Výsledky vyhledávání - "Mechanistic Target of Rapamycin Complex 2 metabolism"

Non-genomic activation of the AKT-mTOR pathway by the mitochondrial stress response in thyroid cancer

Autoři: Woo Kyung Lee Doolittle Sunmi Park Seul Gi Lee a další

Přispěvatelé: Woo Kyung Lee Doolittle Sunmi Park Seul Gi Lee a další

Zdroj: Oncogene. 41:4893-4904

Témata: 0301 basic medicine, 0303 health sciences, TOR Serine-Threonine Kinases, TOR Serine-Threonine Kinases / genetics, TOR Serine-Threonine Kinases / metabolism, Mechanistic Target of Rapamycin Complex 2, Thyroid Neoplasms* / genetics, Mechanistic Target of Rapamycin Complex 1, Proto-Oncogene Proteins c-akt* / metabolism, 3. Good health, 03 medical and health sciences, Mechanistic Target of Rapamycin Complex 2 / genetics, Mechanistic Target of Rapamycin Complex 2 / metabolism, Mechanistic Target of Rapamycin Complex 1 / metabolism, Humans, Thyroid Neoplasms, Thyroid Neoplasms* / pathology, Proto-Oncogene Proteins c-akt

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/36195659

Loss of mTORC2-induced metabolic reprogramming in monocytes uncouples migration and maturation from production of proinflammatory mediators.

Autoři: Jangani, Maryam Vuononvirta, Juho Yamani, Lamya a další

Zdroj: Journal of leukocyte biology 111(5), 967-980 (2022). doi:10.1002/JLB.1A0920-588R

Témata: info:eu-repo/classification/ddc/570, Macrophages: metabolism, Mechanistic Target of Rapamycin Complex 2: metabolism, Monocytes: metabolism, Proto-Oncogene Proteins c-akt: metabolism, Rapamycin-Insensitive Companion of mTOR Protein: metabolism, Sirolimus, cell metabolism, mTORC2, macrophage, metabolism, monocyte

Geografické téma: DE

Relation: info:eu-repo/semantics/altIdentifier/pmid/pmid:34585416; info:eu-repo/semantics/altIdentifier/issn/0741-5400; info:eu-repo/semantics/altIdentifier/issn/1938-3673; https://pub.dzne.de/record/162927

Dostupnost: https://pub.dzne.de/record/162927
https://pub.dzne.de/search?p=id:%22DZNE-2021-01579%22

Target of rapamycin complex 2–dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae

Autoři: Bourgoint, Clelia Rispal, Delphine Berti, Marina a další

Zdroj: J Biol Chem
Journal of Biological Chemistry

Témata: Glycerol, 0301 basic medicine, Saccharomyces cerevisiae / drug effects, Serine / metabolism, Signal transduction, Protein Kinases / metabolism, Saccharomyces cerevisiae / ultrastructure, Protein Kinases / genetics, Glycogen Synthase Kinase 3, Saccharomyces cerevisiae Proteins / genetics, Gene Expression Regulation, Fungal, Serine, Glycerol / metabolism, Saccharomyces cerevisiae / metabolism, Phosphorylation, In vitro kinase assay, Endocytosis / drug effects, Saccharomyces cerevisiae Proteins / metabolism, Actin Cytoskeleton / drug effects, 0303 health sciences, Endocytosis / genetics, Microfilament Proteins / genetics, Microfilament Proteins, Pan1, Microfilament Proteins / metabolism, Mechanistic Target of Rapamycin Complex 2 / antagonists & inhibitors, Endocytosis, Actin Cytoskeleton, Mechanistic Target of Rapamycin Complex 2 / metabolism, Saccharomyces cerevisiae / genetics, Signal Transduction, Saccharomyces cerevisiae Proteins, Glycogen Synthase Kinase 3 / genetics, Mechanistic Target of Rapamycin Complex 2, Saccharomyces cerevisiae, Cell Membrane / drug effects, 03 medical and health sciences, Ark1/Prk1 family, Mechanistic Target of Rapamycin Complex 2 / genetics, Membrane function, Target of rapamycin (TOR), Aminophospholipid flippase, Protein Kinase Inhibitors, Actin, Actin Cytoskeleton / metabolism, Phosphorylation / drug effects, Sphingolipids, Actin Cytoskeleton / ultrastructure, Sphingolipids / biosynthesis, Protein Kinase Inhibitors / pharmacology, Cell Membrane, Fpk1, Cell Membrane / metabolism, Cell Membrane / ultrastructure, Glycogen Synthase Kinase 3 / metabolism, Protein Kinases

Popis souboru: application/pdf

Přístupová URL adresa: http://www.jbc.org/content/293/31/12043.full.pdf
https://pubmed.ncbi.nlm.nih.gov/29895620
https://europepmc.org/abstract/MED/29895620
http://www.jbc.org/content/293/31/12043.short
https://pubmed.ncbi.nlm.nih.gov/29895620/
https://www.ncbi.nlm.nih.gov/pubmed/29895620
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078453/
https://www.jbc.org/content/293/31/12043.full.pdf
https://archive-ouverte.unige.ch/unige:169651
https://doi.org/10.1074/jbc.ra117.001615

Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities

Přispěvatelé: Sejin Oh Jeonghun Yeom Hee Jin Cho a další

Témata: Benzamides / pharmacology, Biomarkers, Tumor / genetics, Tumor / metabolism, Brain Neoplasms / genetics, Brain Neoplasms / metabolism, Brain Neoplasms / therapy, Cell Line, Tumor, Cell Survival / drug effects, Cell Survival / genetics, Glioblastoma / genetics, Glioblastoma / metabolism, Glioblastoma / therapy, Humans, Isocitrate Dehydrogenase / classification, Isocitrate Dehydrogenase / genetics, Isocitrate Dehydrogenase / metabolism, Kaplan-Meier Estimate, Mechanistic Target of Rapamycin Complex 1 / antagonists & inhibitors, Mechanistic Target of Rapamycin Complex 1 / metabolism, Mechanistic Target of Rapamycin Complex 2 / antagonists & inhibitors, Mechanistic Target of Rapamycin Complex 2 / metabolism, Morpholines / pharmacology, Mutation, Prognosis, Protein Kinase Inhibitors / pharmacology, Proteogenomics / methods, Proteomics / methods, Pyrimidines / pharmacology

Popis souboru: application/pdf

Relation: NATURE COMMUNICATIONS; J02293; https://ir.ymlib.yonsei.ac.kr/handle/22282913/179465; T202002592; 67093

Dostupnost: https://ir.ymlib.yonsei.ac.kr/handle/22282913/179465
https://doi.org/10.1038/s41467-020-17139-y