Suchergebnisse - "MYASTHENIA gravis"

Efficacy of MLN9708 (ixazomib) in experimental autoimmune myasthenia gravis and in anti-AChR producing primary thymic cell cultures from myasthenia gravis patients.

Autoren: Mané-Damas M Saxena A Nogales-Gadea G et al.

Quelle: Frontiers in immunology [Front Immunol] 2025 May 15; Vol. 16, pp. 1521432. Date of Electronic Publication: 2025 May 15 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Myasthenia Gravis, Autoimmune, Experimental*/drug therapy , Myasthenia Gravis, Autoimmune, Experimental*/immunology , Glycine*/analogs & derivatives , Glycine*/pharmacology , Glycine*/therapeutic use , Boron Compounds*/pharmacology , Boron Compounds*/therapeutic use , Receptors, Cholinergic*/immunology , Thymus Gland*/immunology , Thymus Gland*/drug effects , Thymus Gland*/pathology , Proteasome Inhibitors*/pharmacology , Proteasome Inhibitors*/therapeutic use, Animals ; Female ; Humans ; Rats ; Rats, Inbred Lew ; Autoantibodies/immunology ; Autoantibodies/blood ; Middle Aged ; Adult ; Cells, Cultured ; Aged ; Myasthenia Gravis/drug therapy ; Myasthenia Gravis/immunology ; Disease Models, Animal ; Immunoglobulin G/immunology

Development of Peptide Mimics of the Human Acetylcholine Receptor Main Immunogenic Region for Treating Myasthenia Gravis.

Autoren: Trinh VB Fairclough RH

Quelle: International journal of molecular sciences [Int J Mol Sci] 2024 Dec 30; Vol. 26 (1). Date of Electronic Publication: 2024 Dec 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Cholinergic*/immunology , Receptors, Cholinergic*/chemistry , Peptides*/chemistry , Peptides*/immunology , Peptides*/therapeutic use , Myasthenia Gravis*/immunology , Myasthenia Gravis*/drug therapy, Humans ; Animals ; Rats ; Antibodies, Monoclonal/immunology ; Autoantibodies/immunology ; Amino Acid Sequence ; Myasthenia Gravis, Autoimmune, Experimental/immunology ; Myasthenia Gravis, Autoimmune, Experimental/drug therapy ; Torpedo

miR-125a-5p regulates Treg function by targeting Foxp3 in experimental autoimmune myasthenia gravis mice.

Autoren: Tan S Liu J Chen L et al.

Quelle: Immunology letters [Immunol Lett] 2025 Dec; Vol. 276, pp. 107050. Date of Electronic Publication: 2025 Jun 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7910006 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0542 (Electronic) Linking ISSN: 01652478 NLM ISO Abbreviation: Immunol Lett Subsets: MEDLINE

MeSH-Schlagworte: MicroRNAs*/genetics , T-Lymphocytes, Regulatory*/immunology , T-Lymphocytes, Regulatory*/metabolism , Myasthenia Gravis, Autoimmune, Experimental*/immunology , Myasthenia Gravis, Autoimmune, Experimental*/genetics , Myasthenia Gravis, Autoimmune, Experimental*/metabolism , Forkhead Transcription Factors*/genetics , Forkhead Transcription Factors*/metabolism, Animals ; Mice ; Disease Models, Animal ; Female ; Gene Expression Regulation ; Receptors, Cholinergic/immunology

Measuring the effect of rozanolixizumab using the Myasthenia Gravis Impairment Index: analyses from the randomized phase 3 MycarinG study.

Autoren: Barnett-Tapia C Cortés Vicente E Pascuzzi RM et al.

Körperschaften: Barnett-Tapia C Cortés Vicente E Pascuzzi RM et al.

Quelle: Journal of neurology [J Neurol] 2025 Nov 08; Vol. 272 (12), pp. 752. Date of Electronic Publication: 2025 Nov 08.

