Search Results - "MYELOID differentiation factor 88"

[Effect of aquaporin 5 on TLR4/MyD88/NF-κB signaling pathway in Sjögren syndrome rats].

Authors: Zhu L Chen R Zhou S et al.

Source: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences [Beijing Da Xue Xue Bao Yi Xue Ban] 2025 Oct 18; Vol. 57 (5), pp. 875-883.

Publication Type: English Abstract; Journal Article

Journal Info: Publisher: Beijing da xue Country of Publication: China NLM ID: 101125284 Publication Model: Print Cited Medium: Print ISSN: 1671-167X (Print) Linking ISSN: 1671167X NLM ISO Abbreviation: Beijing Da Xue Xue Bao Yi Xue Ban Subsets: MEDLINE

MeSH Terms: Toll-Like Receptor 4*/metabolism , Toll-Like Receptor 4*/genetics , Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/genetics , Aquaporin 5*/genetics , Aquaporin 5*/metabolism , Sjogren's Syndrome*/metabolism , Sjogren's Syndrome*/genetics , Signal Transduction* , NF-kappa B*/metabolism, Animals ; Rats ; Rats, Sprague-Dawley ; Interleukin-1beta/metabolism ; Female

Inulin aggravates colitis through gut microbiota modulation and MyD88/IL-18 signaling.

Authors: Zhao X Wang Y Gewirtz AT et al.

Source: Gut microbes [Gut Microbes] 2025 Dec 31; Vol. 17 (1), pp. 2570425. Date of Electronic Publication: 2025 Oct 24.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

MeSH Terms: Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/genetics , Inulin*/adverse effects , Inulin*/administration & dosage , Colitis*/chemically induced , Colitis*/microbiology , Colitis*/pathology , Colitis*/immunology , Interleukin-18*/metabolism , Interleukin-18*/genetics , Interleukin-18*/immunology , Gastrointestinal Microbiome*/drug effects, Animals ; Mice, Knockout ; Mice ; Signal Transduction ; Mice, Inbred C57BL ; Disease Models, Animal ; Female ; Toll-Like Receptor 5/genetics ; Dextran Sulfate ; Male

Biphasic Regulation of TLR7/MyD88/IRF7-IFN-β Axis by Toxoplasma gondii Facilitates Immune Evasion.

Authors: Liu X Wang Y Wu K et al.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Dec 15; Vol. 39 (23), pp. e71278.

Publication Type: Journal Article

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH Terms: Toll-Like Receptor 7*/metabolism , Toll-Like Receptor 7*/genetics , Toll-Like Receptor 7*/immunology , Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/immunology , Myeloid Differentiation Factor 88*/genetics , Toxoplasma*/immunology , Interferon Regulatory Factor-7*/metabolism , Interferon Regulatory Factor-7*/genetics , Interferon Regulatory Factor-7*/immunology , Interferon-beta*/metabolism , Interferon-beta*/immunology , Interferon-beta*/genetics , Immune Evasion* , Toxoplasmosis*/immunology , Toxoplasmosis*/metabolism, Animals ; Mice ; RAW 264.7 Cells ; Signal Transduction/immunology ; Mice, Inbred C57BL ; Female ; Membrane Glycoproteins

TLR-2/4 inhibition accelerates bone repair via modulating MyD88/NF-κB signaling and inflammatory microenvironment.

Authors: Chen Q Tang X Cao X et al.

Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Dec 15; Vol. 792, pp. 152994. Date of Electronic Publication: 2025 Nov 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH Terms: Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/immunology , Toll-Like Receptor 2*/antagonists & inhibitors , Toll-Like Receptor 2*/metabolism , Toll-Like Receptor 2*/immunology , NF-kappa B*/metabolism , NF-kappa B*/immunology , Fracture Healing*/drug effects , Toll-Like Receptor 4*/antagonists & inhibitors , Toll-Like Receptor 4*/metabolism, Animals ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Male ; Rats ; Inflammation/pathology ; Inflammation/metabolism ; Sulfonamides/pharmacology ; Cellular Microenvironment/drug effects

MyD88-dependent signalling promotes the recruitment of fibrous cap smooth muscle cells in murine atherosclerosis.

Authors: Gunnersen S Albarrán-Juárez J Jensen LF et al.

