Suchergebnisse - "MICROBIAL sensitivity tests"

The new thiazolidine-2,4-dione-based hybrids with promising antimycobacterial activity: design, synthesis, biological evaluation, and drug interaction analysis.

Autoren: Trotsko N Głogowska A Kaproń B et al.

Quelle: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2442703. Date of Electronic Publication: 2025 Jan 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Microbial Sensitivity Tests* , Mycobacterium tuberculosis*/drug effects , Antitubercular Agents*/pharmacology , Antitubercular Agents*/chemical synthesis , Antitubercular Agents*/chemistry , Drug Design* , Thiazolidinediones*/pharmacology , Thiazolidinediones*/chemistry , Thiazolidinediones*/chemical synthesis , Dose-Response Relationship, Drug*, Structure-Activity Relationship ; Molecular Structure ; Drug Interactions

The epidemiology and gene mutation characteristics of pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates in Southern China.

Autoren: Wang N Meng F Deng L et al.

Quelle: Emerging microbes & infections [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2447607. Date of Electronic Publication: 2025 Jan 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE

MeSH-Schlagworte: Pyrazinamide*/pharmacology , Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/isolation & purification , Antitubercular Agents*/pharmacology , Mutation* , Microbial Sensitivity Tests* , Tuberculosis, Multidrug-Resistant*/microbiology , Tuberculosis, Multidrug-Resistant*/epidemiology, Humans ; China/epidemiology ; Male ; Female ; Adult ; Middle Aged ; Young Adult ; Bacterial Proteins/genetics ; Aged ; Adolescent ; Drug Resistance, Bacterial/genetics ; Amidohydrolases

Isoniazid potentiates tigecycline to kill methicillin-resistant Staphylococcus aureus .

Autoren: Chen XW Chen HQ Wu JH et al.

Quelle: Emerging microbes & infections [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2434587. Date of Electronic Publication: 2024 Dec 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE

MeSH-Schlagworte: Tigecycline*/pharmacology , Methicillin-Resistant Staphylococcus aureus*/drug effects , Isoniazid*/pharmacology , Drug Synergism* , Microbial Sensitivity Tests* , Anti-Bacterial Agents*/pharmacology , Staphylococcal Infections*/drug therapy , Staphylococcal Infections*/microbiology, Animals ; Mice ; Humans

Systematic Evaluation of Helicobacter pylori Susceptibility to Antibiotics Before First-Line Treatment: A Cohort Study.

Autoren: Denis B Plastaras L Amaritei I et al.

Quelle: United European gastroenterology journal [United European Gastroenterol J] 2025 Sep; Vol. 13 (7), pp. 1289-1294. Date of Electronic Publication: 2025 Aug 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 101606807 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2050-6414 (Electronic) Linking ISSN: 20506406 NLM ISO Abbreviation: United European Gastroenterol J Subsets: MEDLINE

MeSH-Schlagworte: Helicobacter pylori*/drug effects , Microbial Sensitivity Tests*/economics , Microbial Sensitivity Tests*/methods , Microbial Sensitivity Tests*/standards , Helicobacter Infections*/diagnosis , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Drug Resistance, Bacterial*/drug effects, Prospective Studies ; Endoscopy, Digestive System ; Biopsy ; Polymerase Chain Reaction/economics ; Polymerase Chain Reaction/methods ; Polymerase Chain Reaction/standards ; France ; Clarithromycin/pharmacology ; Clarithromycin/therapeutic use ; Levofloxacin/pharmacology ; Levofloxacin/therapeutic use ; Amoxicillin/pharmacology ; Amoxicillin/therapeutic use ; Breath Tests ; Urea/analysis ; Treatment Outcome ; Cost-Effectiveness Analysis ; Drug Therapy, Combination ; Humans ; Male ; Female ; Middle Aged

Exploration of quinoxaline triazoles as antimycobacterial agents: design, synthesis and biological evaluation.

Autoren: Kumar BVS Talamadla MK Nandikolla A et al.

