Suchergebnisse - "Metformin/pharmacokinetics"

IA Mimétique & Longévité : un injecteur polymorphe pour la science, l'industrie et la société

Autoren: Tabary, Frédéric

Schlagwörter: AMPK, Elastin/immunology, Polyphenols/metabolism, Imagerie cutanée haute résolution, Spermidine, Receptors, AMPA/genetics, Fibrillar Collagens, Spermidine/immunology, Sirtuins/pharmacokinetics, MTOR Inhibitors/isolation & purification, IA dédiée à la Silver Economy, Ceramides/pharmacology, IA au service de l'industrie de la longévité, Mechanistic Target of Rapamycin Complex 2/genetics, Elastin/pharmacokinetics, Elastin/classification, Kinetin/toxicity, Quercetin/pharmacokinetics, Quercetin/genetics, Quercetin/immunology, Peptides/poisoning, Receptors, AMPA/biosynthesis, BeautyTech, Sustainable longevity, Polyphenols/standards, Curcumin/metabolism, MTOR Inhibitors/blood, Receptors, AMPA/history, Peptides/physiology, Organo-on-a-chip, Egg Yolk, Metformin, Longevity-Focused AI, Peptides biomimétiques, Polyphenols/history, Metformin/classification, Normes ISO/IEC 42001, Mechanistic Target of Rapamycin Complex 1/standards, Collagen, Cyclic AMP/economics, Métabolomique, Transcriptomique, MTOR Inhibitors/immunology, Spermidine/urine, Metformin/chemical synthesis, Ceramides/deficiency, Curcumin/analysis, Mechanistic Target of Rapamycin Complex 2/metabolism, NMN (nicotinamide mononucleotide), Ceramides/urine, Egg Shell/parasitology, Metformine, Organoïdes de peau, Jumeaux numériques santé, Elastin/ultrastructure, Kinetin/blood, Sirtuins/blood, Chimie, MTOR Inhibitors/analysis, Biopsie liquide, Ceramides/poisoning, Resveratrol/classification, Quercetin/poisoning, hyaluronique, Egg Hypersensitivity, ΔM11.3 rollback, Polyphenols/economics, MTOR Inhibitors/toxicity, Kinetin/immunology, Polyphenols, Kinetin/biosynthesis, Santé cellulaire, Fisetin, Vieillissement actif, Elastin, Elastin/toxicity, Sirtuins/chemistry, IA de pointe pour la santé et la longévité, Kinetin/history, Neuro-immuno-dermatologie, Metformin/pharmacokinetics, Resveratrol, Metformin/agonists, Céramides, Receptors, AMPA/analysis, Metformin/standards, Mechanistic Target of Rapamycin Complex 2/analysis, Peptides, Sirtuins/pharmacology, Receptors, AMPA/agonists, Sirtuins/biosynthesis, Quercetin/pharmacology, Sirtuins/economics, NR (nicotinamide riboside), Metformin/blood, Peptides/metabolism, Metformin/metabolism, Egg Shell, IA mimetique, Peptides/history, MTOR Inhibitors/pharmacokinetics, Metformin/pharmacology, Egg Proteins/immunology, Polyphenols/genetics, Épigénomique, Metformin/cerebrospinal fluid, Receptors, AMPA/classification, Metformin/toxicity, IA appliquée aux sciences du vieillissement, Peptides/urine, Curcumin/therapeutic use, Peptides/deficiency, Cyclic AMP/chemistry, Cyclic AMP/pharmacology, Quercetin/blood, Nutraceutiques, IA computationnelle en biologie du vieillissement, Collagen/immunology, Peptides/pharmacokinetics, Healthspan vs Lifespan, Ceramides/genetics, Receptors, AMPA/chemistry, Peptides/analysis, MTOR Inhibitors, Quercetin/history, IA biomédicale pour la longévité, HyperGlottal, Metformin/economics, Peptides/immunology, Ceramides/economics, Smart Longevity AI, Quercetin, MTOR Inhibitors/chemical synthesis, Quercetin/economics, Ceramides/classification, Polyphenols/biosynthesis, Polyphenols/pharmacology, Antimicrobial Peptides, Open source AI, Receptors, Collagen, Polyphenols/classification, Quercetin/metabolism, Elastin/physiology, IA éthique appliquée à la santé, Curcumin/administration & dosage, Polyphenols/poisoning, Chronobiologie & horloges circadiennes, Collagen/blood, Quercetin/radiation effects, RGPD, Receptors, AMPA/metabolism, Spermidine Synthase, Kinetin/urine, Curcumin/radiation effects, Peptides/economics, Quercetin/physiology, Elastin/metabolism, Ceramides/biosynthesis, Microbiome cutané, Kinetin/classification, Rapamycine, Polyphenols/urine, Polyphenols/chemistry, Quercétine, Curcumin/analogs & derivatives, Receptors, AMPA/physiology, Curcumine, Natriuretic Peptides, PolyResonator, Quercetin/biosynthesis, Collagen/economics, Ceramides/agonists, CRISPR/Cas9, Collagen/deficiency, Transparence, AI for Lifespan & Healthspan, Quercetin/toxicity, Mechanistic Target of Rapamycin Complex 1/chemistry, Curcumin/pharmacology, Polyphenols/agonists, Santé préventive, Sirtuins/immunology, Analyse de télomères, Rapamycin-Insensitive Companion of mTOR Protein, Innovation responsable, Kinetin/agonists, Spermidine/agonists, Collagen/toxicity, Elastin/standards, Healthspan, Coenzyme Q10, Kinetin/analysis, Elastin/biosynthesis, Elastin/pharmacology, Egg