Source: Atherosclerosis [Atherosclerosis] 2025 Dec; Vol. 411, pp. 120573. Date of Electronic Publication: 2025 Nov 06.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0242543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1484 (Electronic) Linking ISSN: 00219150 NLM ISO Abbreviation: Atherosclerosis Subsets: MEDLINE

MeSH Terms: Myeloid Differentiation Factor 88*/genetics , Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/deficiency , Myocytes, Smooth Muscle*/metabolism , Myocytes, Smooth Muscle*/pathology , Plaque, Atherosclerotic* , Atherosclerosis*/pathology , Atherosclerosis*/metabolism , Atherosclerosis*/genetics , Muscle, Smooth, Vascular*/pathology , Muscle, Smooth, Vascular*/metabolism , Aortic Diseases*/pathology , Aortic Diseases*/genetics , Aortic Diseases*/metabolism, Animals ; Signal Transduction ; Mice, Knockout ; Disease Models, Animal ; Mice, Inbred C57BL ; Cell Movement ; Male ; Cell Proliferation ; Cells, Cultured ; Mice ; Rats ; Phenotype ; Fibrosis

Unrestrained MyD88 Signaling in A20-Deficient Keratinocytes Triggers T-Cell-Dependent Psoriatic Arthritis-Like Disease.

Authors: Tobias R Kumar S Liu J et al.

Source: The Journal of investigative dermatology [J Invest Dermatol] 2025 Dec; Vol. 145 (12), pp. 2998-3010.e3. Date of Electronic Publication: 2025 Apr 30.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1747 (Electronic) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE

MeSH Terms: Keratinocytes*/immunology , Keratinocytes*/metabolism , Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/genetics , Arthritis, Psoriatic*/immunology , Arthritis, Psoriatic*/pathology , Arthritis, Psoriatic*/genetics , T-Lymphocytes*/immunology , Tumor Necrosis Factor alpha-Induced Protein 3*/genetics , Tumor Necrosis Factor alpha-Induced Protein 3*/metabolism , Tumor Necrosis Factor alpha-Induced Protein 3*/deficiency, Animals ; Mice ; Signal Transduction/immunology ; Humans ; Disease Models, Animal ; Mice, Knockout ; Psoriasis/immunology ; Cells, Cultured ; Mice, Inbred C57BL

The MyD88 inhibitor TJ-M2010-5 protects against obesity in mice by suppressing macrophage-induced metabolic inflammation.

Authors: Yang X Liang FR Wu YC et al.

Source: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 4), pp. 117378. Date of Electronic Publication: 2025 Oct 01.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH Terms: Myeloid Differentiation Factor 88*/antagonists & inhibitors , Myeloid Differentiation Factor 88*/metabolism , Obesity*/metabolism , Obesity*/prevention & control , Macrophages*/drug effects , Macrophages*/metabolism , Inflammation*/metabolism , Inflammation*/prevention & control, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Diet, High-Fat/adverse effects ; Toll-Like Receptor 4/metabolism

The regulatory effect of chitooligosaccharides on islet inflammation in T2D individuals after islet cell transplantation: the mechanism behind Candida albicans abundance and macrophage polarization.

Authors: Zhang Y Ji X Chang K et al.

Source: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2442051. Date of Electronic Publication: 2024 Dec 18.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

MeSH Terms: Candida albicans*/drug effects , Oligosaccharides*/pharmacology , Gastrointestinal Microbiome*/drug effects , Macrophages*/drug effects , Macrophages*/immunology , Diabetes Mellitus, Type 2*/microbiology , Islets of Langerhans Transplantation* , Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/genetics , Inflammation*, Animals ; Mice ; Humans ; Male ; Mice, Inbred C57BL ; Chitosan/pharmacology ; Islets of Langerhans/drug effects ; STAT6 Transcription Factor/metabolism ; STAT6 Transcription Factor/genetics ; NF-kappa B/metabolism ; NF-kappa B/genetics

[Study on the innate immune regulatory mechanism of transcutaneous electrical acupoint stimulation in sleep-deprived rats based on TLR4/MyD88/NF-κB signaling pathway].

Authors: Zhang Y Xue Y Wang D et al.

Source: Zhen ci yan jiu = Acupuncture research [Zhen Ci Yan Jiu] 2025 Nov 25; Vol. 50 (11), pp. 1276-1285.

