Suchergebnisse - "Multigene Family/genetics"

The selection landscape and genetic legacy of ancient Eurasians

Autoren: Irving-Pease, EK Refoyo-Martínez, A Barrie, W et al.

Weitere Verfasser: Irving-Pease, EK Refoyo-Martínez, A Barrie, W et al.

Quelle: Nature
Irving-Pease, E K, Refoyo-Martínez, A, Barrie, W, Ingason, A, Pearson, A, Fischer, A, Sjögren, K-G, Halgren, A S, Macleod, R, Demeter, F, Henriksen, R A, Vimala, T, McColl, H, Vaughn, A H, Speidel, L, Stern, A J, Scorrano, G, Ramsøe, A, Schork, A J, Rosengren, A, Zhao, L, Kristiansen, K, Iversen, A K N, Fugger, L, Sudmant, P H, Lawson, D J, Durbin, R, Korneliussen, T, Werge, T, Allentoft, M E, Sikora, M, Nielsen, R, Racimo, F & Willerslev, E 2024, ' The selection landscape and genetic legacy of ancient Eurasians ', Nature, vol. 625, no. 7994, pp. 312-320 . https://doi.org/10.1038/s41586-023-06705-1
Nature, vol 625, iss 7994
Irving-Pease, E K, Refoyo-Martínez, A, Barrie, W, Ingason, A, Pearson, A, Fischer, A, Sjögren, K G, Halgren, A S, Macleod, R, Demeter, F, Henriksen, R A, Vimala, T, McColl, H, Vaughn, A H, Speidel, L, Stern, A J, Scorrano, G, Ramsøe, A, Schork, A J, Rosengren, A, Zhao, L, Kristiansen, K, Iversen, A K N, Fugger, L, Sudmant, P H, Lawson, D J, Durbin, R, Korneliussen, T, Werge, T, Allentoft, M E, Sikora, M, Nielsen, R, Racimo, F & Willerslev, E 2024, 'The selection landscape and genetic legacy of ancient Eurasians', Nature, vol. 625, no. 7994, pp. 312-320. https://doi.org/10.1038/s41586-023-06705-1

Schlagwörter: History, Multifactorial Inheritance, European People, Population genetics, Diabetes Mellitus/genetics, Historical Studies, History, Ancient, 2. Zero hunger, Asia/ethnology, Human/genetics, Genome, Farmers, Settore BIOS-03/B - Antropologia, Agriculture, Genomics, Multigene Family/genetics, Biological Sciences, Europe, Phenotype, Archaeology, Multigene Family, Agriculture/history, Genetic Loci/genetics, Human, UK Biobank, Asia, General Science & Technology, Human Migration, Settore BIO/08, Europe/ethnology, Evolutionary genetics, Article, Ancient, Genetic, Farmers/history, Alzheimer Disease, evolution, Genetics, Diabetes Mellitus, Hunting, Humans, Genetic Predisposition to Disease, Selection, Genetic, Heritage and Archaeology, Multifactorial Inheritance/genetics, Selection, Alleles, Alzheimer Disease/genetics, Hunting/history, Asian, Asian/genetics, Genome, Human, Molecular, 15. Life on land, Human Society, Affect, Good Health and Well Being, Genetic Loci, Anthropology, European People/genetics, 2.4 Surveillance and distribution

Dateibeschreibung: application/pdf; application/zip; text/xml

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38200293
https://curis.ku.dk/ws/files/413742373/s41586_023_06705_1.pdf
https://www.repository.cam.ac.uk/handle/1810/363427
https://doi.org/10.1038/s41586-023-06705-1
https://www.repository.cam.ac.uk/handle/1810/363366
https://doi.org/10.1038/s41586-023-06705-1
https://www.repository.cam.ac.uk/handle/1810/363243
https://doi.org/10.1038/s41586-023-06705-1
https://www.repository.cam.ac.uk/handle/1810/358292
https://doi.org/10.17863/cam.102009
https://doi.org/10.1038/s41586-023-06705-1
https://discovery-pp.ucl.ac.uk/id/eprint/10186055/
https://escholarship.org/uc/item/11n930bt
https://escholarship.org/content/qt11n930bt/qt11n930bt.pdf
https://pure.au.dk/portal/en/publications/ad057386-7274-4fac-b19d-14717dd4dcb2
http://www.scopus.com/inward/record.url?scp=85181453656&partnerID=8YFLogxK
https://doi.org/10.1038/s41586-023-06705-1

APOBEC3C, a nucleolar protein induced by genotoxins, is excluded from DNA damage sites

Autoren: Daniel Constantin Gilles Dubuis María del Carmen Conde‐Rubio et al.

Quelle: FEBS J
The FEBS journal, vol. 289, no. 3, pp. 808-831

Schlagwörter: 0301 basic medicine, 0303 health sciences, DNA End-Joining Repair, DNA Repair, Genome, Human, Cell Nucleolus/genetics, Cytidine Deaminase/genetics, DNA Breaks, Double-Stranded/drug effects, DNA Damage/drug effects, DNA Damage/genetics, DNA End-Joining Repair/genetics, DNA Repair/drug effects, DNA Repair/genetics, Etoposide/pharmacology, Gene Expression Regulation/drug effects, Genome, Human/genetics, Homologous Recombination/genetics, Humans, Multigene Family/genetics, Mutagens/pharmacology, Mutation/genetics, Tumor Suppressor Protein p53/genetics, APOBEC3C, DNA repair, cancer biology, nucleolus, p53, Original Articles, 03 medical and health sciences, Gene Expression Regulation, Cytidine Deaminase, Multigene Family, Mutation, DNA Breaks, Double-Stranded, Tumor Suppressor Protein p53, Homologous Recombination, Cell Nucleolus, DNA Damage, Etoposide, Mutagens

Dateibeschreibung: application/pdf

Zugangs-URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.16202
https://pubmed.ncbi.nlm.nih.gov/34528388
https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.16202
https://serval.unil.ch/notice/serval:BIB_549304C0D4F3
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_549304C0D4F30
https://serval.unil.ch/resource/serval:BIB_549304C0D4F3.P001/REF.pdf

Complete Genomes of the Anaerobic Degradation Specialists Aromatoleum petrolei ToN1T and Aromatoleum bremense PbN1T

Autoren: Weiten, Arne Kalvelage, Kristin Becker, Patrick et al.