Publikationsart: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study

Info zur Zeitschrift: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE

MeSH-Schlagworte: Myasthenia Gravis*/drug therapy , Myasthenia Gravis*/diagnosis , Antibodies, Monoclonal, Humanized*/therapeutic use , Antibodies, Monoclonal, Humanized*/pharmacology , Antibodies, Monoclonal, Humanized*/administration & dosage , Severity of Illness Index* , Outcome Assessment, Health Care*, Humans ; Male ; Female ; Middle Aged ; Double-Blind Method ; Adult ; Aged ; Treatment Outcome

Long-term effectiveness of thymectomy in late-onset myasthenia gravis.

Autoren: Latini E Guida M Zirafa CC et al.

Quelle: Journal of neurology [J Neurol] 2025 Oct 21; Vol. 272 (11), pp. 714. Date of Electronic Publication: 2025 Oct 21.

Publikationsart: Journal Article; Observational Study

Info zur Zeitschrift: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE

MeSH-Schlagworte: Thymectomy* , Myasthenia Gravis*/surgery , Myasthenia Gravis*/drug therapy, Humans ; Male ; Female ; Middle Aged ; Adult ; Retrospective Studies ; Case-Control Studies ; Young Adult ; Age of Onset ; Follow-Up Studies ; Adolescent ; Treatment Outcome ; Aged

Agonist antibody to MuSK protects mice from MuSK myasthenia gravis.

Autoren: Oury J Gamallo-Lana B Santana L et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Sep 24; Vol. 121 (39), pp. e2408324121. Date of Electronic Publication: 2024 Sep 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: Receptor Protein-Tyrosine Kinases*/immunology , Receptor Protein-Tyrosine Kinases*/metabolism , Neuromuscular Junction*/drug effects , Neuromuscular Junction*/immunology , Receptors, Cholinergic*/immunology , Receptors, Cholinergic*/metabolism , Myasthenia Gravis*/immunology , Myasthenia Gravis*/drug therapy, Animals ; Mice ; Humans ; LDL-Receptor Related Proteins/immunology ; Autoantibodies/immunology ; Female ; Myasthenia Gravis, Autoimmune, Experimental/immunology ; Myasthenia Gravis, Autoimmune, Experimental/drug therapy ; Antibodies/immunology ; Antibodies/pharmacology ; Disease Models, Animal ; Fatty Acids, Monounsaturated

Pregnancy in myasthenia gravis: a retrospective analysis of maternal and neonatal outcome from a large tertiary care centre in Germany.

Autoren: Draxler J Meisel A Stascheit F et al.

Quelle: Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2024 Jul; Vol. 310 (1), pp. 277-284. Date of Electronic Publication: 2024 Mar 16.

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8710213 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0711 (Electronic) Linking ISSN: 09320067 NLM ISO Abbreviation: Arch Gynecol Obstet Subsets: MEDLINE

MeSH-Schlagworte: Myasthenia Gravis*/epidemiology , Myasthenia Gravis*/therapy , Tertiary Care Centers*/statistics & numerical data , Pregnancy Complications*/epidemiology , Pregnancy Outcome*/epidemiology, Humans ; Female ; Pregnancy ; Retrospective Studies ; Adult ; Germany/epidemiology ; Infant, Newborn ; Immunoglobulins, Intravenous/therapeutic use ; Cesarean Section/statistics & numerical data ; Plasma Exchange ; Myasthenia Gravis, Neonatal/epidemiology ; Young Adult

Treatment strategy for myasthenia gravis with GAD65-IgG associated neurological disorders: A case report.

Autoren: Xu XN Luo WJ Li HN et al.