Shell/immunology, Tarification éthique, Peptides/genetics, Sirtuins/analysis, Elastin/blood, Isatin, Ceramides/analysis, Acide hyaluronique, Collagen/standards, VEX, Kinetin/pharmacology, Rapamycin-Insensitive Companion of mTOR Protein/deficiency, MTOR Inhibitors/standards, Curcumin/supply & distribution, Rapamycin-Insensitive Companion of mTOR Protein/biosynthesis, Sirtuins/genetics, Rapamycin-Insensitive Companion of mTOR Protein/standards, Polyphenols/analysis, MTOR Inhibitors/history, Resveratrol/blood, Rapamycin-Insensitive Companion of mTOR Protein/metabolism, AMP Deaminase, MTOR Inhibitors/metabolism, Protéomique, Loreal, Curcumin/standards, MTOR Inhibitors/therapeutic use, MTOR Inhibitors/urine, Compliance AI, Sirtuins/deficiency, MTOR Inhibitors/chemistry, Peptides/pharmacology, MTOR Inhibitors/pharmacology, Collagen/pharmacokinetics, Spermidine/pharmacokinetics, Curcumin/chemical synthesis, IA multi-omique pour la longévité, Polyphénols, Data sovereignty, Sirtuins/classification, Microbiome cutané & intestinal, Elastin/chemistry, Collagen/urine, Reproducibility, Oxydation protéines/lipides, Collagène, Sirtuins/urine, Resveratrol/metabolism, Opioid Peptides, Rapamycin-Insensitive Companion of mTOR Protein/pharmacokinetics, RGPD santé, AI for Longevity Science, Injecteur polymorphe, Société du vieillissement, Collagen/chemistry, Receptors, AMPA/blood, Curcumin/isolation & purification, IA prédictive multi-omique, Mechanistic Target of Rapamycin Complex 2/toxicity, Ceramides/chemistry, Receptors, AMPA/ultrastructure, Ceramides, Kinetin/genetics, Polyprenols, Sirtuins/physiology, Resvératrol, Kinetin/standards, AI for Healthy Aging, Curcumin/economics, IA appliquée aux biotechnologies du vieillissement, Egg White, Polyphenols/immunology, AI Act, Silver economy, Egg, Polyphenols/blood, Longevite, Quercetin/chemistry, Collagen/classification, AI Act Compliance, MTOR Inhibitors/poisoning, IA translationnelle en gérontologie, Sirtuins/metabolism, Épigénétique, Egg Proteins, Metformin/analysis, Mechanistic Target of Rapamycin Complex 2/urine, Ceramides/blood, Peptides/toxicity, Kinetin, Elastin/analysis, MTOR Inhibitors/administration & dosage, Ceramides/immunology, Egg Shell/chemistry, Sirtuins/poisoning, Egg Shell/abnormalities, C2PA, Cobamides, Mechanistic Target of Rapamycin Complex 1/metabolism, Sirtuins/history, EGCG, Standards inclusifs, Egg Shell/cytology, Elastin/agonists, Mechanistic Target of Rapamycin Complex 1/deficiency, Metformin/isolation & purification, Quercetin/urine, Resveratrol/standards, Egg Proteins/history, Collagen/analysis, Peptides/chemistry, Egg Proteins/urine, Spermidine/classification, Receptors, AMPA/immunology, Ceramides/pharmacokinetics, Kinetin/physiology, Polyphenols/physiology, Cyclic AMP, Sirtuins, Peptides/standards, Suppléments longévité, Curcumin/pharmacokinetics, Biomarqueurs, Elastin/urine, MTOR Inhibitors/classification, Ceramides/physiology, Kinetin/pharmacokinetics, Metformin/immunology, IA dédiée à la recherche en longévité, Metformin/urine, Egg Proteins/pharmacokinetics, Collagen/physiology, Sirtuins/ultrastructure, NAD⁺ (nicotinamide adenine dinucleotide), Elastin/poisoning, Next-Gen Longevity AI, mTOR, Sex, Resveratrol/economics, Ceramides/history, Gouvernance IA, Egg Shell/embryology, Collagen/poisoning, Curcumin, Coenzyme Q10 (CoQ10, Ubiquinone), Elastin/genetics, Sirtuins/standards, Élastine, Quercetin/agonists, Receptors, AMPA/deficiency, Metformin/chemistry, NR, Mechanistic Target of Rapamycin Complex 2, Mechanistic Target of Rapamycin Complex 1, Collagen/biosynthesis, Cosmétiques anti-âge, Vieillissement, Peptides, Cyclic, Cyclic AMP/history, Polyphenols/pharmacokinetics, Curcumin/toxicity, Ceramides/metabolism, CycloneDX SBOM, Sirtuins/toxicity, Kinetin/metabolism, Quercetin/classification, Mechanistic Target of Rapamycin Complex 1/pharmacology, Receptors, AMPA, Normes éthiques, Curcumin/adverse effects, Kinetin/chemistry, Mechanistic Target of Rapamycin Complex 2/classification, Collagen/agonists, Collagen Diseases, Quercetin/standards, Polyphenols/toxicity, Spermidine/metabolism, MTOR Inhibitors/cerebrospinal fluid, Ceramides/standards, EthicChain, Curcumin/classification, Quercetin/analysis, Spermidine/pharmacology, Curcumin/poisoning, Metformin/antagonists & inhibitors, MTOR Inhibitors/economics, Kinetin/poisoning, Egg Proteins/pharmacology, Curcumin/chemistry, Sirtuines

Understanding adefovir pharmacokinetics as a component of a transporter phenotyping cocktail

Autoren: Dong, Qian Chen, Chunli Taubert, Max et al.