Quelle: Microbial Physiology. 31:16-35

Schlagwörter: 0301 basic medicine, Rhodocyclaceae, Hydrocarbons, Aromatic, 12. Responsible consumption, 03 medical and health sciences, Nitrogenase, 11. Sustainability, Benzene Derivatives, Anaerobiosis, 14. Life underwater, Phylogeny, 2. Zero hunger, 0303 health sciences, Whole Genome Sequencing, Terpenes, Nitrogenase/genetics [MeSH], Rhodocyclaceae/genetics [MeSH], Rhodocyclaceae/classification [MeSH], Physiology, Terpenes/metabolism [MeSH], Type VI Secretion Systems/genetics [MeSH], Benzene Derivatives/metabolism [MeSH], Gluconeogenesis/genetics [MeSH], Mobilome, Genome, Bacterial/genetics [MeSH], Energy Metabolism/genetics [MeSH], Anaerobic degradation, Metabolism, Research Article, Comparative genomics, Rhodocyclaceae/metabolism [MeSH], Whole Genome Sequencing [MeSH], Hydrocarbons, Aromatic/metabolism [MeSH], Aromatic compounds, Denitrification, Multigene Family/genetics [MeSH], Interspersed Repetitive Sequences/genetics [MeSH], Phylogeny [MeSH], Anaerobiosis/genetics [MeSH], Complete genome, Genetic Techniques [MeSH], Carbohydrate Metabolism/genetics [MeSH], Gluconeogenesis, Type VI Secretion Systems, 15. Life on land, 6. Clean water, 3. Good health, Interspersed Repetitive Sequences, Genetic Techniques, 13. Climate action, Multigene Family, Carbohydrate Metabolism, Energy Metabolism, Genome, Bacterial

Zugangs-URL: https://www.karger.com/Article/Pdf/513167
https://pubmed.ncbi.nlm.nih.gov/33477134
https://www.ncbi.nlm.nih.gov/pubmed/33477134
https://pubmed.ncbi.nlm.nih.gov/33477134/
https://repository.publisso.de/resource/frl:6476608

Genetic mechanisms of critical illness in COVID-19

Autoren: Pairo-Castineira, Erola Clohisey, Sara Klaric, Lucija et al.

Weitere Verfasser: Pairo-Castineira, Erola Clohisey, Sara Klaric, Lucija et al.

