Výsledky vyhľadávania - "Lung Neoplasms metabolism"

Dual-tracer autoradiographic analysis of glucose metabolism and hypoxia in orthotopic and PDX tumor models

Autori: Morten Busk Martin K Thomsen Jens Overgaard a ďalší

Zdroj: Busk, M, Thomsen, M K, Overgaard, J, Berthelsen, M F, Hager, H, Bussink, J, Hansen, K V, Jakobsen, S, Lilja-Fischer, J K, Boedtkjers, E & Vendelbo, M H 2025, 'Dual-tracer autoradiographic analysis of glucose metabolism and hypoxia in orthotopic and PDX tumor models', Acta oncologica (Stockholm, Sweden), vol. 64, pp. 1152-1159. https://doi.org/10.2340/1651-226X.2025.44002

Predmety: Mice, Transgenic, Autoradiography/methods, Triazoles, Positron-Emission Tomography/methods, Mice, Nitroimidazoles, Fluorodeoxyglucose F18, Adenocarcinoma/metabolism, Animals, Humans, Glucose/metabolism, Tumor Hypoxia, Female, Lung Neoplasms/metabolism, Radiopharmaceuticals, Adenocarcinoma of Lung/diagnostic imaging

Long-Term Survival Outcomes With First-Line Nivolumab Plus Ipilimumab–Based Treatment in Patients With Metastatic NSCLC and Tumor Programmed Death-Ligand 1 Lower Than 1%: A Pooled Analysis

Autori: Peters, Solange Paz-Ares, Luis G. Reck, Martin a ďalší

Prispievatelia: Peters, Solange Paz-Ares, Luis G. Reck, Martin a ďalší

Zdroj: Digital.CSIC. Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Journal of thoracic oncology, vol. 20, no. 1, pp. 94-108

Predmety: PD-L1, Nivolumab, Non–small cell lung cancer, Humans, Nivolumab/pharmacology, Nivolumab/therapeutic use, Nivolumab/administration & dosage, Carcinoma, Non-Small-Cell Lung/drug therapy, Carcinoma, Non-Small-Cell Lung/pathology, Carcinoma, Non-Small-Cell Lung/mortality, Lung Neoplasms/drug therapy, Lung Neoplasms/pathology, Lung Neoplasms/mortality, Lung Neoplasms/metabolism, Ipilimumab/pharmacology, Ipilimumab/therapeutic use, Ipilimumab/administration & dosage, Male, Female, Middle Aged, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, B7-H1 Antigen/metabolism, Aged, Adult, Survival Rate, Aged, 80 and over, Follow-Up Studies, Immunotherapy, Ipilimumab

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39369790
http://hdl.handle.net/10261/390933
https://api.elsevier.com/content/abstract/scopus_id/85208360083
https://serval.unil.ch/resource/serval:BIB_89D370D6F09D.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_89D370D6F09D
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_89D370D6F09D7

TTF-1 negativity in synchronous M1b/M1c wildtype lung adenocarcinoma brain metastases predicts worse survival with increased risk of intracranial progression

Autori: Wasilewski, David Araceli, Tommaso Bischoff, Philip a ďalší

Zdroj: J Neurooncol

Predmety: 0301 basic medicine, 03 medical and health sciences, 0302 clinical medicine, Research, Disease Progression [MeSH], Aged, 80 and over [MeSH], Aged [MeSH], TTF-1, Adenocarcinoma of Lung/surgery [MeSH], Survival, Male [MeSH], Brain Neoplasms/mortality [MeSH], Brain Metastasis, Ki67, Edema volume, LUAD, Female [MeSH], Lung Neoplasms/mortality [MeSH], Follow-Up Studies [MeSH], Brain Neoplasms/secondary [MeSH], Adult [MeSH], Humans [MeSH], Tumor volume, Retrospective Studies [MeSH], Middle Aged [MeSH], Adenocarcinoma of Lung/metabolism [MeSH], Survival Rate [MeSH], Biomarkers, Tumor/metabolism [MeSH], Adenocarcinoma of Lung/mortality [MeSH], Prognosis [MeSH], Lung Neoplasms/pathology [MeSH], Lung Neoplasms/metabolism [MeSH], Adenocarcinoma of Lung/pathology [MeSH], Brain Neoplasms/metabolism [MeSH], Thyroid Nuclear Factor 1/metabolism [MeSH]

