Search Results - "Mechanistic Target of Rapamycin Complex 1"

Interplay between mTORC1 signaling and iron homeostasis in muscle atrophy.

Authors: Jee E Ouf W Kim J et al.

Source: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 970-980. Date of Electronic Publication: 2025 Oct 12.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH Terms: Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/genetics , Iron*/metabolism , Muscular Atrophy*/metabolism , Muscular Atrophy*/pathology , Muscular Atrophy*/genetics, Humans ; Homeostasis ; Signal Transduction ; Animals ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Autophagy

Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging.

Authors: Choy SM Goh KY Lee WX et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Dec 02; Vol. 122 (48), pp. e2508893122. Date of Electronic Publication: 2025 Nov 24.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH Terms: Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/genetics , Muscle, Skeletal*/metabolism , Muscle, Skeletal*/physiology , Aging*/metabolism , Aging*/physiology , Physical Conditioning, Animal*/physiology, Animals ; Mice ; Humans ; Male ; TOR Serine-Threonine Kinases/metabolism ; Sarcopenia/metabolism

MCL1 modulates mTORC1 signaling to promote bioenergetics and tumorigenesis.

Authors: Gui W Paral P Dhamija B et al.

Source: Nature communications [Nat Commun] 2025 Dec 01; Vol. 16 (1), pp. 10841. Date of Electronic Publication: 2025 Dec 01.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Myeloid Cell Leukemia Sequence 1 Protein*/metabolism , Myeloid Cell Leukemia Sequence 1 Protein*/genetics , Myeloid Cell Leukemia Sequence 1 Protein*/antagonists & inhibitors , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/genetics , Energy Metabolism* , Carcinogenesis*/metabolism , Carcinogenesis*/genetics, Animals ; Humans ; Signal Transduction ; Mice ; Hexokinase/metabolism ; Hexokinase/genetics ; Apoptosis ; Cell Line, Tumor

SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signalling pathway to facilitate viral replication.

Authors: Zhou S Hui X Wang W et al.

Source: Emerging microbes & infections [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2447620. Date of Electronic Publication: 2025 Feb 24.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE

MeSH Terms: Virus Replication* , SARS-CoV-2*/physiology , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/genetics , Adenosine*/analogs & derivatives , Adenosine*/metabolism , Coronavirus OC43, Human*/physiology , Coronavirus Infections*/virology , Coronavirus Infections*/metabolism, Humans ; Signal Transduction ; Methylation ; Viral Nonstructural Proteins/metabolism ; Viral Nonstructural Proteins/genetics ; S-Adenosylmethionine/metabolism ; Methionine Adenosyltransferase/metabolism ; Methionine Adenosyltransferase/genetics ; HEK293 Cells ; Host-Pathogen Interactions ; COVID-19/virology ; COVID-19/metabolism ; RNA, Viral/metabolism

Comprehensive analysis of gene expression alterations in breast cancer patients via PKCθ-TBK1-mTORC1 signaling pathway.

Authors: Hafeez A Basit M Zafar S et al.

Source: BMC cancer [BMC Cancer] 2025 Nov 28; Vol. 25 (1), pp. 1844. Date of Electronic Publication: 2025 Nov 28.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE

MeSH Terms: Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Mechanistic Target of Rapamycin Complex 1*/genetics , Mechanistic Target of Rapamycin Complex 1*/metabolism , Gene Expression Regulation, Neoplastic* , Protein Serine-Threonine Kinases*/genetics , Protein Serine-Threonine Kinases*/metabolism , Protein Kinase C-theta*/genetics , Protein Kinase C-theta*/metabolism, Humans ; Female ; Signal Transduction ; Proto-Oncogene Mas ; Middle Aged ; Adult ; Biomarkers, Tumor/genetics ; Aged ; Prognosis

The CTLH ubiquitin ligase substrates ZMYND19 and MKLN1 negatively regulate mTORC1 at the lysosomal membrane.

Authors: Wang Y Liao Y Sun Y et al.

Source: Nature communications [Nat Commun] 2025 Nov 28; Vol. 16 (1), pp. 10731. Date of Electronic Publication: 2025 Nov 28.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Lysosomes*/metabolism , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/genetics , Ubiquitin-Protein Ligases*/metabolism , Ubiquitin-Protein Ligases*/genetics , Intracellular Membranes*/metabolism, Humans ; HEK293 Cells ; Cell Line, Tumor ; CRISPR-Cas Systems ; Signal Transduction ; Phosphatidylinositol 3-Kinases/metabolism ; Cell Proliferation

Mitochondrial metabolic rewiring sensitizes mTORC1 inhibitor persister cells to cuproptosis.