Quelle: Nature (Lond.) 591 (2021): 92–98. doi:10.1038/s41586-020-03065-y
info:cnr-pdr/source/autori:Pairo-Castineira E.; Clohisey S.; Klaric L.; Bretherick A.D.; Rawlik K.; Pasko D.; Walker S.; Parkinson N.; Fourman M.H.; Russell C.D.; Furniss J.; Richmond A.; Gountouna E.; Wrobel N.; Harrison D.; Wang B.; Wu Y.; Meynert A.; Griffiths F.; Oosthuyzen W.; Kousathanas A.; Moutsianas L.; Yang Z.; Zhai R.; Zheng C.; Grimes G.; Beale R.; Millar J.; Shih B.; Keating S.; Zechner M.; Haley C.; Porteous D.J.; Hayward C.; Yang J.; Knight J.; Summers C.; Shankar-Hari M.; Klenerman P.; Turtle L.; Ho A.; Moore S.C.; Hinds C.; Horby P.; Nichol A.; Maslove D.; Ling L.; McAuley D.; Montgomery H.; Walsh T.; Pereira A.C.; Renieri A.; Millar J.; Nichol A.; Walsh T.; Shankar-Hari M.; Ponting C.; Meikle J.; Finernan P.; Mcmaster E.; Law A.; Baillie J.K.; Paterson T.; Wackett T.; Armstrong R.; Clark R.; Coutts A.; Donnelly L.; Gilchrist T.; Hafezi K.; Macgillivray L.; Maclean A.; McCafferty S.; Morrice K.; Weaver J.; Boz C.; Golightly A.; Ward M.; Mal H.; Szoor-McElhinney H.; Brown A.; 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Whittle H.; Prady H.; Chan R.; Ahmed A.; Morris A.; Gibson C.; Gordon E.; Keenan S.; Quinn H.; Benyon S.; Marriott S.; Zitter L.; Park L.; Baines K.; Lyons M.; Holland M.; Keenan N.; Young M.; Garrioch S.; Dawson J.; Tolson M.; Scholefield B.; Bi R.; Richardson N.; Schumacher N.; Cosier T.; Millen G.; Higham A.; Simpson K.; Turki S.; Allen L.; Crisp N.; Hazleton T.; Knight A.; Deery J.; Price C.; Turney S.; Tilbey S.; Beranova E.; Wright D.; George L.; Twiss S.; Cowton A.; Wadd S.; Postlethwaite K.; Gondo P.; Masunda B.; Kayani A.; Hadebe B.; Whiteside J.; Campbell R.; Clarke N.; Donnison P.; Trim F.; Leadbitter I.; Butcher D.; O'Sullivan S.; Purewal B.; Bell S.; Rivers V.; O'Leary R.; Birch J.; Collins E.; Anderson S.; Hammerton K.; Andrews E.; Higham A.; Burns K.; Edmond I.; Salutous D.; Todd A.; Donnachie J.; Turner P.; Prentice L.; Symon L.; Runciman N.; Auld F.; Halkes M.; Mercer P.; Thornton L.; Debreceni G.; Wilkins J.; Brown A.; Crickmore V.; Subramanian G.; Marshall R.; Jennings C.; Latif M.; Bunni L.; Spivey M.; Bean S.; Burt K.; Linnett V.; Ritzema J.; Sanderson A.; McCormick W.; Bokhari M.; Kapoor R.; Loader D.; Ayers A.; Harrison W.; North J.; Belagodu Z.; Paramsothy R.; Olufuwa O.; Gherman A.; Fuller B.; Stuart C.; Kelsall O.; Davis C.; Wild L.; Wood H.; Thrush J.; Durie A.; Austin K.; Archer K.; Anderson P.; Vigurs C.; Thorpe C.; Thomas A.; Knights E.; Boyle N.; Price A.; Kubisz-Pudelko A.; Wood D.; Lewis A.; Board S.; Pippard L.; Perry J.; Beesley K.; Rattray A.; Taylor M.; Lee E.; Lennon L.; Douglas K.; Bell D.; Boyle R.; Glass L.; Nauman Akhtar M.; Dent K.; Potoczna D.; Pearson S.; Horsley E.; Spencer S.; Phillips C.; Mullan D.; Skinner D.; Gaylard J.; Ortiz-Ruiz de Gordoa L.; Barber R.; Hewitt C.; Hilldrith A.; Shepardson S.; Wills M.; Jackson-Lawrence K.; Gupta A.; Easthope A.; Timlick E.; Gorman C.; Otahal I.; Gales A.; Coetzee S.; Sell C.; Raj M.; Peiu M.; Parris V.; Quaid S.; Watson E.; Elliott K.; Mallinson J.; Chandler B.; Turnbull A.; Quinn A.; Finch C.; Holl C.; Cooper J.; Evans A.; Khaliq W.; Collins A.; Gude E.T.; Love N.; van Koutrik L.; Hunt J.; Kaye D.; Fisher E.; Brayne A.; Tuckey V.; Jackson P.; Parkin J.; Brealey D.; Raith E.; Tariq A.; Houlden H.; Tucci A.; Hardy J.; Moncur E.; Highgate J.; Cowley A.; Mitra A.; Stead R.; Behan T.; Burnett C.; Newton M.; Heeney E.; Pollard R.; Hatton J.; Patel A.; Kasipandian V.; Allibone S.; Genetu R.M.; Otahal I.; O'Brien L.; Omar Z.; Perkins E.; Davies K.; Tetla D.; Pothecary C.; Deacon B.; Shelley B.; Irvine V.; Williams S.; Williams P.; Birch J.; Goodsell J.; Tutton R.; Bough L.; Winter-Goodwin B.; Kitson R.; Pinnell J.; Wilson A.; Nortcliffe T.; Wood T.; Home M.; Holdroyd K.; Robinson M.; Hanson K.; Shaw R.; Greig J.; Brady M.; Haigh A.; Matupe L.; Usher M.; Mellor S.; Dale S.; Gledhill L.; Shaw L.; Turner G.; Kelly D.; Anwar B.; Riley H.; Sturgeon H.; Ali A.; Thomis L.; Melia D.; Dance A.; Humphreys S.; Frost I.; Gopal V.; Godden J.; Holden A.; Swann S.; Smith T.; Clapham M.; Poultney U.; Harper R.; Rice P.; Khaliq W.; Reece-Anthony R.; Gurung B.; Moultrie S.; Odam M.; Mayer A.; Bellini A.; Pickard A.; Bryant J.; Roe N.; Sowter J.; Butcher D.; Lang K.; Taylor J.; Barry P.; Hobrok M.; Tench H.; Wolf-Roberts R.; McGuinness H.; Loosley R.; Hawcutt D.; Rad L.; O'Malley L.; Saunderson P.; Seddon G.; Anderson T.; Rogers N.; Ruddy J.; Harkins M.; Taylor M.; Beith C.; McAlpine A.; Ferguson L.; Grant P.; MacFadyen S.; McLaughlin M.; Baird T.; Rundell S.; Glass L.; Welsh B.; Hamill R.; Fisher F.; Smith T.; Gregory J.; Brown A.; Campbell A.; Smuts S.; Kenneth Baillie J.; Carson G.; Alex B.; Bach B.; Barclay W.S.; Bogaert D.; Chand M.; Cooke G.S.; Docherty A.B.; Dunning J.; da Silva Filipe A.; Fletcher T.; Green C.A.; Harrison E.M.; Hiscox J.A.; Ho A.Y.W.; Horby P.W.; Ijaz S.; Khoo S.; Klenerman P.; Lim W.S.; Mentzer A.J.; Merson L.; Meynert A.M.; Noursadeghi M.; Moore S.C.; Palmarini M.; Paxton W.A.; Pollakis G.; Price N.; Rambaut A.; Robertson D.L.; Sancho-Shimizu V.; Scott J.T.; de Silva T.; Sigfrid L.; Solomon T.; Sriskandan S.; Stuart D.; Tedder R.S.; Thomson E.C.; Thompson A.A.R.; Thwaites R.S.; Turtle L.C.W.; Zambon M.; Hardwick H.; Donohue C.; Lyons R.; Norman L.; Pius R.; Drake T.M.; Fairfield C.J.; Knight S.R.; Mclean K.A.; Murphy D.; Shaw C.A.; Dalton J.; Girvan M.; Saviciute E.; Roberts S.; Harrison J.; Marsh L.; Connor M.; Halpin S.; Jackson C.; Gamble C.; Leeming G.; Wham M.; Greenhalf W.; Shaw V.; McDonald S.; Keating S.; Ganna A.; Sulem P.; van Heel D.A.; Cordioli M.; Sveinbjornsson G.; Niemi M.E.K.; Shelton J.F.; Shastri A.J.; Ye C.; Weldon C.H.; Filshtein-Sonmez T.; Coker D.; Symons A.; Esparza-Gordillo J.; Aslibekyan S.; Auton A.; Krieger J.E.; Marques E.; Jannes C.E.; Mari F.; Daga S.; Baldassarri M.; Benetti E.; Furini S.; Fallerini C.; Fava F.; Valentino F.; Doddato G.; Giliberti A.; Tita R.; Amitrano S.; Bruttini M.; Croci S.; Meloni I.; Pinto A.M.; Frullanti E.; Mencarelli M.A.; Rizzo C.L.; Montagnani F.; Di Sarno L.; Tommasi A.; Palmieri M.; Emiliozzi A.; Fabbiani M.; Rossetti B.; Zanelli G.; Bargagli E.; Bergantini L.; D'Alessandro M.; Cameli P.; Bennet D.; Anedda F.; Marcantonio S.; Scolletta S.; Franchi F.; Mazzei M.A.; Guerrini S.; Conticini E.; Cantarini L.; Frediani B.; Tacconi D.; Spertilli C.; Feri M.; Donati A.; Scala R.; Guidelli L.; Spargi G.; Corridi M.; Nencioni C.; Croci L.; Caldarelli G.P.; Spagnesi M.; Piacentini P.; Bandini M.; Desanctis E.; Cappelli S.; Canaccini A.; Verzuri A.; Anemoli V.; Ognibene A.; Vaghi M.; D'Arminio Monforte A.; Merlini E.; Mondelli M.U.; Mantovani S.; Ludovisi S.; Girardis M.; Venturelli S.; Sita M.; Cossarizza A.; Antinori A.; Vergori A.; Rusconi S.; Siano M.; Gabrieli A.; Riva A.; Francisci D.; Schiaroli E.; Scotton P.G.; Andretta F.; Panese S.; Scaggiante R.; Gatti F.; Parisi S.G.; Castelli F.; Quiros-Roldan M.E.; Magro P.; Zanella I.; Della Monica M.; Piscopo C.; Capasso M.; Russo R.; Andolfo I.; Iolascon A.; Fiorentino G.; Carella M.; Castori M.; Merla G.; Aucella F.; Raggi P.; Marciano C.; Perna R.; Bassetti M.; Di Biagio A.; Sanguinetti M.; Masucci L.; Valente S.; Mandala M.; Giorli A.; Salerni L.; Zucchi P.; Parravicini P.; Menatti E.; Baratti S.; Trotta T.; Giannattasio F.; Coiro G.; Lena F.; Coviello D.A.; Mussini C.; Bosio G.; Martinelli E.; Mancarella S.; Tavecchia L.; Crotti L.; Picchiotti N.; Gori M.; Gabbi C.; Sanarico M.; Ceri S.; Pinoli P.; Raimondi F.; Biscarini F.; Stella A.; Shen X.; Ponting C.P.; Fawkes A.; Tenesa A.; Caulfield M.; Scott R.; Rowan K.; Murphy L.; Openshaw P.J.M.; Semple M.G.; Law A.; Vitart V.; Wilson J.F.; Baillie J.K./titolo:Genetic mechanisms of critical illness in COVID-19/doi:10.1038%2Fs41586-020-03065-y/rivista:Nature (Lond.)/anno:2021/pagina_da:92/pagina_a:98/intervallo_pagine:92–98/volume:591
NATURE
Pairo-Castineira, E, Clohisey, S, Klaric, L, Bretherick, A, Rawlik, K, Parkinson, N, Pasko, D, Walker, S, Richmond, A, Fourman, M H, Law, A, Furniss, J, Gountouna, E, Wrobel, N, Russell, C D, Moutsianas, L, Wang, B, Meynert, A M, Yang, Z, Zhai, R, Zheng, C, Griffith, F, Oosthuyzen, W, Shih, B, Keating, S, Zechner, M, Haley, C S, Porteous, D, Hayward, C, Knight, J, Summers, C, Shankar-Hari, M, Turtle, L, Ho, A, Hinds, C, Horby, P, Nichol, A, Maslove, D M, Ling, L, Klenerman, P, McAuley, D F, Montgomery, H E, Walsh, T S, Shen, X, Rowan, K, Fawkes, A, Murphy, L, Ponting, C P, Tenesa, A & Caulfield, M & Scott, R & Openshaw, P & Semple, M G & Vitart, V & Wilson, J & Baillie, J K 2020, ' Genetic mechanisms of critical illness in Covid-19 ', Nature, vol. n/a, n/a . https://doi.org/10.1038/s41586-020-03065-y
GenOMICC Investigators & Hughes, G 2021, ' Genetic mechanisms of critical illness in COVID-19 ', Nature, vol. 591, 7848, pp. 92-98 . https://doi.org/10.1038/s41586-020-03065-y
Nature

