Suchergebnisse - "Multidrug resistance"

Retrospective analysis of the correlation between MRP2 expression in circulating tumor cells and molecular characteristics of breast cancer.

Autoren: Guan J Li F Zhou W et al.

Quelle: Medicine [Medicine (Baltimore)] 2025 Nov 21; Vol. 104 (47), pp. e45986.

Publikationsart: Journal Article; Observational Study

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

MeSH-Schlagworte: Neoplastic Cells, Circulating*/metabolism , Neoplastic Cells, Circulating*/pathology , Breast Neoplasms*/pathology , Breast Neoplasms*/genetics , Breast Neoplasms*/metabolism , Breast Neoplasms*/blood , Multidrug Resistance-Associated Proteins*/metabolism, Humans ; Female ; Multidrug Resistance-Associated Protein 2 ; Middle Aged ; Retrospective Studies ; Adult ; Biomarkers, Tumor/metabolism ; Aged ; Receptors, Progesterone/metabolism ; Receptors, Estrogen/metabolism ; Triple Negative Breast Neoplasms/pathology ; Triple Negative Breast Neoplasms/metabolism

Associations between host efflux pump gene polymorphisms (ABCB1, ABCC1, ABCG2) and drug-resistant tuberculosis in a Chinese cohort.

Autoren: Tang D La B He JQ

Quelle: Gene [Gene] 2025 Nov 20; Vol. 972, pp. 149826. Date of Electronic Publication: 2025 Oct 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE

MeSH-Schlagworte: ATP Binding Cassette Transporter, Subfamily G, Member 2*/genetics , Multidrug Resistance-Associated Proteins*/genetics , Neoplasm Proteins*/genetics , Polymorphism, Single Nucleotide* , Tuberculosis, Multidrug-Resistant*/genetics, Adult ; Female ; Humans ; Male ; Middle Aged ; Antitubercular Agents/therapeutic use ; Asian People/genetics ; ATP Binding Cassette Transporter, Subfamily B/genetics ; Case-Control Studies ; China ; Cohort Studies ; Genetic Predisposition to Disease ; Genotype ; Multidrug Resistance-Associated Protein 2 ; East Asian People/genetics

Evaluation of Genetic Marker Polymorphisms (MTHFRC677T and ABCC2 C) for Predicting Methotrexate Toxicity in Psoriasis Patients in Egypt: A Case-Control Study.

Autoren: Ahmed AMS Salam MHA Zohairy EAF et al.

Quelle: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2025 Oct; Vol. 39 (10), pp. e70537.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print Cited Medium: Internet ISSN: 1099-0461 (Electronic) Linking ISSN: 10956670 NLM ISO Abbreviation: J Biochem Mol Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Methotrexate*/adverse effects , Methotrexate*/therapeutic use , Methylenetetrahydrofolate Reductase (NADPH2)*/genetics , Multidrug Resistance-Associated Proteins*/genetics , Polymorphism, Single Nucleotide* , Psoriasis*/drug therapy , Psoriasis*/genetics, Humans ; Multidrug Resistance-Associated Protein 2 ; Case-Control Studies ; Male ; Female ; Egypt ; Adult ; Middle Aged ; Genetic Markers ; Alleles

Differential roles of ABCC2, ABCC3, and cadherin in mediating Cry1Ac toxicity in Spodoptera exigua.

Autoren: Jin Z Wang X Wu Y et al.

Quelle: Pesticide biochemistry and physiology [Pestic Biochem Physiol] 2026 Jan; Vol. 216 (Pt 1), pp. 106721. Date of Electronic Publication: 2025 Sep 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 1301573 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9939 (Electronic) Linking ISSN: 00483575 NLM ISO Abbreviation: Pestic Biochem Physiol Subsets: MEDLINE

MeSH-Schlagworte: Bacillus thuringiensis Toxins* , Spodoptera*/drug effects , Spodoptera*/genetics , Spodoptera*/metabolism , Multidrug Resistance-Associated Proteins*/genetics , Multidrug Resistance-Associated Proteins*/metabolism , Hemolysin Proteins*/toxicity , Endotoxins*/toxicity , Cadherins*/genetics , Cadherins*/metabolism , Bacterial Proteins*/toxicity , Insect Proteins*/genetics , Insect Proteins*/metabolism , Insecticides*/toxicity, Animals ; Multidrug Resistance-Associated Protein 2 ; Sf9 Cells ; Gene Knockout Techniques ; Insecticide Resistance/genetics

Nano-pectic polysaccharide from vinegar-baked Radix Bupleuri enhances methotrexate efficacy against hepatocellular carcinoma via BCRP and MRP2 downregulation.

