Suchergebnisse - "Macrocyclic Compounds"

Development of pyrazolo[1,5-a]pyrimidine based macrocyclic kinase inhibitors targeting AAK1.

Autoren: Mensing TE Kurz CG Amrhein JA et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 05; Vol. 299, pp. 118076. Date of Electronic Publication: 2025 Aug 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Pyrimidines*/chemistry , Pyrimidines*/pharmacology , Pyrimidines*/chemical synthesis , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyrazoles*/chemical synthesis , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Antiviral Agents*/chemical synthesis , Intracellular Signaling Peptides and Proteins*/antagonists & inhibitors , Intracellular Signaling Peptides and Proteins*/metabolism , Macrocyclic Compounds*/chemistry , Macrocyclic Compounds*/pharmacology , Macrocyclic Compounds*/chemical synthesis , Nucleoside-Phosphate Kinase*/antagonists & inhibitors , Nucleoside-Phosphate Kinase*/metabolism , Protein Serine-Threonine Kinases*/antagonists & inhibitors , Protein Serine-Threonine Kinases*/metabolism, Humans ; Structure-Activity Relationship ; SARS-CoV-2/drug effects ; Molecular Structure ; Dose-Response Relationship, Drug

Discovery of macrocyclic derivatives bearing N-sulfonyl-pyrazole moiety as new potent hematopoietic progenitor kinase 1 inhibitors.

Autoren: Wang L Li ZL Duan CX et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109196. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyrazoles*/chemical synthesis , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Protein Serine-Threonine Kinases*/antagonists & inhibitors , Protein Serine-Threonine Kinases*/metabolism , Macrocyclic Compounds*/chemistry , Macrocyclic Compounds*/pharmacology , Macrocyclic Compounds*/chemical synthesis , Drug Discovery*, Humans ; Animals ; Mice ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Cell Proliferation/drug effects ; Microsomes, Liver/metabolism ; Cell Line, Tumor ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/pathology

Accurate de novo design of high-affinity protein-binding macrocycles using deep learning.

Autoren: Rettie SA Juergens D Adebomi V et al.

Quelle: Nature chemical biology [Nat Chem Biol] 2025 Dec; Vol. 21 (12), pp. 1948-1956. Date of Electronic Publication: 2025 Jun 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

MeSH-Schlagworte: Deep Learning* , Macrocyclic Compounds*/chemistry , Macrocyclic Compounds*/metabolism , Drug Design*, Protein Binding ; Humans ; Models, Molecular ; Crystallography, X-Ray ; Binding Sites

Near-Infrared Conjugated Macrocyclic BODIPYs for Photothermal Cancer Therapy.

Autoren: Cheng F Qiang T Li M et al.

Quelle: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Nov 17; Vol. 64 (47), pp. e202511125. Date of Electronic Publication: 2025 Sep 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

MeSH-Schlagworte: Boron Compounds*/chemistry , Boron Compounds*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/therapeutic use , Photothermal Therapy* , Photosensitizing Agents*/chemistry , Photosensitizing Agents*/pharmacology , Photosensitizing Agents*/therapeutic use , Photosensitizing Agents*/chemical synthesis , Macrocyclic Compounds*/chemistry , Macrocyclic Compounds*/pharmacology , Neoplasms*/drug therapy , Neoplasms*/therapy, Animals ; Mice ; Humans ; Infrared Rays ; Molecular Structure ; Cell Survival/drug effects

Cucurbituril-aerolysin nanopore interactions for molecular recognition.

Autoren: Ouldali H Dejoux C Pastoriza-Gallego M et al.