Schlagwörter: Male, 0301 basic medicine, 2',5'-Oligoadenylate Synthetase/genetics, Chromosomes, Human, Pair 21, Pair 19/genetics, Receptor, Interferon alpha-beta, Genome-wide association studies, 23andMe Investigators, Interferon alpha-beta, Inflammation/genetics, Receptors, 2',5'-Oligoadenylate Synthetase, Receptors, CCR2/genetics, Pair 12, Receptor, Interferon alpha-beta/genetics, genetics, CCR2/genetics, Lung, 2', 5'-Oligoadenylate Synthetase, COVID-19, Chromosomes, Human, Pair 19, Pair 21, Critical Care, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, Drug Repositioning, Female, Genome-Wide Association Study, Humans, Inflammation, Multigene Family, Receptor, CCR2, TYK2 Kinase, United Kingdom, Critical Illness, BRACOVID Investigators, Pair 12/genetics, 0303 health sciences, Multidisciplinary, Chromosomes, Human, Pair 21/genetics, Multigene Family/genetics, GenOMICC Investigators, COVID-19/genetics, 3. Good health, covid-19, Dipeptidyl-Peptidases and Tripeptidyl-Peptidase, General Science & Technology, Receptors, CCR2, Genome-wide association studiesm, Lung/pathology, Chromosomes, Human, Pair 19/genetics, 5'-Oligoadenylate Synthetase/genetics, 03 medical and health sciences, Immunogenetics, critical illness, Gen-COVID Investigators, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/genetics, TYK2 Kinase/genetics, Chromosomes, Human, Pair 12/genetics, Chromosomes, Human, Pair 12, Interferon alpha-beta/genetics, SARS-CoV-2, covid 19, Pair 21/genetics, COVID-19 Human Genetics Initiative, Viral infection, Chromosomes, Human, Pair 19, ISARICC Investigators