Autoren: Wang X Gan J Han M et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Jul; Vol. 318 (Pt 2), pp. 145046. Date of Electronic Publication: 2025 Jun 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/genetics , Liver Neoplasms*/drug therapy , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Liver Neoplasms*/genetics , Bupleurum*/chemistry , ATP Binding Cassette Transporter, Subfamily G, Member 2*/genetics , ATP Binding Cassette Transporter, Subfamily G, Member 2*/metabolism , Neoplasm Proteins*/genetics , Neoplasm Proteins*/metabolism , Methotrexate*/pharmacology , Multidrug Resistance-Associated Proteins*/metabolism , Multidrug Resistance-Associated Proteins*/genetics , Polysaccharides*/chemistry , Polysaccharides*/pharmacology , Pectins*/chemistry , Pectins*/pharmacology , Down-Regulation*/drug effects , Nanoparticles*/chemistry, Humans ; Animals ; Multidrug Resistance-Associated Protein 2 ; Mice ; Acetic Acid/chemistry ; Cell Line, Tumor ; Drug Synergism ; Gene Expression Regulation, Neoplastic/drug effects ; Hep G2 Cells ; Cell Proliferation/drug effects ; Xenograft Model Antitumor Assays

Oxidative stress promotes post-translational down-regulation of MRP2 in Caco-2 cells: Involvement of proteasomal degradation and toxicological implications.

Autoren: Ricardi LL Zecchinati F Perdomo VG et al.

Quelle: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2025 Jul; Vol. 201, pp. 115459. Date of Electronic Publication: 2025 Apr 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Oxidative Stress*/drug effects , Down-Regulation*/drug effects , Proteasome Endopeptidase Complex*/metabolism , Multidrug Resistance-Associated Proteins*/metabolism , Multidrug Resistance-Associated Proteins*/genetics , Protein Processing, Post-Translational*, Humans ; Caco-2 Cells ; Multidrug Resistance-Associated Protein 2 ; tert-Butylhydroperoxide/toxicity ; tert-Butylhydroperoxide/pharmacology ; Reactive Oxygen Species/metabolism ; Glutathione/metabolism ; Lipid Peroxidation/drug effects

Acute Response of Hepatocyte MRP2 Internalization as an Indicator of Ischemia-reperfusion Injury in Liver Transplantation.

Autoren: Monti C Hong SK Lee A et al.

Quelle: Transplantation [Transplantation] 2025 Sep 01; Vol. 109 (9), pp. 1495-1505. Date of Electronic Publication: 2025 May 05.

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0132144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-6080 (Electronic) Linking ISSN: 00411337 NLM ISO Abbreviation: Transplantation Subsets: MEDLINE

MeSH-Schlagworte: Liver Transplantation*/adverse effects , Reperfusion Injury*/metabolism , Reperfusion Injury*/diagnosis , Reperfusion Injury*/pathology , Reperfusion Injury*/etiology , Hepatocytes*/metabolism , Hepatocytes*/pathology , Multidrug Resistance-Associated Proteins*/metabolism, Animals ; Male ; Multidrug Resistance-Associated Protein 2 ; Biomarkers/metabolism ; Rats ; Perfusion ; Humans ; Disease Models, Animal ; Liver/metabolism ; Liver/pathology ; Time Factors ; Bile/metabolism ; ATP-Binding Cassette Transporters

A recurrent ABCC2 c.2439 + 5G > A variant disturbs mRNA splicing and causes Dubin-Johnson syndrome.

Autoren: Sun R Zhu T Zhou T et al.

Quelle: BMC medical genomics [BMC Med Genomics] 2025 Jul 18; Vol. 18 (1), pp. 118. Date of Electronic Publication: 2025 Jul 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101319628 Publication Model: Electronic Cited Medium: Internet ISSN: 1755-8794 (Electronic) Linking ISSN: 17558794 NLM ISO Abbreviation: BMC Med Genomics Subsets: MEDLINE

MeSH-Schlagworte: RNA Splicing* , Jaundice, Chronic Idiopathic*/genetics , Jaundice, Chronic Idiopathic*/pathology , Multidrug Resistance-Associated Proteins*/genetics, Humans ; Multidrug Resistance-Associated Protein 2 ; Male ; Female ; Exome Sequencing ; Pedigree ; RNA, Messenger/genetics

Impact of low BMI and ABCC2 genotype on the clinical response of sequential anthracycline-taxane chemotherapy receiving breast cancer patients: a hospital-based study.

