Suchergebnisse - "MU"

Herkinorin Promotes μ-Opioid Receptor Internalization and Protects iPSC-Derived Neurons from Hypoxic/Ischemic Injury.

Autoren: Ju Z Wang G Yan Y et al.

Quelle: Journal of integrative neuroscience [J Integr Neurosci] 2025 Oct 29; Vol. 24 (10), pp. 43165.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: IMR Press Country of Publication: Singapore NLM ID: 101156357 Publication Model: Print Cited Medium: Internet ISSN: 0219-6352 (Print) Linking ISSN: 02196352 NLM ISO Abbreviation: J Integr Neurosci Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Opioid, mu*/metabolism , Receptors, Opioid, mu*/drug effects , Neurons*/drug effects , Neurons*/metabolism , Induced Pluripotent Stem Cells*/drug effects , Induced Pluripotent Stem Cells*/metabolism , Receptors, Opioid, kappa*/metabolism , Receptors, Opioid, kappa*/drug effects , Hypoxia-Ischemia, Brain*/metabolism , Neuroprotective Agents*/pharmacology, Humans ; Apoptosis/drug effects ; Cells, Cultured ; Intracellular Signaling Peptides and Proteins

The involvement of the endogenous opioid system in binge eating, food devaluation and food reward in mice.

Autoren: Era IH Hamid A Lutfy K

Quelle: Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2025 Oct 02; Vol. 142, pp. 111539. Date of Electronic Publication: 2025 Oct 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 8211617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4216 (Electronic) Linking ISSN: 02785846 NLM ISO Abbreviation: Prog Neuropsychopharmacol Biol Psychiatry Subsets: MEDLINE

MeSH-Schlagworte: Reward* , Receptors, Opioid, mu*/genetics , Receptors, Opioid, mu*/metabolism , Receptors, Opioid, mu*/deficiency , Bulimia*/metabolism , Bulimia*/genetics , Enkephalins*/metabolism , beta-Endorphin*/metabolism , Feeding Behavior*/physiology , Eating*/physiology , Food*, Animals ; Male ; Mice ; Mice, Knockout ; Mice, Inbred C57BL ; Diet, High-Fat/adverse effects

Ketamine Evokes Acute Behavioral Effects Via μ Opioid Receptor-Expressing Neurons of the Central Amygdala.

Autoren: Pomrenze MB Vaillancourt S Llorach P et al.

Quelle: Biological psychiatry [Biol Psychiatry] 2025 Oct 01; Vol. 98 (7), pp. 538-548. Date of Electronic Publication: 2025 May 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2402 (Electronic) Linking ISSN: 00063223 NLM ISO Abbreviation: Biol Psychiatry Subsets: MEDLINE

MeSH-Schlagworte: Ketamine*/pharmacology , Receptors, Opioid, mu*/metabolism , Receptors, Opioid, mu*/antagonists & inhibitors , Receptors, Opioid, mu*/genetics , Neurons*/drug effects , Neurons*/metabolism , Central Amygdaloid Nucleus*/drug effects , Central Amygdaloid Nucleus*/metabolism , Behavior, Animal*/drug effects , Excitatory Amino Acid Antagonists*/pharmacology, Animals ; Male ; Female ; Naltrexone/pharmacology ; Mice ; Narcotic Antagonists/pharmacology ; Mice, Inbred C57BL ; Locomotion/drug effects ; Motor Activity/drug effects ; Proto-Oncogene Proteins c-fos/metabolism

Improving opioid analgesia: Modulation of the mu-opioid receptor phosphorylation state via combination therapy.

Autoren: Zhang Y Tan W Song X et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118138. Date of Electronic Publication: 2025 Sep 04.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Opioid, mu*/metabolism , Analgesics, Opioid*/pharmacology , Analgesics, Opioid*/therapeutic use , Analgesics, Opioid*/chemistry , Pain*/drug therapy , Pain*/metabolism, Humans ; Phosphorylation/drug effects ; Animals ; Drug Therapy, Combination ; Analgesia

A novel peptide-fentanyl conjugate with μ-opioid and neuropeptide FF receptor agonism produces antinociception with limited side effects in male mice.

Autoren: Li N Zhang M Xu B et al.

Quelle: British journal of pharmacology [Br J Pharmacol] 2025 Dec; Vol. 182 (24), pp. 6136-6157. Date of Electronic Publication: 2025 Aug 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Opioid, mu*/agonists , Receptors, Opioid, mu*/metabolism , Analgesics, Opioid*/pharmacology , Analgesics, Opioid*/chemistry , Analgesics, Opioid*/adverse effects , Fentanyl*/pharmacology , Fentanyl*/chemistry , Fentanyl*/adverse effects , Receptors, Neuropeptide*/agonists , Receptors, Neuropeptide*/metabolism, Animals ; Male ; Mice ; Humans ; Mice, Inbred C57BL ; Pain/drug therapy ; Oligopeptides

Activation of µ-δ Opioid Receptor Heteromer Attenuates Chemotherapy-Induced Neuropathic Pain in Mice.