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39630375
https://repository.publisso.de/resource/frl:6499899

Polyol pathway-generated fructose is indispensable for growth and survival of non-small cell lung cancer

Autori: Annemarie Schwab Mohammad Aarif Siddiqui Vignesh Ramesh a ďalší

Zdroj: Cell Death Differ
Schwab, A, Siddiqui, M A, Ramesh, V, Gollavilli, P N, Turtos, A M, Møller, S S, Pinna, L, Havelund, J F, Rømer, A M A, Ersan, P G, Parma, B, Marschall, S, Dettmer, K, Alhusayan, M, Bertoglio, P, Querzoli, G, Mielenz, D, Sahin, O, Færgeman, N J, Asangani, I A & Ceppi, P 2024, ' Polyol pathway-generated fructose is indispensable for growth and survival of non-small cell lung cancer ', Cell Death and Differentiation, vol. 32, pp. 587–597 . https://doi.org/10.1038/s41418-024-01415-1

Predmety: 0301 basic medicine, L-Iditol 2-Dehydrogenase, Lung Neoplasms, Aldehyde Reductase/metabolism, Polymers, Cell Survival, Nude, 610 Medizin, Mice, Nude, Apoptosis, Fructose, Article, Non-Small-Cell Lung/metabolism, Cell Line, Mice, 03 medical and health sciences, Aldehyde Reductase, Polymers/metabolism, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Humans, Animals, Fructose/metabolism, L-Iditol 2-Dehydrogenase/metabolism, Cell Proliferation, ddc:610, 0303 health sciences, Tumor, Carcinoma, Non-Small-Cell Lung/metabolism, Carcinoma, Cancer metabolism, Non-small-cell lung cancer, Lung Neoplasms/metabolism, Signal Transduction

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39567724
https://curis.ku.dk/ws/files/447595238/s41418-024-01415-1_1_.pdf
https://portal.findresearcher.sdu.dk/da/publications/39c8917e-3691-4685-b47f-ac0ced70876a
https://doi.org/10.1038/s41418-024-01415-1
https://epub.uni-regensburg.de/76561/

TTF-1 is a highly sensitive but not fully specific marker for pulmonary and thyroidal cancer: a tissue microarray study evaluating more than 17,000 tumors from 152 different tumor entities

Autori: Katharina Möller Tayyaba Gulzar Maximilian Lennartz a ďalší

Zdroj: Virchows Arch

Predmety: Lung Neoplasms, Thyroid Nuclear Factor 1, Nuclear Proteins, Adenocarcinoma, Sensitivity and Specificity, Immunohistochemistry, Tissue Array Analysis, Transcription Factors/analysis [MeSH], Lung Neoplasms/diagnosis [MeSH], TTF-1, Aspartic Acid Endopeptidases [MeSH], Tissue Array Analysis [MeSH], Tissue microarray, Adenocarcinoma/metabolism [MeSH], Original Article, Nuclear Proteins/metabolism [MeSH], Sensitivity and Specificity [MeSH], Thyroid Neoplasms/metabolism [MeSH], Adenocarcinoma/pathology [MeSH], Diagnosis, Transcription Factors/metabolism [MeSH], Biomarkers, Tumor/analysis [MeSH], Nuclear Proteins/analysis [MeSH], Thyroid Neoplasms/diagnosis [MeSH], Thyroid Nuclear Factor 1/analysis [MeSH], Humans [MeSH], Pulmonary adenocarcinomas, Thyroid Neoplasms/pathology [MeSH], Immunohistochemistry [MeSH], Lung Neoplasms/pathology [MeSH], Adenocarcinoma/diagnosis [MeSH], Lung Neoplasms/metabolism [MeSH], Thyroid Nuclear Factor 1/metabolism [MeSH], Biomarkers, Tumor, Humans, Aspartic Acid Endopeptidases, Thyroid Neoplasms, Transcription Factors

