Výsledky vyhledávání - "Map Kinase Signaling System"

Appropriate doses of ionizing radiation facilitate the proliferation and anti-tumor effects of γδ T cells through ERK and p38MAPK pathways in vitro.

Autoři: Wang LL Yang Y Feng YB a další

Zdroj: Molecular immunology [Mol Immunol] 2025 Dec; Vol. 188, pp. 80-88. Date of Electronic Publication: 2025 Nov 10.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Pergamon Press Country of Publication: England NLM ID: 7905289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9142 (Electronic) Linking ISSN: 01615890 NLM ISO Abbreviation: Mol Immunol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Cell Proliferation*/radiation effects , p38 Mitogen-Activated Protein Kinases*/metabolism , p38 Mitogen-Activated Protein Kinases*/immunology , Receptors, Antigen, T-Cell, gamma-delta*/immunology , Receptors, Antigen, T-Cell, gamma-delta*/metabolism , MAP Kinase Signaling System*/radiation effects , MAP Kinase Signaling System*/immunology , Radiation, Ionizing* , T-Lymphocytes*/immunology , T-Lymphocytes*/radiation effects, Humans ; Granzymes/metabolism ; Dose-Response Relationship, Radiation ; Interferon-gamma/metabolism

REG3A promotes gemcitabine resistance in pancreatic cancer via the GPR54/ARRB2/ERK1/2 ligand-directed signaling pathway.

Autoři: Liu J Li S Zhou H a další

Zdroj: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 2), pp. 117322. Date of Electronic Publication: 2025 Sep 09.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Deoxycytidine*/analogs & derivatives , Deoxycytidine*/pharmacology , Deoxycytidine*/therapeutic use , Drug Resistance, Neoplasm*/drug effects , Drug Resistance, Neoplasm*/physiology , Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/pathology , Receptors, G-Protein-Coupled*/metabolism , Receptors, G-Protein-Coupled*/genetics , MAP Kinase Signaling System*/drug effects , MAP Kinase Signaling System*/physiology , Pancreatitis-Associated Proteins*/metabolism , Pancreatitis-Associated Proteins*/genetics , Antimetabolites, Antineoplastic*/pharmacology , Antimetabolites, Antineoplastic*/therapeutic use, Humans ; Gemcitabine ; Animals ; Mice ; Cell Line, Tumor ; Mice, Knockout ; Male ; Mice, Nude ; Ligands ; Female

FSTL1 promotes osteoclast differentiation and Accelerates periprosthetic osteolysis via PP2A Cα-Mediated activation of the JNK signaling pathway.

Autoři: Li M Wang L Lu F a další

Zdroj: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 4), pp. 117450. Date of Electronic Publication: 2025 Oct 21.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Osteolysis*/metabolism , Osteolysis*/pathology , Osteolysis*/chemically induced , Osteoclasts*/metabolism , Osteoclasts*/drug effects , Osteoclasts*/pathology , Cell Differentiation*/physiology , Cell Differentiation*/drug effects , Follistatin-Related Proteins*/genetics , Follistatin-Related Proteins*/metabolism , Protein Phosphatase 2*/metabolism , Protein Phosphatase 2*/genetics , MAP Kinase Signaling System*/physiology , MAP Kinase Signaling System*/drug effects, Animals ; Humans ; Mice ; Proto-Oncogene Mas ; Male ; Mice, Inbred C57BL ; Female ; Osteogenesis

RRBP1 Inhibition Reduces Microglial M1 Polarization and Inflammation-Mediated Neuronal Loss and Oxidative Stress by Regulating ERK Pathway in Alzheimer's Disease.

