Výsledky vyhľadávania - "MICRORNA"

Comprehensive profiling of plasma and exosomal microRNAs in medication-related osteonecrosis of the jaw.

Autori: Oh S Park M Hwang H a ďalší

Zdroj: Scientific reports [Sci Rep] 2025 Oct 24; Vol. 15 (1), pp. 37333. Date of Electronic Publication: 2025 Oct 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Exosomes*/genetics , Exosomes*/metabolism , MicroRNAs*/blood , MicroRNAs*/genetics , Bisphosphonate-Associated Osteonecrosis of the Jaw*/genetics , Bisphosphonate-Associated Osteonecrosis of the Jaw*/blood , Circulating MicroRNA*/blood , Circulating MicroRNA*/genetics, Humans ; Female ; Male ; Middle Aged ; Case-Control Studies ; Aged ; Gene Expression Profiling ; Pilot Projects ; Biomarkers/blood

Circulating MiRNAs in thyroid cancer: prognostic promise of miR-155 and limitations of miR-429.

Autori: Ibrahim DR El-Kholany SH Ghattas MH a ďalší

Zdroj: Molecular biology reports [Mol Biol Rep] 2025 Dec 01; Vol. 53 (1), pp. 147. Date of Electronic Publication: 2025 Dec 01.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: MicroRNAs*/genetics , MicroRNAs*/blood , Thyroid Neoplasms*/genetics , Thyroid Neoplasms*/blood , Thyroid Neoplasms*/pathology , Thyroid Neoplasms*/diagnosis , Circulating MicroRNA*/genetics , Circulating MicroRNA*/blood, Humans ; Female ; Male ; Middle Aged ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/blood ; Prognosis ; Adult ; Gene Expression Regulation, Neoplastic ; Thyroid Cancer, Papillary/genetics ; Case-Control Studies ; Aged

Circulating microRNAs as biomarkers for risk assessment and prognostic stratification of pleural mesothelioma.

Autori: Sharova E Del Bianco P Urso L a ďalší

Zdroj: Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2025 Dec; Vol. 210, pp. 108852. Date of Electronic Publication: 2025 Nov 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8800805 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8332 (Electronic) Linking ISSN: 01695002 NLM ISO Abbreviation: Lung Cancer Subsets: MEDLINE

Výrazy zo slovníka MeSH: Circulating MicroRNA*/blood , Circulating MicroRNA*/genetics , Biomarkers, Tumor*/blood , Biomarkers, Tumor*/genetics , Pleural Neoplasms*/diagnosis , Pleural Neoplasms*/blood , Pleural Neoplasms*/genetics , Pleural Neoplasms*/mortality , Mesothelioma*/diagnosis , Mesothelioma*/blood , Mesothelioma*/genetics , Mesothelioma*/mortality , Lung Neoplasms*/diagnosis , Lung Neoplasms*/blood , Lung Neoplasms*/genetics , MicroRNAs*/blood , MicroRNAs*/genetics, Humans ; Male ; Prognosis ; Female ; Middle Aged ; Aged ; Risk Assessment ; Asbestos/adverse effects ; Mesothelioma, Malignant

Identification of circulating miRNA alterations in diabetes patients excluding periodontitis effects: insights into target gene downregulation in diabetic complications.

Autori: Lee HS Yu Y Kim HJ a ďalší

Zdroj: Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2567609. Date of Electronic Publication: 2025 Nov 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Circulating MicroRNA*/blood , Circulating MicroRNA*/genetics , Diabetes Complications*/genetics , Diabetes Complications*/blood , Diabetes Mellitus, Type 2*/genetics , Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/blood , MicroRNAs*/blood , MicroRNAs*/genetics, Humans ; Down-Regulation ; Male ; Middle Aged ; Female ; Exosomes/metabolism ; Exosomes/genetics ; Gene Expression Profiling ; Aged ; Periodontitis/genetics ; Sequence Analysis, RNA ; Gene Expression Regulation

Standardization of preclinical methodologies for discovery and validation of circulating microRNA biomarkers for post-traumatic epileptogenesis - Lessons learned from the EpiBioS4Rx Project 1.

Autori: Puhakka N Heiskanen M Ndode-Ekane XE a ďalší

Zdroj: Epilepsy research [Epilepsy Res] 2025 Dec; Vol. 218, pp. 107667. Date of Electronic Publication: 2025 Sep 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8703089 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6844 (Electronic) Linking ISSN: 09201211 NLM ISO Abbreviation: Epilepsy Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Epilepsy, Post-Traumatic*/blood , Epilepsy, Post-Traumatic*/diagnosis , Epilepsy, Post-Traumatic*/etiology , Brain Injuries, Traumatic*/complications , Brain Injuries, Traumatic*/blood , Circulating MicroRNA*/blood, Animals ; Male ; Rats, Sprague-Dawley ; Rats ; Biomarkers/blood ; Electroencephalography ; Disease Models, Animal

Circulating microRNAs as biomarkers for diabetic retinopathy stage identification: A DTA systematic review and meta-analysis.