Quelle: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Jun 01; Vol. 121, pp. 130177. Date of Electronic Publication: 2025 Mar 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH-Schlagworte: Quinoxalines*/pharmacology , Quinoxalines*/chemical synthesis , Quinoxalines*/chemistry , Mycobacterium tuberculosis*/drug effects , Drug Design* , Microbial Sensitivity Tests* , Triazoles*/pharmacology , Triazoles*/chemistry , Triazoles*/chemical synthesis , Antitubercular Agents*/pharmacology , Antitubercular Agents*/chemical synthesis , Antitubercular Agents*/chemistry, Structure-Activity Relationship ; Molecular Structure ; Molecular Docking Simulation ; Dose-Response Relationship, Drug ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry

Phenyl urea based adjuvants for β-lactam antibiotics against methicillin resistant Staphylococcus aureus.

Autoren: Butman HS Stefaniak MA Walsh DJ et al.

Quelle: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Jun 01; Vol. 121, pp. 130164. Date of Electronic Publication: 2025 Mar 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH-Schlagworte: Methicillin-Resistant Staphylococcus aureus*/drug effects , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Microbial Sensitivity Tests* , beta-Lactams*/pharmacology , beta-Lactams*/chemistry , beta-Lactams*/chemical synthesis, Structure-Activity Relationship ; Penicillin-Binding Proteins/antagonists & inhibitors ; Penicillin-Binding Proteins/metabolism ; Molecular Structure ; Urea/pharmacology ; Urea/chemistry ; Dose-Response Relationship, Drug ; beta Lactam Antibiotics

Potent synergistic effect of natural product-inspired Sinomenine derivatives with fluconazole against azole-resistant Candida albicans.

Autoren: Liu W Du J Qin Z et al.

Quelle: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Jun 01; Vol. 121, pp. 130159. Date of Electronic Publication: 2025 Mar 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH-Schlagworte: Candida albicans*/drug effects , Morphinans*/pharmacology , Morphinans*/chemistry , Morphinans*/chemical synthesis , Fluconazole*/pharmacology , Antifungal Agents*/pharmacology , Antifungal Agents*/chemistry , Antifungal Agents*/chemical synthesis , Drug Resistance, Fungal*/drug effects , Microbial Sensitivity Tests* , Drug Synergism*, Structure-Activity Relationship ; Biological Products/pharmacology ; Biological Products/chemistry ; Biological Products/chemical synthesis ; Molecular Structure ; Reactive Oxygen Species/metabolism ; Dose-Response Relationship, Drug ; Azoles/pharmacology ; Azoles/chemistry ; Azoles/chemical synthesis ; Apoptosis/drug effects

N-alkyl substituted armeniaspirol analogs show potent antibiotic activity and have low susceptibility to resistance.

Autoren: Darnowski MG Lanosky TD Spada AD et al.

Quelle: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Jun 01; Vol. 121, pp. 130137. Date of Electronic Publication: 2025 Feb 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH-Schlagworte: Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Microbial Sensitivity Tests* , Methicillin-Resistant Staphylococcus aureus*/drug effects, Structure-Activity Relationship ; Molecular Structure ; Drug Resistance, Bacterial/drug effects ; Dose-Response Relationship, Drug

Discovery of 1,3-Disubstituted Pyrazole derivatives as Mycobacterium tuberculosis inhibitors.

Autoren: Wan G Gao C Zhang X et al.

Quelle: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Jun 01; Vol. 121, pp. 130156. Date of Electronic Publication: 2025 Feb 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MeSH-Schlagworte: Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyrazoles*/chemical synthesis , Mycobacterium tuberculosis*/drug effects , Antitubercular Agents*/pharmacology , Antitubercular Agents*/chemistry , Antitubercular Agents*/chemical synthesis , Microbial Sensitivity Tests*, Humans ; Structure-Activity Relationship ; Chlorocebus aethiops ; Vero Cells ; Animals ; Molecular Docking Simulation ; Molecular Structure ; Drug Discovery ; Hep G2 Cells ; Dose-Response Relationship, Drug

The discovery of novel antimicrobial peptides against drug-resistant bacteria based on fragments fusion strategy.