Authors: Du H Liu HJ Losko M et al.

Source: JCI insight [JCI Insight] 2025 Nov 24; Vol. 10 (22). Date of Electronic Publication: 2025 Nov 24 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

MeSH Terms: Mechanistic Target of Rapamycin Complex 1*/antagonists & inhibitors , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mitochondria*/metabolism , Mitochondria*/drug effects, Humans ; Cell Line, Tumor ; Animals ; Mice ; Oxidative Phosphorylation/drug effects ; Sirolimus/pharmacology ; Xenograft Model Antitumor Assays ; Drug Resistance, Neoplasm/drug effects ; Glycolysis/drug effects ; Female

mTORC1 regulates autophagosomal components recycling through SNX16 phosphorylation.

Authors: Que H Liu F Chen Y et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 18; Vol. 122 (46), pp. e2511069122. Date of Electronic Publication: 2025 Nov 14.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH Terms: Sorting Nexins*/metabolism , Sorting Nexins*/genetics , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/genetics , Autophagy*/physiology , Autophagosomes*/metabolism, Humans ; Phosphorylation ; HeLa Cells ; rab GTP-Binding Proteins/metabolism ; HEK293 Cells ; Lysosomes/metabolism

Lysosomal and mTORC1 signaling dysregulation underpin the pathology of spastic paraplegia type 80.

Authors: Zhi Y Zhang T Lu D et al.

Source: Nature communications [Nat Commun] 2025 Nov 07; Vol. 16 (1), pp. 9833. Date of Electronic Publication: 2025 Nov 07.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Lysosomes*/metabolism , Lysosomes*/drug effects , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/antagonists & inhibitors , Mechanistic Target of Rapamycin Complex 1*/genetics , Spastic Paraplegia, Hereditary*/genetics , Spastic Paraplegia, Hereditary*/metabolism , Spastic Paraplegia, Hereditary*/pathology , Spastic Paraplegia, Hereditary*/drug therapy , Endosomal Sorting Complexes Required for Transport*/genetics , Endosomal Sorting Complexes Required for Transport*/metabolism, Animals ; Signal Transduction/drug effects ; Humans ; Mice ; TOR Serine-Threonine Kinases/metabolism ; Sirolimus/pharmacology ; Mice, Knockout ; Phosphorylation ; Mutation ; Disease Models, Animal ; Male ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

Structural basis for mTORC1 activation on the lysosomal membrane.

Authors: Cui Z Esposito A Napolitano G et al.

Source: Nature [Nature] 2025 Nov; Vol. 647 (8089), pp. 536-543. Date of Electronic Publication: 2025 Sep 17.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

MeSH Terms: Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/chemistry , Mechanistic Target of Rapamycin Complex 1*/ultrastructure , Cryoelectron Microscopy* , Lysosomes*/metabolism , Lysosomes*/chemistry , Lysosomes*/ultrastructure , Intracellular Membranes*/metabolism , Intracellular Membranes*/ultrastructure , Intracellular Membranes*/chemistry, Ras Homolog Enriched in Brain Protein/metabolism ; Ras Homolog Enriched in Brain Protein/chemistry ; Ras Homolog Enriched in Brain Protein/ultrastructure ; Humans ; Regulatory-Associated Protein of mTOR/metabolism ; Regulatory-Associated Protein of mTOR/ultrastructure ; Regulatory-Associated Protein of mTOR/chemistry ; Models, Molecular ; Catalytic Domain ; Enzyme Activation ; TOR Serine-Threonine Kinases/metabolism ; TOR Serine-Threonine Kinases/chemistry ; TOR Serine-Threonine Kinases/ultrastructure ; Animals ; Monomeric GTP-Binding Proteins/metabolism

The MTORC1 signaling pathway related gene POLR3G serves as a potential prognostic biomarker in Hepatocellular Carcinoma.

Authors: Wang Z Chen J Zhang B et al.

Source: Clinical and experimental medicine [Clin Exp Med] 2025 Oct 31; Vol. 25 (1), pp. 352. Date of Electronic Publication: 2025 Oct 31.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100973405 Publication Model: Electronic Cited Medium: Internet ISSN: 1591-9528 (Electronic) Linking ISSN: 15918890 NLM ISO Abbreviation: Clin Exp Med Subsets: MEDLINE

MeSH Terms: Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/mortality , Carcinoma, Hepatocellular*/metabolism , Liver Neoplasms*/genetics , Liver Neoplasms*/pathology , Liver Neoplasms*/mortality , Liver Neoplasms*/metabolism , Biomarkers, Tumor*/genetics , Biomarkers, Tumor*/metabolism , Signal Transduction*/genetics , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/genetics, Humans ; Prognosis ; Gene Expression Regulation, Neoplastic ; Male ; DNA Copy Number Variations ; Cell Proliferation/genetics ; Female ; Cell Line, Tumor ; Middle Aged

mTORC1-dependent suppression of autophagic activity in somatic cell nuclear transfer mouse embryos.

