Suchergebnisse - "Molecular Targeted Therapy"

[Personalized systemic therapy of penile cancer: molecular targets and new therapeutic horizons].

Transliterierter Titel: Personalisierte Systemtherapie beim Peniskarzinom: Molekulare Zielstrukturen und neue therapeutische Horizonte.

Autoren: von Amsberg G; Professur für Uroonkologie, Universitäres Cancer Center Hamburg und Martini-Klinik, Martini-Klinik Haus O40, Martinistr. 52, 20246, Hamburg, Deutschland. g.von-amsberg@uke.de.

Quelle: Urologie (Heidelberg, Germany) [Urologie] 2025 Dec; Vol. 64 (12), pp. 1280-1287. Date of Electronic Publication: 2025 Nov 12.

Publikationsart: English Abstract; Journal Article; Review

Info zur Zeitschrift: Publisher: Springer Medizin Country of Publication: Germany NLM ID: 9918384886606676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-7072 (Electronic) Linking ISSN: 27317064 NLM ISO Abbreviation: Urologie Subsets: MEDLINE

MeSH-Schlagworte: Penile Neoplasms*/drug therapy , Penile Neoplasms*/therapy , Penile Neoplasms*/genetics , Molecular Targeted Therapy*/methods , Molecular Targeted Therapy*/trends , Precision Medicine*/methods , Precision Medicine*/trends, Humans ; Male ; Immunotherapy/methods

Advances in Cardiovascular Pharmacotherapy. V. Molecular Targets in Transthyretin Amyloid Cardiomyopathy.

Autoren: Pagel PS Hang D Freed JK et al.

Quelle: Journal of cardiothoracic and vascular anesthesia [J Cardiothorac Vasc Anesth] 2025 Dec; Vol. 39 (12), pp. 3506-3524. Date of Electronic Publication: 2025 Aug 06.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 9110208 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8422 (Electronic) Linking ISSN: 10530770 NLM ISO Abbreviation: J Cardiothorac Vasc Anesth Subsets: MEDLINE

MeSH-Schlagworte: Amyloid Neuropathies, Familial*/drug therapy , Amyloid Neuropathies, Familial*/genetics , Amyloid Neuropathies, Familial*/metabolism , Cardiomyopathies*/drug therapy , Cardiomyopathies*/metabolism , Cardiomyopathies*/genetics , Prealbumin*/genetics , Prealbumin*/metabolism , Molecular Targeted Therapy*/methods , Molecular Targeted Therapy*/trends , Cardiovascular Agents*/therapeutic use, Humans ; Animals

SCR Disease Name: Amyloidosis, Hereditary, Transthyretin-Related

Mitochondrial dysfunction in hepatocellular carcinoma: from metabolism to targeted therapies.

Autoren: Sharafi F Rismani E Rhmanian M et al.

Quelle: Molecular and cellular biochemistry [Mol Cell Biochem] 2025 Dec; Vol. 480 (12), pp. 6015-6038. Date of Electronic Publication: 2025 Aug 30.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol Cell Biochem Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/therapy , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/drug therapy , Liver Neoplasms*/therapy , Molecular Targeted Therapy* , Mitochondria*/metabolism , Mitochondria*/pathology , Mitochondria, Liver*/metabolism , Mitochondria, Liver*/pathology, Humans ; Animals ; Mitophagy ; Oxidative Stress

Advances in Tissue-Agnostic Targeting in Cancer Therapeutics: Current Approvals, Challenges, and Future Directions.

Autoren: Rubinstein M Hong ML Nanda RK et al.

Quelle: Oncology research [Oncol Res] 2025 Oct 22; Vol. 33 (11), pp. 3161-3183. Date of Electronic Publication: 2025 Oct 22 (Print Publication: 2025).

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Tech Science Press Country of Publication: United States NLM ID: 9208097 Publication Model: eCollection Cited Medium: Internet ISSN: 1555-3906 (Electronic) Linking ISSN: 09650407 NLM ISO Abbreviation: Oncol Res Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/drug therapy , Neoplasms*/pathology , Neoplasms*/genetics , Molecular Targeted Therapy*/methods , Molecular Targeted Therapy*/trends , Precision Medicine*/methods , Precision Medicine*/trends , Antineoplastic Agents*/therapeutic use, Humans ; Biomarkers, Tumor/genetics ; Drug Approval

[Selective, controlled release of ruthenium-based therapeutic agents: a targeted weapon against ovarian cancer].