Autoren: Mistry T Sengupta S Kumar RS et al.

Quelle: The pharmacogenomics journal [Pharmacogenomics J] 2025 Jul 16; Vol. 25 (4), pp. 22. Date of Electronic Publication: 2025 Jul 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101083949 Publication Model: Electronic Cited Medium: Internet ISSN: 1473-1150 (Electronic) Linking ISSN: 1470269X NLM ISO Abbreviation: Pharmacogenomics J Subsets: MEDLINE

MeSH-Schlagworte: Multidrug Resistance-Associated Proteins*/genetics , Body Mass Index* , Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Antineoplastic Combined Chemotherapy Protocols*/administration & dosage , Anthracyclines*/administration & dosage, Humans ; Multidrug Resistance-Associated Protein 2 ; Female ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Genotype ; Adult ; Aged ; ATP Binding Cassette Transporter, Subfamily B/genetics ; Treatment Outcome

Functional Characterization and In Silico Prediction Tools Improve the Pathogenicity Prediction of Novel Bile Acid Transporter Variants.

Autoren: Peng Z Wang X Li Y et al.

Quelle: Clinical genetics [Clin Genet] 2025 Jul; Vol. 108 (1), pp. 3-13. Date of Electronic Publication: 2025 Jan 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 0253664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-0004 (Electronic) Linking ISSN: 00099163 NLM ISO Abbreviation: Clin Genet Subsets: MEDLINE

MeSH-Schlagworte: Bile Acids and Salts*/metabolism , Bile Acids and Salts*/genetics , Multidrug Resistance-Associated Proteins*/genetics , Genetic Predisposition to Disease* , Cholestasis*/genetics , Cholestasis*/pathology, Humans ; Male ; Female ; Multidrug Resistance-Associated Protein 2 ; Mutation, Missense ; Computer Simulation ; Adult ; Middle Aged ; Computational Biology/methods ; Mutation ; Child ; Adolescent ; Glycosylation

ABCC2 as a novel covariate influencing oxcarbazepine pharmacokinetics in pediatric epilepsy: Insights from population modeling.

Autoren: Shen X Zhu J He Y et al.

Quelle: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2025 Jun; Vol. 53 (6), pp. 100090. Date of Electronic Publication: 2025 May 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

MeSH-Schlagworte: Oxcarbazepine*/pharmacokinetics , Oxcarbazepine*/administration & dosage , Multidrug Resistance-Associated Proteins*/genetics , Multidrug Resistance-Associated Proteins*/metabolism , Epilepsy*/drug therapy , Epilepsy*/genetics , Epilepsy*/blood , Anticonvulsants*/pharmacokinetics , Anticonvulsants*/administration & dosage , Anticonvulsants*/blood , Carbamazepine*/analogs & derivatives , Carbamazepine*/pharmacokinetics , Carbamazepine*/administration & dosage , Carbamazepine*/blood , Models, Biological*, Humans ; Multidrug Resistance-Associated Protein 2 ; Child ; Male ; Female ; Child, Preschool ; Adolescent ; Monte Carlo Method ; Polymorphism, Single Nucleotide ; Infant ; Body Weight

Two pathways mediate toxicity of Cry1Ac in Mythimna separata: one is ABCC2-dependent and the other involves ABCC3-CAD interaction.

Autoren: Wang H Bian H Liu Z et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 May; Vol. 310 (Pt 2), pp. 143392. Date of Electronic Publication: 2025 Apr 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Multidrug Resistance-Associated Proteins*/metabolism , Multidrug Resistance-Associated Proteins*/genetics , Bacillus thuringiensis Toxins*/toxicity , Hemolysin Proteins*/toxicity , Endotoxins*/toxicity , Bacterial Proteins*/toxicity , Cadherins*/metabolism , Cadherins*/genetics , Moths*/drug effects , Moths*/metabolism , Moths*/genetics , Insect Proteins*/metabolism , Insect Proteins*/genetics, Animals ; Multidrug Resistance-Associated Protein 2 ; Larva/drug effects ; Larva/metabolism ; Cell Line ; Bacillus thuringiensis

PDZK1 inhibits MRP2-mediated oxaliplatin chemosensitivity in hepatocellular carcinoma.

Autoren: Duan Z Li J Ren C et al.

