Výsledky vyhledávání - "Mesenchymal stem cell"

Mesenchymal stem cells combined with IFN-γ treatment versus mesenchymal stem cells monotherapy: safety and efficacy over five years extension follow-up.

Autoři: Yang Y He X Yao M a další

Zdroj: Stem cell research & therapy [Stem Cell Res Ther] 2025 Nov 17; Vol. 16 (1), pp. 642. Date of Electronic Publication: 2025 Nov 17.

Způsob vydávání: Journal Article; Randomized Controlled Trial

Informace o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE

Výrazy ze slovníku MeSH: Interferon-gamma*/therapeutic use , Interferon-gamma*/adverse effects , Mesenchymal Stem Cells*/cytology , Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cell Transplantation*/methods , Mesenchymal Stem Cell Transplantation*/adverse effects , Arthritis, Rheumatoid*/therapy , Arthritis, Rheumatoid*/pathology, Humans ; Male ; Female ; Middle Aged ; Follow-Up Studies ; Adult ; Treatment Outcome ; Aged

Fixed-effect or random-effect models? A methodological reappraisal of subgroup analyses in mesenchymal stem cell therapy for knee osteoarthritis.

Autoři: Wu S; Clinical Laboratory Department, The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33 Beiling Street, Shenyang, 110032, Liaoning, China. wuma19811982@163.com.

Zdroj: Stem cell research & therapy [Stem Cell Res Ther] 2025 Oct 17; Vol. 16 (1), pp. 572. Date of Electronic Publication: 2025 Oct 17.

Způsob vydávání: Journal Article; Systematic Review; Letter

Informace o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE

Výrazy ze slovníku MeSH: Osteoarthritis, Knee*/therapy , Mesenchymal Stem Cell Transplantation*/methods , Mesenchymal Stem Cells*/cytology, Humans

Therapeutic potential of mesenchymal stem cell-based therapy for inflammatory bowel disease: Current advances and future perspectives.

Autoři: Zhang K Wang Q

Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Dec 15; Vol. 792, pp. 152962. Date of Electronic Publication: 2025 Nov 14.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

Výrazy ze slovníku MeSH: Inflammatory Bowel Diseases*/therapy , Mesenchymal Stem Cell Transplantation*/methods , Mesenchymal Stem Cell Transplantation*/trends , Mesenchymal Stem Cells*/cytology, Humans ; Animals ; Cell Differentiation ; Medicine, Chinese Traditional/methods

Injectable chitosan-based thermosensitive hydrogel loaded with adipose-derived mesenchymal stem cells promotes pressure ulcer healing.

Autoři: He S Lin B Zhang C a další

Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2025 Dec; Vol. 256 (Pt 2), pp. 115089. Date of Electronic Publication: 2025 Aug 29.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE

Výrazy ze slovníku MeSH: Chitosan*/chemistry , Chitosan*/pharmacology , Pressure Ulcer*/therapy , Pressure Ulcer*/pathology , Mesenchymal Stem Cells*/cytology , Mesenchymal Stem Cells*/drug effects , Hydrogels*/chemistry , Hydrogels*/pharmacology , Wound Healing*/drug effects , Adipose Tissue*/cytology , Mesenchymal Stem Cell Transplantation*, Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Temperature ; Glycerophosphates/chemistry ; Injections ; Cell Proliferation/drug effects ; Gelatin/chemistry ; Cells, Cultured ; Cell Survival/drug effects

Exploring the salivary proteome following intraglandular mesenchymal stromal cell therapy for radiation-induced hyposalivation in previous head and neck cancer patients: a secondary study protocol for the MESRIX-III, randomised, controlled trial.

Autoři: Carlander AF Jakobsen KK Jersie-Christensen R a další

Zdroj: Trials [Trials] 2025 Nov 28; Vol. 26 (1), pp. 554. Date of Electronic Publication: 2025 Nov 28.

Způsob vydávání: Journal Article; Clinical Trial Protocol

Informace o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE

Výrazy ze slovníku MeSH: Xerostomia*/etiology , Xerostomia*/therapy , Xerostomia*/metabolism , Xerostomia*/diagnosis , Xerostomia*/physiopathology , Head and Neck Neoplasms*/radiotherapy , Mesenchymal Stem Cell Transplantation*/methods , Mesenchymal Stem Cell Transplantation*/adverse effects , Proteome*/metabolism , Saliva*/metabolism , Radiation Injuries*/etiology , Radiation Injuries*/metabolism , Radiation Injuries*/therapy , Radiation Injuries*/diagnosis , Radiation Injuries*/surgery , Salivary Proteins and Peptides*/metabolism, Humans ; Double-Blind Method ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Male ; Female ; Middle Aged ; Salivation ; Adult ; Time Factors

Evaluation of safety and efficacy: a case series of chronic limb-threatening ischemia treated with endovascular revascularization and umbilical cord mesenchymal stem cell therapy.