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39377914
https://repository.publisso.de/resource/frl:6504593

Acute Hypoxia Does Not Alter Tumor Sensitivity to FLASH Radiation Therapy

Autori: Ron J. Leavitt Aymeric Almeida Veljko Grilj a ďalší

Zdroj: International journal of radiation oncology, biology, physics, vol. 119, no. 5, pp. 1493-1505
International journal of radiation oncology, biology, physics

Predmety: Computer. Automation, Lung Neoplasms, Pyridones, Pyrimidinones, Cell Cycle Checkpoints, Carbon Dioxide, Radiation Tolerance, Oxidative Phosphorylation, 3. Good health, Oxygen, Animals, Humans, Mice, Pyrimidinones/pharmacology, Pyrimidinones/therapeutic use, Tumor Hypoxia, Glioblastoma/radiotherapy, Glioblastoma/metabolism, Glycolysis, Pyridones/pharmacology, Pyridones/therapeutic use, Nitroimidazoles, Cell Line, Tumor, Lung Neoplasms/radiotherapy, Lung Neoplasms/pathology, Lung Neoplasms/metabolism, Head and Neck Neoplasms/radiotherapy, Cell Cycle Checkpoints/radiation effects, Oxygen/metabolism, Head and Neck Neoplasms, Human medicine, Glioblastoma

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38387809
https://serval.unil.ch/resource/serval:BIB_44E104806F28.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_44E104806F28
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_44E104806F289
https://repository.uantwerpen.be/docstore/d:irua:24893
https://hdl.handle.net/10067/2076170151162165141

Depletion-dependent activity-based protein profiling using SWATH/DIA-MS detects serine hydrolase lipid remodeling in lung adenocarcinoma progression

Autori: Sajic, Tatjana Vizovišek, Matej Arni, Stephan a ďalší

Prispievatelia: Sajic, Tatjana Vizovišek, Matej Arni, Stephan a ďalší

Zdroj: Nat Commun
Nature Communications, Vol 16, Iss 1, Pp 1-24 (2025)
Nature communications, vol. 16, no. 1, pp. 4889
Nature Communications, 16 (1)

Predmety: Humans, Lung Neoplasms/pathology, Lung Neoplasms/metabolism, Lung Neoplasms/enzymology, Adenocarcinoma of Lung/pathology, Adenocarcinoma of Lung/metabolism, Adenocarcinoma of Lung/genetics, Adenocarcinoma of Lung/enzymology, Proteomics/methods, Disease Progression, Mass Spectrometry/methods, Proteome/metabolism, Lipid Metabolism, 10255 Clinic for Thoracic Surgery, 1300 General Biochemistry, Genetics and Molecular Biology, Science, 610 Medicine & health, 1600 General Chemistry, 3100 General Physics and Astronomy, Article

Popis súboru: application/pdf; application/application/pdf; ZORA278830.pdf - application/pdf

Prístupová URL adresa: https://doaj.org/article/5ed40093c17942c4ad588f09639912ce
https://serval.unil.ch/resource/serval:BIB_A8042DF76EC3.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_A8042DF76EC3
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_A8042DF76EC34
http://hdl.handle.net/20.500.11850/739221
https://www.zora.uzh.ch/id/eprint/278830/
https://doi.org/10.5167/uzh-278830

Pharmacokinetic analysis and simplified uptake measures for tumour lesion [18F]F-AraG PET imaging in patients with non-small cell lung cancer