Quelle: Scientific reports [Sci Rep] 2025 Apr 18; Vol. 15 (1), pp. 13438. Date of Electronic Publication: 2025 Apr 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/genetics , Liver Neoplasms*/drug therapy , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Liver Neoplasms*/genetics , Oxaliplatin*/pharmacology , Oxaliplatin*/therapeutic use , Multidrug Resistance-Associated Proteins*/metabolism , Multidrug Resistance-Associated Proteins*/genetics , Drug Resistance, Neoplasm*, Humans ; Multidrug Resistance-Associated Protein 2 ; Animals ; Male ; Female ; Cell Line, Tumor ; Mice ; Gene Expression Regulation, Neoplastic/drug effects ; Middle Aged ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Proliferation/drug effects ; Prognosis ; Cell Movement/drug effects ; Xenograft Model Antitumor Assays ; Signal Transduction ; Retrospective Studies ; Membrane Proteins

[Clinical and molecular genetic analysis of nine patients with neonatal Dubin-Johnson syndrome].

Autoren: Xu T Li D Guo L et al.

Quelle: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology [Zhonghua Gan Zang Bing Za Zhi] 2025 May 20; Vol. 33 (5), pp. 481-488.

Publikationsart: English Abstract; Journal Article

Info zur Zeitschrift: Publisher: Chongqing yi ke da xue, di 2 lin chuang xue yuan Bing du xing gan yan yan jiu suo Country of Publication: China NLM ID: 9710009 Publication Model: Print Cited Medium: Print ISSN: 1007-3418 (Print) Linking ISSN: 10073418 NLM ISO Abbreviation: Zhonghua Gan Zang Bing Za Zhi Subsets: MEDLINE

MeSH-Schlagworte: Multidrug Resistance-Associated Proteins*/genetics , Jaundice, Chronic Idiopathic*/genetics , Jaundice, Chronic Idiopathic*/diagnosis, Humans ; Multidrug Resistance-Associated Protein 2 ; Male ; Female ; Infant, Newborn ; Infant ; Mutation ; Genotype ; Phenotype

Genetic polymorphisms of ABCC2 and CBR3 can influence the efficacy and toxicity of doxorubicin therapy in Egyptian patients with non-Hodgkin lymphoma.

Autoren: Elmekawy HA Abdelkawy K Magdy G et al.

Quelle: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2025 May; Vol. 55 (5), pp. 349-359. Date of Electronic Publication: 2025 May 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1366-5928 (Electronic) Linking ISSN: 00498254 NLM ISO Abbreviation: Xenobiotica Subsets: MEDLINE

MeSH-Schlagworte: Doxorubicin*/therapeutic use , Doxorubicin*/adverse effects , Multidrug Resistance-Associated Proteins*/genetics , Lymphoma, Non-Hodgkin*/drug therapy , Lymphoma, Non-Hodgkin*/genetics , Polymorphism, Single Nucleotide*/genetics , Sulfonylurea Receptors*/genetics , Antibiotics, Antineoplastic*/therapeutic use , Antibiotics, Antineoplastic*/adverse effects, Humans ; Multidrug Resistance-Associated Protein 2 ; Egypt ; Female ; Male ; Middle Aged ; Adult ; Aged ; Genotype ; Alcohol Oxidoreductases

Association of ABC Efflux Transporter Genetic Variants and Adverse Drug Reactions and Survival in Patients with Non-Small Lung Cancer.

Autoren: Seguin CS Fidelis GFS Dagli-Hernandez C et al.

Quelle: Genes [Genes (Basel)] 2025 Apr 15; Vol. 16 (4). Date of Electronic Publication: 2025 Apr 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Non-Small-Cell Lung*/genetics , Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/mortality , Carcinoma, Non-Small-Cell Lung*/pathology , Lung Neoplasms*/genetics , Lung Neoplasms*/drug therapy , Lung Neoplasms*/mortality , Lung Neoplasms*/pathology , Multidrug Resistance-Associated Proteins*/genetics , Drug-Related Side Effects and Adverse Reactions*/genetics, Humans ; Male ; Female ; Multidrug Resistance-Associated Protein 2 ; Middle Aged ; Aged ; ATP Binding Cassette Transporter, Subfamily B/genetics ; Polymorphism, Single Nucleotide ; Paclitaxel/adverse effects ; Paclitaxel/administration & dosage ; Carboplatin/adverse effects ; Carboplatin/administration & dosage ; Adult ; Genotype

CYP3A4 and MRP2 are predominant metabolic regulators attribute to the toxicity/efficacy of aconitine derived from Fuzi.