Quelle: Eur J Clin Pharmacol

Schlagwörter: Male, Adult, 0301 basic medicine, Digoxin, Metformin/administration, Digoxin/pharmacokinetics [MeSH], Models, Biological [MeSH], OAT1-mediated drug-drug interactions, Male [MeSH], Organophosphonates/administration, Nonlinear renal elimination, Drug Interactions [MeSH], Organophosphonates/pharmacokinetics [MeSH], Phenotype [MeSH], Sitagliptin Phosphate/pharmacokinetics [MeSH], Adefovir, Adenine/analogs, Female [MeSH], Metformin/pharmacokinetics [MeSH], Adult [MeSH], Humans [MeSH], Middle Aged [MeSH], Adenine/pharmacokinetics [MeSH], Metformin/blood [MeSH], Organic Anion Transport Protein 1/metabolism [MeSH], Adenine/administration, Population pharmacokinetics, Digoxin/blood [MeSH], Research, Young Adult [MeSH], Digoxin/administration, Biological Availability [MeSH], Organic Anion Transport Protein 1/genetics [MeSH], Organophosphonates/blood [MeSH], Adenine, Sitagliptin Phosphate, Organophosphonates, Biological Availability, Middle Aged, Models, Biological, Metformin, Young Adult, 03 medical and health sciences, Organic Anion Transport Protein 1, Phenotype, 0302 clinical medicine, Humans, Female, Drug Interactions

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38546841
https://repository.publisso.de/resource/frl:6523916

Metformin Is Associated with Reduced Tissue Factor Procoagulant Activity in Patients with Poorly Controlled Diabetes

Autoren: Marco Witkowski Julian Friebel Termeh Tabaraie et al.

Quelle: Cardiovasc Drugs Ther

Schlagwörter: Male, 0301 basic medicine, Metformin/administration, Hypoglycemic Agents/pharmacokinetics [MeSH], Leukocyte Count/methods [MeSH], Diabetes Mellitus, Type 2/drug therapy [MeSH], THP-1 Cells [MeSH], Heart Disease Risk Factors [MeSH], thrombosis, Fibrinolytic Agents/administration, Male [MeSH], microRNA, Glycated Hemoglobin A/analysis [MeSH], Hypoglycemic Agents/administration, diabetes mellitus, Female [MeSH], Metformin/pharmacokinetics [MeSH], Thromboplastin/metabolism [MeSH], Humans [MeSH], Metformin, MicroRNAs/metabolism [MeSH], Peroxidase/blood [MeSH], Middle Aged [MeSH], Vascular Cell Adhesion Molecule-1/blood [MeSH], Diabetes Mellitus, Type 2/blood [MeSH], Drug Resistance [MeSH], coagulation, tissue factor, cardiovascular disease, C-Reactive Protein/analysis [MeSH], vascular complications, vascular inflammation, Diabetes Mellitus, Type 2/metabolism [MeSH], Short Communication, Fibrinolytic Agents/pharmacology [MeSH], Thromboplastin/isolation, THP-1 Cells, Drug Resistance, Vascular Cell Adhesion Molecule-1, Thromboplastin, Leukocyte Count, 03 medical and health sciences, 0302 clinical medicine, Fibrinolytic Agents, Humans, Hypoglycemic Agents, Peroxidase, Glycated Hemoglobin, Middle Aged, 3. Good health, MicroRNAs, C-Reactive Protein, Diabetes Mellitus, Type 2, Heart Disease Risk Factors, Female, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

Zugangs-URL: https://link.springer.com/content/pdf/10.1007/s10557-020-07040-7.pdf
https://pubmed.ncbi.nlm.nih.gov/32940892
https://europepmc.org/articles/PMC8266708/
https://link.springer.com/article/10.1007/s10557-020-07040-7
https://www.ncbi.nlm.nih.gov/pubmed/32940892
https://link.springer.com/content/pdf/10.1007/s10557-020-07040-7.pdf
https://pubmed.ncbi.nlm.nih.gov/32940892/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266708
https://repository.publisso.de/resource/frl:6470796
https://refubium.fu-berlin.de/handle/fub188/35642
https://doi.org/10.1007/s10557-020-07040-7
https://doi.org/10.17169/refubium-35356

In Utero Exposure to Metformin Reduces the Fertility of Male Offspring in Adulthood

Autoren: Mélanie C. Faure Rita Khoueiry Jusal Quanico et al.

Weitere Verfasser: Mélanie C. Faure Rita Khoueiry Jusal Quanico et al.

