Suchergebnisse - "MAINTENANCE"

CRL4 ^DCAF12 regulation of MCMBP ensures optimal licensing of DNA replication.

Autoren: Yadav AK Abdirov A Ondruskova K et al.

Quelle: Nature communications [Nat Commun] 2025 Oct 27; Vol. 16 (1), pp. 9391. Date of Electronic Publication: 2025 Oct 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: DNA Replication* , Minichromosome Maintenance Proteins*/metabolism , Minichromosome Maintenance Proteins*/genetics , Cell Cycle Proteins*/metabolism , Cell Cycle Proteins*/genetics, Humans ; Chromatin/metabolism ; HeLa Cells ; Genomic Instability ; Cell Nucleus/metabolism ; Minichromosome Maintenance Complex Component 2/metabolism ; Minichromosome Maintenance Complex Component 2/genetics ; Minichromosome Maintenance Complex Component 3/metabolism ; Minichromosome Maintenance Complex Component 3/genetics ; Minichromosome Maintenance Complex Component 7/metabolism ; Minichromosome Maintenance Complex Component 7/genetics ; Nuclear Proteins ; Adaptor Proteins, Signal Transducing

Minichromosome Maintenance Complex Genes Are Candidate Biomarkers of Retinal Degeneration.

Autoren: Sun N Hu X Wang J et al.

Quelle: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics [J Ocul Pharmacol Ther] 2025 Oct; Vol. 41 (8), pp. 463-474. Date of Electronic Publication: 2025 Jun 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Association For Ocular Pharmacology And Therapeutics Country of Publication: United States NLM ID: 9511091 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7732 (Electronic) Linking ISSN: 10807683 NLM ISO Abbreviation: J Ocul Pharmacol Ther Subsets: MEDLINE

MeSH-Schlagworte: Retinal Degeneration*/genetics , Retinal Degeneration*/metabolism , Minichromosome Maintenance Proteins*/genetics, Animals ; Humans ; Biomarkers/metabolism ; Cell Line ; Iodates/toxicity ; Mice ; DNA Replication/genetics ; Disease Models, Animal ; Retinal Pigment Epithelium/metabolism ; Gene Expression Profiling/methods ; Protein Interaction Maps/genetics ; Minichromosome Maintenance Complex Component 7/genetics ; Mice, Inbred C57BL

Celastrol promotes DNA damage and apoptosis in uterine corpus endometrial carcinoma via promotion of KAT2B-mediated RBPJ acetylation and repression of MCM4 transcription.

Autoren: Pei L Zhu Y Li W et al.

Quelle: Molecular medicine (Cambridge, Mass.) [Mol Med] 2025 Feb 03; Vol. 31 (1), pp. 39. Date of Electronic Publication: 2025 Feb 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 9501023 Publication Model: Electronic Cited Medium: Internet ISSN: 1528-3658 (Electronic) Linking ISSN: 10761551 NLM ISO Abbreviation: Mol Med Subsets: MEDLINE

MeSH-Schlagworte: DNA Damage*/drug effects , Apoptosis*/drug effects , Endometrial Neoplasms*/metabolism , Endometrial Neoplasms*/genetics , Endometrial Neoplasms*/pathology , Endometrial Neoplasms*/drug therapy , Minichromosome Maintenance Proteins*/genetics , Minichromosome Maintenance Proteins*/metabolism , Triterpenes*/pharmacology, Pentacyclic Triterpenes ; Humans ; Female ; Animals ; Cell Line, Tumor ; Mice ; Acetylation/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Mice, Nude ; Cell Proliferation/drug effects ; Xenograft Model Antitumor Assays ; Transcription, Genetic/drug effects ; Cell Survival/drug effects ; Minichromosome Maintenance Complex Component 4

MCM proteins are up-regulated in placentas of women with reduced insulin sensitivity.

Autoren: Bandres-Meriz J Sanz-Cuadrado MI Hurtado de Mendoza I et al.

Quelle: Bioscience reports [Biosci Rep] 2024 Oct 30; Vol. 44 (10).