Autori: Jessica E. Wijngaarden Maarten Slebe Johanna E. E. Pouw a ďalší

Zdroj: Eur J Nucl Med Mol Imaging

Predmety: Male, Lung Neoplasms, Activated T-cells, Biological Transport, Middle Aged, Models, Biological, ImmunoPET, [F]F-AraG, Pharmacokinetic modelling, Carcinoma, Non-Small-Cell Lung/metabolism [MeSH], Carcinoma, Non-Small-Cell Lung/diagnostic imaging [MeSH], Carcinoma, Non-Small-Cell Lung/pathology [MeSH], Female [MeSH], Lung Neoplasms/diagnostic imaging [MeSH], Aged [MeSH], Humans [MeSH], Middle Aged [MeSH], Models, Biological [MeSH], Original Article, Positron-Emission Tomography/methods [MeSH], Male [MeSH], Lung Neoplasms/pathology [MeSH], Lung Neoplasms/metabolism [MeSH], [, Biological Transport [MeSH], Carcinoma, Non-Small-Cell Lung, Positron-Emission Tomography, Humans, Female, Aged

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39377810
https://repository.publisso.de/resource/frl:6497771

Metabolic heterogeneity in tumor cells impacts immunology in lung squamous cell carcinoma

Autori: Wang, Qian Sun, Na Zhang, Chaoyang a ďalší

Zdroj: Oncoimmunology
OncoImmunology, Vol 14, Iss 1 (2025)
Oncoimmunology, vol. 14, no. 1, pp. 2457797

Predmety: Male, Lung Neoplasms, metabolic tumor subpopulation, FOS: Clinical medicine, Immunology, Humans, Lung Neoplasms/immunology, Lung Neoplasms/metabolism, Lung Neoplasms/pathology, Carcinoma, Squamous Cell/immunology, Carcinoma, Squamous Cell/pathology, Carcinoma, Squamous Cell/metabolism, Carcinoma, Squamous Cell/genetics, Lymphocytes, Tumor-Infiltrating/immunology, Lymphocytes, Tumor-Infiltrating/metabolism, Female, Middle Aged, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Aged, Metabolomics/methods, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, Spatial metabolomics, lung cancer, metabolic heterogeneity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC581-607, CD8-Positive T-Lymphocytes, Lymphocytes, Tumor-Infiltrating, Carcinoma, Squamous Cell, Metabolomics, Immunologic diseases. Allergy, RC254-282, Original Research

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39924768
https://doaj.org/article/b9d0c7215a0a49e9bcd00f346be6d77b
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_D61DADE787A33
https://serval.unil.ch/notice/serval:BIB_D61DADE787A3
https://serval.unil.ch/resource/serval:BIB_D61DADE787A3.P001/REF.pdf

The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRASG12D-driven non-small cell lung cancer

Autori: McDaid, W J Wilson, L Adderley, H a ďalší

Zdroj: Mol Cancer
Molecular Cancer, Vol 23, Iss 1, Pp 1-18 (2024)
McDaid, W J, Wilson, L, Adderley, H, Martinez-Lopez, A, Baker, M J, Searle, J, Ginn, L, Budden, T, Aldea, M, Marinello, A, Aredo, J V, Viros, A, Besse, B, Wakelee, H A, Blackhall, F, Castillo-Lluva, S, Lindsay, C R & Malliri, A 2024, 'The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRASG12D-driven non-small cell lung cancer', Molecular Cancer, vol. 23, no. 1, pp. 253. https://doi.org/10.1186/s12943-024-02157-x

Predmety: 0301 basic medicine, Lung Neoplasms, TOR Serine-Threonine Kinases/metabolism, NSCLC, Non-Small-Cell Lung/metabolism, Cell Line, Proto-Oncogene Proteins p21(ras)/genetics, Proto-Oncogene Proteins p21(ras), Mice, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, Signal Transduction/drug effects, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Proto-Oncogene Proteins c-akt/metabolism, KRAS, Animals, Humans, RC254-282, 0303 health sciences, Carcinoma, Non-Small-Cell Lung/metabolism, Tumor, Animal, Research, TOR Serine-Threonine Kinases, Carcinoma, KRASG12D inhibition, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, PI3K-AKT-mTOR pathway, Disease Models, Animal, Disease Models, Mutation, Lung Neoplasms/metabolism, Phosphatidylinositol 3-Kinases/metabolism, Proto-Oncogene Proteins c-akt, Signal Transduction

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39533328
https://doaj.org/article/175d4ffa97f048a68d951ca757e5b52e