Quelle: Journal of neuroimmunology [J Neuroimmunol] 2025 Dec 15; Vol. 409, pp. 578741. Date of Electronic Publication: 2025 Aug 31.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8421 (Electronic) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE

MeSH-Schlagworte: Myasthenia Gravis*/complications , Myasthenia Gravis*/immunology , Myasthenia Gravis*/therapy , Myasthenia Gravis*/blood , Myasthenia Gravis*/drug therapy , Glutamate Decarboxylase*/immunology , Autoantibodies*/blood , Autoantibodies*/immunology , Immunoglobulin G*/blood , Immunoglobulin G*/immunology , Nervous System Diseases*/immunology , Nervous System Diseases*/complications , Nervous System Diseases*/therapy, Humans ; Female ; Middle Aged ; Immunotherapy/methods

What is in the Neuromuscular Junction Literature?

Autoren: Smith J Lacomis D

Quelle: Journal of clinical neuromuscular disease [J Clin Neuromuscul Dis] 2025 Dec 01; Vol. 27 (2), pp. 34-44.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 100887391 Publication Model: Print Cited Medium: Internet ISSN: 1537-1611 (Electronic) Linking ISSN: 15220443 NLM ISO Abbreviation: J Clin Neuromuscul Dis Subsets: MEDLINE

MeSH-Schlagworte: Myasthenia Gravis*/epidemiology , Myasthenia Gravis*/therapy , Myasthenia Gravis*/diagnosis , Neuromuscular Junction*/physiopathology, Humans ; Female ; Male

Interconnection between myasthenia gravis and type 2 diabetes: emerging role of metformin in modulating PI3K/AKT/mTOR/AMPK axis.

Autoren: Al-Dhahi AS Al-Kuraishy HM Al-Gareeb AI et al.

Quelle: Metabolic brain disease [Metab Brain Dis] 2025 Dec 01; Vol. 40 (8), pp. 329. Date of Electronic Publication: 2025 Dec 01.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 8610370 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7365 (Electronic) Linking ISSN: 08857490 NLM ISO Abbreviation: Metab Brain Dis Subsets: MEDLINE

MeSH-Schlagworte: Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/metabolism , Metformin*/therapeutic use , Metformin*/pharmacology , Myasthenia Gravis*/metabolism , Myasthenia Gravis*/drug therapy , Hypoglycemic Agents*/therapeutic use , Hypoglycemic Agents*/pharmacology, Humans ; TOR Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Phosphatidylinositol 3-Kinases/metabolism ; Animals ; AMP-Activated Protein Kinases/metabolism

Diagnostic Performance of Three Serological Assays in Myasthenia Gravis: A Prospective Multicentre Study.

Autoren: Cuomo L De Giglio L Isgrò MA et al.

Quelle: Scandinavian journal of immunology [Scand J Immunol] 2025 Dec; Vol. 102 (6), pp. e70072.

Publikationsart: Journal Article; Multicenter Study; Comparative Study

Info zur Zeitschrift: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0323767 Publication Model: Print Cited Medium: Internet ISSN: 1365-3083 (Electronic) Linking ISSN: 03009475 NLM ISO Abbreviation: Scand J Immunol Subsets: MEDLINE

MeSH-Schlagworte: Myasthenia Gravis*/diagnosis , Myasthenia Gravis*/immunology , Myasthenia Gravis*/blood , Autoantibodies*/blood , Autoantibodies*/immunology, Humans ; Female ; Enzyme-Linked Immunosorbent Assay/methods ; Male ; Prospective Studies ; Middle Aged ; Receptors, Cholinergic/immunology ; Adult ; Sensitivity and Specificity ; Aged ; Receptor Protein-Tyrosine Kinases/immunology ; Radioimmunoprecipitation Assay/methods ; Young Adult ; Adolescent ; Serologic Tests/methods

Single-Cell Immune Profiling Reveals Neutrophils Promote Myasthenia Gravis Exacerbation Through BAFF Secretion.

Autoren: Zhang Z Dong J Qiu M et al.