Publication Type: English Abstract; Journal Article

Journal Info: Publisher: Institute Of Acupuncture And Moxibustion Country of Publication: China NLM ID: 8507710 Publication Model: Print Cited Medium: Print ISSN: 1000-0607 (Print) Linking ISSN: 10000607 NLM ISO Abbreviation: Zhen Ci Yan Jiu Subsets: MEDLINE

MeSH Terms: Toll-Like Receptor 4*/genetics , Toll-Like Receptor 4*/immunology , Acupuncture Points* , Myeloid Differentiation Factor 88*/genetics , Myeloid Differentiation Factor 88*/immunology , NF-kappa B*/genetics , NF-kappa B*/immunology , Sleep Deprivation*/immunology , Sleep Deprivation*/genetics , Sleep Deprivation*/therapy , Immunity, Innate* , Transcutaneous Electric Nerve Stimulation*, Animals ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Male ; Humans

MIF downregulation attenuates neuroinflammation via TLR4/MyD88/TRAF6/NF-κB pathway to protect dopaminergic neurons in Parkinson's disease model.

Authors: Huang Y Zhou C Qu S

Source: Communications biology [Commun Biol] 2025 Nov 18; Vol. 8 (1), pp. 1595. Date of Electronic Publication: 2025 Nov 18.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

MeSH Terms: Macrophage Migration-Inhibitory Factors*/metabolism , Macrophage Migration-Inhibitory Factors*/genetics , Toll-Like Receptor 4*/metabolism , Toll-Like Receptor 4*/genetics , Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/genetics , Dopaminergic Neurons*/metabolism , Dopaminergic Neurons*/pathology , Parkinson Disease*/metabolism , Parkinson Disease*/genetics , Parkinson Disease*/pathology , Neuroinflammatory Diseases*/metabolism , Intramolecular Oxidoreductases*/metabolism , Intramolecular Oxidoreductases*/genetics, Animals ; Mice ; TNF Receptor-Associated Factor 6/metabolism ; TNF Receptor-Associated Factor 6/genetics ; NF-kappa B/metabolism ; Signal Transduction ; Disease Models, Animal ; Down-Regulation ; Mice, Inbred C57BL ; Male ; Microglia/metabolism

Design and synthesis of novel diclofenac-based quinazoline derivatives enhancing cisplatin and radiation impacts via MyD88 and COX-2/PGE2 modulation.

Authors: Ghorab MM El-Gazzar MGM Soliman AM et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 15; Vol. 298, pp. 117997. Date of Electronic Publication: 2025 Jul 23.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH Terms: Diclofenac*/pharmacology , Diclofenac*/chemistry , Diclofenac*/chemical synthesis , Cisplatin*/pharmacology , Cyclooxygenase 2*/metabolism , Drug Design* , Dinoprostone*/metabolism , Dinoprostone*/antagonists & inhibitors , Quinazolines*/pharmacology , Quinazolines*/chemistry , Quinazolines*/chemical synthesis , Analgesics*/pharmacology , Analgesics*/chemical synthesis , Analgesics*/chemistry , Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/antagonists & inhibitors , Cyclooxygenase 2 Inhibitors*/pharmacology , Cyclooxygenase 2 Inhibitors*/chemical synthesis , Cyclooxygenase 2 Inhibitors*/chemistry , Anti-Inflammatory Agents, Non-Steroidal*/pharmacology , Anti-Inflammatory Agents, Non-Steroidal*/chemical synthesis , Anti-Inflammatory Agents, Non-Steroidal*/chemistry, Animals ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Chlorocebus aethiops ; Vero Cells ; Antineoplastic Agents/pharmacology ; Male ; Rats

Candida albicans Enhances Protease Activity and Activates MyD88-Dependent IL-1β Production in Human Keratinocytes.

Authors: Wang J Gow NAR Brewer MG

Source: Mycoses [Mycoses] 2025 Nov; Vol. 68 (11), pp. e70133.

Publication Type: Journal Article

Journal Info: Publisher: Grosse Verlag Country of Publication: Germany NLM ID: 8805008 Publication Model: Print Cited Medium: Internet ISSN: 1439-0507 (Electronic) Linking ISSN: 09337407 NLM ISO Abbreviation: Mycoses Subsets: MEDLINE

MeSH Terms: Candida albicans*/enzymology , Keratinocytes*/microbiology , Keratinocytes*/metabolism , Keratinocytes*/immunology , Interleukin-1beta*/metabolism , Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/genetics , Peptide Hydrolases*/metabolism, Humans ; Signal Transduction ; Matrix Metalloproteinase 9/metabolism ; Matrix Metalloproteinase 9/genetics ; Dermatitis, Atopic/microbiology ; Dermatitis, Atopic/immunology ; Fungal Proteins/metabolism ; Coculture Techniques ; Cell Line

Teleost-specific TLR25/MyD88 signaling promotes K63-linked ubiquitination of IRF1 to induce IFNa gene expression.