Dateibeschreibung: application/pdf; STAMPA

Zugangs-URL: https://www.nature.com/articles/s41586-020-03065-y.pdf
https://pubmed.ncbi.nlm.nih.gov/33307546
http://livrepository.liverpool.ac.uk/3112058/1/genomicc_nature.citemd.pdf
http://hdl.handle.net/11588/874222
https://www.repository.cam.ac.uk/handle/1810/313893
https://discovery.ucl.ac.uk/id/eprint/10117424/
https://www.ndm.ox.ac.uk/publications/1148841
http://pubmed.ncbi.nlm.nih.gov/33307546/
http://eprints.gla.ac.uk/226569/
https://livrepository.liverpool.ac.uk/3112067/
http://hdl.handle.net/10044/1/85822
https://www.pure.ed.ac.uk/ws/files/179716483/genomicc_nature.citemd.pdf
https://hdl.handle.net/20.500.11820/0ea3f7a9-4bd1-45fc-8c51-90c7c5e30a28
https://discovery-pp.ucl.ac.uk/id/eprint/10117424/

Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases

Autoren: István Molnár Yuquan Xu Qingpei Liu et al.

Quelle: Journal of the American Chemical Society. 142:17093-17104

Schlagwörter: Fungal Proteins/chemistry, Models, Molecular, 0301 basic medicine, Protein Conformation, Acyltransferases/chemistry, Phenylacetates/chemistry, Saccharomyces cerevisiae, Thiolester Hydrolases/chemistry, 01 natural sciences, Fungal Proteins, 03 medical and health sciences, Saccharomyces cerevisiae/metabolism, Ascomycota, Models, Combinatorial Chemistry Techniques, Amino Acid Sequence, Polyketide Synthases/biosynthesis, Phenylacetates, Molecular, Multigene Family/genetics, Biosynthetic Pathways, 0104 chemical sciences, Multigene Family, Ascomycota/enzymology, Thiolester Hydrolases, Polyketide Synthases, Acyltransferases

Zugangs-URL: https://europepmc.org/articles/pmc7659983?pdf=render
https://pubmed.ncbi.nlm.nih.gov/32833442
https://cris.vtt.fi/en/publications/b4f15c55-3088-49c1-8049-ffdbc20acc8f
https://doi.org/10.1021/jacs.0c07050
https://pubmed.ncbi.nlm.nih.gov/32833442/
https://www.ncbi.nlm.nih.gov/pubmed/32833442
https://pubs.acs.org/doi/abs/10.1021/jacs.0c07050
https://arizona.pure.elsevier.com/en/publications/intrinsic-and-extrinsic-programming-of-product-chain-length-and-r
http://europepmc.org/article/MED/32833442
https://pubs.acs.org/doi/10.1021/jacs.0c07050

Molecular analysis of the fibrinogen gene cluster in 16 patients with congenital afibrinogenemia: novel truncating mutations in the FGA and FGG genes

Autoren: Neerman-Arbez, M. de Moerloose, P. Honsberger, A. et al.

Schlagwörter: Afibrinogenemia/congenital/*genetics Blotting, Southern DNA/chemistry/genetics DNA Mutational Analysis Fibrinogen/*genetics Humans Infant Infant, Newborn Multigene Family/*genetics Mutation

Relation: Human Genetics; https://iris.unil.ch/handle/iris/69579; serval:BIB_1E4E89639152; 000168063800012

Verfügbarkeit: https://iris.unil.ch/handle/iris/69579
https://doi.org/10.1007/s004390100469

Comparative genomics of ParaHox clusters of teleost fishes: gene cluster breakup and the retention of gene sets following whole genome duplications.

Autoren: Siegel, N. Hoegg, S. Salzburger, W. et al.

Schlagwörter: Animals, Cichlids, Evolution, Fishes/genetics, Gene Duplication, Genes, Homeobox, Genomics/methods, Multigene Family/genetics, Phylogeny

Dateibeschreibung: application/pdf

Relation: BMC Genomics; 1471-2164[electronic], 1471-2164[linking]; https://iris.unil.ch/handle/iris/36325; serval:BIB_3E6A17077602; 000250214400001

Verfügbarkeit: https://iris.unil.ch/handle/iris/36325
https://doi.org/10.1186/1471-2164-8-312

Identification of cancer/testis-antigen genes by massively parallel signature sequencing.

Autoren: Chen, Y.T. Scanlan, M.J. Venditti, C.A. et al.

