Search Results - "METRONIDAZOLE"

Pharmacokinetics of Metronidazole During Prolonged Intermittent Kidney Replacement Therapy.

Authors: Xu JH Cheng V Rawlins M et al.

Source: Hemodialysis international. International Symposium on Home Hemodialysis [Hemodial Int] 2025 Oct; Vol. 29 (4), pp. 713-716. Date of Electronic Publication: 2025 Apr 04.

Publication Type: Case Reports; Journal Article

Journal Info: Publisher: Blackwell Pub Country of Publication: Canada NLM ID: 101093910 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-4758 (Electronic) Linking ISSN: 14927535 NLM ISO Abbreviation: Hemodial Int Subsets: MEDLINE

MeSH Terms: Metronidazole*/pharmacokinetics , Metronidazole*/therapeutic use , Metronidazole*/administration & dosage , Renal Replacement Therapy*/methods , Acute Kidney Injury*/therapy , Anti-Infective Agents*/pharmacokinetics, Humans ; Male ; Middle Aged ; Aged

Metronidazole Pharmacokinetics Across Species: Meta-Analysis Integrating Allometric Scaling and Minimal Physiologically-Based Pharmacokinetic Modeling.

Authors: Kir F Jusko WJ

Source: The AAPS journal [AAPS J] 2025 Dec 05; Vol. 28 (1), pp. 25. Date of Electronic Publication: 2025 Dec 05.

Publication Type: Journal Article; Meta-Analysis

Journal Info: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE

MeSH Terms: Metronidazole*/pharmacokinetics , Metronidazole*/administration & dosage , Models, Biological* , Anti-Infective Agents*/pharmacokinetics , Anti-Infective Agents*/administration & dosage, Animals ; Species Specificity ; Humans ; Administration, Oral ; Sheep ; Tissue Distribution

Topical versus oral metronidazole for post-haemorrhoidectomy pain: A systematic review and meta-analysis of randomized controlled trials.

Authors: Pompeu BF Garcia GL Barone GL et al.

Source: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland [Colorectal Dis] 2025 Dec; Vol. 27 (12), pp. e70321.

Publication Type: Journal Article; Systematic Review; Meta-Analysis; Comparative Study; Review

Journal Info: Publisher: Blackwell Science Ltd Country of Publication: England NLM ID: 100883611 Publication Model: Print Cited Medium: Internet ISSN: 1463-1318 (Electronic) Linking ISSN: 14628910 NLM ISO Abbreviation: Colorectal Dis Subsets: MEDLINE

MeSH Terms: Metronidazole*/administration & dosage , Pain, Postoperative*/drug therapy , Pain, Postoperative*/etiology , Hemorrhoidectomy*/adverse effects , Analgesics*/administration & dosage, Humans ; Randomized Controlled Trials as Topic ; Administration, Topical ; Administration, Oral ; Treatment Outcome ; Male ; Female ; Pain Measurement ; Middle Aged ; Adult

The efficacy of metronidazole rinses in reducing surgical site infections and improving wound healing in patients with purulent appendicitis: a systematic review and meta-analysis.

Authors: Han P Cao S

Source: BMC infectious diseases [BMC Infect Dis] 2025 Nov 12; Vol. 25 (1), pp. 1555. Date of Electronic Publication: 2025 Nov 12.

Publication Type: Journal Article; Systematic Review; Meta-Analysis; Review

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE

MeSH Terms: Metronidazole*/administration & dosage , Metronidazole*/therapeutic use , Appendicitis*/surgery , Appendicitis*/drug therapy , Surgical Wound Infection*/prevention & control , Surgical Wound Infection*/drug therapy , Wound Healing*/drug effects , Anti-Infective Agents*/administration & dosage, Humans ; Treatment Outcome ; Administration, Topical

Metronidazole exposure-response and safety in infants.

Authors: Randell RL Balevic SJ Greenberg RG et al.

Corporate Authors: Randell RL Balevic SJ Greenberg RG et al.

Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2025 Nov 05; Vol. 69 (11), pp. e0037725. Date of Electronic Publication: 2025 Sep 19.

Publication Type: Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

MeSH Terms: Anti-Bacterial Agents*/therapeutic use , Anti-Bacterial Agents*/pharmacokinetics , Anti-Bacterial Agents*/adverse effects , Intraabdominal Infections*/drug therapy , Intraabdominal Infections*/microbiology , Metronidazole*/therapeutic use , Metronidazole*/adverse effects , Metronidazole*/pharmacokinetics, Female ; Humans ; Infant ; Infant, Newborn ; Male ; Enterocolitis, Necrotizing/drug therapy

Comparative efficacy and safety of oral versus intravaginal metronidazole for the treatment of bacterial vaginosis: A systematic review and meta-analysis.