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 8102797 Publication Model: Print Cited Medium: Internet ISSN: 1573-4935 (Electronic) Linking ISSN: 01448463 NLM ISO Abbreviation: Biosci Rep Subsets: MEDLINE

MeSH-Schlagworte: Placenta*/metabolism , Insulin Resistance* , Minichromosome Maintenance Proteins*/metabolism , Minichromosome Maintenance Proteins*/genetics, Humans ; Female ; Pregnancy ; Adult ; DNA Damage ; Pregnancy Trimester, First/metabolism ; Up-Regulation ; Histones/metabolism ; Proteomics ; Trophoblasts/metabolism ; Minichromosome Maintenance Complex Component 6

Clinical, Histologic, and Safety Outcomes With Long-term Maintenance Therapies for Eosinophilic Esophagitis: A Systematic Review and Meta-analysis.

Autoren: Barchi A Massimino L Mandarino FV et al.

Quelle: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2025 Oct; Vol. 23 (11), pp. 1890-1904.e7. Date of Electronic Publication: 2024 Dec 13.

Publikationsart: Journal Article; Systematic Review; Meta-Analysis; Review

Info zur Zeitschrift: Publisher: W.B. Saunders for the American Gastroenterological Association Country of Publication: United States NLM ID: 101160775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-7714 (Electronic) Linking ISSN: 15423565 NLM ISO Abbreviation: Clin Gastroenterol Hepatol Subsets: MEDLINE

MeSH-Schlagworte: Eosinophilic Esophagitis*/drug therapy , Eosinophilic Esophagitis*/pathology , Maintenance Chemotherapy*/methods , Maintenance Chemotherapy*/adverse effects, Humans ; Treatment Outcome ; Adrenal Cortex Hormones/therapeutic use ; Adrenal Cortex Hormones/adverse effects ; Randomized Controlled Trials as Topic ; Proton Pump Inhibitors/therapeutic use ; Proton Pump Inhibitors/adverse effects ; Biological Products/therapeutic use ; Biological Products/adverse effects ; Observational Studies as Topic

The relationship between cobalamin and folate below the cutoff values on anxiety and insomnia symptoms: Findings from the 8-year longitudinal EPISONO study.

Autoren: Cavalcante-Silva V da Silva Vallim JR de Oliveira AC et al.

Quelle: Journal of affective disorders [J Affect Disord] 2025 Dec 15; Vol. 391, pp. 119968. Date of Electronic Publication: 2025 Jul 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE

MeSH-Schlagworte: Folic Acid*/blood , Vitamin B 12*/blood , Sleep Initiation and Maintenance Disorders*/blood , Sleep Initiation and Maintenance Disorders*/epidemiology , Anxiety*/blood , Anxiety*/epidemiology, Humans ; Female ; Male ; Longitudinal Studies ; Adult ; Middle Aged ; Circadian Rhythm/physiology ; Surveys and Questionnaires

Effects of nurse-led, web-based brief behavioral therapy on insomnia severity in patients in the chronic stage of stroke recovery: a preliminary randomized controlled trial.

Autoren: Hasan F Prasetya EC Gordon CJ et al.

Quelle: Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine [J Clin Sleep Med] 2025 Dec 01; Vol. 21 (12), pp. 2031-2040.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: American Academy of Sleep Medicine Country of Publication: United States NLM ID: 101231977 Publication Model: Print Cited Medium: Internet ISSN: 1550-9397 (Electronic) Linking ISSN: 15509389 NLM ISO Abbreviation: J Clin Sleep Med Subsets: MEDLINE

MeSH-Schlagworte: Sleep Initiation and Maintenance Disorders*/therapy , Sleep Initiation and Maintenance Disorders*/nursing , Stroke*/complications , Behavior Therapy*/methods , Internet-Based Intervention* , Stroke Rehabilitation*/methods, Humans ; Male ; Female ; Middle Aged ; Severity of Illness Index ; Treatment Outcome ; Indonesia ; Aged ; Internet ; Chronic Disease

The role of maintenance therapy and its cessation in patients with multiple myeloma.