Transliterierter Titel: Libération sélective et contrôlée d’agents thérapeutiques à base de ruthénium : une arme ciblée contre le cancer de l’ovaire.

Autoren: Marlin A Decaudin D Thomas CM et al.

Quelle: Medecine sciences : M/S [Med Sci (Paris)] 2025 Oct; Vol. 41 (10), pp. 753-759. Date of Electronic Publication: 2025 Nov 19.

Publikationsart: Journal Article; Review; English Abstract

Info zur Zeitschrift: Publisher: EDK Country of Publication: France NLM ID: 8710980 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1958-5381 (Electronic) Linking ISSN: 07670974 NLM ISO Abbreviation: Med Sci (Paris) Subsets: MEDLINE

MeSH-Schlagworte: Ovarian Neoplasms*/drug therapy , Ruthenium*/administration & dosage , Ruthenium*/therapeutic use , Ruthenium*/chemistry , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/chemistry , Drug Delivery Systems*/methods , Molecular Targeted Therapy*/methods , Molecular Targeted Therapy*/trends, Humans ; Female ; Animals ; Delayed-Action Preparations/administration & dosage ; Coordination Complexes/administration & dosage ; Coordination Complexes/therapeutic use

Targeted triplet therapies incorporating FLT3 or IDH inhibitors: ready for prime time?

Autoren: Atluri H Abaza Y Altman JK

Quelle: Hematology. American Society of Hematology. Education Program [Hematology Am Soc Hematol Educ Program] 2025 Dec 05; Vol. 2025 (1), pp. 592-598.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 100890099 Publication Model: Print Cited Medium: Internet ISSN: 1520-4383 (Electronic) Linking ISSN: 15204383 NLM ISO Abbreviation: Hematology Am Soc Hematol Educ Program Subsets: MEDLINE

MeSH-Schlagworte: Isocitrate Dehydrogenase*/antagonists & inhibitors , Isocitrate Dehydrogenase*/genetics , Isocitrate Dehydrogenase*/metabolism , fms-Like Tyrosine Kinase 3*/antagonists & inhibitors , fms-Like Tyrosine Kinase 3*/genetics , fms-Like Tyrosine Kinase 3*/metabolism , Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/genetics , Leukemia, Myeloid, Acute*/enzymology , Molecular Targeted Therapy* , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use, Humans ; Mutation ; Sulfonamides/therapeutic use ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use

All shades of gray in the mediastinum: do we have bright ideas about how to diagnose and treat mediastinal gray zone lymphoma in the era of targeted agents?

Autoren: Sarkozy C Traverse-Glehen A

Quelle: Hematology. American Society of Hematology. Education Program [Hematology Am Soc Hematol Educ Program] 2025 Dec 05; Vol. 2025 (1), pp. 547-554.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 100890099 Publication Model: Print Cited Medium: Internet ISSN: 1520-4383 (Electronic) Linking ISSN: 15204383 NLM ISO Abbreviation: Hematology Am Soc Hematol Educ Program Subsets: MEDLINE

MeSH-Schlagworte: Mediastinal Neoplasms*/diagnosis , Mediastinal Neoplasms*/therapy , Mediastinal Neoplasms*/metabolism , Mediastinal Neoplasms*/drug therapy , Mediastinal Neoplasms*/pathology , Hodgkin Disease*/diagnosis , Hodgkin Disease*/therapy , Hodgkin Disease*/pathology , Lymphoma, Large B-Cell, Diffuse*/diagnosis , Lymphoma, Large B-Cell, Diffuse*/therapy , Lymphoma, B-Cell*/diagnosis , Lymphoma, B-Cell*/therapy , Molecular Targeted Therapy*, Humans ; Herpesvirus 4, Human ; Epstein-Barr Virus Infections/diagnosis

Targeting Microglial Activation to Modulate Neuroinflammation in Alzheimer's Disease.

Autoren: Patil V Sharma A Parekh B et al.