Autoren: Yao J Guo Y Wan T et al.

Quelle: Journal of ethnopharmacology [J Ethnopharmacol] 2025 Mar 13; Vol. 343, pp. 119463. Date of Electronic Publication: 2025 Feb 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Cytochrome P-450 CYP3A*/genetics , Cytochrome P-450 CYP3A*/metabolism , Aconitine*/toxicity , Aconitine*/pharmacology , Multidrug Resistance-Associated Proteins*/metabolism , Multidrug Resistance-Associated Proteins*/genetics , Aconitum*/chemistry, Animals ; Mice, Knockout ; Humans ; Mice ; Multidrug Resistance-Associated Protein 2 ; Male ; Mice, Transgenic ; Mice, Inbred C57BL ; Heart Failure/drug therapy ; Heart Failure/chemically induced ; Pain/drug therapy

Wogonin effects on the efflux transporters BCRP and MRP2, explain its effectiveness in ulcerative colitis: Implications for metabolic and transport interactions.

Autoren: Liu Y Zhang Z Li X et al.

Quelle: Pharmacological research [Pharmacol Res] 2025 Feb; Vol. 212, pp. 107570. Date of Electronic Publication: 2024 Dec 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE

MeSH-Schlagworte: Flavanones*/therapeutic use , Flavanones*/pharmacology , Flavanones*/pharmacokinetics , ATP Binding Cassette Transporter, Subfamily G, Member 2*/metabolism , ATP Binding Cassette Transporter, Subfamily G, Member 2*/genetics , Colitis, Ulcerative*/drug therapy , Colitis, Ulcerative*/metabolism , Colitis, Ulcerative*/chemically induced , Multidrug Resistance-Associated Proteins*/metabolism , Multidrug Resistance-Associated Proteins*/genetics , Neoplasm Proteins*/metabolism , Neoplasm Proteins*/genetics, Animals ; Multidrug Resistance-Associated Protein 2 ; Mice, Knockout ; Humans ; Male ; Mice, Inbred C57BL ; Dextran Sulfate ; Mice ; Colon/metabolism ; Colon/drug effects ; Colon/pathology ; Biological Transport

Protective role of ABCC drug subfamily resistance transporters (ABCC1-7) in intestinal inflammation.

Autoren: Fonseca-Camarillo G Furuzawa-Carballeda J Miguel-Cruz E et al.

Quelle: Immunologic research [Immunol Res] 2025 Jan 14; Vol. 73 (1), pp. 33. Date of Electronic Publication: 2025 Jan 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8611087 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-0755 (Electronic) Linking ISSN: 0257277X NLM ISO Abbreviation: Immunol Res Subsets: MEDLINE

MeSH-Schlagworte: Multidrug Resistance-Associated Proteins*/genetics , Multidrug Resistance-Associated Proteins*/metabolism , Colitis, Ulcerative*/drug therapy , Colitis, Ulcerative*/immunology , Colitis, Ulcerative*/chemically induced , Colitis, Ulcerative*/genetics , Colitis*/chemically induced, Animals ; Humans ; Mice ; Dextran Sulfate ; Disease Models, Animal ; Male ; Female ; Multidrug Resistance-Associated Protein 2 ; Adult ; Mesalamine/therapeutic use ; Methylprednisolone/therapeutic use ; Middle Aged ; Intestinal Mucosa/metabolism

Evaluation of Novel Diaza Cage Compounds as MRP Modulators in Cancer Cells.

Autoren: Döring H Kreutzer D von Veh J et al.

Quelle: Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2025; Vol. 25 (1), pp. 63-74.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 101265649 Publication Model: Print Cited Medium: Internet ISSN: 1875-5992 (Electronic) Linking ISSN: 18715206 NLM ISO Abbreviation: Anticancer Agents Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Multidrug Resistance-Associated Proteins*/antagonists & inhibitors , Multidrug Resistance-Associated Proteins*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Dihydropyridines*/pharmacology , Dihydropyridines*/chemistry , Dihydropyridines*/chemical synthesis , Aza Compounds*/pharmacology , Aza Compounds*/chemistry , Aza Compounds*/chemical synthesis, Humans ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Cell Proliferation/drug effects ; Molecular Structure ; Dose-Response Relationship, Drug ; Multidrug Resistance-Associated Protein 2 ; Cell Line, Tumor ; Drug Resistance, Neoplasm/drug effects