Search Results - "MACROPHAGES"

Hyaluronic Acid-Chitosan Nanoparticles Encapsulating Gal-9 Alleviate Severe Acute Pancreatitis by Promoting M2 Macrophage Polarization.

Authors: Dai J Wang X Li S et al.

Source: Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2025 Dec; Vol. 113 (12), pp. e70006.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101234237 Publication Model: Print Cited Medium: Internet ISSN: 1552-4965 (Electronic) Linking ISSN: 15493296 NLM ISO Abbreviation: J Biomed Mater Res A Subsets: MEDLINE

MeSH Terms: Hyaluronic Acid*/chemistry , Hyaluronic Acid*/pharmacology , Nanoparticles*/chemistry , Chitosan*/chemistry , Pancreatitis*/drug therapy , Pancreatitis*/pathology , Galectins*/pharmacology , Galectins*/therapeutic use , Galectins*/chemistry , Galectins*/administration & dosage , Macrophages*/drug effects, Animals ; Mice ; Mice, Inbred C57BL ; Male ; Macrophages, Peritoneal/drug effects ; Macrophages, Peritoneal/pathology ; Cell Polarity/drug effects ; Cytokines/metabolism ; Macrophage Activation/drug effects ; Acute Disease

Mitochondria-Targeted HA-Coated Nanosystem for ROS/CO Generation and Metabolic Reprogramming to Enhance Tumoricidal Macrophage Polarization.

Authors: Peng N Song C Liu X et al.

Source: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2025 Nov 19; Vol. 17 (46), pp. 63041-63056. Date of Electronic Publication: 2025 Nov 06.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE

MeSH Terms: Reactive Oxygen Species*/metabolism , Mitochondria*/metabolism , Mitochondria*/drug effects , Hyaluronic Acid*/chemistry , Tumor-Associated Macrophages*/drug effects , Tumor-Associated Macrophages*/metabolism , Nanoparticles*/chemistry, Animals ; Mice ; Female ; Macrophages/drug effects ; Macrophages/metabolism ; Porphyrins/chemistry ; Porphyrins/pharmacology ; Zirconium/chemistry ; Humans ; Organophosphorus Compounds/chemistry ; Metabolic Reprogramming

The metabolic regulation of tumor-associated macrophage reprogramming.

Authors: Fan H Lu D Yin X et al.

Source: Molecular immunology [Mol Immunol] 2025 Nov; Vol. 187, pp. 198-209. Date of Electronic Publication: 2025 Oct 14.

Publication Type: Journal Article; Review

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 7905289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9142 (Electronic) Linking ISSN: 01615890 NLM ISO Abbreviation: Mol Immunol Subsets: MEDLINE

MeSH Terms: Tumor Microenvironment*/immunology , Tumor-Associated Macrophages*/metabolism , Tumor-Associated Macrophages*/immunology , Neoplasms*/immunology , Neoplasms*/metabolism , Neoplasms*/pathology , Cellular Reprogramming*/immunology, Humans ; Animals ; Macrophages/immunology ; Macrophages/metabolism

C. albicans airway colonization amplifies inflammation in emphysema through the ROS/NLRP3 pathway of macrophages.

Authors: Li X Wei X Deng J et al.

Source: Microbial pathogenesis [Microb Pathog] 2025 Oct; Vol. 207, pp. 107853. Date of Electronic Publication: 2025 Jun 28.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE

MeSH Terms: NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Reactive Oxygen Species*/metabolism , Candida albicans*/pathogenicity , Candida albicans*/growth & development , Macrophages*/metabolism , Macrophages*/immunology , Inflammation*/microbiology , Pulmonary Emphysema*/microbiology , Emphysema*/microbiology , Candidiasis*/microbiology, Animals ; Mice ; Disease Models, Animal ; Humans ; Interleukin-1beta/metabolism ; Macrophages, Alveolar/metabolism ; Macrophages, Alveolar/immunology ; Lung/microbiology ; Lung/pathology ; Male ; Mice, Inbred C57BL ; Smoke/adverse effects ; Signal Transduction

Fat mass and obesity-associated protein inhibits macrophage-mediated inflammation via the m6A demethylation of c-Jun in COPD.

Authors: Xu HG Liang JY Luo CY et al.