Quelle: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Dec; Vol. 12 (45), pp. e09260. Date of Electronic Publication: 2025 Sep 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH-Schlagworte: B-Cell Activating Factor*/metabolism , B-Cell Activating Factor*/immunology , B-Cell Activating Factor*/genetics , Neutrophils*/immunology , Neutrophils*/metabolism , Myasthenia Gravis*/immunology , Myasthenia Gravis*/metabolism , Myasthenia Gravis*/genetics, Humans ; Animals ; Mice ; Single-Cell Analysis/methods ; Female ; Male ; B-Lymphocytes/immunology ; Disease Models, Animal ; Middle Aged

Calprotectin and neurofilament serum levels correlate with treatment response in myasthenia gravis under intensified therapy-A pilot study.

Autoren: Stascheit F Schulze D Lehnerer S et al.

Quelle: Journal of autoimmunity [J Autoimmun] 2025 Dec; Vol. 157, pp. 103476. Date of Electronic Publication: 2025 Sep 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: England NLM ID: 8812164 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9157 (Electronic) Linking ISSN: 08968411 NLM ISO Abbreviation: J Autoimmun Subsets: MEDLINE

MeSH-Schlagworte: Myasthenia Gravis*/blood , Myasthenia Gravis*/drug therapy , Myasthenia Gravis*/diagnosis , Myasthenia Gravis*/immunology , Neurofilament Proteins*/blood , Leukocyte L1 Antigen Complex*/blood, Humans ; Female ; Pilot Projects ; Male ; Biomarkers/blood ; Middle Aged ; Aged ; Adult ; Treatment Outcome ; Prospective Studies ; Receptors, Cholinergic/immunology ; Receptors, Fc/antagonists & inhibitors ; Autoantibodies/blood ; Autoantibodies/immunology ; Histocompatibility Antigens Class I

Mitochondrial autophagy-related gene signatures associated with myasthenia gravis diagnosis and immunity.

Autoren: Jin S Yin J Li W et al.

Quelle: Autoimmunity [Autoimmunity] 2025 Dec; Vol. 58 (1), pp. 2465410. Date of Electronic Publication: 2025 Feb 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8900070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-842X (Electronic) Linking ISSN: 08916934 NLM ISO Abbreviation: Autoimmunity Subsets: MEDLINE

MeSH-Schlagworte: Myasthenia Gravis*/diagnosis , Myasthenia Gravis*/genetics , Myasthenia Gravis*/immunology , Transcriptome* , Mitochondria*/genetics , Mitochondria*/metabolism , Mitochondria*/immunology , Autophagy*/genetics , Autophagy*/immunology , Mitophagy*/genetics , Mitophagy*/immunology, Humans ; Gene Expression Profiling ; Databases, Genetic

The Etiology Analysis of Myasthenia Gravis with In-Hospital Mortality in the Neurocritical Care Unit.

Autoren: Chen H Wang Y Zhang N et al.

Quelle: Neurocritical care [Neurocrit Care] 2025 Dec; Vol. 43 (3), pp. 1033-1042. Date of Electronic Publication: 2025 Aug 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 101156086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-0961 (Electronic) Linking ISSN: 15416933 NLM ISO Abbreviation: Neurocrit Care Subsets: MEDLINE

MeSH-Schlagworte: Myasthenia Gravis*/mortality , Myasthenia Gravis*/etiology , Hospital Mortality* , Thymoma*/mortality , Thymoma*/complications , Thymus Neoplasms*/mortality , Thymus Neoplasms*/complications , Thymus Neoplasms*/epidemiology , Shock, Septic*/mortality, Humans ; Male ; Female ; Aged ; Middle Aged ; Retrospective Studies ; Adult ; China/epidemiology ; Cause of Death ; Aged, 80 and over

Multiple concurrent opportunistic infections in patient with myasthenia gravis: A case report.

Autoren: Chen J Fang J Sun L et al.

