Výsledky vyhľadávania - "MOLECULAR probes"

Chemical Probe Approach Reveals Endo-α-mannosidase Triages Misfolded Glycoproteins in the Calnexin/Calreticulin Cycle.

Autori: Taira A Hirano M Kuribara T a ďalší

Zdroj: ACS chemical biology [ACS Chem Biol] 2025 Nov 21; Vol. 20 (11), pp. 2671-2680. Date of Electronic Publication: 2025 Oct 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: alpha-Mannosidase*/metabolism , Calnexin*/metabolism , Calnexin*/chemistry , Glycoproteins*/metabolism , Glycoproteins*/chemistry , Molecular Probes*/chemistry , Molecular Probes*/metabolism, Protein Folding ; Humans ; Endoplasmic Reticulum/metabolism ; Glycosylation ; Polysaccharides/metabolism

Synthesis of a novel specific nectin-4 tumor-targeted peptide optical molecular probe and its preliminary study in lung cancer.

Autori: Jiang T Dong K Fu J a ďalší

Zdroj: Scientific reports [Sci Rep] 2025 Nov 17; Vol. 15 (1), pp. 40324. Date of Electronic Publication: 2025 Nov 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Lung Neoplasms*/metabolism , Lung Neoplasms*/diagnostic imaging , Lung Neoplasms*/pathology , Cell Adhesion Molecules*/metabolism , Molecular Probes*/chemical synthesis , Molecular Probes*/chemistry , Peptides*/chemistry , Peptides*/chemical synthesis, Humans ; Animals ; Mice ; Cell Line, Tumor ; Tissue Distribution ; Carbocyanines/chemistry ; Nectins

Development of radiolabeling 2-oxo-2-(4-phenylpiperazin-1-yl)acetamide derivatives as potential molecular probes for excitatory amino acid transporter 2.

Autori: Song P Gong K Xing L a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 15; Vol. 298, pp. 117981. Date of Electronic Publication: 2025 Jul 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Acetamides*/chemistry , Acetamides*/chemical synthesis , Acetamides*/pharmacology , Acetamides*/pharmacokinetics , Excitatory Amino Acid Transporter 2*/metabolism , Excitatory Amino Acid Transporter 2*/antagonists & inhibitors , Molecular Probes*/chemistry , Molecular Probes*/chemical synthesis , Piperazines*/chemistry , Piperazines*/chemical synthesis , Piperazines*/pharmacology, Animals ; Humans ; Male ; Mice ; Rats ; Brain/metabolism ; Iodine Radioisotopes/chemistry ; Molecular Structure ; Structure-Activity Relationship ; Tissue Distribution ; Fluorine Radioisotopes/chemistry

Examination of Acetylated Monosaccharides as Metabolic Probes in Bacteria.

Autori: Nigrovic SE Paul A Maji S a ďalší

Zdroj: ACS infectious diseases [ACS Infect Dis] 2025 Nov 14; Vol. 11 (11), pp. 3355-3363. Date of Electronic Publication: 2025 Oct 13.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

Výrazy zo slovníka MeSH: Monosaccharides*/metabolism , Monosaccharides*/chemistry , Bacteria*/metabolism , Bacteria*/chemistry , Molecular Probes*/metabolism , Molecular Probes*/chemistry, Acetylation ; Polysaccharides/metabolism

Chemical Proteomics Probes: Classification, Applications, and Future Perspectives in Proteome-Wide Studies.

Autori: Tan X Wang D Yao Y a ďalší

Zdroj: Proteomics [Proteomics] 2025 Nov; Vol. 25 (21-22), pp. 62-75. Date of Electronic Publication: 2025 Jul 31.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101092707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-9861 (Electronic) Linking ISSN: 16159853 NLM ISO Abbreviation: Proteomics Subsets: MEDLINE

Výrazy zo slovníka MeSH: Proteomics*/methods , Molecular Probes*/chemistry , Molecular Probes*/classification , Proteome*/metabolism , Proteome*/analysis, Humans ; Drug Discovery/methods ; Animals

Synthesis and evaluation of naphthoquinone-based probes for activity-based protein profiling of oxidoreductases.

Autori: Krammer L Darnhofer B Breinbauer R

Zdroj: Organic & biomolecular chemistry [Org Biomol Chem] 2025 Oct 29; Vol. 23 (42), pp. 9668-9676. Date of Electronic Publication: 2025 Oct 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Naphthoquinones*/chemistry , Naphthoquinones*/chemical synthesis , Oxidoreductases*/metabolism , Oxidoreductases*/chemistry , Molecular Probes*/chemical synthesis , Molecular Probes*/chemistry, Animals ; Mice ; Molecular Structure ; Liver/enzymology ; Proteomics

Activity-Based Ubiquitin Probes Capture the Sulfenylated State of Deubiquitinases.