Autori: Martínez-Santos M Ybarra M Pires ME a ďalší

Zdroj: PloS one [PLoS One] 2025 Nov 21; Vol. 20 (11), pp. e0335434. Date of Electronic Publication: 2025 Nov 21 (Print Publication: 2025).

Spôsob vydávania: Journal Article; Systematic Review; Meta-Analysis

Informácie o časopise: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Výrazy zo slovníka MeSH: Diabetic Retinopathy*/blood , Diabetic Retinopathy*/diagnosis , Circulating MicroRNA*/blood , Circulating MicroRNA*/genetics , Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/blood, Humans ; Biomarkers/blood

Circulating microRNAs and Plasma Gelsolin as Biomarkers of Sepsis: Molecular Insights and Prospects for Precision Medicine.

Autori: Stoian M Azamfirei L Bandila SR a ďalší

Zdroj: Biomolecules [Biomolecules] 2025 Nov 18; Vol. 15 (11). Date of Electronic Publication: 2025 Nov 18.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE

Výrazy zo slovníka MeSH: Gelsolin*/blood , Sepsis*/blood , Sepsis*/diagnosis , Sepsis*/genetics , Circulating MicroRNA*/blood , Circulating MicroRNA*/genetics , Precision Medicine*/methods , MicroRNAs*/blood, Humans ; Biomarkers/blood ; Prognosis

Circulating microRNA Profiles in Acute Spinal Cord Injury: Evidence for Distinct Plasma Signatures Compared with Polytrauma Patients.

Autori: Hörauf JA Saenger M Störmann P a ďalší

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 12; Vol. 26 (22). Date of Electronic Publication: 2025 Nov 12.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Spinal Cord Injuries*/blood , Spinal Cord Injuries*/genetics , Multiple Trauma*/blood , Multiple Trauma*/genetics , Circulating MicroRNA*/blood , Circulating MicroRNA*/genetics , MicroRNAs*/blood , MicroRNAs*/genetics, Humans ; Male ; Female ; Middle Aged ; Adult ; Gene Expression Profiling ; Biomarkers/blood ; High-Throughput Nucleotide Sequencing ; Case-Control Studies

Molecular Network Analysis of Circulating microRNAs Highlights miR-17-5p and miR-29a-3p as Potential Biomarkers of Aortic Valve Calcification.

Autori: Galeone A Minoia A Braggio M a ďalší

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 07; Vol. 26 (22). Date of Electronic Publication: 2025 Nov 07.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: MicroRNAs*/genetics , MicroRNAs*/blood , Calcinosis*/genetics , Calcinosis*/blood , Calcinosis*/pathology , Aortic Valve*/pathology , Aortic Valve*/metabolism , Aortic Valve Stenosis*/genetics , Aortic Valve Stenosis*/blood , Aortic Valve Stenosis*/pathology , Gene Regulatory Networks* , Circulating MicroRNA*/genetics , Circulating MicroRNA*/blood, Humans ; Biomarkers/blood ; Male ; Female ; Middle Aged ; Aged ; Gene Expression Profiling ; Case-Control Studies

SCR Disease Name: Aortic Valve, Calcification of

Circulating microRNA signatures as potential biomarkers differentiating diabetic, prediabetic, and healthy individuals.

Autori: Abu-Toamih Atamni HJ Shapira G Ortenberg R a ďalší

Zdroj: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2025 Nov 04; Vol. 16, pp. 1699100. Date of Electronic Publication: 2025 Nov 04 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Prediabetic State*/blood , Prediabetic State*/diagnosis , Prediabetic State*/genetics , Diabetes Mellitus, Type 2*/blood , Diabetes Mellitus, Type 2*/genetics , Diabetes Mellitus, Type 2*/diagnosis , Biomarkers*/blood , Circulating MicroRNA*/blood , Circulating MicroRNA*/genetics , MicroRNAs*/blood, Humans ; Male ; Female ; Middle Aged ; Adult ; Case-Control Studies ; Aged

Exploring a Circulating miRNA Signature for PMM2-CDG: Initial Insights Toward Diagnosis, Stratification, and Monitoring.