Autoři: Li Y Fan H Han X a další

Zdroj: Molecular neurobiology [Mol Neurobiol] 2025 Nov 06; Vol. 63 (1), pp. 5. Date of Electronic Publication: 2025 Nov 06.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Oxidative Stress*/drug effects , Oxidative Stress*/physiology , Microglia*/metabolism , Microglia*/pathology , Microglia*/drug effects , Alzheimer Disease*/pathology , Alzheimer Disease*/metabolism , Neurons*/metabolism , Neurons*/pathology , Neurons*/drug effects , Inflammation*/pathology , Inflammation*/metabolism , MAP Kinase Signaling System*/drug effects , MAP Kinase Signaling System*/physiology , Cell Polarity*/drug effects, Animals ; Humans ; Mice ; Cell Line ; Reactive Oxygen Species/metabolism ; Amyloid beta-Peptides ; Cell Line, Tumor ; Apoptosis/drug effects

Comprehensive map of the regulatory network triggered by MET exon 14 skipping reveals important involvement of the RAS-ERK signaling pathway.

Autoři: Truong MJ Pawlak G Meneboo JP a další

Zdroj: Cell death & disease [Cell Death Dis] 2025 Nov 03; Vol. 16 (1), pp. 783. Date of Electronic Publication: 2025 Nov 03.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

Výrazy ze slovníku MeSH: Proto-Oncogene Proteins c-met*/genetics , Proto-Oncogene Proteins c-met*/metabolism , MAP Kinase Signaling System*/drug effects , MAP Kinase Signaling System*/genetics , Exons*/genetics , Gene Regulatory Networks* , ras Proteins*/metabolism , Lung Neoplasms*/genetics , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism, Humans ; Pyrimidinones/pharmacology ; Cell Line, Tumor ; Smad3 Protein/metabolism ; Smad3 Protein/genetics ; Proto-Oncogene Protein c-ets-1/metabolism ; Proto-Oncogene Protein c-ets-1/genetics ; Proto-Oncogene Proteins c-fos/metabolism ; Proto-Oncogene Proteins c-fos/genetics ; Hepatocyte Growth Factor/pharmacology ; Hepatocyte Growth Factor/metabolism ; Pyridones/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Signal Transduction ; Cell Movement/drug effects ; Cell Movement/genetics

Regulation of Milk Production by the MAPK/ERK Pathway in Water Buffalo (Bubalus bubalis): Genomic and Molecular Insights.

Autoři: Naz S Ishaque U Chatha AMM a další

Zdroj: Veterinary medicine and science [Vet Med Sci] 2025 Nov; Vol. 11 (6), pp. e70703.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 101678837 Publication Model: Print Cited Medium: Internet ISSN: 2053-1095 (Electronic) Linking ISSN: 20531095 NLM ISO Abbreviation: Vet Med Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Buffaloes*/genetics , Buffaloes*/physiology , MAP Kinase Signaling System*/genetics , MAP Kinase Signaling System*/physiology , Milk*/metabolism , Lactation*/genetics , Lactation*/physiology, Animals ; Phylogeny ; Female ; Genomics

Genomic profiling of high tumor mutational load in microsatellite-stable colorectal cancer uncovers MAPK signaling pathway alterations following anti-EGFR therapy.

Autoři: Boscolo Bielo L Napolitano S Avallone A a další

Zdroj: ESMO open [ESMO Open] 2025 Nov; Vol. 10 (11), pp. 105877. Date of Electronic Publication: 2025 Oct 28.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: England NLM ID: 101690685 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7029 (Electronic) Linking ISSN: 20597029 NLM ISO Abbreviation: ESMO Open Subsets: MEDLINE

Výrazy ze slovníku MeSH: Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/pathology , MAP Kinase Signaling System*/drug effects , MAP Kinase Signaling System*/genetics, Humans ; ErbB Receptors/antagonists & inhibitors ; Female ; Male ; Middle Aged ; Aged ; Mutation ; Microsatellite Instability ; Antineoplastic Agents/therapeutic use

Clonorchis sinensis Crude Antigen Suppresses Osteoclast Differentiation via Modulation of the NF-κB and MAPK Signaling Pathway.