Quelle: Front Endocrinol (Lausanne)
Frontiers in Endocrinology, Vol 12 (2021)

Schlagwörter: 0301 basic medicine, Male, [SDV]Life Sciences [q-bio], Endocrinology, Diabetes and Metabolism, Prenatal Exposure Delayed Effects/chemically induced, Sperm Motility/drug effects, TET1 protein, mouse, Mice, Endocrinology, Pregnancy, Tissue Distribution, Spermatozoa/drug effects, Metformin/adverse effects, Sperm Count, Hypoglycemic Agents/pharmacokinetics, Sperm Head/drug effects, DNA Methylation/drug effects, Life sciences, Spermatozoa, Metformin, 3. Good health, [SDV] Life Sciences [q-bio], DNA-Binding Proteins, pregnancy, metformin, spermatozoa, testis, ovary, embryo, Prenatal Exposure Delayed Effects, Sciences du vivant, Sperm Motility, Female, Anatomy (cytology, histology, embryology...) & physiology, Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, Proto-Oncogene Proteins, Animals, Hypoglycemic Agents, Infertility, Male, Anatomie (cytologie, histologie, embryologie...) & physiologie, DNA Methylation, Hypoglycemic Agents/administration & dosage, RC648-665, Mice, Inbred C57BL, Proto-Oncogene Proteins/genetics, Infertility, Male/chemically induced, Metformin/pharmacokinetics, Sperm Head, DNA-Binding Proteins/genetics, DNA Damage

Dateibeschreibung: application/pdf; application/rdf+xml; charset=utf-8; application/octet-stream

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/34745014
https://doaj.org/article/561fbbeda8784fa78b19930952249e77
https://www.frontiersin.org/articles/10.3389/fendo.2021.750145/full
https://europepmc.org/article/MED/34745014
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565088/
https://pubmed.ncbi.nlm.nih.gov/34745014/
https://hdl.handle.net/2268/299055
https://doi.org/10.3389/fendo.2021.750145
https://hal.inrae.fr/hal-03462578v1/document
https://doi.org/10.3389/fendo.2021.750145
https://hal.inrae.fr/hal-03462578v1
http://hdl.handle.net/20.500.12210/75247

Determination of metformin bio-distribution by LC-MS/MS in mice treated with a clinically relevant paradigm

Autoren: Chaudhari, Kiran Wang, Jianmei Xu, Yong et al.

Quelle: PLoS One

Schlagwörter: Animals, Brain / metabolism, Chromatography, Liquid, Female, Kidney / metabolism, Liver / metabolism, Male, Metformin / administration & dosage, Metformin / blood, Metformin / pharmacokinetics, Mice, Inbred C57BL, Muscles / metabolism, Tandem Mass Spectrometry, Tissue Distribution

Dateibeschreibung: application/pdf

Relation: https://doi.org/10.1371/journal.pone.0234571; https://hdl.handle.net/20.500.12503/31984; 15

Verfügbarkeit: https://hdl.handle.net/20.500.12503/31984

In Utero Exposure to Metformin Reduces the Fertility of Male Offspring in Adulthood.

Autoren: Faure, Mélanie Khoueiry, Rita Quanico, Jusal et al.

Quelle: Frontiers in Endocrinology, 12, 750145 (2021)

Schlagwörter: embryo, metformin, ovary, pregnancy, spermatozoa, testis, DNA-Binding Proteins, Hypoglycemic Agents, Proto-Oncogene Proteins, TET1 protein, mouse, Metformin, Animals, DNA Damage, DNA Methylation/drug effects, DNA-Binding Proteins/genetics, Female, Hypoglycemic Agents/administration & dosage, Hypoglycemic Agents/pharmacokinetics, Infertility, Male/chemically induced, Male, Metformin/adverse effects, Metformin/pharmacokinetics, Mice, Mice, Inbred C57BL, Pregnancy, Prenatal Exposure Delayed Effects/chemically induced, Proto-Oncogene Proteins/genetics, Sperm Count, Sperm Head/drug effects, Sperm Motility/drug effects, Spermatozoa/drug effects, Tissue Distribution, Endocrinology, Diabetes and Metabolism, Life sciences, Anatomy (cytology, histology, embryology...) & physiology, Sciences du vivant, Anatomie (cytologie, histologie, embryologie...) & physiologie

Relation: urn:issn:1664-2392

Zugangs-URL: https://orbi.uliege.be/handle/2268/299055

In Vivo Imaging of Human 11C-Metformin in Peripheral Organs: Dosimetry, Biodistribution, and Kinetic Analyses: Dosimetry, Biodistribution, and Kinetic Analyses

Autoren: Niels Jessen Mikkel H. Vendelbo Mette Marie Hougaard Christensen et al.

Quelle: Gormsen, L C, Sundelin, E I, Jensen, J B, Vendelbo, M H, Jakobsen, S, Munk, O L, Hougaard Christensen, M M, Brøsen, K, Frøkiær, J & Jessen, N 2016, ' In Vivo Imaging of Human 11C-Metformin in Peripheral Organs : Dosimetry, Biodistribution, and Kinetic Analyses ', The Journal of Nuclear Medicine, vol. 57, no. 12, pp. 1920-1926 . https://doi.org/10.2967/jnumed.116.177774
Gormsen, L C, Sundelin, E I, Jensen, J B, Vendelbo, M H, Jakobsen, S, Munk, O L, Christensen, M M H, Brøsen, K, Frøkiær, J & Jessen, N 2016, 'In Vivo Imaging of Human 11C-Metformin in Peripheral Organs: Dosimetry, Biodistribution and Kinetic Analyses', The Journal of Nuclear Medicine, vol. 57, no. 12, pp. 1920-1926. https://doi.org/10.2967/jnumed.116.177774