Autori: Epifani F Cabus L Nolasco GA a ďalší

Zdroj: Journal of inherited metabolic disease [J Inherit Metab Dis] 2025 Nov; Vol. 48 (6), pp. e70104.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley Country of Publication: United States NLM ID: 7910918 Publication Model: Print Cited Medium: Internet ISSN: 1573-2665 (Electronic) Linking ISSN: 01418955 NLM ISO Abbreviation: J Inherit Metab Dis Subsets: MEDLINE

Výrazy zo slovníka MeSH: Congenital Disorders of Glycosylation*/genetics , Congenital Disorders of Glycosylation*/diagnosis , Congenital Disorders of Glycosylation*/blood , Phosphotransferases (Phosphomutases)*/genetics , Phosphotransferases (Phosphomutases)*/deficiency , Circulating MicroRNA*/blood , Circulating MicroRNA*/genetics , MicroRNAs*/blood , MicroRNAs*/genetics, Humans ; Male ; Female ; Biomarkers/blood ; Child, Preschool ; Cross-Sectional Studies ; Child ; Machine Learning ; Infant ; Gene Expression Profiling ; Case-Control Studies ; Adolescent

Total quantification of circulating microRNAs and smallRNAs in plasma and urine as prognostic biomarkers in prostate cancer.

Autori: Lorenzo-Sánchez MV Picazo-Martínez MG Giménez-Bachs JM a ďalší

Zdroj: Actas urologicas espanolas [Actas Urol Esp (Engl Ed)] 2025 Nov; Vol. 49 (9), pp. 501861. Date of Electronic Publication: 2025 Sep 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier España Country of Publication: Spain NLM ID: 101771154 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2173-5786 (Electronic) Linking ISSN: 21735786 NLM ISO Abbreviation: Actas Urol Esp (Engl Ed) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Circulating MicroRNA*/urine , Circulating MicroRNA*/blood , Biomarkers, Tumor*/urine , Biomarkers, Tumor*/blood , Prostatic Neoplasms*/urine , Prostatic Neoplasms*/blood , MicroRNAs*/urine , MicroRNAs*/blood, Humans ; Male ; Prognosis ; Prospective Studies ; Aged ; Longitudinal Studies ; Middle Aged

Recent progress on biosensors for detection of circulating miRNA biomarkers.

Autori: Yang J Chen J Xia L a ďalší

Zdroj: Talanta [Talanta] 2025 Nov 01; Vol. 294, pp. 128219. Date of Electronic Publication: 2025 Apr 25.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE

Výrazy zo slovníka MeSH: Biosensing Techniques*/methods , Circulating MicroRNA*/blood , Circulating MicroRNA*/analysis , Circulating MicroRNA*/genetics , MicroRNAs*/blood, Humans ; Biomarkers/blood ; Electrochemical Techniques

Circulating MicroRNAs as diagnostic indicators in tuberculous Meningitis-A case -control study in North Indian population.

Autori: Ritika Singh V Singh VK a ďalší

Zdroj: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2025 Nov; Vol. 46 (11), pp. 5981-5990. Date of Electronic Publication: 2025 Aug 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100959175 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1590-3478 (Electronic) Linking ISSN: 15901874 NLM ISO Abbreviation: Neurol Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Tuberculosis, Meningeal*/blood , Tuberculosis, Meningeal*/diagnosis , Tuberculosis, Meningeal*/genetics , Circulating MicroRNA*/blood , MicroRNAs*/blood, Humans ; India ; Female ; Case-Control Studies ; Male ; Adult ; Biomarkers/blood ; Middle Aged ; Young Adult

Circulating microRNAs as potential biomarkers in pediatric epilepsy: a pilot study.

Autori: Rzepka-Migut B Kruszniewska-Rajs C Bugowska M a ďalší

Zdroj: Epilepsy & behavior : E&B [Epilepsy Behav] 2025 Oct; Vol. 171, pp. 110631. Date of Electronic Publication: 2025 Aug 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 100892858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-5069 (Electronic) Linking ISSN: 15255050 NLM ISO Abbreviation: Epilepsy Behav Subsets: MEDLINE

Výrazy zo slovníka MeSH: Circulating MicroRNA*/blood , Epilepsy*/blood , Epilepsy*/diagnosis , MicroRNAs*/blood, Humans ; Pilot Projects ; Child ; Male ; Female ; Biomarkers/blood ; Child, Preschool ; Adolescent ; Infant ; Electroencephalography

Integration Analysis of miRNA Circulating Expression Following Cerebellar Transcranial Direct Current Stimulation in Patients with Ischemic Stroke.