Autoren: Sneider AP Derman BA

Quelle: Leukemia & lymphoma [Leuk Lymphoma] 2025 Dec; Vol. 66 (13), pp. 2426-2436. Date of Electronic Publication: 2025 Aug 28.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 9007422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2403 (Electronic) Linking ISSN: 10268022 NLM ISO Abbreviation: Leuk Lymphoma Subsets: MEDLINE

MeSH-Schlagworte: Multiple Myeloma*/therapy , Multiple Myeloma*/mortality , Multiple Myeloma*/drug therapy , Multiple Myeloma*/diagnosis , Multiple Myeloma*/pathology , Maintenance Chemotherapy*/methods , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Antineoplastic Combined Chemotherapy Protocols*/adverse effects, Humans ; Lenalidomide/therapeutic use ; Neoplasm, Residual ; Treatment Outcome ; Hematopoietic Stem Cell Transplantation ; Transplantation, Autologous

Cognitive-affective disengagement: 24h rhythm in insomniacs versus healthy good sleepers.

Autoren: Lushington K Dorrian J Van Dongen HPA et al.

Quelle: Sleep medicine [Sleep Med] 2025 Dec; Vol. 136, pp. 106881. Date of Electronic Publication: 2025 Oct 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100898759 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5506 (Electronic) Linking ISSN: 13899457 NLM ISO Abbreviation: Sleep Med Subsets: MEDLINE

MeSH-Schlagworte: Circadian Rhythm*/physiology , Sleep Initiation and Maintenance Disorders*/psychology , Sleep Initiation and Maintenance Disorders*/physiopathology , Cognition*/physiology , Sleep*/physiology, Humans ; Female ; Male ; Middle Aged ; Aged

Targeting minichromosome maintenance proteins in cancer stem cells: mechanisms and therapeutic opportunities.

Autoren: Cao X Zhang Y Song Y et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 4), pp. 117385. Date of Electronic Publication: 2025 Oct 08.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Minichromosome Maintenance Proteins*/metabolism , Minichromosome Maintenance Proteins*/antagonists & inhibitors , Neoplastic Stem Cells*/drug effects , Neoplastic Stem Cells*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/administration & dosage , Neoplasms*/drug therapy , Neoplasms*/metabolism , Neoplasms*/pathology, Humans ; Animals

Patients' experiences of group-delivered sleep restriction therapy in primary care: a qualitative study undertaken alongside a randomized controlled trial.

Autoren: Bini C Bäckström J Årestedt K et al.

Quelle: Sleep medicine [Sleep Med] 2025 Dec; Vol. 136, pp. 106822. Date of Electronic Publication: 2025 Sep 23.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100898759 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5506 (Electronic) Linking ISSN: 13899457 NLM ISO Abbreviation: Sleep Med Subsets: MEDLINE

MeSH-Schlagworte: Sleep Initiation and Maintenance Disorders*/therapy , Sleep Initiation and Maintenance Disorders*/psychology , Psychotherapy, Group*/methods, Humans ; Male ; Female ; Primary Health Care ; Middle Aged ; Qualitative Research ; Adult ; Sweden ; Aged ; Motivation

Electroacupuncture versus sham for insomnia in patients undergoing maintenance hemodialysis: study protocol for a pilot randomized controlled trial.

Autoren: Lu A Wang M Jiang N et al.

Quelle: Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2496410. Date of Electronic Publication: 2025 Apr 29.

Publikationsart: Clinical Trial Protocol; Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE

MeSH-Schlagworte: Electroacupuncture*/methods , Kidney Failure, Chronic*/therapy , Kidney Failure, Chronic*/complications , Renal Dialysis*/adverse effects , Sleep Initiation and Maintenance Disorders*/therapy , Sleep Initiation and Maintenance Disorders*/etiology, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Quality of Life ; Randomized Controlled Trials as Topic ; Severity of Illness Index ; Sleep Quality ; Treatment Outcome

Maintenance after first-line treatment for advanced soft tissue sarcoma.

