiomics*/methods , Spatio-Temporal Analysis* , Transcriptome*/genetics, Mice ; Brain/cytology ; Brain/embryology ; Brain/metabolism ; Cell Differentiation/genetics ; Embryo, Mammalian/cytology ; Embryo, Mammalian/metabolism ; Epigenesis, Genetic/genetics ; Gene Expression/genetics ; Histone Code ; Neuroglia/metabolism ; Neurons/cytology ; Neurons/metabolism ; Animals

Multi-Omic Analysis of the Differences in Growth and Metabolic Mechanisms Between Chinese Domestic Cattle and Simmental Crossbred Cattle.

Autoren: Wang J Ni J Jia X et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Feb 12; Vol. 26 (4). Date of Electronic Publication: 2025 Feb 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Cattle*/growth & development , Cattle*/genetics , Cattle*/metabolism , Multiomics*, Animals ; Breeding ; China ; Gene Expression Profiling ; Hybridization, Genetic ; Metabolome ; Metabolomics/methods ; Transcriptome

Multiomics-based assessment of the impact of airflow on diverse plant callus cultures.

Autoren: Kim JS Sato M Kojima M et al.

Quelle: Scientific data [Sci Data] 2025 Feb 03; Vol. 12 (1), pp. 197. Date of Electronic Publication: 2025 Feb 03.

Publikationsart: Journal Article; Dataset

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101640192 Publication Model: Electronic Cited Medium: Internet ISSN: 2052-4463 (Electronic) Linking ISSN: 20524463 NLM ISO Abbreviation: Sci Data Subsets: MEDLINE

MeSH-Schlagworte: Multiomics* , Tissue Culture Techniques*, Chromatography, Liquid ; Nicotiana/genetics ; Nicotiana/metabolism ; Oryza/genetics ; Oryza/metabolism ; Plant Growth Regulators ; Air Movements

DCAF13-mediated K63-linked ubiquitination of RNA polymerase I promotes uncontrolled proliferation in Breast Cancer.

Autoren: Yang ZZ Yang B Yan H et al.

Quelle: Nature communications [Nat Commun] 2025 Jan 09; Vol. 16 (1), pp. 557. Date of Electronic Publication: 2025 Jan 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Ubiquitination* , Lysine*/metabolism , RNA Polymerase I*/metabolism , Cell Proliferation* , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , Multiomics* , RNA-Binding Proteins*/metabolism, Ribosomal Proteins/metabolism ; Ribosomes/metabolism ; Humans ; Cell Line, Tumor ; Prognosis ; Transcription, Genetic ; RNA Processing, Post-Transcriptional ; Female ; Mice, Nude ; Mice, Inbred BALB C ; Animals

Temporally integrated multiomics analysis elucidates intricate regulatory mechanisms of ASFV in a wild boar lung-derived clonal cell line.

Autoren: Wang, Hua Ye, Miaomiao Weng, Wenlian et al.

Quelle: Veterinary Research. 10/14/2025, Vol. 56 Issue 1, p1-19. 19p.

Schlagworte: African swine fever virus, Multiomics, Gene expression profiling, Antiviral agents, Cell lines, Host-parasite relationships, Vaccine development

New insights into clinical strategies for acute coronary syndrome based on biomarker-driven multiomics research.

Autoren: Zhao Z Yu K Zhao Y et al.

Quelle: Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2025 Dec 31; Vol. 47 (1), pp. 2593619. Date of Electronic Publication: 2025 Dec 05.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9305929 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6006 (Electronic) Linking ISSN: 10641963 NLM ISO Abbreviation: Clin Exp Hypertens Subsets: MEDLINE

MeSH-Schlagworte: Acute Coronary Syndrome*/diagnosis , Acute Coronary Syndrome*/genetics , Acute Coronary Syndrome*/metabolism , Acute Coronary Syndrome*/therapy , Metabolomics*/methods , Proteomics*/methods , Genomics*/methods, Humans ; Biomarkers/metabolism ; Transcriptome ; Multiomics

Genetic insights into drug targets for alzheimer's disease: integrative multi-omics analysis.

Autoren: Liu X Chen J Zhou S et al.

Quelle: Alzheimer's research & therapy [Alzheimers Res Ther] 2025 Dec 05; Vol. 17 (1), pp. 258. Date of Electronic Publication: 2025 Dec 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE

MeSH-Schlagworte: Alzheimer Disease*/genetics , Alzheimer Disease*/drug therapy , Alzheimer Disease*/cerebrospinal fluid, Humans ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Biomarkers/cerebrospinal fluid ; Proteomics ; Quantitative Trait Loci ; Amyloid beta-Peptides/cerebrospinal fluid ; Multiomics