Source: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 14-23. Date of Electronic Publication: 2025 Sep 12.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH Terms: Pulmonary Disease, Chronic Obstructive*/pathology , Pulmonary Disease, Chronic Obstructive*/genetics , Pulmonary Disease, Chronic Obstructive*/metabolism , Alpha-Ketoglutarate-Dependent Dioxygenase FTO*/genetics , Alpha-Ketoglutarate-Dependent Dioxygenase FTO*/metabolism , Inflammation*/pathology , Inflammation*/genetics , Inflammation*/metabolism , Macrophages*/metabolism , Macrophages*/pathology , Proto-Oncogene Proteins c-jun*/genetics , Proto-Oncogene Proteins c-jun*/metabolism, Humans ; Animals ; Mice ; Adenosine/analogs & derivatives ; Adenosine/metabolism ; Adenosine/genetics ; Demethylation ; Male ; Macrophages, Alveolar/metabolism ; Macrophages, Alveolar/pathology ; U937 Cells ; Mice, Inbred C57BL ; Interleukin-6/genetics ; Tumor Necrosis Factor-alpha/genetics ; Female

Structural characterization of a pectin polysaccharide from Phyllanthus emblica fruits and their antitumor effect via macrophage polarization in the cold immune microenvironment.

Authors: Zong W Liu Z Lan H et al.

Source: Carbohydrate polymers [Carbohydr Polym] 2025 Dec 01; Vol. 369, pp. 124287. Date of Electronic Publication: 2025 Aug 25.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8307156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1344 (Electronic) Linking ISSN: 01448617 NLM ISO Abbreviation: Carbohydr Polym Subsets: MEDLINE

MeSH Terms: Tumor Microenvironment*/drug effects , Pectins*/chemistry , Pectins*/pharmacology , Pectins*/isolation & purification , Macrophages*/drug effects , Macrophages*/immunology , Phyllanthus emblica*/chemistry, Animals ; Mice ; Fruit/chemistry ; Cell Line, Tumor ; Humans ; Apoptosis/drug effects ; Polysaccharides/chemistry ; Polysaccharides/pharmacology ; Mice, Inbred BALB C ; Tumor-Associated Macrophages/drug effects

Macrophages and Tissue Homeostasis: From Physiological Functions to Disease Onset.

Authors: Li Y Chen H Zhou S

Source: Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2025 Nov 19; Vol. 30 (11), pp. 42706.

Publication Type: Journal Article; Review

Journal Info: Publisher: IMR Press Country of Publication: Singapore NLM ID: 101612996 Publication Model: Print Cited Medium: Internet ISSN: 2768-6698 (Electronic) Linking ISSN: 27686698 NLM ISO Abbreviation: Front Biosci (Landmark Ed) Subsets: MEDLINE

MeSH Terms: Homeostasis* , Macrophages*/physiology , Macrophages*/immunology , Macrophages*/metabolism , Neoplasms*/immunology , Neoplasms*/pathology , Neoplasms*/metabolism, Humans ; Tumor Microenvironment/immunology ; Animals ; Tumor-Associated Macrophages/immunology

The anti-aging Klotho protects glioblastoma macrophages from radiotherapy-induced inflammation and predicts immunotherapy response.

Authors: Galluzzo A Maffezzini M Fumagalli ML et al.

Source: International journal of cancer [Int J Cancer] 2025 Nov 15; Vol. 157 (10), pp. 2156-2172. Date of Electronic Publication: 2025 Jul 21.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE

MeSH Terms: Glioblastoma*/therapy , Glioblastoma*/immunology , Glioblastoma*/pathology , Glucuronidase*/metabolism , Glucuronidase*/genetics , Glucuronidase*/blood , Immunotherapy*/methods , Macrophages*/immunology , Macrophages*/metabolism , Macrophages*/radiation effects , Brain Neoplasms*/therapy , Brain Neoplasms*/immunology , Brain Neoplasms*/pathology , Inflammation*/etiology, Klotho Proteins ; Humans ; Animals ; Mice ; Prognosis ; Tumor Microenvironment/immunology ; Female ; Microglia/metabolism ; Microglia/immunology ; Dendritic Cells/immunology ; Dendritic Cells/transplantation ; Cell Line, Tumor ; Male ; Biomarkers, Tumor ; Tumor-Associated Macrophages/immunology

LC3 overexpression in colorectal cancer - strong correlation with M1 tumor-associated macrophages: An observational study.

Authors: Xu X Li Y He S et al.

Source: Medicine [Medicine (Baltimore)] 2025 Nov 14; Vol. 104 (46), pp. e45858.