Schlagwörter: Antigens, Neoplasm/genetics, Base Sequence, Cell Line, Tumor, Chromosomes, Human, X/genetics, Computational Biology, DNA Primers, DNA, Complementary/genetics, Databases, Nucleic Acid, Expressed Sequence Tags, Gene Expression Profiling/methods, Humans, Male, Molecular Sequence Data, Multigene Family/genetics, RNA, Messenger/genetics, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, RNA/methods, Testis/metabolism

Relation: Proceedings of the National Academy of Sciences of the United States of America; 0027-8424[print], 0027-8424[linking]; https://iris.unil.ch/handle/iris/250292; serval:BIB_F162E516267A; 000229531000030

Verfügbarkeit: https://iris.unil.ch/handle/iris/250292
https://doi.org/10.1073/pnas.0502583102

The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol

Autoren: Telenti, A. Philipp, W. J. Sreevatsan, S. et al.

Schlagwörter: Amino Acid Sequence Antitubercular Agents/*pharmacology Cloning, Molecular Drug Resistance, Microbial/genetics Ethambutol/*pharmacology Gene Expression Regulation, Bacterial Genes, Bacterial/genetics Molecular Sequence Data Multigene Family/genetics Mycobacterium/drug effects/genetics Mycobacterium tuberculosis/*drug effects/enzymology/genetics Operon/*genetics Pentosyltransferases/*genetics RNA, Bacterial/genetics RNA, Messenger/genetics Sequence Analysis, DNA Sequence Homology, Amino Acid

Relation: Nature Medicine; https://iris.unil.ch/handle/iris/245251; serval:BIB_F8935806C8A1; A1997WX54300040; 9142129

Verfügbarkeit: https://iris.unil.ch/handle/iris/245251
https://doi.org/10.1038/nm0597-567

Characterization of the PHO1 gene family and the responses to phosphate deficiency of Physcomitrella patens.

Autoren: Wang, Y. Secco, D. Poirier, Y.

Schlagwörter: Amino Acid Sequence, Bryopsida/genetics, Bryopsida/metabolism, Cloning, Molecular, Gene Expression Regulation, Plant, Molecular Sequence Data, Multigene Family/genetics, Phosphates/deficiency, Phylogeny, Plant Proteins/chemistry, Plant Proteins/genetics, Protein Transport

Relation: Plant Physiology; https://iris.unil.ch/handle/iris/228618; serval:BIB_955AE2F7F8A2; 000252892700027

Verfügbarkeit: https://iris.unil.ch/handle/iris/228618
https://doi.org/10.1104/pp.107.108548

Gene cluster lock after pheromone receptor gene choice

Autoren: Roppolo, D. Vollery, S. Kan, C. D. et al.

Schlagwörter: Alleles Animals Chemoreceptors/metabolism Chemotactic Factors/genetics Gene Deletion *Gene Expression Regulation Male Mice Multigene Family/*genetics Neurons, Afferent/cytology/metabolism Receptors, Pheromone/*genetics Vomeronasal Organ/cytology/metabolism

Relation: The EMBO Journal; https://iris.unil.ch/handle/iris/194046; serval:BIB_7DDF710AD8B4; 000248675600013

Verfügbarkeit: https://iris.unil.ch/handle/iris/194046
https://doi.org/10.1038/sj.emboj.7601782

Non-monophyly of the woody bamboos (Bambuseae; Poaceae): a multi-gene region phylogenetic analysis of Bambusoideae s.s.

Autoren: Sungkaew, S. Stapleton, C.M. Salamin, N. et al.

Schlagwörter: DNA, Plant/genetics, Demography, Multigene Family/genetics, Phylogeny, Poaceae/classification, Poaceae/genetics

Relation: Journal of Plant Research; https://iris.unil.ch/handle/iris/181806; serval:BIB_79DDCBBB280B; 000262241300009

Verfügbarkeit: https://iris.unil.ch/handle/iris/181806
https://doi.org/10.1007/s10265-008-0192-6

Biased V beta usage in immature thymocytes is independent of DJ beta proximity and pT alpha pairing.

Autoren: Wilson, A. Maréchal, C. MacDonald, H.R.

Schlagwörter: Animals, Cell Differentiation/genetics, Cell Differentiation/immunology, Cell Division/genetics, Cell Division/immunology, Female, Flow Cytometry, Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor, beta-Chain T-Cell Antigen Receptor, Intracellular Fluid/immunology, Intracellular Fluid/metabolism, Membrane Glycoproteins/biosynthesis, Membrane Glycoproteins/genetics, Mice, Inbred C57BL, Knockout, Multigene Family/genetics, Multigene Family/immunology, Protein Precursors/biosynthesis, Protein Precursors/genetics, Receptors, Antigen, T-Cell, alpha-beta/analysis, alpha-beta/biosynthesis, Staining and Labeling, T-Lymphocytes/chemistry, T-Lymphocytes/cytology, Thymus Gland/chemistry

Relation: The Journal of Immunology; https://iris.unil.ch/handle/iris/113510; serval:BIB_18253; 000166012400009

Verfügbarkeit: https://iris.unil.ch/handle/iris/113510

Structure and expression profile of the Arabidopsis PHO1 gene family indicates a broad role in inorganic phosphate homeostasis.

Autoren: Wang, Y. Ribot, C. Rezzonico, E. et al.

Schlagwörter: Amino Acid Sequence, Arabidopsis/genetics, Arabidopsis/metabolism, Arabidopsis Proteins/genetics, Arabidopsis Proteins/metabolism, Cloning, Molecular, DNA, Complementary/chemistry, Complementary/genetics, Gene Expression Profiling/methods, Gene Expression Regulation, Plant, Homeostasis, Molecular Sequence Data, Multigene Family/genetics, Phosphates/metabolism, Phylogeny, Protein-Serine-Threonine Kinases/genetics, Protein-Serine-Threonine Kinases/metabolism, Sequence Analysis, Sequence Homology, Amino Acid

Relation: Plant Physiology; https://iris.unil.ch/handle/iris/106366; serval:BIB_61212F40FF51; 000221420800041

Verfügbarkeit: https://iris.unil.ch/handle/iris/106366
https://doi.org/10.1104/pp.103.037945

Identification of Leishmania major cysteine proteinases as targets of the immune response in humans.