Schlagwörter: Adult, Male, 0301 basic medicine, PET/CT, Middle Aged, Positron-Emission Tomography/methods, Metformin, 6. Clean water, 3. Good health, Kinetics, 03 medical and health sciences, Biodistribution, Metformin/pharmacokinetics, C-metformin, Positron-Emission Tomography, Humans, Female, Tissue Distribution, Whole Body Imaging, Carbon Radioisotopes, Radiometry

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/27469359
https://www.ncbi.nlm.nih.gov/pubmed/27469359
https://jnm.snmjournals.org/content/jnumed/57/12/1920.full.pdf
https://europepmc.org/article/MED/27469359
https://core.ac.uk/display/80326740
https://portal.findresearcher.sdu.dk/da/publications/in-vivo-imaging-of-human-11c-metformin-in-peripheral-organs-dosim
https://pubmed.ncbi.nlm.nih.gov/27469359/
https://portal.findresearcher.sdu.dk/da/publications/e943063c-2daa-415f-aaeb-e63e1d1dbc39
https://doi.org/10.2967/jnumed.116.177774
https://portal.findresearcher.sdu.dk/da/publications/e943063c-2daa-415f-aaeb-e63e1d1dbc39
https://pure.au.dk/portal/en/publications/a1580650-f7e8-4601-b9d7-1127ab87d65c
http://www.scopus.com/inward/record.url?scp=85001021726&partnerID=8YFLogxK
https://doi.org/10.2967/jnumed.116.177774

Simultaneous determination of anti-diabetic drugs

Autoren: Nawab Sher Nasreen Fatima Shahnaz Perveen et al.

Quelle: Brazilian Journal of Pharmaceutical Sciences, Vol 55 (2019)

Schlagwörter: Metformin/pharmacokinetics, High Pressure Liquid Chromatography, Urine/Plasma methods, Determination/prevention, Diabetes Mellitus/drug therapy, Drug Liberation/drug effects, Pharmacy and materia medica, RS1-441

Dateibeschreibung: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100582&tlng=en; https://doaj.org/toc/2175-9790

Zugangs-URL: https://doaj.org/article/0f6e858e7b6b4b7db817bdf42900ce72

Simultaneous determination of anti-diabetic drugs

Autoren: Sher, Nawab Fatima, Nasreen Perveen, Shahnaz et al.

Quelle: Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17394 ; Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e17394 ; 2175-9790 ; 1984-8250

Schlagwörter: Metformin/pharmacokinetics, High Pressure Liquid Chromatography, Urine/Plasma methods, Determination/prevention, Diabetes Mellitus/drug therapy, Drug Liberation/drug effects

Dateibeschreibung: application/pdf

Relation: https://revistas.usp.br/bjps/article/view/180916/167965; https://revistas.usp.br/bjps/article/view/180916

Verfügbarkeit: https://revistas.usp.br/bjps/article/view/180916

Near-infrared light activatable hydrogels for metformin delivery

Autoren: Chengnan, Li Pagneux, Quentin Voronova, Anna et al.

Weitere Verfasser: Chengnan, Li Pagneux, Quentin Voronova, Anna et al.

Quelle: ISSN: 2040-3364.

Schlagwörter: metformin, graphene, photothermal, transdermal, in vitro and in vivo assays, MESH: Animals, MESH: Cell Line, MESH: Mice, MESH: Skin Absorption, MESH: Diabetes Mellitus, Type 2/drug therapy, Type 2/metabolism, MESH: Drug Delivery Systems, MESH: Graphite*/chemistry, MESH: Graphite*/pharmacology, MESH: Humans, MESH: Hydrogels*/chemistry, MESH: Hydrogels*/pharmacology, MESH: Infrared Rays, MESH: Metformin*/chemistry, MESH: Metformin*/pharmacokinetics, MESH: Metformin*/pharmacology, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences

Relation: info:eu-repo/semantics/altIdentifier/pmid/31270521; info:eu-repo/grantAgreement//690836/EU/Pathogen and Graphene/PANG; PUBMED: 31270521

Verfügbarkeit: https://hal.science/hal-02368024
https://hal.science/hal-02368024v1/document
https://hal.science/hal-02368024v1/file/metformin.pdf
https://doi.org/10.1039/c9nr02707f

Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis

Autoren: Clarke, John D Dzierlenga, Anika L Nelson, Nicholas R et al.

Quelle: Diabetes

Schlagwörter: Octamer Transcription Factor-1 - genetics, 0301 basic medicine, Complications, Methionine - deficiency, Organic Cation Transport Proteins, Mice, Obese, Non-alcoholic Fatty Liver Disease - metabolism, Inbred C57BL, Kidney, Obese, Choline, Non-alcoholic Fatty Liver Disease - pathology, Metformin - metabolism, Mice, 03 medical and health sciences, Methionine, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, Kidney - pathology, Diabetes Mellitus, Animals, Hypoglycemic Agents, Tissue Distribution, RNA, Messenger, Hypoglycemic Agents - metabolism, Octamer Transcription Factor-1 - metabolism, Kidney - metabolism, Messenger - metabolism, Organic Cation Transporter 2, Liver - pathology, Organic Cation Transport Proteins - metabolism, 16. Peace & justice, Metformin, 3. Good health, Mice, Inbred C57BL, Diabetes Mellitus, Type 2, Liver, Liver - metabolism, Hypoglycemic Agents - pharmacokinetics, Organic Cation Transport Proteins - genetics, RNA, Metformin - pharmacokinetics, Type 2, Octamer Transcription Factor-1