Authors: Tatebe T Pham DQ Ogura A et al.

Source: Reproduction (Cambridge, England) [Reproduction] 2025 Oct 28; Vol. 170 (6). Date of Electronic Publication: 2025 Oct 28 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Published for the Society for Reproduction and Fertility by BioScientifica Country of Publication: England NLM ID: 100966036 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1741-7899 (Electronic) Linking ISSN: 14701626 NLM ISO Abbreviation: Reproduction Subsets: MEDLINE

MeSH Terms: Autophagy*/physiology , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/antagonists & inhibitors , Mechanistic Target of Rapamycin Complex 1*/genetics , Nuclear Transfer Techniques* , Embryonic Development* , Blastocyst*/metabolism , Embryo, Mammalian*/metabolism , Embryo, Mammalian*/cytology, Animals ; Mice ; Female ; Signal Transduction ; Gene Expression Regulation, Developmental

Biphasic control of the B cell transcriptome by mTORC1 and GSK3.

Authors: Kalchschmidt J Kanno T Park S et al.

Source: Cell reports [Cell Rep] 2025 Oct 28; Vol. 44 (10), pp. 116361. Date of Electronic Publication: 2025 Sep 29.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH Terms: Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/genetics , B-Lymphocytes*/metabolism , Glycogen Synthase Kinase 3*/metabolism , Glycogen Synthase Kinase 3*/genetics , Transcriptome*/genetics, Humans ; Lymphoma, B-Cell/genetics ; Cell Line, Tumor ; CRISPR-Cas Systems/genetics

[Effects of acupuncture on podocyte autophagy and the LncRNA SOX2OT/mTORC1/ULK1 pathway in rats with diabetic kidney disease].

Authors: Wang X Zhang Y Li H et al.

Source: Zhongguo zhen jiu = Chinese acupuncture & moxibustion [Zhongguo Zhen Jiu] 2025 Oct 12; Vol. 45 (10), pp. 1450-1458. Date of Electronic Publication: 2025 Jul 30.

Publication Type: English Abstract; Journal Article

Journal Info: Publisher: Guoji Shudian Country of Publication: China NLM ID: 8600658 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0255-2930 (Print) Linking ISSN: 02552930 NLM ISO Abbreviation: Zhongguo Zhen Jiu Subsets: MEDLINE

MeSH Terms: Podocytes*/metabolism , Podocytes*/cytology , Diabetic Nephropathies*/therapy , Diabetic Nephropathies*/genetics , Diabetic Nephropathies*/metabolism , Diabetic Nephropathies*/physiopathology , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/genetics , Autophagy* , Acupuncture Therapy* , Autophagy-Related Protein-1 Homolog*/metabolism , Autophagy-Related Protein-1 Homolog*/genetics , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism, Animals ; Rats, Sprague-Dawley ; Male ; Rats ; Humans ; Signal Transduction

SFPQ-TFE3 reciprocally regulates mTORC1 and induces lineage plasticity in a mouse model of renal tumorigenesis.

Authors: Asrani K Amaral A Woo J et al.

Source: Nature communications [Nat Commun] 2025 Oct 03; Vol. 16 (1), pp. 8822. Date of Electronic Publication: 2025 Oct 03.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/genetics , Kidney Neoplasms*/genetics , Kidney Neoplasms*/pathology , Kidney Neoplasms*/metabolism , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*/genetics , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*/metabolism , PTB-Associated Splicing Factor*/genetics , PTB-Associated Splicing Factor*/metabolism , Carcinogenesis*/genetics , Carcinogenesis*/pathology , Carcinogenesis*/metabolism , Oncogene Proteins, Fusion*/genetics , Oncogene Proteins, Fusion*/metabolism, Animals ; Humans ; Mice ; Mice, Transgenic ; Disease Models, Animal ; Kidney/pathology ; Kidney/metabolism ; PAX8 Transcription Factor/metabolism ; PAX8 Transcription Factor/genetics ; Cell Lineage/genetics ; Gene Expression Regulation, Neoplastic ; PAX2 Transcription Factor/metabolism ; PAX2 Transcription Factor/genetics ; Cell Line, Tumor

Inhibiting mTORC1 pathway by rapamycin restores the balance of CD8 ⁺ T cell subsets and reduces CD8 ⁺ T cell-mediated platelet destruction in immune thrombocytopenia.