Autori: Chen Z Li G Zhang J a ďalší

Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Oct 20; Vol. 64 (43), pp. e202512311. Date of Electronic Publication: 2025 Sep 07.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

Výrazy zo slovníka MeSH: Deubiquitinating Enzymes*/metabolism , Deubiquitinating Enzymes*/chemistry , Ubiquitin*/chemistry , Ubiquitin*/metabolism , Molecular Probes*/chemistry , Molecular Probes*/metabolism, Humans ; Biotin/chemistry ; Molecular Structure

Chemical Probes that Target a Dissociative LuxR-Type Quorum Sensing Receptor in Gram-Negative Bacteria.

Autori: Stoutland IM Aguirre-Figueroa G Blackwell HE

Zdroj: ACS chemical biology [ACS Chem Biol] 2025 Oct 17; Vol. 20 (10), pp. 2451-2461. Date of Electronic Publication: 2025 Sep 18.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Quorum Sensing*/drug effects , Trans-Activators*/metabolism , Trans-Activators*/antagonists & inhibitors , Repressor Proteins*/metabolism , Repressor Proteins*/antagonists & inhibitors , Gram-Negative Bacteria*/metabolism , Gram-Negative Bacteria*/drug effects , Bacterial Proteins*/metabolism , Molecular Probes*/pharmacology , Molecular Probes*/chemistry, Ligands

A molecular probe for detecting cholinesterase activity in MRI.

Autori: Sen S Dawson M Thiabaud GD a ďalší

Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Oct 14; Vol. 122 (41), pp. e2504547122. Date of Electronic Publication: 2025 Oct 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Výrazy zo slovníka MeSH: Magnetic Resonance Imaging*/methods , Molecular Probes*/chemistry , Molecular Probes*/metabolism , Cholinesterases*/metabolism, Animals ; Brain/enzymology ; Mice

Bitopic A 3 Adenosine Receptor Molecular Probes: Positive Allosteric Modulation and Noncanonical Activation.

Autori: Kurma SH Pavan M Wan TC a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Oct 09; Vol. 68 (19), pp. 20717-20740. Date of Electronic Publication: 2025 Sep 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Adenosine A3 Receptor Agonists*/pharmacology , Adenosine A3 Receptor Agonists*/chemistry , Adenosine A3 Receptor Agonists*/chemical synthesis , Molecular Probes*/chemistry , Molecular Probes*/pharmacology , Molecular Probes*/chemical synthesis , Molecular Probes*/metabolism , Receptor, Adenosine A3*/metabolism , Receptor, Adenosine A3*/chemistry, Animals ; Humans ; Allosteric Regulation/drug effects ; Molecular Docking Simulation ; Structure-Activity Relationship ; Quinolines/chemical synthesis ; Quinolines/chemistry ; Quinolines/pharmacology

Design, synthesis and biological evaluation of the activity-based probes for FGFR covalent inhibitor.

Autori: Zhu D Zheng Z Huang H a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Oct 05; Vol. 295, pp. 117795. Date of Electronic Publication: 2025 May 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Drug Design* , Receptors, Fibroblast Growth Factor*/antagonists & inhibitors , Receptors, Fibroblast Growth Factor*/metabolism , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Molecular Probes*/chemical synthesis , Molecular Probes*/pharmacology , Molecular Probes*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry, Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Cell Line, Tumor ; Cell Proliferation/drug effects

SHAPE-Based Chemical Probes for Studying preQ 1 -RNA Interactions in Living Bacteria.

Autori: Reyes Franceschi JA Cárdenas EL Klein BJC a ďalší

Zdroj: ACS chemical biology [ACS Chem Biol] 2025 Nov 21; Vol. 20 (11), pp. 2689-2697. Date of Electronic Publication: 2025 Oct 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: RNA, Bacterial*/metabolism , RNA, Bacterial*/chemistry , RNA, Bacterial*/genetics , Triazoles*/chemistry , Triazoles*/metabolism , Molecular Probes*/chemistry, Riboswitch ; Binding Sites ; Acylation

A perspective on cysteine-reactive activity-based probes.

Autori: Nuber CM Schwab MA Konrad DB

Zdroj: Organic & biomolecular chemistry [Org Biomol Chem] 2025 Nov 19; Vol. 23 (45), pp. 10262-10275. Date of Electronic Publication: 2025 Nov 19.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cysteine*/chemistry , Cysteine*/metabolism , Molecular Probes*/chemistry , Proteins*/chemistry , Proteins*/metabolism, Humans ; Proteomics/methods ; Protein Processing, Post-Translational

Bioorthogonal Probe BTD-Az Enables Sensitive and Rapid In Vivo Profiling of Protein Cysteine Sulfenylation.