Authors: Li Y Yi S Tang W et al.

Source: Fish & shellfish immunology [Fish Shellfish Immunol] 2025 Nov; Vol. 166, pp. 110672. Date of Electronic Publication: 2025 Aug 19.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 9505220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9947 (Electronic) Linking ISSN: 10504648 NLM ISO Abbreviation: Fish Shellfish Immunol Subsets: MEDLINE

MeSH Terms: Interferon Regulatory Factor-1*/genetics , Interferon Regulatory Factor-1*/immunology , Interferon Regulatory Factor-1*/metabolism , Interferon Regulatory Factor-1*/chemistry , Myeloid Differentiation Factor 88*/genetics , Myeloid Differentiation Factor 88*/immunology , Myeloid Differentiation Factor 88*/metabolism , Fish Proteins*/genetics , Fish Proteins*/immunology , Fish Proteins*/chemistry , Signal Transduction* , Toll-Like Receptors*/genetics , Toll-Like Receptors*/immunology , Cyprinidae*/immunology , Cyprinidae*/genetics , Gene Expression Regulation*/immunology , Immunity, Innate*/genetics, Animals ; Ubiquitination ; Sequence Alignment/veterinary

Acalabrutinib May Offer a New Therapeutic Approach for Consolidation and Maintenance of Primary CNS Lymphoma with Expression of MYD88 and CD79B Gene Variants: A Case Report and Literature Review of Primary CNS Lymphoma in the BTKi Era.

Authors: Allison E Campbell A Watson AM et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 29; Vol. 26 (21). Date of Electronic Publication: 2025 Oct 29.

Publication Type: Journal Article; Case Reports; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: CD79 Antigens*/genetics , CD79 Antigens*/metabolism , Central Nervous System Neoplasms*/drug therapy , Central Nervous System Neoplasms*/genetics , Central Nervous System Neoplasms*/pathology , Pyrazines*/therapeutic use , Myeloid Differentiation Factor 88*/genetics , Myeloid Differentiation Factor 88*/metabolism , Benzamides*/therapeutic use , Lymphoma*/drug therapy , Lymphoma*/genetics, Humans ; Male ; Agammaglobulinaemia Tyrosine Kinase/antagonists & inhibitors ; Middle Aged

Disruption of fibroblast MYD88 signaling promotes antitumor immunity in pancreatic ductal adenocarcinoma.

Authors: Korah M Reveron-Thornton RF Fallah M et al.

Source: Cell reports [Cell Rep] 2025 Oct 28; Vol. 44 (10), pp. 116347. Date of Electronic Publication: 2025 Sep 24.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH Terms: Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/genetics , Carcinoma, Pancreatic Ductal*/immunology , Carcinoma, Pancreatic Ductal*/pathology , Carcinoma, Pancreatic Ductal*/metabolism , Carcinoma, Pancreatic Ductal*/genetics , Pancreatic Neoplasms*/immunology , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/metabolism , Signal Transduction* , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/immunology , Cancer-Associated Fibroblasts*/pathology, Animals ; Humans ; Mice ; Cell Line, Tumor ; Mice, Inbred C57BL ; T-Lymphocytes/immunology ; Female

[Effects of electroacupuncture on intestinal flora and TLR4/MyD88/NF-κB signaling pathway of articular cartilage in rabbits with knee osteoarthritis].

Authors: Hu Z Ma JJ Ma TM et al.

Source: Zhen ci yan jiu = Acupuncture research [Zhen Ci Yan Jiu] 2025 Oct 25; Vol. 50 (10), pp. 1114-1123.

Publication Type: English Abstract; Journal Article

Journal Info: Publisher: Institute Of Acupuncture And Moxibustion Country of Publication: China NLM ID: 8507710 Publication Model: Print Cited Medium: Print ISSN: 1000-0607 (Print) Linking ISSN: 10000607 NLM ISO Abbreviation: Zhen Ci Yan Jiu Subsets: MEDLINE

MeSH Terms: Toll-Like Receptor 4*/metabolism , Toll-Like Receptor 4*/genetics , Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/genetics , NF-kappa B*/metabolism , NF-kappa B*/genetics , Electroacupuncture* , Osteoarthritis, Knee*/therapy , Osteoarthritis, Knee*/metabolism , Osteoarthritis, Knee*/genetics , Osteoarthritis, Knee*/microbiology , Gastrointestinal Microbiome* , Cartilage, Articular*/metabolism, Animals ; Rabbits ; Signal Transduction ; Humans ; Male ; Female

New Insights into the Structural Profiling of Polyphenol Aggregates from Pu-erh Tea and Their Anti-Inflammatory Activity via the TLR4/MyD88/NF-κB Signaling Pathway and Gut Microbiota.