Autoři: Tang L He S Ma B a další

Zdroj: Immunity, inflammation and disease [Immun Inflamm Dis] 2025 Nov; Vol. 13 (11), pp. e70292.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: John Wiley and Sons Ltd Country of Publication: England NLM ID: 101635460 Publication Model: Print Cited Medium: Internet ISSN: 2050-4527 (Electronic) Linking ISSN: 20504527 NLM ISO Abbreviation: Immun Inflamm Dis Subsets: MEDLINE

Výrazy ze slovníku MeSH: Clonorchis sinensis*/immunology , Osteoclasts*/metabolism , Osteoclasts*/immunology , Osteoclasts*/cytology , Osteoclasts*/drug effects , Cell Differentiation*/drug effects , Cell Differentiation*/immunology , Antigens, Helminth*/immunology , Antigens, Helminth*/pharmacology , NF-kappa B*/metabolism , MAP Kinase Signaling System*/drug effects , MAP Kinase Signaling System*/immunology, Animals ; Mice ; Macrophages/metabolism ; Osteogenesis/drug effects ; Signal Transduction ; Cells, Cultured

Glimepiride overcomes acquired resistance to EGFR TKIs in lung cancer via the AMPK/ERK/MMP7 signaling pathway.

Autoři: Zhang H Li M Li Y a další

Zdroj: Biochemical pharmacology [Biochem Pharmacol] 2025 Nov; Vol. 241, pp. 117162. Date of Electronic Publication: 2025 Jul 12.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Drug Resistance, Neoplasm*/drug effects , Drug Resistance, Neoplasm*/physiology , Lung Neoplasms*/drug therapy , Lung Neoplasms*/metabolism , Sulfonylurea Compounds*/pharmacology , Sulfonylurea Compounds*/therapeutic use , Protein Kinase Inhibitors*/pharmacology , MAP Kinase Signaling System*/drug effects , MAP Kinase Signaling System*/physiology , Matrix Metalloproteinase 7*/metabolism , AMP-Activated Protein Kinases*/metabolism, Humans ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Animals ; Signal Transduction/drug effects ; Cell Line, Tumor ; Mice ; Mice, Nude ; A549 Cells

Reciprocal c-Abl-GPx1 regulation controls CA1 neuronal viability to oxidative stress via ERK1/2-DRP1-mediated mitochondrial dynamics.

Autoři: Kim JE Wang SH Kang TC

Zdroj: Neuropharmacology [Neuropharmacology] 2025 Nov 01; Vol. 278, pp. 110586. Date of Electronic Publication: 2025 Jul 05.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

Výrazy ze slovníku MeSH: Oxidative Stress*/physiology , Oxidative Stress*/drug effects , Mitochondrial Dynamics*/physiology , Mitochondrial Dynamics*/drug effects , Dynamins*/metabolism , Proto-Oncogene Proteins c-abl*/metabolism , Proto-Oncogene Proteins c-abl*/antagonists & inhibitors , Neurons*/drug effects , Neurons*/metabolism , Glutathione Peroxidase*/metabolism , Glutathione Peroxidase*/genetics , CA1 Region, Hippocampal*/metabolism , CA1 Region, Hippocampal*/drug effects , MAP Kinase Signaling System*/drug effects , MAP Kinase Signaling System*/physiology, Animals ; Glutathione Peroxidase GPX1 ; Phosphorylation/drug effects ; Male ; Cell Survival/drug effects ; Cell Survival/physiology ; Buthionine Sulfoximine/pharmacology ; Rats ; Imatinib Mesylate/pharmacology ; Status Epilepticus/metabolism ; Mitochondria/metabolism ; Mitochondria/drug effects

BH4 Oxidation-Derived H 2 O 2 Activates ERK1/2 Signaling via B-Raf in Rat Dorsal Root Ganglion Neurons.