Autoři: Pasciolly RMRJ Indriani S Ismail MT a další

Zdroj: Stem cell research & therapy [Stem Cell Res Ther] 2025 Nov 27; Vol. 16 (1), pp. 665. Date of Electronic Publication: 2025 Nov 27.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE

Výrazy ze slovníku MeSH: Mesenchymal Stem Cell Transplantation*/methods , Endovascular Procedures*/methods , Ischemia*/therapy , Chronic Limb-Threatening Ischemia*/therapy, Humans ; Male ; Female ; Middle Aged ; Aged ; Pilot Projects ; Mesenchymal Stem Cells/cytology ; Umbilical Cord/cytology ; Treatment Outcome ; Ankle Brachial Index ; Adult ; Longitudinal Studies

The effect of therapeutic potential and safety of bone marrow-derived against adipose-derived mesenchymal stem cells in aged mice associated with septic arthritis.

Autoři: Khalid Ahmed AM Khalaf Ali M Kh Alani B

Zdroj: PloS one [PLoS One] 2025 Nov 26; Vol. 20 (11), pp. e0335011. Date of Electronic Publication: 2025 Nov 26 (Print Publication: 2025).

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Výrazy ze slovníku MeSH: Mesenchymal Stem Cells*/cytology , Mesenchymal Stem Cells*/metabolism , Arthritis, Infectious*/therapy , Arthritis, Infectious*/pathology , Mesenchymal Stem Cell Transplantation*/methods , Mesenchymal Stem Cell Transplantation*/adverse effects , Adipose Tissue*/cytology , Bone Marrow Cells*/cytology , Aging*, Animals ; Mice ; Male ; Disease Models, Animal ; Mice, Inbred C57BL

Safety and efficacy of human umbilical cord-derived mesenchymal stem cells in COVID-19 patients: A real-world observation.

Autoři: Wang S Yang T Li T a další

Zdroj: Chinese medical journal [Chin Med J (Engl)] 2025 Nov 20; Vol. 138 (22), pp. 2984-2992. Date of Electronic Publication: 2025 Mar 07.

Způsob vydávání: Journal Article; Multicenter Study

Informace o časopise: Publisher: Chinese Medical Association ; produced by Wolters Kluwer Country of Publication: China NLM ID: 7513795 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2542-5641 (Electronic) Linking ISSN: 03666999 NLM ISO Abbreviation: Chin Med J (Engl) Subsets: MEDLINE

Výrazy ze slovníku MeSH: COVID-19*/therapy , Mesenchymal Stem Cell Transplantation*/methods , Mesenchymal Stem Cell Transplantation*/adverse effects , Umbilical Cord*/cytology , Mesenchymal Stem Cells*/cytology, Humans ; Female ; Male ; Middle Aged ; Adult ; SARS-CoV-2 ; Aged ; Treatment Outcome

Mesenchymal stromal cell therapy for scarring: a systematic review of clinical and preclinical studies.

Autoři: Hansen L Laustsen-Kiel CM Rangatchew F a další

Zdroj: Stem cells (Dayton, Ohio) [Stem Cells] 2025 Nov 17; Vol. 43 (12).

Způsob vydávání: Journal Article; Systematic Review; Review

Informace o časopise: Publisher: Oxford University Press Country of Publication: England NLM ID: 9304532 Publication Model: Print Cited Medium: Internet ISSN: 1549-4918 (Electronic) Linking ISSN: 10665099 NLM ISO Abbreviation: Stem Cells Subsets: MEDLINE

Výrazy ze slovníku MeSH: Mesenchymal Stem Cell Transplantation*/methods , Mesenchymal Stem Cells*/cytology , Mesenchymal Stem Cells*/metabolism , Cicatrix*/therapy , Cicatrix*/pathology, Humans ; Animals

[Human umbilical cord mesenchymal stem cells protect against neonatal white matter injury by activating the Nrf2/Keap1/HO-1 signaling pathway].

Autoři: Wang C Wang MX Zhu YP

Zdroj: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics [Zhongguo Dang Dai Er Ke Za Zhi] 2025 Nov 15; Vol. 27 (11), pp. 1398-1407.