Quelle: Virulence [Virulence] 2025 Dec; Vol. 16 (1), pp. 2545570. Date of Electronic Publication: 2025 Aug 28.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

MeSH-Schlagworte: Myasthenia Gravis*/complications , Myasthenia Gravis*/drug therapy , Opportunistic Infections*/drug therapy , Opportunistic Infections*/microbiology , Opportunistic Infections*/diagnosis , Coinfection*/microbiology, Humans ; Male ; Middle Aged ; Bronchoalveolar Lavage Fluid/microbiology ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Stenotrophomonas maltophilia/isolation & purification ; Aspergillus fumigatus/isolation & purification

Mental Health Experiences and Challenges Among Individuals with Myasthenia Gravis: Insights from Patient-Centered, Qualitative Analyses.

Autoren: Rodriguez RD Anderson AEL Gwathmey KG et al.

Quelle: Advances in therapy [Adv Ther] 2025 Dec; Vol. 42 (12), pp. 6209-6233. Date of Electronic Publication: 2025 Oct 22.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Health Communications Inc Country of Publication: United States NLM ID: 8611864 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-8652 (Electronic) Linking ISSN: 0741238X NLM ISO Abbreviation: Adv Ther Subsets: MEDLINE

MeSH-Schlagworte: Myasthenia Gravis*/psychology , Myasthenia Gravis*/epidemiology , Anxiety*/epidemiology , Anxiety*/etiology , Anxiety*/psychology , Depression*/epidemiology , Depression*/etiology , Depression*/psychology, Humans ; Qualitative Research ; Female ; Male ; United States/epidemiology ; Middle Aged ; Adult ; Prevalence ; Focus Groups ; Aged ; Patient-Centered Care ; Stress, Psychological/epidemiology ; Mental Health

Rapid response of eculizumab: a rescue therapy for ventilator-dependent refractory myasthenic crisis.

Autoren: Takenobu Y Ikeda K Hasebe S et al.

Quelle: Immunological medicine [Immunol Med] 2025 Dec; Vol. 48 (4), pp. 391-396. Date of Electronic Publication: 2025 May 06.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Informa UK Limited Country of Publication: England NLM ID: 101736847 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2578-5826 (Electronic) Linking ISSN: 25785826 NLM ISO Abbreviation: Immunol Med Subsets: MEDLINE

MeSH-Schlagworte: Myasthenia Gravis*/drug therapy , Myasthenia Gravis*/therapy , Myasthenia Gravis*/complications , Myasthenia Gravis*/diagnosis , Antibodies, Monoclonal, Humanized*/therapeutic use , Complement Inactivating Agents*/therapeutic use, Humans ; Respiration, Artificial ; Treatment Outcome ; Female ; Middle Aged ; Male ; Respiratory Insufficiency ; Immunoglobulins, Intravenous/therapeutic use

The Potential Implications of Neutrophil to Albumin Ratio for Short-term Prognosis in Myasthenia Gravis Patients.

Autoren: Lin H Lin S Pan S et al.

Quelle: Molecular neurobiology [Mol Neurobiol] 2025 Nov 27; Vol. 63 (1), pp. 192. Date of Electronic Publication: 2025 Nov 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: Myasthenia Gravis*/blood , Myasthenia Gravis*/diagnosis , Neutrophils*/metabolism , Neutrophils*/pathology , Albumins*/metabolism, Humans ; Female ; Male ; Middle Aged ; Prognosis ; Adult ; Retrospective Studies ; Aged ; Nomograms ; ROC Curve

Exploring the Role of B-Cell Biotherapy in Myasthenia Gravis from a Genetic Perspective: A Mendelian Randomization Study.

Autoren: Zhang M Yue C Fang J et al.

Quelle: Molecular neurobiology [Mol Neurobiol] 2025 Nov 21; Vol. 63 (1), pp. 115. Date of Electronic Publication: 2025 Nov 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: Myasthenia Gravis*/genetics , Myasthenia Gravis*/therapy , Myasthenia Gravis*/immunology , Mendelian Randomization Analysis*/methods , B-Lymphocytes*/immunology, Humans ; Genome-Wide Association Study ; Polymorphism, Single Nucleotide/genetics ; Genetic Predisposition to Disease