Autoři: Mohammadi M Siobal M Isensee J a další

Zdroj: Journal of neurochemistry [J Neurochem] 2025 Nov; Vol. 169 (11), pp. e70271.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print Cited Medium: Internet ISSN: 1471-4159 (Electronic) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE

Výrazy ze slovníku MeSH: Ganglia, Spinal*/metabolism , Ganglia, Spinal*/drug effects , Ganglia, Spinal*/cytology , Hydrogen Peroxide*/metabolism , Hydrogen Peroxide*/pharmacology , MAP Kinase Signaling System*/drug effects , MAP Kinase Signaling System*/physiology , Biopterins*/analogs & derivatives , Biopterins*/metabolism , Biopterins*/pharmacology , Neurons*/metabolism , Neurons*/drug effects, Animals ; Rats ; Oxidation-Reduction ; Rats, Sprague-Dawley ; Male ; Cells, Cultured

SIRT1-mediated deacetylation and activation of MEK/ERK pathway decreased IL-6 in spinal dorsal horn to promote oxycodone tolerance.

Autoři: Hu S Zhou F Lin B a další

Zdroj: Neuropharmacology [Neuropharmacology] 2025 Nov 01; Vol. 278, pp. 110585. Date of Electronic Publication: 2025 Jul 04.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

Výrazy ze slovníku MeSH: Oxycodone*/pharmacology , Sirtuin 1*/metabolism , Interleukin-6*/metabolism , MAP Kinase Signaling System*/drug effects , MAP Kinase Signaling System*/physiology , Analgesics, Opioid*/pharmacology , Drug Tolerance*/physiology , Spinal Cord Dorsal Horn*/metabolism , Spinal Cord Dorsal Horn*/drug effects, Animals ; Male ; Mice, Inbred ICR ; Mice ; Acetylation/drug effects

Tailoring MAPK Pathways: New Therapeutic Avenues for Treating Alzheimer's Disease.

Autoři: Sharma A Mehra V Kumar V a další

Zdroj: Molecular neurobiology [Mol Neurobiol] 2025 Nov; Vol. 62 (11), pp. 14315-14343. Date of Electronic Publication: 2025 Apr 21.

Způsob vydávání: Journal Article; Review

Informace o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Alzheimer Disease*/drug therapy , Alzheimer Disease*/enzymology , MAP Kinase Signaling System*/drug effects , MAP Kinase Signaling System*/physiology , Protein Kinase Inhibitors*/therapeutic use , Protein Kinase Inhibitors*/pharmacology, Humans ; Animals

BRD4-S Drives Colorectal Cancer Progression via DDX27-Regulated Splicing and MAPK Signaling Activation.

Autoři: Wang C Hong H Zhou L a další

Zdroj: Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2025 Oct 30; Vol. 30 (10), pp. 46158.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: IMR Press Country of Publication: Singapore NLM ID: 101612996 Publication Model: Print Cited Medium: Internet ISSN: 2768-6698 (Electronic) Linking ISSN: 27686698 NLM ISO Abbreviation: Front Biosci (Landmark Ed) Subsets: MEDLINE

Výrazy ze slovníku MeSH: Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , Transcription Factors*/genetics , Transcription Factors*/metabolism , DEAD-box RNA Helicases*/metabolism , DEAD-box RNA Helicases*/genetics , Cell Cycle Proteins*/genetics , Cell Cycle Proteins*/metabolism , MAP Kinase Signaling System*, Humans ; Animals ; Mice ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Mice, Nude ; Cell Proliferation ; Protein Isoforms/genetics ; Cell Movement/genetics ; Female ; Male ; Alternative Splicing ; Bromodomain Containing Proteins

Glabridin Improves Depression-Like Behaviors in Mice by Modulating Neuroinflammation via MAPK/NF-κB Signaling Pathway.