Zugangs-URL: https://diabetes.diabetesjournals.org/content/diabetes/64/9/3305.full.pdf
https://pubmed.ncbi.nlm.nih.gov/26016715
https://pubmed.ncbi.nlm.nih.gov/26016715/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542448
https://arizona.pure.elsevier.com/en/publications/mechanism-of-altered-metformin-distribution-in-nonalcoholic-steat
http://intl-diabetes.diabetesjournals.org/content/64/9/3305
http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db14-1947
https://diabetes.diabetesjournals.org/content/diabetes/64/9/3305.full.pdf

Many drugs – both new and old – lower blood glucose levels / Många läkemedel – både nya och gamla – sänker blodglukos

Autoren: Nyström, Thomas Nathanson, David

Quelle: Läkartidningen. 115(8):366

Verapamil decreases the glucose‐lowering effect of metformin in healthy volunteers

Autoren: Eun Seok Park Jae Yong Chung Sung Kweon Cho et al.

Weitere Verfasser: Eun Seok Park Jae Yong Chung Sung Kweon Cho et al.

Quelle: British Journal of Clinical Pharmacology. 78:1426-1432

Schlagwörter: Adult, Blood Glucose, Male, 0301 basic medicine, verapamil, Organic Cation Transport Proteins, Organic Cation, Organic Cation Transport Proteins/antagonists & inhibitors, OCT1, Hypoglycemic Agents/pharmacology, 03 medical and health sciences, 0302 clinical medicine, Humans, Hypoglycemic Agents, Drug Interactions, drug interaction, Organic Cation Transporter 1, Blood Glucose/analysis, Transporter 1/antagonists & inhibitors, Metformin, 3. Good health, Metformin/pharmacokinetics, Verapamil, metformin, Metformin/pharmacology, Verapamil/pharmacology

Dateibeschreibung: application/pdf

Zugangs-URL: https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.12476
https://pubmed.ncbi.nlm.nih.gov/25060604
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165028
https://aasldpubs.onlinelibrary.wiley.com/doi/10.1111/bcp.12476
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bcp.12476
https://ir.ymlib.yonsei.ac.kr/bitstream/22282913/165028/1/T999900112.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111/bcp.12476
https://ascpt.onlinelibrary.wiley.com/doi/10.1111/bcp.12476

Pharmacokinetic Interaction Between Rosuvastatin and Metformin in Healthy Korean Male Volunteers: A Randomized, Open-label, 3-period, Crossover, Multiple-dose Study

Autoren: Donghwan Lee Hyerang Roh Hankil Son et al.

Weitere Verfasser: Donghwan Lee Hyerang Roh Hankil Son et al.

Quelle: Clinical Therapeutics. 36:1171-1181

Schlagwörter: Oral, Asian Continental Ancestry Group, Adult, Male, Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects, Rosuvastatin Calcium/adverse effects, Administration, Oral, Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacokinetics, Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage, Hypoglycemic Agents/adverse effects, Young Adult, 03 medical and health sciences, Metformin/administration & dosage, 0302 clinical medicine, Drug Therapy, Asian People, Drug–drug interaction, Republic of Korea, Humans, Hypoglycemic Agents, Drug Interactions, Rosuvastatin Calcium, Hypoglycemic Agents/pharmacokinetics, Metformin/adverse effects, Combination/adverse effects, Cross-Over Studies, Metformin/pharmacokinetics, Middle Aged, Hypoglycemic Agents/administration & dosage, Healthy Volunteers, Metformin, 3. Good health, Rosuvastatin Calcium/pharmacokinetics, Area Under Curve, Administration, Rosuvastatin Calcium/administration & dosage, Drug Therapy, Combination, Hydroxymethylglutaryl-CoA Reductase Inhibitors, metformin, pharmacokinetics, rosuvastatin

Dateibeschreibung: 1171~1181

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/24976448

Functional characterization of MATE2-K genetic variants and their effects on metformin pharmacokinetics

Autoren: Ji Ha Choi Joo Youn Cho In Jin Jang et al.

Weitere Verfasser: Ji Ha Choi Joo Youn Cho In Jin Jang et al.

Quelle: Pharmacogenetics and Genomics. 23:365-373

Schlagwörter: Asian Continental Ancestry Group, 0301 basic medicine, Polymorphism, Genetic, Organic Cation Transport Proteins, Genetic Variation, Homozygote, Organic Cation Transport Proteins/genetics, Metformin/pharmacokinetics, Metformin, 3. Good health, Promoter Regions, 03 medical and health sciences, 0302 clinical medicine, Genetic, Asian People, Haplotypes, Humans, Hypoglycemic Agents, Polymorphism, Promoter Regions, Genetic, Hypoglycemic Agents/pharmacokinetics

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/23652408
https://ewha.elsevierpure.com/en/publications/functional-characterization-of-mate2-k-genetic-variants-and-their
https://pure.ewha.ac.kr/en/publications/functional-characterization-of-mate2-k-genetic-variants-and-their
https://snucm.elsevierpure.com/en/publications/functional-characterization-of-mate2-k-genetic-variants-and-their
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165025
https://dspace.ewha.ac.kr/handle/2015.oak/227281
https://www.ncbi.nlm.nih.gov/pubmed/23652408

Rifampin Enhances the Glucose-Lowering Effect of Metformin and Increases OCT1 mRNA Levels in Healthy Participants

Autoren: Kyungsoo Park Sung Kweon Cho J‐Y Chung et al.