Publication Type: Journal Article; Observational Study

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

MeSH Terms: Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/immunology , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/mortality , Tumor-Associated Macrophages*/metabolism , Tumor-Associated Macrophages*/immunology , Microtubule-Associated Proteins*/metabolism , Adenocarcinoma*/pathology , Adenocarcinoma*/immunology, Humans ; Retrospective Studies ; Male ; Female ; Middle Aged ; Aged ; Prognosis ; Immunohistochemistry ; Macrophages

LILRB4 in tumor-associated macrophage regulates macrophage polarization and glioblastoma progression via STAT3/IL10 axis.

Authors: Pei J Li C Liu Q et al.

Source: Gene [Gene] 2025 Nov 05; Vol. 971, pp. 149805. Date of Electronic Publication: 2025 Sep 30.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE

MeSH Terms: Glioblastoma*/pathology , Glioblastoma*/genetics , Glioblastoma*/metabolism , Glioblastoma*/immunology , Receptors, Immunologic*/genetics , Receptors, Immunologic*/metabolism , Tumor-Associated Macrophages*/metabolism , Tumor-Associated Macrophages*/immunology , Tumor-Associated Macrophages*/pathology , STAT3 Transcription Factor*/metabolism , STAT3 Transcription Factor*/genetics , Interleukin-10*/metabolism , Interleukin-10*/genetics , Membrane Glycoproteins*/genetics , Membrane Glycoproteins*/metabolism , Brain Neoplasms*/pathology , Brain Neoplasms*/genetics , Brain Neoplasms*/metabolism , Brain Neoplasms*/immunology, Humans ; Disease Progression ; Tumor Microenvironment ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Prognosis ; THP-1 Cells ; Signal Transduction ; Macrophages/metabolism

Targeting CXCR2 in prostate cancer cells can block CD47-SIRPα interaction and reverse M2 macrophage polarization in the TME.

Authors: Sun Y Ren S Wen W et al.

Source: Molecular cancer [Mol Cancer] 2025 Oct 30; Vol. 24 (1), pp. 273. Date of Electronic Publication: 2025 Oct 30.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE

MeSH Terms: Prostatic Neoplasms*/metabolism , Prostatic Neoplasms*/pathology , CD47 Antigen*/metabolism , Tumor Microenvironment*/immunology , Receptors, Interleukin-8B*/metabolism , Receptors, Interleukin-8B*/antagonists & inhibitors , Receptors, Immunologic*/metabolism , Macrophages*/metabolism , Macrophages*/immunology , Antigens, Differentiation*/metabolism, Male ; Animals ; Humans ; Mice ; Tumor-Associated Macrophages/metabolism ; Tumor-Associated Macrophages/immunology ; Cell Line, Tumor ; Mice, Inbred C57BL ; Phagocytosis

HMOX1+ macrophages determine immunosuppressive microenvironment and immunotherapy efficacy in hepatocellular carcinoma.

Authors: Du Y Xu W Liu Z et al.

Source: Hepatology communications [Hepatol Commun] 2025 Oct 14; Vol. 9 (11). Date of Electronic Publication: 2025 Oct 14 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 101695860 Publication Model: eCollection Cited Medium: Internet ISSN: 2471-254X (Electronic) Linking ISSN: 2471254X NLM ISO Abbreviation: Hepatol Commun Subsets: MEDLINE

MeSH Terms: Carcinoma, Hepatocellular*/immunology , Carcinoma, Hepatocellular*/therapy , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/genetics , Tumor Microenvironment*/immunology , Liver Neoplasms*/immunology , Liver Neoplasms*/therapy , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics , Heme Oxygenase-1*/metabolism , Heme Oxygenase-1*/genetics , Immunotherapy*/methods , Macrophages*/immunology , Macrophages*/metabolism, Humans ; Animals ; Mice ; Programmed Cell Death 1 Receptor/metabolism ; Male ; Female ; Tumor-Associated Macrophages/immunology ; T-Lymphocytes, Regulatory/immunology

Lipid-Metabolically Active TREM2 ^high Microglia‑Derived Macrophages Predict Poor Prognosis and Represent an Immunotherapeutic Target in Glioma.

Authors: Li J Yu X Yang D et al.

Source: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2025 Oct 14; Vol. 20 (1), pp. 92. Date of Electronic Publication: 2025 Oct 14.