Autoren: Rafati, S. Salmanian, A.H. Hashemi, K. et al.

Schlagwörter: Animals, Antibodies, Protozoan/immunology, Antigens, Protozoan/biosynthesis, Protozoan/genetics, Blotting, Southern, Cathepsins/biosynthesis, Cathepsins/genetics, Cloning, Molecular, Cysteine Endopeptidases/biosynthesis, Cysteine Endopeptidases/genetics, Genome, Protozoan, Humans, Immune Sera/immunology, Immunoblotting, Leishmania major/enzymology, Leishmania major/immunology, Leishmaniasis, Cutaneous/immunology, Mice, Inbred BALB C, Molecular Sequence Data, Multigene Family/genetics, Recombinant Proteins/biosynthesis, Recombinant Proteins/immunology

Relation: Molecular and Biochemical Parasitology; https://iris.unil.ch/handle/iris/105496; serval:BIB_5CAE97E74F6C; 000167753200004

Verfügbarkeit: https://iris.unil.ch/handle/iris/105496
https://doi.org/10.1016/S0166-6851(00)00377-7

Identification of the catalytic residues of the first family of beta(1-3)glucanosyltransferases identified in fungi

Autoren: Mouyna, I. Monod, M. Fontaine, T. et al.

Schlagwörter: Amino Acid Sequence Aspergillus fumigatus/*enzymology Binding Sites Blotting, Western *Catalytic Domain Conserved Sequence/genetics Fungal Proteins/*chemistry/classification/genetics/*metabolism Glucan Endo-1,3-beta-D-Glucosidase/*chemistry/classification/genetics/*metabolism Glutamic Acid/genetics/metabolism Glycosylphosphatidylinositols/metabolism Molecular Sequence Data Multigene Family/genetics Mutation/genetics Protein Structure, Secondary Recombinant Proteins/chemistry/classification/genetics/metabolism Sequence Alignment

Relation: Biochemical Journal; https://iris.unil.ch/handle/iris/246010; serval:BIB_FC6D84CC638B; 000087187700017

Verfügbarkeit: https://iris.unil.ch/handle/iris/246010
https://doi.org/10.1042/0264-6021:3470741

Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution.

Autoren: International Chicken Genome Sequencing, Consortium including Duplanloup, I. Kaessmann, H. et al.

Schlagwörter: Animals, Avian Proteins/genetics, Chickens/genetics, Conserved Sequence/genetics, DNA Transposable Elements/genetics, Evolution, Molecular, Gene Duplication, Genes/genetics, Genome, Genomics, Humans, Long Interspersed Nucleotide Elements/genetics, Multigene Family/genetics, Mutagenesis/genetics, Physical Chromosome Mapping, Pseudogenes/genetics, RNA, Untranslated/genetics, Retroviridae/genetics, Sequence Analysis, DNA, Short Interspersed Nucleotide Elements/genetics, Synteny, Vertebrates/genetics

Relation: Nature; 1476-4687[electronic]; https://iris.unil.ch/handle/iris/135258; serval:BIB_BE48F0F02A81; 000225597200038

Verfügbarkeit: https://iris.unil.ch/handle/iris/135258
https://doi.org/10.1038/nature03154

Long-Read Metagenome-Assembled Genomes Improve Identification of Novel Complete Biosynthetic Gene Clusters in a Complex Microbial Activated Sludge Ecosystem

Autoren: Roberto Sánchez-Navarro Matin Nuhamunada Omkar S. Mohite et al.

Quelle: mSystems
mSystems, Vol 7, Iss 6 (2022)
Sanchez Navarro, R, Nuhamunada, M, Mohite, O, Wasmund, K, Albertsen, M, Gram, L, Nielsen, P H, Weber, T & Singleton, C M 2022, 'Long-Read Metagenome-Assembled Genomes Improve Identification of Novel Complete Biosynthetic Gene Clusters in a Complex Microbial Activated Sludge Ecosystem', mSystems, vol. 7, no. 6, e00632-22. https://doi.org/10.1128/msystems.00632-22
Sánchez-Navarro, R, Nuhamunada, M, Mohite, O S, Wasmund, K, Albertsen, M, Gram, L, Nielsen, P H, Weber, T & Singleton, C M 2022, ' Long-Read Metagenome-Assembled Genomes Improve Identification of Novel Complete Biosynthetic Gene Clusters in a Complex Microbial Activated Sludge Ecosystem ', mSystems, vol. 7, no. 6, e0063222 . https://doi.org/10.1128/msystems.00632-22

Schlagwörter: 0301 basic medicine, Wastewater treatment plant, Biosynthetic gene cluster, Metagenome-assembled genome, secondary metabolite, metagenome-assembled genome, Microbiology, 12. Responsible consumption, Secondary metabolite, 03 medical and health sciences, 11. Sustainability, Microbiota/genetics, activated sludge, wastewater treatment plant, 0303 health sciences, biosynthetic gene cluster, Sewage, Microbiota, Genome, Bacterial/genetics, Multigene Family/genetics, QR1-502, 6. Clean water, Activated sludge, Multigene Family, Metagenome, Metagenome/genetics, Genome, Bacterial, Research Article

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/36445112
https://doaj.org/article/0947fcb43073427ebb4b30695a50a305
https://vbn.aau.dk/ws/files/518922905/msystems.00632_22.pdf
https://doi.org/10.1128/msystems.00632-22
https://vbn.aau.dk/da/publications/3e9a8af2-52aa-48f2-a7d8-9cbaa6b554e1
http://www.scopus.com/inward/record.url?scp=85144355474&partnerID=8YFLogxK
https://orbit.dtu.dk/en/publications/16a91c8c-f203-47bc-bb59-22d072a10142

Identification of a functional FADS1 3′UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels

Autoren: Hermant, X. Delay, C. Flaig, A. et al.