Způsob vydávání: English Abstract; Journal Article

Informace o časopise: Publisher: Zhongguo dang dai er ke za zhi she Country of Publication: China NLM ID: 100909956 Publication Model: Print Cited Medium: Print ISSN: 1008-8830 (Print) Linking ISSN: 10088830 NLM ISO Abbreviation: Zhongguo Dang Dai Er Ke Za Zhi Subsets: MEDLINE

Výrazy ze slovníku MeSH: NF-E2-Related Factor 2*/physiology , Signal Transduction*/physiology , White Matter*/injuries , White Matter*/pathology , Kelch-Like ECH-Associated Protein 1*/physiology , Umbilical Cord*/cytology , Heme Oxygenase-1*/physiology , Mesenchymal Stem Cell Transplantation* , Heme Oxygenase (Decyclizing)*/physiology , Mesenchymal Stem Cells*/physiology, Animals ; Rats, Sprague-Dawley ; Humans ; Rats ; Animals, Newborn ; Male ; Female ; Hypoxia-Ischemia, Brain

Autophagy activation within inflammatory microenvironment improved the therapeutic effect of MSC-Derived extracellular Vesicle in SLE.

Autoři: Liao S Guo F Xiao Z a další

Zdroj: Journal of advanced research [J Adv Res] 2025 Nov; Vol. 77, pp. 321-339. Date of Electronic Publication: 2025 Jan 27.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE

Výrazy ze slovníku MeSH: Lupus Erythematosus, Systemic*/therapy , Lupus Erythematosus, Systemic*/immunology , Lupus Erythematosus, Systemic*/pathology , Lupus Erythematosus, Systemic*/metabolism , Extracellular Vesicles*/metabolism , Extracellular Vesicles*/transplantation , Autophagy*/drug effects , Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cells*/cytology , Mesenchymal Stem Cell Transplantation*/methods, Animals ; Mice ; Sirolimus/pharmacology ; Mice, Inbred MRL lpr ; Cellular Microenvironment/immunology ; Female ; Disease Models, Animal ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Inflammation/pathology ; Humans

Hanging drop culture reprograms mesenchymal stem cell transcriptome to enhance cell delivery efficiency via attenuated pulmonary entrapment.

Autoři: Lee HT Fu SY Weng WH a další

Zdroj: Drug delivery and translational research [Drug Deliv Transl Res] 2025 Nov; Vol. 15 (11), pp. 4187-4201. Date of Electronic Publication: 2025 Sep 06.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE

Výrazy ze slovníku MeSH: Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cells*/cytology , Transcriptome* , Mesenchymal Stem Cell Transplantation*, Humans ; Animals ; Spheroids, Cellular/metabolism ; Spheroids, Cellular/cytology ; Cells, Cultured ; Cell Culture Techniques, Three Dimensional ; Lung/metabolism ; Male

Intravenous umbilical cord-derived mesenchymal stromal cell therapy may improve overall survival in Japanese patients with idiopathic pneumonia syndrome after hematopoietic stem cell transplantation: a multicenter, single-arm, phase II trial.

Autoři: Doki N Fujii N Kako S a další

Zdroj: International journal of hematology [Int J Hematol] 2025 Nov; Vol. 122 (5), pp. 733-743. Date of Electronic Publication: 2025 Jul 15.

Způsob vydávání: Journal Article; Clinical Trial, Phase II; Multicenter Study

Informace o časopise: Publisher: Springer Japan Country of Publication: Japan NLM ID: 9111627 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-3774 (Electronic) Linking ISSN: 09255710 NLM ISO Abbreviation: Int J Hematol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Hematopoietic Stem Cell Transplantation*/adverse effects , Mesenchymal Stem Cell Transplantation*/methods , Mesenchymal Stem Cell Transplantation*/adverse effects , Pneumonia*/therapy , Pneumonia*/mortality , Pneumonia*/etiology , Umbilical Cord*/cytology, Humans ; Male ; Adult ; Middle Aged ; Japan ; Treatment Outcome ; Survival Rate ; East Asian People

A preliminary study of synovial fluid-derived mesenchymal stromal cell therapy for canine osteoarthritis.

Autoři: Koga Y Fujiki M Hifumi T a další

Zdroj: Research in veterinary science [Res Vet Sci] 2025 Nov; Vol. 196, pp. 105897. Date of Electronic Publication: 2025 Sep 15.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: British Veterinary Association Country of Publication: England NLM ID: 0401300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2661 (Electronic) Linking ISSN: 00345288 NLM ISO Abbreviation: Res Vet Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Synovial Fluid*/cytology , Osteoarthritis*/veterinary , Osteoarthritis*/therapy , Dog Diseases*/therapy , Mesenchymal Stem Cell Transplantation*/veterinary , Mesenchymal Stem Cell Transplantation*/methods , Mesenchymal Stem Cells*/cytology , Mesenchymal Stem Cells*/physiology, Animals ; Dogs ; Male ; Female

Advances in the Research of Mesenchymal Stromal Cells in the Treatment of Maxillofacial Neurological Disorders and the Promotion of Facial Nerve Regeneration.