Autori: Pang X Xiao F Zheng T a ďalší

Zdroj: Biochemical genetics [Biochem Genet] 2025 Oct; Vol. 63 (5), pp. 4022-4036. Date of Electronic Publication: 2024 Sep 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 0126611 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4927 (Electronic) Linking ISSN: 00062928 NLM ISO Abbreviation: Biochem Genet Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ischemic Stroke*/genetics , Ischemic Stroke*/blood , Ischemic Stroke*/therapy , Transcranial Direct Current Stimulation* , MicroRNAs*/genetics , MicroRNAs*/blood , Circulating MicroRNA*/genetics , Circulating MicroRNA*/blood, Humans ; Male ; Female ; Middle Aged ; Gene Regulatory Networks ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/blood ; Aged ; RNA, Circular/genetics ; Gene Expression Profiling ; Cerebellum/metabolism ; RNA, Messenger/genetics

High-throughput nucleotide sequencing reveals new circulatory miRNA genes in cervical cancer patients.

Autori: Abbas HH Rodrigues FAE Krishnan D a ďalší

Zdroj: Computers in biology and medicine [Comput Biol Med] 2025 Oct; Vol. 197 (Pt B), pp. 111116. Date of Electronic Publication: 2025 Sep 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1250250 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0534 (Electronic) Linking ISSN: 00104825 NLM ISO Abbreviation: Comput Biol Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Uterine Cervical Neoplasms*/genetics , Uterine Cervical Neoplasms*/blood , High-Throughput Nucleotide Sequencing* , Gene Expression Regulation, Neoplastic* , Biomarkers, Tumor*/blood , Biomarkers, Tumor*/genetics , MicroRNAs*/blood , MicroRNAs*/genetics , Circulating MicroRNA*/genetics , Circulating MicroRNA*/blood , RNA, Neoplasm*/blood , RNA, Neoplasm*/genetics, Humans ; Female ; Middle Aged ; Adult ; Gene Expression Profiling

Circulating miRNAs and inflammatory markers - Associations between miRNAs and cytokine levels point to miRNA-mediated sCD40L release from platelets.

Autori: Van der Auwera S Ameling S Wiechert A a ďalší

Zdroj: Cytokine [Cytokine] 2025 Oct; Vol. 194, pp. 157012. Date of Electronic Publication: 2025 Aug 12.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005353 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0023 (Electronic) Linking ISSN: 10434666 NLM ISO Abbreviation: Cytokine Subsets: MEDLINE

Výrazy zo slovníka MeSH: CD40 Ligand*/blood , CD40 Ligand*/metabolism , Blood Platelets*/metabolism , Cytokines*/blood , MicroRNAs*/blood , MicroRNAs*/genetics , Circulating MicroRNA*/blood , Circulating MicroRNA*/genetics , Inflammation*/blood, Humans ; Male ; Female ; Middle Aged ; Adult ; Aged ; Biomarkers/blood ; Young Adult ; Cohort Studies

Differential miR-195-5p and its potential role during the development of carotid artery stenosis.

Autori: Gao H Zhao L Cao X a ďalší

Zdroj: Vascular [Vascular] 2025 Oct; Vol. 33 (5), pp. 1208-1214. Date of Electronic Publication: 2024 Aug 14.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Sage Country of Publication: England NLM ID: 101196722 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1708-539X (Electronic) Linking ISSN: 17085381 NLM ISO Abbreviation: Vascular Subsets: MEDLINE

Výrazy zo slovníka MeSH: MicroRNAs*/genetics , MicroRNAs*/blood , MicroRNAs*/metabolism , Carotid Stenosis*/genetics , Carotid Stenosis*/blood , Carotid Stenosis*/pathology , Carotid Stenosis*/metabolism , Muscle, Smooth, Vascular*/metabolism , Muscle, Smooth, Vascular*/pathology , Myocytes, Smooth Muscle*/metabolism , Myocytes, Smooth Muscle*/pathology , Circulating MicroRNA*/genetics , Circulating MicroRNA*/blood , Circulating MicroRNA*/metabolism, Humans ; Male ; Female ; Cell Proliferation ; Middle Aged ; Cell Movement ; Aged ; Case-Control Studies ; Cells, Cultured ; Risk Factors

Integrated periodontal pathogens and circulating miRNAs: a novel non-invasive panel of biomarkers for pancreatic cancer.

Autori: Hesami Z Pazienza V Olfatifar M a ďalší

Zdroj: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2025 Oct 31; Vol. 15, pp. 1678114. Date of Electronic Publication: 2025 Oct 31 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Pancreatic Neoplasms*/diagnosis , Pancreatic Neoplasms*/blood , Pancreatic Neoplasms*/microbiology , Biomarkers, Tumor*/blood , MicroRNAs*/blood , Circulating MicroRNA*/blood, Humans ; Female ; Male ; Middle Aged ; Porphyromonas gingivalis/isolation & purification ; Saliva/microbiology ; Aggregatibacter actinomycetemcomitans/isolation & purification ; Aged ; ROC Curve ; Case-Control Studies ; Bacterial Load ; Biomarkers/blood