Authors: Wu YL Yang L Shahidin et al.

Source: Journal of agricultural and food chemistry [J Agric Food Chem] 2025 Oct 08; Vol. 73 (40), pp. 25573-25590. Date of Electronic Publication: 2025 Aug 28.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

MeSH Terms: Gastrointestinal Microbiome*/drug effects , Toll-Like Receptor 4*/genetics , Toll-Like Receptor 4*/immunology , Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents*/administration & dosage , NF-kappa B*/genetics , NF-kappa B*/immunology , Polyphenols*/chemistry , Polyphenols*/administration & dosage , Myeloid Differentiation Factor 88*/genetics , Myeloid Differentiation Factor 88*/immunology , Colitis*/drug therapy , Colitis*/immunology , Colitis*/microbiology , Colitis*/genetics , Camellia sinensis*/chemistry , Plant Extracts*/chemistry , Plant Extracts*/administration & dosage , Tea*/chemistry, Animals ; Mice ; RAW 264.7 Cells ; Signal Transduction/drug effects ; Male ; Mice, Inbred C57BL ; Humans

Molecular characterization and functional analysis of MyD88 in red-spotted grouper (Epinephelus akaara): Insights into immune regulation and antiviral defense.

Authors: Jeyakanesh JT Tharanga EMT Sirisena DMKP et al.

Source: Fish & shellfish immunology [Fish Shellfish Immunol] 2025 Oct; Vol. 165, pp. 110499. Date of Electronic Publication: 2025 Jun 14.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 9505220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9947 (Electronic) Linking ISSN: 10504648 NLM ISO Abbreviation: Fish Shellfish Immunol Subsets: MEDLINE

MeSH Terms: Myeloid Differentiation Factor 88*/genetics , Myeloid Differentiation Factor 88*/immunology , Myeloid Differentiation Factor 88*/chemistry , Fish Diseases*/immunology , Immunity, Innate*/genetics , Bass*/immunology , Bass*/genetics , Gene Expression Regulation*/immunology, Animals ; Fish Proteins/genetics ; Fish Proteins/chemistry ; Fish Proteins/immunology ; Phylogeny ; Amino Acid Sequence ; Sequence Alignment/veterinary ; Poly I-C/pharmacology ; Nodaviridae/physiology ; Gene Expression Profiling/veterinary ; Lipopolysaccharides/pharmacology ; Base Sequence ; RNA Virus Infections/immunology ; RNA Virus Infections/veterinary

Dysregulation of MicroRNA-455-5p Contributes to Pulpitis Pathogenesis Through Modulating MYD88.

Authors: Hu Q Fu Y Xu H

Source: International dental journal [Int Dent J] 2025 Oct; Vol. 75 (5), pp. 100933. Date of Electronic Publication: 2025 Aug 05.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 0374714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-595X (Electronic) Linking ISSN: 00206539 NLM ISO Abbreviation: Int Dent J Subsets: MEDLINE

MeSH Terms: MicroRNAs*/metabolism , MicroRNAs*/genetics , Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/genetics , Pulpitis*/genetics , Pulpitis*/metabolism , Pulpitis*/pathology, Humans ; Oxidative Stress ; Apoptosis ; Dental Pulp/cytology ; Dental Pulp/metabolism ; Real-Time Polymerase Chain Reaction ; Cell Survival ; Cells, Cultured ; Male ; Adult

Protective effects of silymarin against diquat-induced hepatitis in layer by inhibiting oxidative stress and TLR4/MyD88/NF-κB signaling pathway.

Authors: Sun X Li J Wang Z et al.

Source: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2025 Oct; Vol. 204, pp. 115626. Date of Electronic Publication: 2025 Jul 08.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE

MeSH Terms: Silymarin*/pharmacology , Oxidative Stress*/drug effects , Toll-Like Receptor 4*/metabolism , Toll-Like Receptor 4*/genetics , Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/genetics , Diquat*/toxicity , NF-kappa B*/metabolism , NF-kappa B*/genetics , Signal Transduction*/drug effects , Herbicides*/toxicity , Chemical and Drug Induced Liver Injury*/prevention & control , Chemical and Drug Induced Liver Injury*/metabolism, Animals ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Male