Quelle: The European physical journal. E, Soft matter [Eur Phys J E Soft Matter] 2025 Nov 07; Vol. 48 (10-12), pp. 66. Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: EDP Sciences Country of Publication: France NLM ID: 101126530 Publication Model: Electronic Cited Medium: Internet ISSN: 1292-895X (Electronic) Linking ISSN: 12928941 NLM ISO Abbreviation: Eur Phys J E Soft Matter Subsets: MEDLINE

MeSH-Schlagworte: Nanopores* , Pore Forming Cytotoxic Proteins*/chemistry , Pore Forming Cytotoxic Proteins*/metabolism , Bacterial Toxins*/chemistry , Bacterial Toxins*/metabolism , Macrocyclic Compounds*/chemistry , Macrocyclic Compounds*/metabolism , Bridged-Ring Compounds*/chemistry, Molecular Docking Simulation ; Protein Binding ; Hydrophobic and Hydrophilic Interactions

Activatable and multifunctional supramolecular photosensitizers via macrocycle-based host-guest interactions: enabling safe and efficient photodynamic therapy.

Autoren: Li S Gu M Wang J et al.

Quelle: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2025 Nov 07; Vol. 61 (90), pp. 17589-17600. Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE

MeSH-Schlagworte: Photosensitizing Agents*/chemistry , Photosensitizing Agents*/pharmacology , Photosensitizing Agents*/therapeutic use , Photochemotherapy* , Macrocyclic Compounds*/chemistry , Macrocyclic Compounds*/pharmacology, Humans ; Macromolecular Substances/chemistry ; Macromolecular Substances/pharmacology ; Macromolecular Substances/chemical synthesis ; Reactive Oxygen Species/metabolism ; Neoplasms/drug therapy ; Animals

Biocompatible synthesis of macrocyclic thiazole peptides from chiral α-amino nitriles.

Autoren: Shang M He J Gardiner MG et al.

Quelle: Organic & biomolecular chemistry [Org Biomol Chem] 2025 Nov 05; Vol. 23 (43), pp. 9815-9818. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE

MeSH-Schlagworte: Nitriles*/chemistry , Thiazoles*/chemistry , Thiazoles*/chemical synthesis , Biocompatible Materials*/chemistry , Biocompatible Materials*/chemical synthesis , Peptides, Cyclic*/chemical synthesis , Peptides, Cyclic*/chemistry , Macrocyclic Compounds*/chemistry , Macrocyclic Compounds*/chemical synthesis , Peptides*/chemical synthesis , Peptides*/chemistry, Stereoisomerism

Novel triazolyl macrocycles incorporating glycolipids: a new protocol.

Autoren: Sabah KJ Kareem NS Sadiq HM et al.

Quelle: Carbohydrate research [Carbohydr Res] 2025 Nov; Vol. 557, pp. 109653. Date of Electronic Publication: 2025 Aug 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0043535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-426X (Electronic) Linking ISSN: 00086215 NLM ISO Abbreviation: Carbohydr Res Subsets: MEDLINE

MeSH-Schlagworte: Triazoles*/chemistry , Glycolipids*/chemistry , Macrocyclic Compounds*/chemistry , Macrocyclic Compounds*/chemical synthesis, Catalysis ; Molecular Structure ; Cycloaddition Reaction

La ³⁺ and Dy ³⁺ hexaaza macrocycles revisited: Enhanced stabilization of G-quadruplex DNA - spectroscopic and in silico studies.

Autoren: Ewert E Marcinkowski D Pospieszna-Markiewicz I et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 330 (Pt 4), pp. 148269. Date of Electronic Publication: 2025 Oct 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: G-Quadruplexes*/drug effects , DNA*/chemistry , Dysprosium*/chemistry , Macrocyclic Compounds*/chemistry , Macrocyclic Compounds*/pharmacology, Circular Dichroism ; Molecular Docking Simulation ; Humans ; Telomere/chemistry

A Dual-Target-Based Screening Strategy for Anti-SARS-CoV-2 Active Compounds Enabling the Identification of Macrocyclic Peptide Natural Products: Chloropeptins.

Autoren: Kimishima A Ikeda T Takahashi O et al.