Autoren: Penel N Pautier P Blay JY

Quelle: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2025 Dec; Vol. 216, pp. 104959. Date of Electronic Publication: 2025 Sep 18.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Scientific Publishers Country of Publication: Netherlands NLM ID: 8916049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0461 (Electronic) Linking ISSN: 10408428 NLM ISO Abbreviation: Crit Rev Oncol Hematol Subsets: MEDLINE

MeSH-Schlagworte: Sarcoma*/drug therapy , Sarcoma*/mortality , Sarcoma*/pathology , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Maintenance Chemotherapy*/methods, Humans ; Randomized Controlled Trials as Topic ; Doxorubicin/therapeutic use

Pharmacological interventions for sleep disturbance ("insomnia") in patients with advanced cancer receiving specialist palliative care: a scoping review.

Autoren: Ryan S Munir S Davies A

Quelle: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2025 Nov 24; Vol. 33 (12), pp. 1124. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Scoping Review; Journal Article; Review

Info zur Zeitschrift: Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE

MeSH-Schlagworte: Palliative Care*/methods , Neoplasms*/complications , Sleep Initiation and Maintenance Disorders*/drug therapy , Sleep Initiation and Maintenance Disorders*/etiology, Humans ; Hypnotics and Sedatives/therapeutic use ; Antidepressive Agents/therapeutic use ; Melatonin/therapeutic use ; Benzodiazepines/therapeutic use

["I can't sleep!": insomnia as the most common non-organic sleep disorder].

Transliterierter Titel: „Ich kann nicht schlafen!“ – Insomnie als häufigste nichtkörperliche Schlafstörung.

Autoren: Fietze I; Interdisziplinäres Schlafmedizinisches Zentrum, CC12, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland. ingo.fietze@charite.de.; Universitätsmedizin Essen, Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH, Essen, Deutschland. ingo.fietze@charite.de.

Quelle: Innere Medizin (Heidelberg, Germany) [Inn Med (Heidelb)] 2025 Nov; Vol. 66 (11), pp. 1154-1163. Date of Electronic Publication: 2025 Oct 10.

Publikationsart: English Abstract; Journal Article

Info zur Zeitschrift: Publisher: Springer Medizin Country of Publication: Germany NLM ID: 9918384885306676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-7099 (Electronic) Linking ISSN: 27317080 NLM ISO Abbreviation: Inn Med (Heidelb) Subsets: MEDLINE

MeSH-Schlagworte: Sleep Initiation and Maintenance Disorders*/diagnosis , Sleep Initiation and Maintenance Disorders*/therapy , Sleep Initiation and Maintenance Disorders*/etiology , Sleep Initiation and Maintenance Disorders*/classification, Humans ; Cognitive Behavioral Therapy ; Hypnotics and Sedatives/therapeutic use ; Melatonin/therapeutic use ; Quality of Life

Types of Insomnia Mediate the Bidirectional Relation Between Anxiety and Depressive Symptoms Longitudinally in Older Adults.

Autoren: Bolstad CJ Lin Z Pollock MA et al.

Quelle: International journal of aging & human development [Int J Aging Hum Dev] 2025 Oct; Vol. 101 (3), pp. 356-375. Date of Electronic Publication: 2024 Dec 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Sage Publications Country of Publication: United States NLM ID: 0370033 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1541-3535 (Electronic) Linking ISSN: 00914150 NLM ISO Abbreviation: Int J Aging Hum Dev Subsets: MEDLINE

MeSH-Schlagworte: Sleep Initiation and Maintenance Disorders*/epidemiology , Sleep Initiation and Maintenance Disorders*/psychology , Depression*/epidemiology , Anxiety*/epidemiology, Humans ; Aged ; Male ; Female ; Aged, 80 and over ; Longitudinal Studies ; United States/epidemiology

The Prevalence of Insomnia Disorder in the General Population: A Meta-Analysis.