Weitere Verfasser: Kyungsoo Park Sung Kweon Cho J‐Y Chung et al.

Quelle: Clinical Pharmacology & Therapeutics. 89:416-421

Schlagwörter: Liver/metabolism, Adult, Blood Glucose, Male, 0301 basic medicine, Receptors, Steroid, Time Factors, Organic Cation Transport Proteins, Octamer Transcription Factor-1/drug effects, Organic Cation Transport Proteins/genetics, Messenger/drug effects, Messenger/metabolism, Hypoglycemic Agents/pharmacology, Young Adult, 03 medical and health sciences, Blood Glucose/drug effects, Steroid/agonists, 0302 clinical medicine, Antibiotics, Metformin/pharmacology, Receptors, Antitubercular/pharmacology, Humans, Hypoglycemic Agents, Drug Interactions, Prospective Studies, RNA, Messenger, Antibiotics, Antitubercular, Hypoglycemic Agents/pharmacokinetics, Pregnane X Receptor, Organic Cation Transporter 2, Metformin/pharmacokinetics, Octamer Transcription Factor-1/genetics, Glucose Tolerance Test, Metformin, 3. Good health, Liver, Area Under Curve, RNA, Female, Rifampin, Rifampin/pharmacology, Organic Cation Transport Proteins/drug effects, Octamer Transcription Factor-1

Dateibeschreibung: 416~421

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/21270793
https://aasldpubs.onlinelibrary.wiley.com/doi/10.1038/clpt.2010.266
https://snucm.elsevierpure.com/en/publications/rifampin-enhances-the-glucose-lowering-effect-of-metformin-and-in
https://s-space.snu.ac.kr/handle/10371/83260
https://pubmed.ncbi.nlm.nih.gov/21270793/?dopt=Abstract
https://bpspubs.onlinelibrary.wiley.com/doi/10.1038/clpt.2010.266
https://ascpt.onlinelibrary.wiley.com/doi/full/10.1038/clpt.2010.266

Comparison of the bioavailability and tolerability of fixed-dose combination glimepiride/metformin 2/500-mg tablets versus separate tablets: A single-dose, randomized-sequence, open-label, two-period crossover study in healthy Korean volunteers

Autoren: Hyun Suk Shin Sang-Goo Shin Jung-Ryul Kim et al.

Weitere Verfasser: Hyun Suk Shin Sang-Goo Shin Jung-Ryul Kim et al.

Quelle: Clinical Therapeutics. 32:1408-1418

Schlagwörter: Asian Continental Ancestry Group, Adult, Male, Adolescent, Tandem Mass Spectrometry/methods, Hypoglycemic Agents/adverse effects, Young Adult, 03 medical and health sciences, Metformin/administration & dosage, 0302 clinical medicine, Drug Therapy, Asian People, Tandem Mass Spectrometry, Humans, Hypoglycemic Agents, Sulfonylurea Compounds/pharmacokinetics, glimepiride, Sulfonylurea Compounds/adverse effects, Hypoglycemic Agents/pharmacokinetics, Metformin/adverse effects, Chromatography, Cross-Over Studies, Korea, Metformin/pharmacokinetics, Hypoglycemic Agents/administration & dosage, Metformin, 3. Good health, Drug Combinations, Sulfonylurea Compounds, Therapeutic Equivalency, Liquid/methods, Area Under Curve, Combination, healthy subjects, Drug Therapy, Combination, Female, metformin, Sulfonylurea Compounds/administration & dosage, pharmacokinetics, Chromatography, Liquid, Tablets

Dateibeschreibung: 1408~1418

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/20678687
https://www.ncbi.nlm.nih.gov/pubmed/20678687
http://europepmc.org/abstract/MED/20678687
https://pubmed.ncbi.nlm.nih.gov/20678687/
https://www.sciencedirect.com/science/article/pii/S0149291810002390
https://snucm.elsevierpure.com/en/publications/comparison-of-the-bioavailability-and-tolerability-of-fixed-dose-

Isolation, characterization and antibiotic susceptibility pattern of Staphylococcus aureus isolated from in-patients in selected hospitals in Kaduna Metropolis, Kaduna State Nigeria

Autoren: M.A. Garba S.S. Bello M.A. Usman et al.

Quelle: Journal of Pharmaceutical and Allied Sciences; Vol 14, No 4 (2017); 2584-2592
Journal of Pharmaceutical and Allied Sciences; Vol 14, No 4 (2017); 2646-2658
Journal of Pharmaceutical and Allied Sciences; Vol 14, No 4 (2017); 2625-2631
Journal of Pharmaceutical and Allied Sciences; Vol 14, No 4 (2017); 2607-2615
Journal of Pharmaceutical and Allied Sciences; Vol 14, No 4 (2017); 2593-2606
Journal of Pharmaceutical and Allied Sciences; Vol 14, No 4 (2017); 2632-2637
Journal of Pharmaceutical and Allied Sciences; Vol 14, No 4 (2017); 2638-2645
Journal of Pharmaceutical and Allied Sciences; Vol 14, No 4 (2017); 2616-2624
Journal of Pharmaceutical and Allied Sciences; Vol 14, No 4 (2017); 2659-2669
Journal of Pharmaceutical and Allied Sciences; Vol 14, No 4 (2017); 2578-2583