Autori: Xu M Wang C Liu R a ďalší

Zdroj: Bioconjugate chemistry [Bioconjug Chem] 2025 Nov 19; Vol. 36 (11), pp. 2396-2409. Date of Electronic Publication: 2025 Oct 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cysteine*/metabolism , Cysteine*/chemistry , Azides*/chemistry , Molecular Probes*/chemistry , Proteins*/chemistry , Proteins*/metabolism, Animals ; Mice ; Humans ; Protein Processing, Post-Translational ; Proteomics/methods ; Oxidation-Reduction

Fully-Functionalized Natural Product Probes to Expand the Chemical Tractability of the Human Proteome.

Autori: Chaheine CM Tang J Conway LP a ďalší

Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Nov 03; Vol. 64 (45), pp. e202502648. Date of Electronic Publication: 2025 Sep 12.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

Výrazy zo slovníka MeSH: Biological Products*/chemistry , Proteome*/chemistry , Proteome*/analysis , Molecular Probes*/chemistry, Humans ; Proteomics ; Ligands ; Small Molecule Libraries/chemistry ; Molecular Structure

BODIPY-based small molecular probes for fluorescence and photoacoustic dual-modality imaging of superoxide anion in vivo.

Autori: Zhou Y Ji P Sun Q a ďalší

Zdroj: Talanta [Talanta] 2025 Nov 01; Vol. 294, pp. 128269. Date of Electronic Publication: 2025 May 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE

Výrazy zo slovníka MeSH: Superoxides*/analysis , Superoxides*/metabolism , Boron Compounds*/chemistry , Photoacoustic Techniques*/methods , Fluorescent Dyes*/chemistry , Fluorescent Dyes*/chemical synthesis , Optical Imaging*/methods , Molecular Probes*/chemistry, Humans ; Animals ; Hep G2 Cells ; Mice

Development of Single-Molecule Enzyme Activity Assay for Serine Hydrolases Using Activity-Based Protein Labeling Probes.

Autori: Ishii S Minoda M Mizuno T a ďalší

Zdroj: Small methods [Small Methods] 2025 Nov; Vol. 9 (11), pp. e01643. Date of Electronic Publication: 2025 Sep 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: WILEY-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 101724536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2366-9608 (Electronic) Linking ISSN: 23669608 NLM ISO Abbreviation: Small Methods Subsets: MEDLINE

Výrazy zo slovníka MeSH: Granzymes*/blood , Granzymes*/metabolism , Enzyme Assays*/methods , Hydrolases*/metabolism , Single Molecule Imaging*/methods , Molecular Probes*/chemistry, Humans ; Fluorescent Dyes/chemistry

A Multifunctional Molecular Probe for Multimodal Imaging-Guided Potent Photothermal/Photodynamic Therapy of Endometriosis.

Autori: Zhong Q Yang S Li X a ďalší

Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Nov; Vol. 12 (43), pp. e11126. Date of Electronic Publication: 2025 Aug 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Endometriosis*/therapy , Endometriosis*/diagnostic imaging , Photochemotherapy*/methods , Multimodal Imaging*/methods , Photothermal Therapy*/methods , Molecular Probes*, Female ; Animals ; Humans ; Rats ; Mice

Probing Rigidity and Fluidity in the Interfacial Region of Lipid Bilayers with a Novel IR Probe.

Autori: Islam MM Nawagamuwage SU Dennis CA a ďalší

Zdroj: The journal of physical chemistry. B [J Phys Chem B] 2025 Oct 30; Vol. 129 (43), pp. 11220-11229. Date of Electronic Publication: 2025 Oct 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101157530 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5207 (Electronic) Linking ISSN: 15205207 NLM ISO Abbreviation: J Phys Chem B Subsets: MEDLINE

Výrazy zo slovníka MeSH: Lipid Bilayers*/chemistry , Molecular Probes*/chemistry, 1,2-Dipalmitoylphosphatidylcholine/chemistry ; Phosphatidylglycerols/chemistry ; Phase Transition ; Sphingomyelins/chemistry ; Spectroscopy, Fourier Transform Infrared

Two-mode ratiometric electrochemical and turn-on fluorescence strategy for detecting biothiols in serum with all-in-one molecular probe.

Autori: Dong H Xu K Wang Z a ďalší

Zdroj: Bioelectrochemistry (Amsterdam, Netherlands) [Bioelectrochemistry] 2025 Oct; Vol. 165, pp. 108995. Date of Electronic Publication: 2025 Apr 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 100953583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-562X (Electronic) Linking ISSN: 15675394 NLM ISO Abbreviation: Bioelectrochemistry Subsets: MEDLINE

Výrazy zo slovníka MeSH: Electrochemical Techniques*/methods , Glutathione*/blood , Cysteine*/blood , Sulfhydryl Compounds*/blood , Hydrogen Sulfide*/blood , Fluorescent Dyes*/chemistry , Molecular Probes*/chemistry, Humans ; Spectrometry, Fluorescence/methods ; Limit of Detection