Autoren: van Straten A Weinreich KJ Fábián B et al.

Quelle: Journal of sleep research [J Sleep Res] 2025 Oct; Vol. 34 (5), pp. e70089. Date of Electronic Publication: 2025 May 14.

Publikationsart: Journal Article; Meta-Analysis; Review

Info zur Zeitschrift: Publisher: Published on behalf of the European Sleep Research Society by Blackwell Scientific Publications Country of Publication: England NLM ID: 9214441 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2869 (Electronic) Linking ISSN: 09621105 NLM ISO Abbreviation: J Sleep Res Subsets: MEDLINE

MeSH-Schlagworte: Sleep Initiation and Maintenance Disorders*/epidemiology , Sleep Initiation and Maintenance Disorders*/diagnosis, Humans ; Prevalence ; Surveys and Questionnaires ; Self Report

Pathways to better sleep: Depression, anxiety, and stress as mediators in the relationship between social support and insomnia severity in Appalachian adults.

Autoren: Moloney ME Slade E Chung J et al.

Quelle: Journal of affective disorders [J Affect Disord] 2025 Dec 15; Vol. 391, pp. 119929. Date of Electronic Publication: 2025 Jul 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE

MeSH-Schlagworte: Sleep Initiation and Maintenance Disorders*/psychology , Sleep Initiation and Maintenance Disorders*/epidemiology , Social Support* , Anxiety*/psychology , Depression*/psychology , Stress, Psychological*/psychology , Stress, Psychological*/complications, Humans ; Female ; Male ; Middle Aged ; Adult ; Severity of Illness Index ; Rural Population/statistics & numerical data ; Kentucky/epidemiology ; Appalachian Region ; Aged

Acupuncture for insomnia in people with cancer.

Autoren: Ma Q Liu C Zhao G et al.

Quelle: The Cochrane database of systematic reviews [Cochrane Database Syst Rev] 2025 Dec 05; Vol. 12. Cochrane AN: CD015177. Date of Electronic Publication: 2025 Dec 05.

Publikationsart: Journal Article; Systematic Review; Meta-Analysis; Review

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 100909747 Publication Model: Electronic Cited Medium: Internet ISSN: 1469-493X (Electronic) Linking ISSN: 13616137 NLM ISO Abbreviation: Cochrane Database Syst Rev Subsets: MEDLINE

MeSH-Schlagworte: Sleep Initiation and Maintenance Disorders*/therapy , Sleep Initiation and Maintenance Disorders*/etiology , Acupuncture Therapy*/adverse effects , Acupuncture Therapy*/methods , Neoplasms*/complications, Humans ; Randomized Controlled Trials as Topic ; Female ; Sleep Quality ; Bias ; Male ; Middle Aged

Targeting MCM6 Enhances Melphalan Chemosensitivity in Retinoblastoma by Modulating DNA Damage Response.

Autoren: Wang M Tang J Li J et al.

Quelle: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2025 Dec 01; Vol. 66 (15), pp. 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE

MeSH-Schlagworte: Retinoblastoma*/drug therapy , Retinoblastoma*/genetics , Retinoblastoma*/metabolism , Retinoblastoma*/pathology , Melphalan*/pharmacology , Melphalan*/therapeutic use , Antineoplastic Agents, Alkylating*/pharmacology , Antineoplastic Agents, Alkylating*/therapeutic use , Retinal Neoplasms*/drug therapy , Retinal Neoplasms*/genetics , Retinal Neoplasms*/metabolism , Retinal Neoplasms*/pathology , DNA Damage* , Minichromosome Maintenance Complex Component 6*/genetics , Minichromosome Maintenance Complex Component 6*/biosynthesis , Minichromosome Maintenance Complex Component 6*/metabolism , Gene Expression Regulation, Neoplastic*, Humans ; Animals ; Mice ; Cell Proliferation ; Xenograft Model Antitumor Assays ; Cell Line, Tumor ; Gene Knockdown Techniques ; Cell Cycle ; Drug Resistance, Neoplasm