Autoři: Shan M Zhang J Yang F a další

Zdroj: Neurochemical research [Neurochem Res] 2025 Oct 30; Vol. 50 (6), pp. 339. Date of Electronic Publication: 2025 Oct 30.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7613461 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6903 (Electronic) Linking ISSN: 03643190 NLM ISO Abbreviation: Neurochem Res Subsets: MEDLINE

Výrazy ze slovníku MeSH: Isoflavones*/therapeutic use , Isoflavones*/pharmacology , Phenols*/therapeutic use , Phenols*/pharmacology , NF-kappa B*/metabolism , Depression*/drug therapy , Depression*/metabolism , Neuroinflammatory Diseases*/drug therapy , Neuroinflammatory Diseases*/metabolism , Antidepressive Agents*/pharmacology , Antidepressive Agents*/therapeutic use , MAP Kinase Signaling System*/drug effects , MAP Kinase Signaling System*/physiology, Animals ; Male ; Mice ; Signal Transduction/drug effects ; Behavior, Animal/drug effects ; Stress, Psychological/drug therapy ; Stress, Psychological/metabolism ; Hippocampus/drug effects ; Hippocampus/metabolism

Diabetic vascular calcification inhibited by soluble epoxide hydrolase gene deletion via regressing NID2-mediated IGF2-ERK1/2 signaling pathway.

Autoři: Cai Y Hu S Liu J a další

Zdroj: Chinese medical journal [Chin Med J (Engl)] 2025 Oct 20; Vol. 138 (20), pp. 2657-2668. Date of Electronic Publication: 2025 Sep 12.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Chinese Medical Association ; produced by Wolters Kluwer Country of Publication: China NLM ID: 7513795 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2542-5641 (Electronic) Linking ISSN: 03666999 NLM ISO Abbreviation: Chin Med J (Engl) Subsets: MEDLINE

Výrazy ze slovníku MeSH: Vascular Calcification*/genetics , Vascular Calcification*/metabolism , Epoxide Hydrolases*/genetics , Epoxide Hydrolases*/metabolism , MAP Kinase Signaling System*/physiology , MAP Kinase Signaling System*/genetics, Animals ; Mice ; Mice, Inbred C57BL ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/genetics ; Male ; Gene Deletion ; Cell Line ; Immunohistochemistry ; Muscle, Smooth, Vascular/metabolism ; Signal Transduction/physiology ; Signal Transduction/genetics ; Mice, Knockout

Treg cells mitigate inflammatory responses and symptoms via β2-AR/β-Arr2/ERK signaling in an experimental rheumatoid arthritis.

Autoři: Liu Y Wang XQ Lu JH a další

Zdroj: Arthritis research & therapy [Arthritis Res Ther] 2025 Oct 17; Vol. 27 (1), pp. 194. Date of Electronic Publication: 2025 Oct 17.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101154438 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-6362 (Electronic) Linking ISSN: 14786354 NLM ISO Abbreviation: Arthritis Res Ther Subsets: MEDLINE

Výrazy ze slovníku MeSH: Arthritis, Experimental*/immunology , Arthritis, Experimental*/metabolism , Arthritis, Experimental*/pathology , T-Lymphocytes, Regulatory*/immunology , T-Lymphocytes, Regulatory*/metabolism , Arthritis, Rheumatoid*/immunology , Arthritis, Rheumatoid*/metabolism , Arthritis, Rheumatoid*/pathology , Receptors, Adrenergic, beta-2*/metabolism , Receptors, Adrenergic, beta-2*/immunology , MAP Kinase Signaling System*/immunology , MAP Kinase Signaling System*/physiology , beta-Arrestin 2*/metabolism , beta-Arrestin 2*/immunology, Animals ; Mice ; Mice, Inbred DBA ; Male ; Inflammation/immunology ; Inflammation/metabolism

A PP2A molecular glue overcomes RAS/MAPK inhibitor resistance in KRAS-mutant non-small cell lung cancer.