Autoři: Zhao DZ Wei HX Yang YB a další

Zdroj: Molecular neurobiology [Mol Neurobiol] 2025 Nov; Vol. 62 (11), pp. 14407-14423. Date of Electronic Publication: 2025 Apr 28.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Nerve Regeneration*/physiology , Mesenchymal Stem Cells*/cytology , Nervous System Diseases*/therapy , Mesenchymal Stem Cell Transplantation*/methods , Mesenchymal Stem Cell Transplantation*/trends , Facial Nerve*/physiology, Humans ; Animals ; Tissue Engineering

Intraosseous adipose mesenchymal stem cells and plasma rich in growth factors: A promising approach for articular cartilage and subchondral bone regeneration.

Autoři: Torres-Torrillas M Damiá E Peláez P a další

Zdroj: Research in veterinary science [Res Vet Sci] 2025 Nov; Vol. 196, pp. 105896. Date of Electronic Publication: 2025 Sep 12.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: British Veterinary Association Country of Publication: England NLM ID: 0401300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2661 (Electronic) Linking ISSN: 00345288 NLM ISO Abbreviation: Res Vet Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Cartilage, Articular*/physiology , Bone Regeneration* , Mesenchymal Stem Cell Transplantation*/veterinary , Mesenchymal Stem Cell Transplantation*/methods , Intercellular Signaling Peptides and Proteins*/administration & dosage , Mesenchymal Stem Cells*/physiology, Animals ; Rabbits ; Adipose Tissue/cytology ; Male

Mesenchymal stem cell therapy for type 2 diabetes: mechanisms, clinical evidence, and future directions.

Autoři: Zarei M; Department of Pharmacology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. m.zarei@sbmu.ac.ir.

Zdroj: Molecular biology reports [Mol Biol Rep] 2025 Oct 21; Vol. 52 (1), pp. 1046. Date of Electronic Publication: 2025 Oct 21.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: Diabetes Mellitus, Type 2*/therapy , Mesenchymal Stem Cell Transplantation*/methods , Mesenchymal Stem Cell Transplantation*/trends , Mesenchymal Stem Cells*/cytology , Mesenchymal Stem Cells*/metabolism, Humans ; Animals

Increased BMP/SMAD Signaling by PD-MSCs Promotes Bone Formation in an Ovariectomized Mouse Model of Osteoporosis.

Autoři: Lee DH Park H Kim S a další

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 15; Vol. 26 (20). Date of Electronic Publication: 2025 Oct 15.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Osteoporosis*/metabolism , Osteoporosis*/therapy , Osteoporosis*/pathology , Osteoporosis*/etiology , Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cells*/cytology , Signal Transduction* , Osteogenesis* , Smad Proteins*/metabolism , Mesenchymal Stem Cell Transplantation* , Bone Morphogenetic Proteins*/metabolism , Placenta*/cytology, Animals ; Female ; Mice ; Disease Models, Animal ; Ovariectomy ; Pregnancy ; Bone Density ; Mice, Inbred C57BL

Evaluating the Dose-Dependent Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in a Preclinical Model of Interstitial Lung Disease.

Autoři: Kotani T Saito T Masutani R a další

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 15; Vol. 26 (20). Date of Electronic Publication: 2025 Oct 15.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Mesenchymal Stem Cells*/cytology , Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cell Transplantation*/methods , Umbilical Cord*/cytology , Lung Diseases, Interstitial*/therapy , Lung Diseases, Interstitial*/pathology , Lung Diseases, Interstitial*/chemically induced , Lung Diseases, Interstitial*/metabolism, Animals ; Humans ; Mice ; Female ; Disease Models, Animal ; Mice, Inbred C57BL ; Bleomycin ; Matrix Metalloproteinase 9/metabolism ; Pulmonary Fibrosis/therapy ; Pulmonary Fibrosis/pathology ; Cytokines/metabolism ; Macrophages/metabolism ; Tissue Inhibitor of Metalloproteinase-1/metabolism

Assessment of the safety of hypoxia-primed mesenchymal stem cells derived from umbilical cord and adipose tissues in animals.

Autoři: Dinh NT Nguyen QT Hang NT a další

Zdroj: Scientific reports [Sci Rep] 2025 Oct 15; Vol. 15 (1), pp. 36055. Date of Electronic Publication: 2025 Oct 15.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy ze slovníku MeSH: Mesenchymal Stem Cells*/cytology , Mesenchymal Stem Cells*/metabolism , Adipose Tissue*/cytology , Umbilical Cord*/cytology , Mesenchymal Stem Cell Transplantation*/adverse effects , Mesenchymal Stem Cell Transplantation*/methods, Animals ; Rabbits ; Rats ; Mice ; Male ; Cell Hypoxia ; Cells, Cultured ; Cytokines/metabolism ; Humans