Quelle: Neuromolecular medicine [Neuromolecular Med] 2025 Dec 04; Vol. 27 (1), pp. 76. Date of Electronic Publication: 2025 Dec 04.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 101135365 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1174 (Electronic) Linking ISSN: 15351084 NLM ISO Abbreviation: Neuromolecular Med Subsets: MEDLINE

MeSH-Schlagworte: Alzheimer Disease*/drug therapy , Alzheimer Disease*/immunology , Alzheimer Disease*/pathology , Microglia*/physiology , Microglia*/drug effects , Microglia*/immunology , Neuroinflammatory Diseases*/drug therapy , Molecular Targeted Therapy*, Humans ; Animals ; Signal Transduction/drug effects ; Receptors, Immunologic/antagonists & inhibitors ; Receptors, Immunologic/physiology ; Membrane Glycoproteins/physiology ; Membrane Glycoproteins/antagonists & inhibitors ; Neuroprotective Agents/therapeutic use ; Neuroprotective Agents/pharmacology ; Plaque, Amyloid ; Amyloid beta-Peptides

Multi-omics integrated analysis identifies causal risk factors and therapeutic targets for diabetic retinopathy.

Autoren: Xu J Chen S Sun M et al.

Quelle: Journal of translational medicine [J Transl Med] 2025 Dec 03; Vol. 23 (1), pp. 1374. Date of Electronic Publication: 2025 Dec 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH-Schlagworte: Diabetic Retinopathy*/genetics , Diabetic Retinopathy*/therapy , Molecular Targeted Therapy*, Humans ; Risk Factors ; Mendelian Randomization Analysis ; Nutrition Surveys ; Causality ; Computational Biology ; Gene Expression Profiling ; Multiomics

Integration of PSMA-Targeted Theranostics into Multidisciplinary Care for Improved Efficiencies and Patient Care.

Autoren: Kuo PH Poku EK Yamauchi DM et al.

Quelle: Journal of nuclear medicine technology [J Nucl Med Technol] 2025 Dec 03; Vol. 53 (4), pp. 300-304. Date of Electronic Publication: 2025 Dec 03.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0430303 Publication Model: Electronic Cited Medium: Internet ISSN: 1535-5675 (Electronic) Linking ISSN: 00914916 NLM ISO Abbreviation: J Nucl Med Technol Subsets: MEDLINE

MeSH-Schlagworte: Glutamate Carboxypeptidase II*/metabolism , Patient Care* , Antigens, Surface*/metabolism , Theranostic Nanomedicine*/methods , Prostatic Neoplasms*/diagnostic imaging , Prostatic Neoplasms*/therapy , Prostatic Neoplasms*/metabolism , Prostatic Neoplasms*/radiotherapy , Molecular Targeted Therapy*/methods, Humans ; Male

Reprogramming the Course of Precancer with Targeted Therapeutic Intervention: Lessons from Interception in Gastric Preneoplasia.

Autoren: Goldenring JR Choi E Nomura S

Quelle: Cancer prevention research (Philadelphia, Pa.) [Cancer Prev Res (Phila)] 2025 Dec 02; Vol. 18 (12), pp. 721-726.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101479409 Publication Model: Print Cited Medium: Internet ISSN: 1940-6215 (Electronic) Linking ISSN: 19406215 NLM ISO Abbreviation: Cancer Prev Res (Phila) Subsets: MEDLINE

MeSH-Schlagworte: Precancerous Conditions*/drug therapy , Precancerous Conditions*/pathology , Precancerous Conditions*/prevention & control , Stomach Neoplasms*/prevention & control , Stomach Neoplasms*/pathology , Stomach Neoplasms*/drug therapy , Molecular Targeted Therapy*/methods, Humans ; Animals ; Gastric Mucosa/pathology ; Gastric Mucosa/drug effects

Feasibility of targeted alpha therapy for Alzheimer's disease using ²¹¹ At-labeled agent targeting amyloid-β aggregates.

Autoren: Kashiyama R Watanabe H Akasaka T et al.