Quelle: Journal of natural products [J Nat Prod] 2025 Oct 24; Vol. 88 (10), pp. 2351-2359. Date of Electronic Publication: 2025 Sep 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

MeSH-Schlagworte: Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Biological Products*/pharmacology , Biological Products*/chemistry , Macrocyclic Compounds*/pharmacology , Macrocyclic Compounds*/chemistry , Peptides, Cyclic*/pharmacology , Peptides, Cyclic*/chemistry , SARS-CoV-2*/drug effects, Humans ; Angiotensin-Converting Enzyme 2/metabolism ; Coronavirus 3C Proteases/antagonists & inhibitors ; COVID-19/virology ; COVID-19 Drug Treatment ; Molecular Docking Simulation ; Spike Glycoprotein, Coronavirus/metabolism ; Chlorophenols

Macrocyclic Compounds: Unveiling Their Distinctive Antiviral Advantages in Medicinal Research.

Autoren: Yang X Jiao Z Fan C et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Oct 23; Vol. 68 (20), pp. 21035-21071. Date of Electronic Publication: 2025 Oct 10.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Antiviral Agents*/therapeutic use , Macrocyclic Compounds*/pharmacology , Macrocyclic Compounds*/chemistry , Macrocyclic Compounds*/therapeutic use, Humans ; Structure-Activity Relationship ; Animals ; Hepacivirus/drug effects ; Virus Diseases/drug therapy

Developing New Strategies to Construct Pseudo-natural Macrocycles for Undruggable Targets.

Autoren: Wang H Bi T Yang W

Quelle: Accounts of chemical research [Acc Chem Res] 2025 Oct 07; Vol. 58 (19), pp. 3096-3110. Date of Electronic Publication: 2025 Sep 14.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0157313 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4898 (Electronic) Linking ISSN: 00014842 NLM ISO Abbreviation: Acc Chem Res Subsets: MEDLINE

MeSH-Schlagworte: Macrocyclic Compounds*/chemistry , Macrocyclic Compounds*/chemical synthesis , Macrocyclic Compounds*/pharmacology , Biological Products*/chemistry , Biological Products*/pharmacology , Biological Products*/chemical synthesis, Humans

Distinct roles of tandem acyl carrier protein domains in the assembly of a macrocyclic polylactone.

Autoren: Deelee T Wattana-Amorn P

Quelle: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2025 Oct 07; Vol. 61 (81), pp. 15850-15853. Date of Electronic Publication: 2025 Oct 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE

MeSH-Schlagworte: Acyl Carrier Protein*/metabolism , Acyl Carrier Protein*/chemistry , Acyl Carrier Protein*/genetics , Lactones*/chemistry , Lactones*/metabolism , Macrocyclic Compounds*/chemistry , Macrocyclic Compounds*/metabolism, Protein Domains ; Polyketide Synthases/metabolism ; Polyketide Synthases/chemistry ; Polyketide Synthases/genetics

Design, synthesis, and biological evaluation of 2-substituted-pyridin-4-yl macrocyclic derivatives as new selective HPK1 inhibitors.

Autoren: Duan CX Li ZL Liu ZR et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Oct; Vol. 165, pp. 108925. Date of Electronic Publication: 2025 Aug 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Drug Design* , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Macrocyclic Compounds*/pharmacology , Macrocyclic Compounds*/chemistry , Macrocyclic Compounds*/chemical synthesis , Protein Serine-Threonine Kinases*/antagonists & inhibitors , Protein Serine-Threonine Kinases*/metabolism , Pyridines*/pharmacology , Pyridines*/chemistry , Pyridines*/chemical synthesis , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry, Animals ; Structure-Activity Relationship ; Mice ; Humans ; Molecular Structure ; Dose-Response Relationship, Drug ; Molecular Docking Simulation ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor

Design, synthesis and structure-activity relationship studies of novel macrocyclic 2,4-diaminopyrimidines as HPK1 inhibitors.

Autoren: Wu F Sun J Xu M et al.

Quelle: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Oct 01; Vol. 128, pp. 118265. Date of Electronic Publication: 2025 Jun 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Pyrimidines*/chemistry , Pyrimidines*/pharmacology , Pyrimidines*/chemical synthesis , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Drug Design* , Protein Serine-Threonine Kinases*/antagonists & inhibitors , Protein Serine-Threonine Kinases*/metabolism , Macrocyclic Compounds*/chemistry , Macrocyclic Compounds*/pharmacology , Macrocyclic Compounds*/chemical synthesis, Humans ; Structure-Activity Relationship ; Jurkat Cells ; Molecular Structure ; Dose-Response Relationship, Drug ; Phosphorylation/drug effects

Programmable Helicity and Macrocycle Symmetry in β-Peptides via Site-Selective Thioamide Substitution.