Autoren: Agrawal S Tiwari V

Quelle: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2025 Nov 15; Vol. 20 (1), pp. 103. Date of Electronic Publication: 2025 Nov 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 101256586 Publication Model: Electronic Cited Medium: Internet ISSN: 1557-1904 (Electronic) Linking ISSN: 15571890 NLM ISO Abbreviation: J Neuroimmune Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Neuralgia*/chemically induced , Neuralgia*/metabolism , Neuralgia*/drug therapy , Neuralgia*/prevention & control , Receptors, Opioid, delta*/agonists , Receptors, Opioid, delta*/metabolism , Receptors, Opioid, mu*/agonists , Receptors, Opioid, mu*/metabolism , Antineoplastic Agents*/toxicity , Antineoplastic Agents*/adverse effects, Animals ; Mice ; Male ; Paclitaxel/toxicity ; Mice, Inbred C57BL

Bacteriophage Mu contamination impacts interbacterial competition.

Autoren: Pick K Tsviklist V Stadel L et al.

Quelle: Infection and immunity [Infect Immun] 2025 Nov 11; Vol. 93 (11), pp. e0026825. Date of Electronic Publication: 2025 Oct 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE

MeSH-Schlagworte: Bacteriophage mu*/physiology , Bacteriophage mu*/genetics , Citrobacter rodentium*/virology

Single-molecule characterization of opioid receptor heterodimers reveals soluble µ-δ dimer blocker peptide alleviates morphine tolerance.

Autoren: Zhou P Kasai RS Fujita W et al.

Quelle: Nature communications [Nat Commun] 2025 Nov 07; Vol. 16 (1), pp. 9859. Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Morphine*/pharmacology , Receptors, Opioid, mu*/metabolism , Receptors, Opioid, mu*/antagonists & inhibitors , Receptors, Opioid, mu*/chemistry , Receptors, Opioid, mu*/genetics , Receptors, Opioid, delta*/metabolism , Receptors, Opioid, delta*/antagonists & inhibitors , Receptors, Opioid, delta*/chemistry , Receptors, Opioid, delta*/genetics , Drug Tolerance* , Peptides*/pharmacology , Peptides*/chemistry, Animals ; Mice ; Protein Multimerization/drug effects ; Humans ; Single Molecule Imaging ; HEK293 Cells ; Binding Sites ; Male ; Receptors, Opioid, kappa/metabolism ; Receptors, Opioid, kappa/chemistry ; Receptors, Opioid, kappa/antagonists & inhibitors ; Receptors, Opioid, kappa/genetics ; Mice, Inbred C57BL ; Analgesics, Opioid/pharmacology

Effects of two structurally diverse positive allosteric modulators on signaling bias at the μ-opioid receptor.

Autoren: Li M Kochan KE Stanczyk MA et al.

Quelle: Molecular pharmacology [Mol Pharmacol] 2025 Nov; Vol. 107 (11), pp. 100079. Date of Electronic Publication: 2025 Sep 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Opioid, mu*/metabolism , Receptors, Opioid, mu*/agonists , Signal Transduction*/drug effects, Allosteric Regulation/drug effects ; Allosteric Regulation/physiology ; Humans ; Animals ; HEK293 Cells ; Analgesics, Opioid/pharmacology ; beta-Arrestins/metabolism ; CHO Cells

Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.

Autoren: Liu R Chen Y Huang H et al.

Quelle: British journal of pharmacology [Br J Pharmacol] 2025 Nov; Vol. 182 (22), pp. 5489-5516. Date of Electronic Publication: 2025 Jul 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Recovery of Function*/drug effects , Spinal Cord Injuries*/drug therapy , Spinal Cord Injuries*/metabolism , Receptors, Opioid, mu*/genetics , Receptors, Opioid, mu*/metabolism , Peptide Fragments*/pharmacology , Neuroprotective Agents*/pharmacology, Animals ; Female ; Ubiquitination/drug effects ; Mice, Inbred C57BL ; Mice ; PC12 Cells ; Rats ; Disease Models, Animal

Roles of peripheral and central µ 1 -opioid receptors in the fentanyl-induced cardiorespiratory responses.

Autoren: Zhuang J Gao X Chen Z et al.