Authors: Ni X Guo J Zhu X et al.

Source: Thrombosis research [Thromb Res] 2025 Oct; Vol. 254, pp. 109475. Date of Electronic Publication: 2025 Sep 09.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon Press Country of Publication: United States NLM ID: 0326377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2472 (Electronic) Linking ISSN: 00493848 NLM ISO Abbreviation: Thromb Res Subsets: MEDLINE

MeSH Terms: Mechanistic Target of Rapamycin Complex 1*/antagonists & inhibitors , Mechanistic Target of Rapamycin Complex 1*/metabolism , Sirolimus*/pharmacology , Sirolimus*/therapeutic use , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/drug effects , CD8-Positive T-Lymphocytes*/metabolism , Purpura, Thrombocytopenic, Idiopathic*/drug therapy , Purpura, Thrombocytopenic, Idiopathic*/immunology , Purpura, Thrombocytopenic, Idiopathic*/pathology , Blood Platelets*/drug effects , Blood Platelets*/immunology , Blood Platelets*/pathology, Humans ; Animals ; Mice ; Female ; Male ; Adult ; Signal Transduction/drug effects ; Middle Aged

Structural basis for the dynamic regulation of mTORC1 by amino acids.

Authors: Valenstein ML Wranik M Lalgudi PV et al.

Source: Nature [Nature] 2025 Oct; Vol. 646 (8084), pp. 493-500. Date of Electronic Publication: 2025 Aug 20.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

MeSH Terms: Amino Acids*/metabolism , Amino Acids*/chemistry , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/chemistry , Mechanistic Target of Rapamycin Complex 1*/ultrastructure, Humans ; Binding Sites ; Cryoelectron Microscopy ; Leucine/metabolism ; Leucine/chemistry ; Models, Molecular ; Nuclear Proteins/metabolism ; Nuclear Proteins/chemistry ; Nuclear Proteins/ultrastructure ; Protein Binding ; Sestrins ; Intracellular Signaling Peptides and Proteins

Structural basis for mTORC1 regulation by the CASTOR1-GATOR2 complex.

Authors: Jansen RM Maghe C Tapia K et al.

Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2025 Oct; Vol. 32 (10), pp. 1980-1988. Date of Electronic Publication: 2025 Jul 25.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

MeSH Terms: Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/chemistry , GTPase-Activating Proteins*/metabolism , GTPase-Activating Proteins*/chemistry , GTPase-Activating Proteins*/ultrastructure , Intracellular Signaling Peptides and Proteins*/metabolism , Intracellular Signaling Peptides and Proteins*/chemistry, Humans ; Cryoelectron Microscopy ; Models, Molecular ; Protein Binding ; Arginine/metabolism ; Monomeric GTP-Binding Proteins

mTORC1 Selective Nano-Inhibitor by Disrupting the Lysosomal Arginine-SLC38A9- mTORC1-CDKs Axis for Precision Bladder Cancer Therapy.

Authors: Kong L Xu K Bao X et al.

Source: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2025 Oct; Vol. 37 (39), pp. e2504798. Date of Electronic Publication: 2025 Jul 04.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9885358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4095 (Electronic) Linking ISSN: 09359648 NLM ISO Abbreviation: Adv Mater Subsets: MEDLINE

MeSH Terms: Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/antagonists & inhibitors , Lysosomes*/metabolism , Lysosomes*/drug effects , Urinary Bladder Neoplasms*/drug therapy , Urinary Bladder Neoplasms*/metabolism , Urinary Bladder Neoplasms*/pathology , Arginine*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use , Nanoparticles*/chemistry, Humans ; Animals ; Cell Line, Tumor ; Mice ; Nanomedicine

ER-phagy Activation by AMFR Attenuates Cardiac Fibrosis Post-Myocardial Infarction via mTORC1 Pathway.

Authors: Wang Z Niu K Liu W et al.

Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Oct; Vol. 12 (37), pp. e04552. Date of Electronic Publication: 2025 Jul 17.

Publication Type: Journal Article

Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH Terms: Myocardial Infarction*/metabolism , Myocardial Infarction*/pathology , Myocardial Infarction*/genetics , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/genetics , Autophagy*/physiology , Autophagy*/genetics , Endoplasmic Reticulum*/metabolism, Animals ; Fibrosis/metabolism ; Mice ; Mice, Knockout ; Myocardium/metabolism ; Myocardium/pathology ; Signal Transduction ; Fibroblasts/metabolism ; Mice, Inbred C57BL ; Male