Autoři: Raines B Tseng-Rogenski S Dowdican AC a další

Zdroj: The Journal of clinical investigation [J Clin Invest] 2025 Oct 14; Vol. 135 (23). Date of Electronic Publication: 2025 Oct 14 (Print Publication: 2025).

Způsob vydávání: Journal Article

Informace o časopise: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

Výrazy ze slovníku MeSH: Carcinoma, Non-Small-Cell Lung*/genetics , Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/enzymology , Carcinoma, Non-Small-Cell Lung*/metabolism , Protein Phosphatase 2*/metabolism , Protein Phosphatase 2*/genetics , Protein Phosphatase 2*/antagonists & inhibitors , Lung Neoplasms*/genetics , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Lung Neoplasms*/enzymology , Lung Neoplasms*/metabolism , Drug Resistance, Neoplasm*/drug effects , Drug Resistance, Neoplasm*/genetics , Proto-Oncogene Proteins p21(ras)*/genetics , Proto-Oncogene Proteins p21(ras)*/metabolism , Proto-Oncogene Proteins p21(ras)*/antagonists & inhibitors , Protein Kinase Inhibitors*/pharmacology , Mutation* , MAP Kinase Signaling System*/drug effects , MAP Kinase Signaling System*/genetics, Humans ; Animals ; Mice ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Female

Temporin-1CEa and its Analog LK2(6)A(L) Confer Neuroprotective Effects in Parkinson's Disease Model by Attenuating Neuroinflammation Via the NF-κB and MAPK Signaling Pathways.

Autoři: Zhang W Qu M Wang C a další

Zdroj: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2025 Oct 06; Vol. 20 (1), pp. 82. Date of Electronic Publication: 2025 Oct 06.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 101256586 Publication Model: Electronic Cited Medium: Internet ISSN: 1557-1904 (Electronic) Linking ISSN: 15571890 NLM ISO Abbreviation: J Neuroimmune Pharmacol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use , NF-kappa B*/metabolism , MAP Kinase Signaling System*/drug effects , MAP Kinase Signaling System*/physiology , Neuroinflammatory Diseases*/metabolism , Neuroinflammatory Diseases*/drug therapy , Antimicrobial Peptides*/pharmacology, Animals ; Rats ; PC12 Cells ; Mice ; Caenorhabditis elegans ; Microglia/drug effects ; Microglia/metabolism ; Lipopolysaccharides ; Parkinson Disease/metabolism ; Signal Transduction/drug effects

DUSP1-mediated suppression of p38 MAPK signaling pathway reduces ferroptosis in cerebral ischemia-reperfusion injury.

Autoři: Ma S Zhang X Fan J a další

Zdroj: Neurochemistry international [Neurochem Int] 2025 Oct; Vol. 189, pp. 106024. Date of Electronic Publication: 2025 Jul 31.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Pergamon Press Country of Publication: England NLM ID: 8006959 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9754 (Electronic) Linking ISSN: 01970186 NLM ISO Abbreviation: Neurochem Int Subsets: MEDLINE

Výrazy ze slovníku MeSH: Ferroptosis*/physiology , Ferroptosis*/drug effects , Reperfusion Injury*/metabolism , Reperfusion Injury*/pathology , Dual Specificity Phosphatase 1*/metabolism , Dual Specificity Phosphatase 1*/biosynthesis , Dual Specificity Phosphatase 1*/antagonists & inhibitors , Dual Specificity Phosphatase 1*/genetics , p38 Mitogen-Activated Protein Kinases*/metabolism , p38 Mitogen-Activated Protein Kinases*/antagonists & inhibitors , MAP Kinase Signaling System*/physiology , MAP Kinase Signaling System*/drug effects , Brain Ischemia*/metabolism, Animals ; Rats ; Male ; Rats, Sprague-Dawley ; PC12 Cells ; Infarction, Middle Cerebral Artery/metabolism