Quelle: American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2025 Nov 01; Vol. 329 (5), pp. L629-L641. Date of Electronic Publication: 2025 Oct 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901229 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1504 (Electronic) Linking ISSN: 10400605 NLM ISO Abbreviation: Am J Physiol Lung Cell Mol Physiol Subsets: MEDLINE

MeSH-Schlagworte: Fentanyl*/pharmacology , Receptors, Opioid, mu*/metabolism , Receptors, Opioid, mu*/antagonists & inhibitors, Animals ; Male ; Female ; Rats ; Naloxone/pharmacology ; Naloxone/analogs & derivatives ; Rats, Sprague-Dawley ; Narcotic Antagonists/pharmacology ; Naltrexone/analogs & derivatives ; Naltrexone/pharmacology ; Apnea/chemically induced ; Apnea/metabolism ; Apnea/physiopathology ; Analgesics, Opioid/pharmacology ; Heart Rate/drug effects ; Respiratory Insufficiency/chemically induced ; Respiratory Insufficiency/metabolism

Role of β-Arrestin 2 in the antinociceptive and side effect profile of morphine and the novel mu opioid receptor agonists, kurkinorin and kurkinol.

Autoren: van de Wetering R Alder AF Biggerstaff A et al.

Quelle: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2025 Nov; Vol. 50 (12), pp. 1777-1786. Date of Electronic Publication: 2025 Sep 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE

MeSH-Schlagworte: Morphine*/pharmacology , Morphine*/adverse effects , beta-Arrestin 2*/genetics , beta-Arrestin 2*/metabolism , Receptors, Opioid, mu*/agonists , Receptors, Opioid, mu*/metabolism , Analgesics, Opioid*/pharmacology , Analgesics, Opioid*/adverse effects, Animals ; Mice, Knockout ; Male ; Mice ; Mice, Inbred C57BL ; Drug Tolerance ; Pain Measurement/drug effects ; Disease Models, Animal ; Respiratory Insufficiency/chemically induced

μOR-ligand: target-aware view-based hybrid feature selection for μ-opioid receptor ligand functional classification.

Autoren: Ugurlu SY; Novexus Ltd, 07058, Antalya, Turkey. s.yavuz.ugurlu@gmail.com.; Department of Materials Science and Engineering, Faculty of Engineering, Akdeniz University, Dumlupinar Bulvari, 07058, Antalya, Turkey. s.yavuz.ugurlu@gmail.com.

Quelle: Journal of computer-aided molecular design [J Comput Aided Mol Des] 2025 Oct 24; Vol. 39 (2), pp. 103. Date of Electronic Publication: 2025 Oct 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Netherlands NLM ID: 8710425 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4951 (Electronic) Linking ISSN: 0920654X NLM ISO Abbreviation: J Comput Aided Mol Des Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Opioid, mu*/agonists , Receptors, Opioid, mu*/antagonists & inhibitors , Receptors, Opioid, mu*/chemistry , Receptors, Opioid, mu*/metabolism, Ligands ; Humans ; Machine Learning ; Neural Networks, Computer ; Drug Discovery/methods ; ROC Curve

Elucidating zerumbone's low-efficacy agonism at the μ-opioid receptor via molecular dynamics simulation and Markov state modeling.

Autoren: Ayub WMW Marjohan NA Khalid MH et al.

Quelle: Journal of computer-aided molecular design [J Comput Aided Mol Des] 2025 Oct 24; Vol. 39 (2), pp. 94. Date of Electronic Publication: 2025 Oct 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Netherlands NLM ID: 8710425 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4951 (Electronic) Linking ISSN: 0920654X NLM ISO Abbreviation: J Comput Aided Mol Des Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Opioid, mu*/agonists , Receptors, Opioid, mu*/chemistry , Receptors, Opioid, mu*/metabolism , Sesquiterpenes*/chemistry , Sesquiterpenes*/pharmacology , Analgesics, Opioid*/chemistry , Analgesics, Opioid*/pharmacology, Molecular Dynamics Simulation ; Markov Chains ; Humans ; Hydrogen Bonding ; Protein Binding ; Morphine/chemistry ; Morphine/pharmacology ; Principal Component Analysis

Interconversion of the (+)-O-desmethyltramadol to the lowest-energy conformer when coupled to µ-opioid receptor: comprehensive analysis using in silico molecular modeling.

Autoren: Velázquez-Ponce M Marin-Aranda CA Tovar-Domínguez AH et al.

Quelle: Journal of computer-aided molecular design [J Comput Aided Mol Des] 2025 Oct 24; Vol. 39 (2), pp. 95. Date of Electronic Publication: 2025 Oct 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Netherlands NLM ID: 8710425 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4951 (Electronic) Linking ISSN: 0920654X NLM ISO Abbreviation: J Comput Aided Mol Des Subsets: MEDLINE

MeSH-Schlagworte: Tramadol*/chemistry , Tramadol*/analogs & derivatives , Tramadol*/metabolism , Receptors, Opioid, mu*/chemistry , Receptors, Opioid, mu*/metabolism , Analgesics, Opioid*/chemistry , Analgesics, Opioid*/pharmacology, Molecular Dynamics Simulation ; Molecular Docking Simulation ; Humans ; Protein Binding ; Ligands ; Molecular Conformation ; Thermodynamics

Novel dual kappa/mu opioid ligands based on a tetrahydroisoquinoline-valine hybrid nucleus.