Schlagwörter: Ampiclox®, Diabetes, HPLC, Metformin, Pharmacokinetics, Parquentina nigrescens, antidepressant, forced swim test, methanol extract, phytochemical tests, 1. No poverty, Tuberculosis, Health Related Quality of life (HRQol), World Health Organization Quality of Life Bref (WHO-Qol Bref), 02 engineering and technology, Miconazole nitrate, Softisan® 154, Intravaginal drug delivery, Physicochemical performance, vaginal tolerance test (VTT), Biocompatible phytolipids, Antibiotic, hospital, in-patients, MAR index, Staphylococcus aureus, susceptibility, 01 natural sciences, Miconazole nitrate, Softisan® 154, Intravaginal drug delivery, PEGylated solid lipid microparticles, Sustained release, Sunseed oil, 6. Clean water, Azadirachta indica, phytochemical, well diffusion, antibacterial activity, Escherichia coli and Staphylococcus aureus, 12. Responsible consumption, 3. Good health, Honey, Wound, Antibacterial activity, Infection, Bacteria, 0210 nano-technology, Antipsychotics, herbal medicines, concurrent intake, prevalence, herb drug interaction, 0105 earth and related environmental sciences, Lisinopril, Buffers, Assay, Spectrophotometry

Dateibeschreibung: application/pdf

Zugangs-URL: https://www.ajol.info/index.php/jophas/article/view/164501
https://www.ajol.info/index.php/jophas/article/view/164515
https://www.ajol.info/index.php/jophas/article/view/164510
https://www.ajol.info/index.php/jophas/article/view/164507
https://www.ajol.info/index.php/jophas/article/view/164506
https://www.ajol.info/index.php/jophas/article/view/164512
https://www.ajol.info/index.php/jophas/article/view/164513
https://www.ajol.info/index.php/jophas/article/view/164508
https://www.ajol.info/index.php/jophas/article/view/164517
https://www.ajol.info/index.php/jophas/article/view/164500
https://www.africaneditors.org/journal/JOPHAS/abstract/84391-78141
https://www.ajol.info/index.php/jophas/article/view/164508
https://www.ajol.info/index.php/jophas/article/view/164515
https://www.africaneditors.org/journal/JOPHAS/abstract/52899-78145
https://www.africaneditors.org/journal/JOPHAS/abstract/10605-78144
https://www.ajol.info/index.php/jophas/article/view/164513
https://www.africaneditors.org/journal/JOPHAS/abstract/41493-78143
https://www.ajol.info/index.php/jophas/article/view/164512
https://www.africaneditors.org/journal/JOPHAS/abstract/89045-78140
https://www.ajol.info/index.php/jophas/article/view/164507

Aspectele farmacogenetice ale utilizării metforminei ; Pharmacogenetic aspects of metformin use ; Генетические аспекты применения метформина

Autoren: Bacinschi, Nicolae Beşliu, Alexandrina Bacinschi, Georgel et al.

Schlagwörter: pharmacogenetic, metformin, diabetes mellitus, CZU: 615.252.349.7, Pharmacogenetics, Metformin--therapeutic use, Metformin--pharmacokinetics, Polymorphism, Genetic, Single Nucleotide, Diabetes Mellitus--drug therapy, Hypoglycemic Agents--therapeutic use, Precision Medicine

Dateibeschreibung: application/pdf

Relation: Sănătate Publică, Economie şi Management în Medicină: Congresul al doilea Național al Societăţii Endocrinologilor din Republica Moldova cu participare internațională, 4-5 octombrie 2019, Chișinău, Republica Moldova; http://repository.usmf.md/handle/20.500.12710/7638

Verfügbarkeit: http://repository.usmf.md/handle/20.500.12710/7638
https://hdl.handle.net/20.500.12710/7638
http://revistaspemm.md/wp-content/uploads/2020/04/Revista_SPEMM_2019_nr.3_81_2019.pdf

Study protocol of a phase IB/II clinical trial of metformin and chloroquine in patients withIDH1-mutated orIDH2-mutated solid tumours

Autoren: Judith V.M.G. Bovée Hans Gelderblom Hanneke W. M. van Laarhoven et al.

Quelle: BMJ Open

Schlagwörter: Adult, Male, 0301 basic medicine, Chloroquine/pharmacokinetics, Antineoplastic Agents/pharmacokinetics, Chondrosarcoma, Antineoplastic Agents, Isocitrate Dehydrogenase/genetics, 7. Clean energy, Dose-Response Relationship, Cholangiocarcinoma, 03 medical and health sciences, Drug Therapy, Cholangiocarcinoma/drug therapy, Humans, 0303 health sciences, Dose-Response Relationship, Drug, Chloroquine, Glioma, Isocitrate Dehydrogenase, Metformin, 3. Good health, Metformin/pharmacokinetics, Oncology, Research Design, Combination, Glioma/drug therapy, Drug Therapy, Combination, Female, Drug, Chondrosarcoma/drug therapy

Zugangs-URL: https://bmjopen.bmj.com/content/bmjopen/7/6/e014961.full.pdf
https://pubmed.ncbi.nlm.nih.gov/28601826
http://bmjopen.bmj.com/content/7/6/e014961
https://bmjopen.bmj.com/content/7/6/e014961.full.pdf
https://research.vumc.nl/en/publications/study-protocol-of-a-phase-ibii-clinical-trial-of-metformin-and-ch
https://bmjopen.bmj.com/content/bmjopen/7/6/e014961.full.pdf
https://bmjopen.bmj.com/content/7/6/e014961
https://europepmc.org/abstract/MED/28601826
https://hdl.handle.net/1887/94614