Quelle: Annals of nuclear medicine [Ann Nucl Med] 2025 Dec; Vol. 39 (12), pp. 1319-1325. Date of Electronic Publication: 2025 Aug 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Japan Country of Publication: Japan NLM ID: 8913398 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1864-6433 (Electronic) Linking ISSN: 09147187 NLM ISO Abbreviation: Ann Nucl Med Subsets: MEDLINE

MeSH-Schlagworte: Alzheimer Disease*/radiotherapy , Alzheimer Disease*/metabolism , Amyloid beta-Peptides*/metabolism , Amyloid beta-Peptides*/chemistry , Alpha Particles*/therapeutic use , Protein Aggregates*/radiation effects , Molecular Targeted Therapy*/methods, Animals ; Mice ; Feasibility Studies ; Tissue Distribution ; Benzofurans/chemistry ; Benzofurans/pharmacokinetics ; Benzofurans/therapeutic use ; Humans ; Male ; Isotope Labeling

Clinical Impact of Next-Generation Sequencing-Guided Targeted Therapies in Advanced Cancer: A Systematic Review and Meta-Analysis.

Autoren: Kazmi F Katyal R Liu TFD et al.

Quelle: Clinical oncology (Royal College of Radiologists (Great Britain)) [Clin Oncol (R Coll Radiol)] 2025 Dec; Vol. 48, pp. 103943. Date of Electronic Publication: 2025 Sep 23.

Publikationsart: Journal Article; Systematic Review; Meta-Analysis

Info zur Zeitschrift: Publisher: W.B. Saunders Country of Publication: England NLM ID: 9002902 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-2981 (Electronic) Linking ISSN: 09366555 NLM ISO Abbreviation: Clin Oncol (R Coll Radiol) Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/genetics , Neoplasms*/drug therapy , Neoplasms*/pathology , High-Throughput Nucleotide Sequencing*/methods , Molecular Targeted Therapy*/methods, Humans ; Precision Medicine/methods ; Randomized Controlled Trials as Topic

Updates on molecular targets and clinical trials with targeted therapies for pancreatic cancer.

Autoren: Safyan RA Chiorean EG

Quelle: Surgical oncology [Surg Oncol] 2025 Dec; Vol. 63, pp. 102268. Date of Electronic Publication: 2025 Jul 18.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9208188 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3320 (Electronic) Linking ISSN: 09607404 NLM ISO Abbreviation: Surg Oncol Subsets: MEDLINE

MeSH-Schlagworte: Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/pathology , Molecular Targeted Therapy*/methods , Biomarkers, Tumor*/antagonists & inhibitors , Biomarkers, Tumor*/genetics , Carcinoma, Pancreatic Ductal*/drug therapy , Carcinoma, Pancreatic Ductal*/genetics , Carcinoma, Pancreatic Ductal*/pathology, Humans ; Clinical Trials as Topic ; Precision Medicine

Mining tumor and surrounding tissue information using artificial intelligence to predict responses to EGFR-targeted therapies and immunotherapy in lung cancer: a multicenter attribution analysis.

Autoren: Zhang X He Y Rao T et al.

Quelle: La Radiologia medica [Radiol Med] 2025 Dec; Vol. 130 (12), pp. 1959-1972. Date of Electronic Publication: 2025 Oct 04.

Publikationsart: Journal Article; Multicenter Study

Info zur Zeitschrift: Publisher: Springer Milan Country of Publication: Italy NLM ID: 0177625 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1826-6983 (Electronic) Linking ISSN: 00338362 NLM ISO Abbreviation: Radiol Med Subsets: MEDLINE

MeSH-Schlagworte: Lung Neoplasms*/therapy , Lung Neoplasms*/genetics , Lung Neoplasms*/drug therapy , Lung Neoplasms*/diagnostic imaging , Carcinoma, Non-Small-Cell Lung*/therapy , Carcinoma, Non-Small-Cell Lung*/genetics , Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/diagnostic imaging , Artificial Intelligence* , Immunotherapy*/methods , Protein Kinase Inhibitors*/therapeutic use , Molecular Targeted Therapy* , Data Mining*, Humans ; ErbB Receptors/genetics ; ErbB Receptors/antagonists & inhibitors ; Male ; Female ; Middle Aged ; Aged ; Mutation ; China

Pathogenesis of Craniopharyngiomas and Targeted Approaches to Therapy.