Authors: Hirai J Arakawa Y Kato H et al.

Source: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy [J Infect Chemother] 2025 Nov; Vol. 31 (11), pp. 102826. Date of Electronic Publication: 2025 Oct 09.

Publication Type: Journal Article; Systematic Review; Meta-Analysis; Comparative Study

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9608375 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1437-7780 (Electronic) Linking ISSN: 1341321X NLM ISO Abbreviation: J Infect Chemother Subsets: MEDLINE

MeSH Terms: Vaginosis, Bacterial*/drug therapy , Vaginosis, Bacterial*/microbiology , Metronidazole*/administration & dosage , Metronidazole*/adverse effects , Anti-Bacterial Agents*/administration & dosage , Anti-Bacterial Agents*/adverse effects, Humans ; Female ; Administration, Intravaginal ; Administration, Oral ; Randomized Controlled Trials as Topic ; Treatment Outcome

Electrochemical sensor based on α-Fe 2 O 3 /rGO core-enhanced carbon interfaces for ultra-sensitive metronidazole detection.

Authors: Alqahtani AS Elshafie H Mubarakali A et al.

Source: Scientific reports [Sci Rep] 2025 Oct 09; Vol. 15 (1), pp. 35348. Date of Electronic Publication: 2025 Oct 09.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Metronidazole*/analysis , Metronidazole*/urine , Metronidazole*/chemistry , Graphite*/chemistry , Biosensing Techniques*/methods , Carbon*/chemistry , Ferric Compounds*/chemistry , Electrochemical Techniques*/methods, Electrodes ; Limit of Detection ; Dielectric Spectroscopy ; Humans ; X-Ray Diffraction

Metronidazole-An Old Drug for Structure Optimization and Repurposing.

Authors: Suvarna V Murahari M Pawar S

Source: Chemistry & biodiversity [Chem Biodivers] 2025 Oct; Vol. 22 (10), pp. e03389. Date of Electronic Publication: 2025 Jun 07.

Publication Type: Journal Article; Review

Journal Info: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

MeSH Terms: Metronidazole*/pharmacology , Metronidazole*/chemistry , Drug Repositioning* , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry, Humans ; Animals ; Molecular Structure ; Structure-Activity Relationship ; Bacteria/drug effects

Emerging Clostridioides difficile strains belonging to PCR ribotype 955 in Serbia are distinct from metronidazole-resistant RT955 outbreak isolates from the UK.

Authors: Stojanovic P Kraakman M Notermans DW et al.

Corporate Authors: Stojanovic P Kraakman M Notermans DW et al.

Source: Emerging microbes & infections [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2544733. Date of Electronic Publication: 2025 Sep 03.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE

MeSH Terms: Clostridioides difficile*/genetics , Clostridioides difficile*/drug effects , Clostridioides difficile*/classification , Clostridioides difficile*/isolation & purification , Clostridium Infections*/epidemiology , Clostridium Infections*/microbiology , Drug Resistance, Bacterial* , Metronidazole*/pharmacology, Humans ; Serbia/epidemiology ; Male ; Ribotyping ; Female ; Anti-Bacterial Agents/pharmacology ; Middle Aged ; Disease Outbreaks ; Aged ; United Kingdom/epidemiology ; Multilocus Sequence Typing ; Adult ; Aged, 80 and over ; Microbial Sensitivity Tests ; Whole Genome Sequencing

Cu,Fe,B/Cur-CDs with peroxidase- and ascorbic acid oxidase-like catalytic activity for dual-signal fluorescence sensing of metronidazole.

Authors: Hou L Li Q Li J et al.

Source: Food chemistry [Food Chem] 2025 Nov 30; Vol. 493 (Pt 2), pp. 145757. Date of Electronic Publication: 2025 Aug 05.

Publication Type: Journal Article; Evaluation Study

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH Terms: Metronidazole*/analysis , Ascorbate Oxidase*/chemistry , Peroxidase*/chemistry, Copper/chemistry ; Iron/chemistry ; Spectrometry, Fluorescence/methods ; Catalysis ; Fluorescence ; Ascorbic Acid/chemistry ; Oxidation-Reduction ; Carbon/chemistry ; Quantum Dots/chemistry

Raman spectroscopy as a tool to accelerate development of complex medicinal products.

Authors: Zarmpi P Tsikritsis D Watson AC et al.