Autoren: Zeng C Ning Z Xu Y et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 May 05; Vol. 289, pp. 117493. Date of Electronic Publication: 2025 Mar 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Microbial Sensitivity Tests* , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Antimicrobial Peptides*/pharmacology , Antimicrobial Peptides*/chemistry , Antimicrobial Peptides*/chemical synthesis, Animals ; Mice ; Peritonitis/drug therapy ; Peritonitis/microbiology ; Structure-Activity Relationship ; Humans ; Drug Discovery ; Molecular Structure ; Drug Resistance, Multiple, Bacterial/drug effects ; Dose-Response Relationship, Drug ; Hemolysis/drug effects

A systematic review on the anti-microbial activities and structure-activity relationship (SAR) of quinoxaline derivatives.

Autoren: Bellapukonda SM Bandela R Singampalli A et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 May 05; Vol. 289, pp. 117472. Date of Electronic Publication: 2025 Mar 05.

Publikationsart: Journal Article; Systematic Review

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Quinoxalines*/pharmacology , Quinoxalines*/chemistry , Quinoxalines*/chemical synthesis , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Microbial Sensitivity Tests*, Structure-Activity Relationship ; Molecular Structure ; Humans ; Bacteria/drug effects

Synthesis and antibacterial evaluations of novel vancomycin analogues targeting bacteria membrane to combat Gram-negative infections.

Autoren: Li T Zhang R Gong H et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 May 05; Vol. 289, pp. 117483. Date of Electronic Publication: 2025 Mar 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemical synthesis , Anti-Bacterial Agents*/chemistry , Microbial Sensitivity Tests* , Vancomycin*/pharmacology , Vancomycin*/chemistry , Vancomycin*/chemical synthesis, Structure-Activity Relationship ; Animals ; Mice ; Molecular Structure ; Dose-Response Relationship, Drug ; Gram-Negative Bacterial Infections/drug therapy ; Acinetobacter baumannii/drug effects ; Gram-Negative Bacteria/drug effects ; Cell Membrane/drug effects ; Humans

Pyrylium derivatives as outer membrane permeabilizers against MDR gram-negative bacteria via multi-target mode of action.

Autoren: Duan Q Yuan M Ma X et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 May 05; Vol. 289, pp. 117387. Date of Electronic Publication: 2025 Feb 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Acinetobacter baumannii*/drug effects , Microbial Sensitivity Tests* , Escherichia coli*/drug effects , Drug Resistance, Multiple, Bacterial*/drug effects, Molecular Structure ; Animals ; Structure-Activity Relationship ; Bacterial Outer Membrane/drug effects ; Bacterial Outer Membrane/metabolism ; Cell Membrane Permeability/drug effects ; Dose-Response Relationship, Drug ; Gram-Negative Bacteria/drug effects ; Moths/drug effects

Naturally inspired chimeric quinolone derivatives to reverse bacterial drug resistance.

Autoren: Wen Q He Y Chi J et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 May 05; Vol. 289, pp. 117496. Date of Electronic Publication: 2025 Mar 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Microbial Sensitivity Tests*, Structure-Activity Relationship ; Quinolones/pharmacology ; Quinolones/chemistry ; Quinolones/chemical synthesis ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Molecular Structure ; Animals ; Humans ; Drug Resistance, Bacterial/drug effects ; Dose-Response Relationship, Drug ; Mice ; Molecular Dynamics Simulation ; Ciprofloxacin/pharmacology ; Ciprofloxacin/chemistry

Exploration of membrane-active cephalosporin derivatives as potent antibacterial agents against Staphylococcus aureus biofilms and persisters.

Autoren: Chen S Qu Y Li R et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 May 05; Vol. 289, pp. 117484. Date of Electronic Publication: 2025 Mar 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Biofilms*/drug effects , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Staphylococcus aureus*/drug effects , Microbial Sensitivity Tests* , Cephalosporins*/pharmacology , Cephalosporins*/chemistry , Cephalosporins*/chemical synthesis, Structure-Activity Relationship ; Animals ; Molecular Structure ; Dose-Response Relationship, Drug ; Cell Membrane/drug effects ; Humans ; Reactive Oxygen Species/metabolism ; Mice

Rapid discovery of pseudorabies virus inhibitors repurposed from the antimicrobial agent ciprofloxacin.