Weitere Verfasser: Hermant, X. Delay, C. Flaig, A. et al.

Quelle: Journal of Clinical Lipidology. 12:1280-1289

Schlagwörter: Fatty Acid Desaturases, Male, 0301 basic medicine, Erythrocytes, [SDV]Life Sciences [q-bio], MESH: Base Sequence, MESH: Multigene Family/genetics, Delta-5 Fatty Acid Desaturase, Omega-6/metabolism, Genetic epidemiology, 3' Untranslated Regions, MESH: Aged, 0303 health sciences, MESH: Middle Aged, Gene polymorphism, Hep G2 Cells, Middle Aged, MESH: Fatty Acids, [SDV] Life Sciences [q-bio], Phenotype, Multigene Family, Female, MESH: MicroRNAs/genetics, MESH: Computational Biology, Adult, MESH: Erythrocytes/metabolism, Desaturase, Down-Regulation, MESH: Hep G2 Cells, MESH: Phenotype, Polymorphism, Single Nucleotide, MESH: Down-Regulation/genetics, 03 medical and health sciences, Fatty Acids, Omega-6, Functional variant, Humans, FADS1, MESH: Polymorphism, Alleles, miRNA, Aged, MESH: Humans, Base Sequence, MESH: Fatty Acid Desaturases/genetics, MESH: Alleles, Computational Biology, MESH: Adult, MESH: 3' Untranslated Regions/genetics, Single Nucleotide, MESH: Male, MicroRNAs, Polyunsaturated fatty acids, MESH: Female

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/30170993
https://pubmed.ncbi.nlm.nih.gov/30170993/
https://www.ncbi.nlm.nih.gov/pubmed/30170993
https://www.sciencedirect.com/science/article/pii/S1933287418303520
https://www.lipidjournal.com/article/S1933-2874(18)30352-0/fulltext
https://hal.science/hal-02003441v1
https://doi.org/10.1016/j.jacl.2018.07.012

Spatial enhancer clustering and regulation of enhancer-proximal genes by cohesin

Autoren: Ing-Simmons, E Seitan, VC Faure, AJ et al.

Weitere Verfasser: Ing-Simmons, E Seitan, VC Faure, AJ et al.

Quelle: Genome Res
Ing-Simmons, E, Seitan, V C, Faure, A J, Flicek, P, Carroll, T, Dekker, J, Fisher, A G, Lenhard, B & Merkenschlager, M 2015, ' Spatial enhancer clustering and regulation of enhancer-proximal genes by cohesin ', Genome Research, vol. 25, no. 4, pp. 504-513 . https://doi.org/10.1101/gr.184986.114

Schlagwörter: 0301 basic medicine, CCCTC-Binding Factor, Chromosomal Proteins, Non-Histone, cohesin, Cell Cycle Proteins, CHROMATIN ARCHITECTURE, Binding Sites/genetics, Histones, Mice, Structural Biology, IDENTITY GENES, Promoter Regions, Genetic, 11 Medical and Health Sciences, Cells, Cultured, Genetics & Heredity, 0303 health sciences, Cultured, Thymocytes, Systems Biology, Genomics, Multigene Family/genetics, Chromosomal Proteins, Thymocytes/cytology, DIFFERENTIATION, Enhancer Elements, Genetic, Multigene Family, Life Sciences & Biomedicine, Protein Binding, EXPRESSION, Biochemistry & Molecular Biology, Enhancer Elements, Bioinformatics, Cells, Gene Expression Regulation/genetics, Protein Binding/genetics, Promoter Regions, Chromosomal Proteins, Non-Histone/genetics, GENOME ORGANIZATION, 03 medical and health sciences, Genetic, Animals, Cohesins, Genetic/genetics, Cell Cycle Proteins/genetics, Histones/genetics, Science & Technology, Binding Sites, LANDSCAPE, INSULATORS, Repressor Proteins/metabolism, Research, Enhancer Elements, Genetic/genetics, Computational Biology, Non-Histone, 06 Biological Sciences, CTCF, Promoter Regions, Genetic/genetics, SUPER-ENHANCERS, Repressor Proteins, Biotechnology & Applied Microbiology, Gene Expression Regulation, 13. Climate action, Non-Histone/genetics, EMBRYONIC STEM-CELLS

Dateibeschreibung: application/pdf

Zugangs-URL: http://genome.cshlp.org/content/25/4/504.full.pdf
https://pubmed.ncbi.nlm.nih.gov/25677180
https://www.ncbi.nlm.nih.gov/pubmed/25677180
http://europepmc.org/articles/PMC4381522
https://escholarship.umassmed.edu/sysbio_pubs/60/
https://kclpure.kcl.ac.uk/portal/en/publications/spatial-enhancer-clustering-and-regulation-of-enhancerproximal-genes-by-cohesin(330233f4-9802-4b92-8dfb-3f5047b49524).html
https://pubmed.ncbi.nlm.nih.gov/25677180/
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1059&context=sysbio_pubs
http://hdl.handle.net/10044/1/19519
https://kclpure.kcl.ac.uk/en/publications/330233f4-9802-4b92-8dfb-3f5047b49524
https://kclpure.kcl.ac.uk/portal/en/publications/330233f4-9802-4b92-8dfb-3f5047b49524