Autoren: Abdelwaly A Safwan H Chatterjee S et al.

Quelle: Scientific reports [Sci Rep] 2025 Oct 16; Vol. 15 (1), pp. 36138. Date of Electronic Publication: 2025 Oct 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Opioid, kappa*/metabolism , Receptors, Opioid, kappa*/antagonists & inhibitors , Receptors, Opioid, kappa*/agonists , Tetrahydroisoquinolines*/chemistry , Tetrahydroisoquinolines*/pharmacology , Receptors, Opioid, mu*/metabolism , Receptors, Opioid, mu*/antagonists & inhibitors , Receptors, Opioid, mu*/agonists , Valine*/chemistry , Valine*/pharmacology, Animals ; Ligands ; Humans ; Mice ; Male ; Analgesics, Opioid/pharmacology ; Analgesics, Opioid/chemistry ; Structure-Activity Relationship

Electroacupuncture alleviates pain-like behaviors through modulating DNMT3a/MOR signaling pathway in CCI rats.

Autoren: Wang F Zhou C Xie C et al.

Quelle: PloS one [PLoS One] 2025 Oct 16; Vol. 20 (10), pp. e0334695. Date of Electronic Publication: 2025 Oct 16 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH-Schlagworte: Electroacupuncture*/methods , DNA (Cytosine-5-)-Methyltransferases*/metabolism , DNA (Cytosine-5-)-Methyltransferases*/genetics , Signal Transduction* , Neuralgia*/therapy , Neuralgia*/metabolism , Neuralgia*/etiology , Receptors, Opioid, mu*/metabolism , Receptors, Opioid, mu*/genetics, Animals ; DNA Methyltransferase 3A ; Rats ; Male ; Rats, Sprague-Dawley ; Ganglia, Spinal/metabolism ; Disease Models, Animal ; Behavior, Animal ; Spinal Cord Dorsal Horn/metabolism

Mu opioid receptor activation in microglia enhances HIV-1 infection and HIV-infection-induced inflammatory responses.

Autoren: Skeete C Sgambettera G Gojanovich AD et al.

Quelle: Frontiers in immunology [Front Immunol] 2025 Oct 06; Vol. 16, pp. 1628872. Date of Electronic Publication: 2025 Oct 06 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Microglia*/metabolism , Microglia*/immunology , Microglia*/virology , Microglia*/drug effects , Receptors, Opioid, mu*/metabolism , Receptors, Opioid, mu*/genetics , HIV-1*/physiology , HIV-1*/immunology , HIV Infections*/immunology , HIV Infections*/metabolism , HIV Infections*/virology , Inflammation*/immunology , Inflammation*/metabolism, Humans ; Morphine/pharmacology ; Signal Transduction ; Induced Pluripotent Stem Cells/metabolism ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/virology

Chronic administration of methocinnamox, a mu-opioid receptor antagonist, reduces hedonic response without impacting motivation in mice.

Autoren: Sheikh M Cambre E Langreck C et al.

Quelle: Psychopharmacology [Psychopharmacology (Berl)] 2025 Oct; Vol. 242 (10), pp. 2327-2339. Date of Electronic Publication: 2025 May 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Opioid, mu*/antagonists & inhibitors , Motivation*/drug effects , Narcotic Antagonists*/pharmacology , Narcotic Antagonists*/administration & dosage, Animals ; Male ; Mice ; Reward ; Mice, Inbred C57BL ; Behavior, Animal/drug effects

Opposing effects of mu opioid receptors on dopamine D1 and D2 receptor expressing neurons in opioid mediated antinociception.

Autoren: Alderete J Tanzillo A Miller J et al.

Quelle: The journal of pain [J Pain] 2025 Oct; Vol. 35, pp. 105474. Date of Electronic Publication: 2025 Jun 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Churchill Livingstone Country of Publication: United States NLM ID: 100898657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-8447 (Electronic) Linking ISSN: 15265900 NLM ISO Abbreviation: J Pain Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Opioid, mu*/metabolism , Receptors, Opioid, mu*/genetics , Receptors, Dopamine D2*/metabolism , Receptors, Dopamine D1*/metabolism , Analgesics, Opioid*/pharmacology , Nociception*/drug effects , Nociception*/physiology , Oxycodone*/pharmacology , Neurons*/metabolism , Neurons*/drug effects, Animals ; Mice ; Male ; Mice, Transgenic ; Receptor, Adenosine A2A/metabolism ; Mice, Inbred C57BL