Autoren: Hong J Kim J Gong J et al.

Quelle: Journal of the American Chemical Society [J Am Chem Soc] 2025 Dec 03; Vol. 147 (48), pp. 44216-44224. Date of Electronic Publication: 2025 Oct 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

MeSH-Schlagworte: Thioamides*/chemistry , Peptides*/chemistry , Peptides*/chemical synthesis , Macrocyclic Compounds*/chemistry, Protein Structure, Secondary ; Models, Molecular

Supramolecular macrocyclic-mediated logic-gated antitumor therapy nanoplatform.

Autoren: Hu X Wang H Yu J et al.

Quelle: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2025 Dec 02; Vol. 61 (97), pp. 19273-19276. Date of Electronic Publication: 2025 Dec 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE

MeSH-Schlagworte: Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Metal Nanoparticles*/chemistry , Macrocyclic Compounds*/chemistry, Humans ; Gold/chemistry ; beta-Cyclodextrins/chemistry ; Metal-Organic Frameworks/chemistry ; Folic Acid/chemistry ; Naphthoquinones/chemistry ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Screening Assays, Antitumor ; Cell Proliferation/drug effects ; Infrared Rays

Advanced supramolecular food safety sensing technology: principles and applications.

Autoren: Pu H Shi C Sun DW

Quelle: Food chemistry [Food Chem] 2025 Nov 30; Vol. 493 (Pt 1), pp. 145698. Date of Electronic Publication: 2025 Jul 26.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Food Safety*/methods , Food Contamination*/analysis , Biosensing Techniques*/methods , Biosensing Techniques*/instrumentation , Macrocyclic Compounds*/chemistry , Food Analysis*/methods , Food Analysis*/instrumentation

Active Transport of Macrocycles into Micelles Using Molecular Pumps.

Autoren: Seale JSW Sharma S Lee CK et al.

Quelle: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Nov 10; Vol. 64 (46), pp. e202512899. Date of Electronic Publication: 2025 Sep 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

MeSH-Schlagworte: Micelles* , Macrocyclic Compounds*/chemistry, Hydrophobic and Hydrophilic Interactions ; Polymers/chemistry

Sofosbuvir/Velpatasvir/Voxilaprevir Versus Sofosbuvir/Velpatasvir Plus Ribavirin in Patients With Hepatitis C Virus Genotype 3b and Compensated Cirrhosis: A Multicentre Randomized Controlled Trial.

Autoren: Huang R Ji F Jiang Y et al.

Quelle: Journal of medical virology [J Med Virol] 2025 Nov; Vol. 97 (11), pp. e70709.

Publikationsart: Journal Article; Randomized Controlled Trial; Multicenter Study

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE

MeSH-Schlagworte: Sofosbuvir*/therapeutic use , Heterocyclic Compounds, 4 or More Rings*/therapeutic use , Antiviral Agents*/therapeutic use , Hepacivirus*/genetics , Hepacivirus*/drug effects , Hepacivirus*/classification , Ribavirin*/therapeutic use , Carbamates*/therapeutic use , Liver Cirrhosis*/virology , Liver Cirrhosis*/drug therapy , Macrocyclic Compounds*/therapeutic use , Hepatitis C, Chronic*/drug therapy , Hepatitis C, Chronic*/virology , Hepatitis C, Chronic*/complications , Sulfonamides*/therapeutic use, Humans ; Male ; Female ; Middle Aged ; Genotype ; Proline/analogs & derivatives ; Leucine/analogs & derivatives ; Adult ; Sustained Virologic Response ; Aminoisobutyric Acids ; Aged ; Cyclopropanes ; Treatment Outcome ; Drug Therapy, Combination ; China ; Valine/analogs & derivatives ; Lactams, Macrocyclic ; Benzimidazoles ; Benzopyrans ; Quinoxalines