Publication Type: Journal Article

Journal Info: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 101256586 Publication Model: Electronic Cited Medium: Internet ISSN: 1557-1904 (Electronic) Linking ISSN: 15571890 NLM ISO Abbreviation: J Neuroimmune Pharmacol Subsets: MEDLINE

MeSH Terms: Glioma*/metabolism , Glioma*/immunology , Glioma*/therapy , Glioma*/pathology , Glioma*/genetics , Membrane Glycoproteins*/metabolism , Membrane Glycoproteins*/genetics , Membrane Glycoproteins*/biosynthesis , Membrane Glycoproteins*/immunology , Receptors, Immunologic*/metabolism , Receptors, Immunologic*/genetics , Receptors, Immunologic*/biosynthesis , Microglia*/metabolism , Microglia*/immunology , Brain Neoplasms*/metabolism , Brain Neoplasms*/immunology , Brain Neoplasms*/therapy , Brain Neoplasms*/pathology , Brain Neoplasms*/genetics , Lipid Metabolism*/physiology , Macrophages*/metabolism , Macrophages*/immunology , Immunotherapy*/methods, Humans ; Prognosis ; Male ; Female ; Middle Aged ; Tumor-Associated Macrophages/metabolism ; Tumor-Associated Macrophages/immunology

CD68- and CD163-positive tumor-associated macrophages in renal clear cell carcinoma.

Authors: Yang Y Sun D Ma X et al.

Source: Scientific reports [Sci Rep] 2025 Oct 08; Vol. 15 (1), pp. 35138. Date of Electronic Publication: 2025 Oct 08.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Antigens, Differentiation, Myelomonocytic*/metabolism , Receptors, Cell Surface*/metabolism , Antigens, CD*/metabolism , Carcinoma, Renal Cell*/pathology , Carcinoma, Renal Cell*/metabolism , Carcinoma, Renal Cell*/mortality , Carcinoma, Renal Cell*/immunology , Carcinoma, Renal Cell*/surgery , Kidney Neoplasms*/pathology , Kidney Neoplasms*/metabolism , Kidney Neoplasms*/mortality , Kidney Neoplasms*/surgery , Kidney Neoplasms*/immunology , Tumor-Associated Macrophages*/metabolism , Tumor-Associated Macrophages*/pathology , Tumor-Associated Macrophages*/immunology, Humans ; CD163 Antigen ; Female ; Male ; Middle Aged ; Prognosis ; Aged ; Adult ; Kaplan-Meier Estimate ; Macrophages/metabolism ; Immunohistochemistry ; CD68 Molecule

'Smelling' lipid cues: chemosensory receptors tune tumor-associated macrophage behavior.

Authors: Farber M Vegna S

Source: Trends in immunology [Trends Immunol] 2025 Oct; Vol. 46 (10), pp. 656-658. Date of Electronic Publication: 2025 Sep 12.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 100966032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-4981 (Electronic) Linking ISSN: 14714906 NLM ISO Abbreviation: Trends Immunol Subsets: MEDLINE

MeSH Terms: Tumor-Associated Macrophages*/immunology , Tumor-Associated Macrophages*/metabolism , Neoplasms*/immunology , Lipids*/immunology, Humans ; Tumor Microenvironment/immunology ; Animals ; Lipid Metabolism ; Macrophages/immunology

IL-17A-secreting γδ T cells promote resistance to CDK4/CDK6 inhibitors in HR ⁺ HER2 ^- breast cancer via CX3CR1 ⁺ macrophages.

Authors: Petroni G Galassi C Gouin KH 3rd et al.

Source: Nature cancer [Nat Cancer] 2025 Oct; Vol. 6 (10), pp. 1656-1675. Date of Electronic Publication: 2025 Jul 07.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE

MeSH Terms: Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/immunology , Breast Neoplasms*/metabolism , Breast Neoplasms*/genetics , Cyclin-Dependent Kinase 4*/antagonists & inhibitors , Cyclin-Dependent Kinase 6*/antagonists & inhibitors , CX3C Chemokine Receptor 1*/metabolism , Interleukin-17*/metabolism , Drug Resistance, Neoplasm*/immunology , Intraepithelial Lymphocytes*/immunology , Intraepithelial Lymphocytes*/metabolism , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/therapeutic use , Tumor-Associated Macrophages*/immunology , Tumor-Associated Macrophages*/metabolism, Female ; Humans ; Animals ; Receptor, ErbB-2/metabolism ; Receptor, ErbB-2/genetics ; Mice ; Macrophages/metabolism ; Macrophages/immunology ; Receptors, Estrogen/metabolism

Inhibiting SLAMF8 modulates tumor-associated macrophages and restores CD8+ T cell-mediated antitumor immunity in colorectal cancer.

Authors: Han X Bai X Wang N et al.