Source: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Nov 10; Vol. 387, pp. 114190. Date of Electronic Publication: 2025 Sep 02.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH Terms: Spectrum Analysis, Raman*/methods , Metronidazole*/pharmacokinetics , Metronidazole*/administration & dosage , Drug Development*/methods , Drugs, Generic*/pharmacokinetics , Drugs, Generic*/administration & dosage, Humans ; Skin/metabolism ; Gels ; Animals ; Therapeutic Equivalency

Development of ZnO-resistant starch prebiotic matrix conjugate for metronidazole delivery for enhanced probiotic viability and antimicrobial activity.

Authors: Panda P Mohapatra R

Source: International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 329 (Pt 2), pp. 147904. Date of Electronic Publication: 2025 Sep 24.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH Terms: Zinc Oxide*/chemistry , Probiotics*/chemistry , Prebiotics* , Metronidazole*/chemistry , Metronidazole*/pharmacology , Starch*/chemistry , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry, Nanoparticles/chemistry ; Molecular Docking Simulation ; Microbial Viability/drug effects ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Drug Carriers/chemistry

Susceptibility of multidrug-resistant Aggregatibacter actinomycetemcomitans in vitro to amoxicillin-metronidazole and ciprofloxacin.

Authors: Rams TE van Winkelhoff AJ

Source: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy [J Infect Chemother] 2025 Nov; Vol. 31 (11), pp. 102836. Date of Electronic Publication: 2025 Oct 21.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9608375 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1437-7780 (Electronic) Linking ISSN: 1341321X NLM ISO Abbreviation: J Infect Chemother Subsets: MEDLINE

MeSH Terms: Ciprofloxacin*/pharmacology , Amoxicillin*/pharmacology , Metronidazole*/pharmacology , Anti-Bacterial Agents*/pharmacology , Aggregatibacter actinomycetemcomitans*/drug effects , Aggregatibacter actinomycetemcomitans*/isolation & purification , Drug Resistance, Multiple, Bacterial*/drug effects, Humans ; Microbial Sensitivity Tests ; Biofilms/drug effects ; Periodontitis/microbiology ; Periodontitis/drug therapy ; Drug Synergism ; Drug Therapy, Combination

Antibiotic protection assay revisited: Metronidazole is unable to completely eliminate Porphyromonas gingivalis.

Authors: de Jongh CA Volle L Sun C et al.

Source: Journal of microbiological methods [J Microbiol Methods] 2025 Oct; Vol. 237, pp. 107214. Date of Electronic Publication: 2025 Aug 06.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Biomedical Country of Publication: Netherlands NLM ID: 8306883 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8359 (Electronic) Linking ISSN: 01677012 NLM ISO Abbreviation: J Microbiol Methods Subsets: MEDLINE

MeSH Terms: Porphyromonas gingivalis*/drug effects , Metronidazole*/pharmacology , Anti-Bacterial Agents*/pharmacology, Humans ; Mice ; Animals ; Macrophages/microbiology ; Macrophages/drug effects ; Microbial Viability/drug effects ; Microbial Sensitivity Tests ; Gentamicins/pharmacology ; Cell Line ; Antimicrobial Peptides/pharmacology ; Antimicrobial Cationic Peptides/pharmacology

Addition of metronidazole to standard-of-care perioperative prophylaxis at the time of hysterectomy for gynecologic malignancies.

Authors: Gorman M Kredentser A Katehis IA et al.

Source: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society [Int J Gynecol Cancer] 2025 Oct; Vol. 35 (10), pp. 102036. Date of Electronic Publication: 2025 Aug 05.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 9111626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-1438 (Electronic) Linking ISSN: 1048891X NLM ISO Abbreviation: Int J Gynecol Cancer Subsets: MEDLINE

MeSH Terms: Metronidazole*/therapeutic use , Metronidazole*/administration & dosage , Hysterectomy*/methods , Hysterectomy*/adverse effects , Surgical Wound Infection*/prevention & control , Surgical Wound Infection*/epidemiology , Genital Neoplasms, Female*/surgery , Antibiotic Prophylaxis*/methods , Anti-Bacterial Agents*/therapeutic use , Anti-Bacterial Agents*/administration & dosage, Humans ; Female ; Retrospective Studies ; Middle Aged ; Aged ; Cefazolin/therapeutic use ; Cefazolin/administration & dosage ; Adult ; Standard of Care

Preparation and characterization of a secnidazole-mandelic acid coamorphous system: enhanced dissolution profile, antibacterial properties, and theoretical druglikeness assessment.

Authors: de Oliveira Neto JG Moreira ABN Moura AC et al.