Autoren: Gritsch S Brastianos PK

Quelle: Endocrinology and metabolism clinics of North America [Endocrinol Metab Clin North Am] 2025 Dec; Vol. 54 (4), pp. 703-714. Date of Electronic Publication: 2025 Jul 25.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 8800104 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-4410 (Electronic) Linking ISSN: 08898529 NLM ISO Abbreviation: Endocrinol Metab Clin North Am Subsets: MEDLINE

MeSH-Schlagworte: Craniopharyngioma*/genetics , Craniopharyngioma*/etiology , Craniopharyngioma*/pathology , Craniopharyngioma*/drug therapy , Craniopharyngioma*/therapy , Pituitary Neoplasms*/genetics , Pituitary Neoplasms*/pathology , Pituitary Neoplasms*/etiology , Pituitary Neoplasms*/drug therapy , Pituitary Neoplasms*/therapy , Molecular Targeted Therapy*/methods, Humans ; Proto-Oncogene Mas ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; Mutation

Systematic review of novel target therapies and clinical trials in chordoma.

Autoren: Zeinali M Seraj FQM Rawson C et al.

Quelle: Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2025 Dec; Vol. 259, pp. 109222. Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article; Systematic Review; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7502039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6968 (Electronic) Linking ISSN: 03038467 NLM ISO Abbreviation: Clin Neurol Neurosurg Subsets: MEDLINE

MeSH-Schlagworte: Chordoma*/drug therapy , Chordoma*/therapy , Chordoma*/genetics , Molecular Targeted Therapy*/methods , Central Nervous System Neoplasms*/drug therapy , Central Nervous System Neoplasms*/therapy , Central Nervous System Neoplasms*/genetics , Antineoplastic Agents*/therapeutic use, Humans ; Clinical Trials as Topic ; Animals

The role of nursing in enhancing quality of life for lung cancer patients receiving targeted and immunotherapy: Challenges, opportunities, and future directions.

Autoren: Sun YY Wei LM Qian Y

Quelle: Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2025 Dec; Vol. 21 (1), pp. 2506302. Date of Electronic Publication: 2025 May 20.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-554X (Electronic) Linking ISSN: 21645515 NLM ISO Abbreviation: Hum Vaccin Immunother Subsets: MEDLINE

MeSH-Schlagworte: Quality of Life* , Lung Neoplasms*/therapy , Lung Neoplasms*/nursing , Lung Neoplasms*/psychology , Immunotherapy*/methods , Immunotherapy*/adverse effects , Nurse's Role* , Molecular Targeted Therapy*, Humans

Theranostics 2.0: Target-driven, artificial intelligence-enabled cancer therapy across tumor types.

Autoren: Oldan JD Anugu A Islam MZ et al.

Quelle: Diagnostic and interventional imaging [Diagn Interv Imaging] 2025 Dec; Vol. 106 (12), pp. 413-420. Date of Electronic Publication: 2025 Aug 05.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Masson Country of Publication: France NLM ID: 101568499 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-5684 (Electronic) Linking ISSN: 22115684 NLM ISO Abbreviation: Diagn Interv Imaging Subsets: MEDLINE

MeSH-Schlagworte: Artificial Intelligence* , Neoplasms*/diagnostic imaging , Neoplasms*/therapy , Theranostic Nanomedicine*/methods , Molecular Targeted Therapy*, Humans ; Precision Medicine

Emerging molecular targets in deep vein thrombosis: from inflammation to coagulation.

Autoren: Zhang Z Hu J Bai Y et al.

Quelle: Hematology (Amsterdam, Netherlands) [Hematology] 2025 Dec; Vol. 30 (1), pp. 2548735. Date of Electronic Publication: 2025 Sep 02.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9708388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-8454 (Electronic) Linking ISSN: 10245332 NLM ISO Abbreviation: Hematology Subsets: MEDLINE

MeSH-Schlagworte: Venous Thrombosis*/drug therapy , Venous Thrombosis*/metabolism , Venous Thrombosis*/pathology , Venous Thrombosis*/etiology , Inflammation*/metabolism , Inflammation*/pathology , Blood Coagulation*/drug effects , Molecular Targeted Therapy*, Humans ; Extracellular Traps/metabolism ; Animals ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Protein-Arginine Deiminase Type 4/metabolism