Source: Oncoimmunology [Oncoimmunology] 2025 Dec 31; Vol. 14 (1), pp. 2581910. Date of Electronic Publication: 2025 Nov 10.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2162-402X (Electronic) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: MEDLINE

MeSH Terms: Colorectal Neoplasms*/immunology , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/therapy , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , Signaling Lymphocytic Activation Molecule Family*/antagonists & inhibitors , Signaling Lymphocytic Activation Molecule Family*/metabolism , Signaling Lymphocytic Activation Molecule Family*/immunology , Signaling Lymphocytic Activation Molecule Family*/genetics , Tumor-Associated Macrophages*/immunology , Tumor-Associated Macrophages*/metabolism , Tumor-Associated Macrophages*/drug effects, Animals ; Mice ; Tumor Microenvironment/immunology ; Humans ; Mice, Inbred C57BL ; Female ; Cell Line, Tumor ; Male ; Signal Transduction ; Immunotherapy/methods ; Macrophages/immunology

NDC80 promotes epithelial to mesenchymal transition of esophageal squamous cell carcinoma through macrophages polarization and PI3K/AKT pathway activation.

Authors: Shu J Yang C Sun Z et al.

Source: European journal of medical research [Eur J Med Res] 2025 Nov 10; Vol. 30 (1), pp. 1092. Date of Electronic Publication: 2025 Nov 10.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9517857 Publication Model: Electronic Cited Medium: Internet ISSN: 2047-783X (Electronic) Linking ISSN: 09492321 NLM ISO Abbreviation: Eur J Med Res Subsets: MEDLINE

MeSH Terms: Epithelial-Mesenchymal Transition*/genetics , Esophageal Squamous Cell Carcinoma*/pathology , Esophageal Squamous Cell Carcinoma*/genetics , Esophageal Squamous Cell Carcinoma*/metabolism , Proto-Oncogene Proteins c-akt*/metabolism , Phosphatidylinositol 3-Kinases*/metabolism , Esophageal Neoplasms*/pathology , Esophageal Neoplasms*/metabolism , Esophageal Neoplasms*/genetics , Macrophages*/metabolism, Humans ; Animals ; Mice ; Signal Transduction ; Male ; Female ; Cell Line, Tumor ; Cell Movement ; Tumor-Associated Macrophages/metabolism ; Gene Expression Regulation, Neoplastic

Structural characteristics of a fructan-type polysaccharide from Asparagus cochinchinensis rhizome and its anti-osteosarcoma activity mediated via macrophage polarization.

Authors: Xia Y Zong W Lan H et al.

Source: International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 330 (Pt 3), pp. 148198. Date of Electronic Publication: 2025 Oct 08.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH Terms: Rhizome*/chemistry , Osteosarcoma*/drug therapy , Osteosarcoma*/pathology , Osteosarcoma*/metabolism , Osteosarcoma*/immunology , Macrophages*/drug effects , Macrophages*/metabolism , Macrophages*/immunology , Fructans*/chemistry , Fructans*/pharmacology , Polysaccharides*/chemistry , Polysaccharides*/pharmacology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry, Animals ; Mice ; Cell Line, Tumor ; Humans ; Apoptosis/drug effects ; RAW 264.7 Cells ; Macrophage Activation/drug effects ; Reactive Oxygen Species/metabolism ; Tumor-Associated Macrophages/drug effects ; Nitric Oxide/metabolism

FPR3 sustains the immunosuppression of tumor-associated macrophages and accelerates the progression of gastric adenocarcinoma.

Authors: Sun M Tan Z Lin K et al.

Source: Oncogene [Oncogene] 2025 Nov; Vol. 44 (44), pp. 4309-4323. Date of Electronic Publication: 2025 Sep 23.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

MeSH Terms: Stomach Neoplasms*/pathology , Stomach Neoplasms*/immunology , Stomach Neoplasms*/genetics , Stomach Neoplasms*/metabolism , Tumor-Associated Macrophages*/immunology , Tumor-Associated Macrophages*/pathology , Tumor-Associated Macrophages*/metabolism , Adenocarcinoma*/pathology , Adenocarcinoma*/immunology , Adenocarcinoma*/genetics , Adenocarcinoma*/metabolism , Receptors, Formyl Peptide*/metabolism , Receptors, Formyl Peptide*/genetics, Humans ; Tumor Microenvironment/immunology ; Disease Progression ; Animals ; Mice ; Cell Line, Tumor ; Cell Proliferation ; Macrophages/immunology ; Frizzled Receptors/genetics ; Frizzled Receptors/metabolism ; Immune Tolerance ; Female ; Male