Autoren: Wei L You Y Hu Y et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 May 05; Vol. 289, pp. 117490. Date of Electronic Publication: 2025 Mar 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Herpesvirus 1, Suid*/drug effects , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Antiviral Agents*/chemical synthesis , Ciprofloxacin*/pharmacology , Ciprofloxacin*/chemistry , Virus Replication*/drug effects , Microbial Sensitivity Tests*, Animals ; Mice ; Structure-Activity Relationship ; Drug Repositioning ; Molecular Structure ; Dose-Response Relationship, Drug ; Drug Discovery ; Pseudorabies/drug therapy ; Pseudorabies/virology ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/chemical synthesis ; Chlorocebus aethiops ; Swine

Discovery of novel pyrimidinetrione derivatives as DprE1 inhibitors with potent antimycobacterial activities.

Autoren: Liang J Liu Y Guan Q et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 May 05; Vol. 289, pp. 117416. Date of Electronic Publication: 2025 Feb 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/drug effects , Antitubercular Agents*/pharmacology , Antitubercular Agents*/chemistry , Antitubercular Agents*/chemical synthesis , Microbial Sensitivity Tests*, Structure-Activity Relationship ; Molecular Structure ; Drug Discovery ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/chemical synthesis ; Humans ; Molecular Docking Simulation ; Bacterial Proteins/antagonists & inhibitors ; Bacterial Proteins/metabolism ; Oxidoreductases/antagonists & inhibitors ; Oxidoreductases/metabolism ; Alcohol Oxidoreductases

LPS-enriched interaction drives spectrum conversion in antimicrobial peptides: Design and optimization of AA16 derivatives for targeting gram-negative bacteria.

Autoren: Xiao W Sun R Lou J et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 May 05; Vol. 289, pp. 117462. Date of Electronic Publication: 2025 Feb 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Lipopolysaccharides*/pharmacology , Lipopolysaccharides*/antagonists & inhibitors , Drug Design* , Microbial Sensitivity Tests* , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Gram-Negative Bacteria*/drug effects, Structure-Activity Relationship ; Pseudomonas aeruginosa/drug effects ; Antimicrobial Peptides/pharmacology ; Antimicrobial Peptides/chemistry ; Antimicrobial Peptides/chemical synthesis ; Escherichia coli/drug effects ; Molecular Structure ; Dose-Response Relationship, Drug ; Humans

Discovery of 3-hydroxypyridin-4(1H)-ones ester of ciprofloxacin as prodrug to combat biofilm-associated Pseudomonas aeruginosa.

Autoren: Wang YY Luo BZ Li CM et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 May 05; Vol. 289, pp. 117396. Date of Electronic Publication: 2025 Feb 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Pseudomonas aeruginosa*/drug effects , Pseudomonas aeruginosa*/physiology , Biofilms*/drug effects , Ciprofloxacin*/pharmacology , Ciprofloxacin*/chemistry , Ciprofloxacin*/chemical synthesis , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Prodrugs*/pharmacology , Prodrugs*/chemistry , Prodrugs*/chemical synthesis , Microbial Sensitivity Tests*, Animals ; Structure-Activity Relationship ; Molecular Structure ; Drug Discovery ; Caenorhabditis elegans/drug effects ; Esters/chemistry ; Esters/pharmacology ; Esters/chemical synthesis ; Dose-Response Relationship, Drug ; Pyridines/chemistry ; Pyridines/pharmacology ; Pyridines/chemical synthesis

Dodecapeptides derived from human cathelicidin with potent activity against carbapenem-resistant Acinetobacter baumannii.

Autoren: Jiang Y Zhao G Gong Y et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 May 05; Vol. 289, pp. 117477. Date of Electronic Publication: 2025 Mar 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Acinetobacter baumannii*/drug effects , Cathelicidins*/pharmacology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Carbapenems*/pharmacology , Carbapenems*/chemistry , Carbapenems*/chemical synthesis , Microbial Sensitivity Tests*, Humans ; Animals ; Mice ; Acinetobacter Infections/drug therapy ; Acinetobacter Infections/microbiology ; Structure-Activity Relationship ; Drug Resistance, Bacterial/drug effects ; Molecular Structure ; Dose-Response Relationship, Drug ; Antimicrobial Cationic Peptides/pharmacology ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Cationic Peptides/chemical synthesis