Source: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2025 Oct 01; Vol. 213, pp. 107231. Date of Electronic Publication: 2025 Aug 08.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE

MeSH Terms: Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/pharmacokinetics , Mandelic Acids*/chemistry , Mandelic Acids*/pharmacology , Metronidazole*/analogs & derivatives , Metronidazole*/chemistry , Metronidazole*/pharmacology , Metronidazole*/pharmacokinetics, Solubility ; Drug Liberation ; Density Functional Theory ; Thermodynamics ; Drug Stability ; X-Ray Diffraction ; Microbial Sensitivity Tests ; Staphylococcus aureus/drug effects

Assessing the Longitudinal outcomes of Piperacillin/tazobactam versus ceftriAxone and metronidazole for Children with perforated Appendicitis (ALPACA): A protocol for a pilot randomized controlled trial.

Authors: Briatico D Safa N Flageole H et al.

Source: PloS one [PLoS One] 2025 Nov 07; Vol. 20 (11), pp. e0335991. Date of Electronic Publication: 2025 Nov 07 (Print Publication: 2025).

Publication Type: Journal Article; Clinical Trial Protocol

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH Terms: Appendicitis*/drug therapy , Appendicitis*/surgery , Metronidazole*/therapeutic use , Ceftriaxone*/therapeutic use , Anti-Bacterial Agents*/therapeutic use, Humans ; Child ; Pilot Projects ; Piperacillin, Tazobactam Drug Combination/therapeutic use ; Male ; Female ; Double-Blind Method ; Adolescent ; Appendectomy ; Treatment Outcome ; Child, Preschool ; Longitudinal Studies ; Piperacillin/therapeutic use ; Randomized Controlled Trials as Topic

Piperacillin/tazobactam versus ceftriaxone/metronidazole for children with perforated appendicitis: a systematic review and meta-analysis.

Authors: Armstrong J Sriranjan J Briatico D et al.

Source: Pediatric surgery international [Pediatr Surg Int] 2025 Nov 04; Vol. 42 (1), pp. 3. Date of Electronic Publication: 2025 Nov 04.

Publication Type: Journal Article; Systematic Review; Meta-Analysis; Comparative Study; Review

Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 8609169 Publication Model: Electronic Cited Medium: Internet ISSN: 1437-9813 (Electronic) Linking ISSN: 01790358 NLM ISO Abbreviation: Pediatr Surg Int Subsets: MEDLINE

MeSH Terms: Appendicitis*/surgery , Appendicitis*/drug therapy , Ceftriaxone*/therapeutic use , Metronidazole*/therapeutic use , Anti-Bacterial Agents*/therapeutic use , Piperacillin, Tazobactam Drug Combination*/therapeutic use, Humans ; Appendectomy/methods ; Child ; Laparoscopy

Exploring drug resistance and genetic polymorphisms in Iranian Trichomonas vaginalis isolates: focused on the ntr4 Tv and ntr6 Tv genes.

Authors: Abolghazi A Foroughi-Parvar F Fallah M et al.

Source: Acta tropica [Acta Trop] 2025 Nov; Vol. 271, pp. 107844. Date of Electronic Publication: 2025 Sep 17.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6254 (Electronic) Linking ISSN: 0001706X NLM ISO Abbreviation: Acta Trop Subsets: MEDLINE

MeSH Terms: Trichomonas vaginalis*/genetics , Trichomonas vaginalis*/drug effects , Trichomonas vaginalis*/isolation & purification , Metronidazole*/pharmacology , Polymorphism, Genetic* , Antiprotozoal Agents*/pharmacology , Nitroreductases*/genetics , Drug Resistance*, Female ; Humans ; Iran/epidemiology ; Adult ; Trichomonas Vaginitis/parasitology ; Trichomonas Vaginitis/epidemiology ; Prevalence ; Microbial Sensitivity Tests ; Parasitic Sensitivity Tests ; Sequence Analysis, DNA ; Young Adult ; Point Mutation ; Middle Aged ; Trichomonas Infections/parasitology ; Trichomonas Infections/epidemiology

Stratification of bacterial communities and extracellular polymeric substances in anodic and cathodic biofilms of bioelectrochemical system under metronidazole stress in seawater.

Authors: Xin H Chen X Ma S et al.

Source: Bioresource technology [Bioresour Technol] 2025 Nov; Vol. 436, pp. 133040. Date of Electronic Publication: 2025 Jul 28.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Country of Publication: England NLM ID: 9889523 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2976 (Electronic) Linking ISSN: 09608524 NLM ISO Abbreviation: Bioresour Technol Subsets: MEDLINE

MeSH Terms: Biofilms*/drug effects , Biofilms*/growth & development , Seawater*/microbiology , Seawater*/chemistry , Extracellular Polymeric Substance Matrix*/metabolism , Extracellular Polymeric Substance Matrix*/drug effects , Metronidazole*/pharmacology , Bacteria*/drug effects , Bacteria*/metabolism , Bacteria*/genetics , Bioelectric Energy Sources*/microbiology , Stress, Physiological*/drug effects, Electrodes