Elevated expression levels of the protein kinase DYRK1B induce mesenchymal features in A549 lung cancer cells

Autori: Sester, Soraya Wilms, Gerrit Ahlburg, Joana a ďalší

Zdroj: BMC Cancer
BMC Cancer, Vol 24, Iss 1, Pp 1-15 (2024)
BMC cancer 24(1), 1341 (2024). doi:10.1186/s12885-024-13057-0

Predmety: Lung adenocarcinoma, Epithelial-Mesenchymal Transition, Lung Neoplasms, Adenocarcinoma of Lung, Phenotypic plasticity, Protein Serine-Threonine Kinases, Adenocarcinoma, Dyrk Kinases, Protein kinase, Gene Expression Regulation, Neoplastic [MeSH], Cell Line, Tumor [MeSH], Lung Neoplasms/genetics [MeSH], Protein-Tyrosine Kinases/genetics [MeSH], Adenocarcinoma/metabolism [MeSH], Dyrk Kinases [MeSH], Adenocarcinoma/pathology [MeSH], Adenocarcinoma of Lung/genetics [MeSH], Protein-Tyrosine Kinases/metabolism [MeSH], Stress fibers, DYRK1B, Snail Family Transcription Factors/metabolism [MeSH], A549 Cells [MeSH], Cell Proliferation [MeSH], Cell Movement/genetics [MeSH], Humans [MeSH], Protein Serine-Threonine Kinases/genetics [MeSH], Cancer cell migration, A549, Adenocarcinoma of Lung/metabolism [MeSH], Epithelial-Mesenchymal Transition/genetics [MeSH], Research, Adenocarcinoma/genetics [MeSH], Lung Neoplasms/pathology [MeSH], Lung Neoplasms/metabolism [MeSH], Protein Serine-Threonine Kinases/metabolism [MeSH], Adenocarcinoma of Lung/pathology [MeSH], Snail Family Transcription Factors/genetics [MeSH], Cell Movement, Cell Line, Tumor, Humans, RC254-282, Cell Proliferation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Protein-Tyrosine Kinases, Gene Expression Regulation, Neoplastic, A549 Cells, Snail Family Transcription Factors

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39482615
https://doaj.org/article/ac9580bd985c4899aeda27c32269f6a5
https://repository.publisso.de/resource/frl:6508823
https://publications.rwth-aachen.de/record/996871

'Metabolic fingerprints' of cachexia in lung cancer patients

Autori: Frille, Armin Arends, Jann Abenavoli, Elisabetta M. a ďalší

Zdroj: Eur J Nucl Med Mol Imaging
Frille, A, Arends, J, Abenavoli, E M, Duke, S A, Ferrara, D, Gruenert, S, Hacker, M, Hesse, S, Hofmann, L, Holm, S H, Lund, T B, Rullmann, M, Sandøe, P, Sciagrà, R, Shiyam Sundar, L K, Tönjes, A, Wirtz, H, Yu, J, Sabri, O, Beyer, T & (the LuCaPET consortium) 2024, ' "Metabolic fingerprints" of cachexia in lung cancer patients ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 51, pp. 2067–2069 . https://doi.org/10.1007/s00259-024-06689-8

Predmety: Cachexia/metabolism [MeSH], Lung Neoplasms/diagnostic imaging [MeSH], Humans [MeSH], Lung Neoplasms/complications [MeSH], Cachexia/diagnostic imaging [MeSH], Lung Neoplasms/metabolism [MeSH], Letter to the Editor, Cachexia, Lung Neoplasms, Humans, Lung cancer, Cachexia, FDG PET

Popis súboru: application/pdf; pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38504039
https://curis.ku.dk/ws/files/393417956/_Metabolic_fingerprints_of_cachexia_in_lung_cancer_patients.pdf
https://repository.publisso.de/resource/frl:6503313
https://hdl.handle.net/2158/1356172
https://doi.org/10.1007/s00259-024-06689-8

Effect of TTF-1 expression on progression free survival of immunotherapy and chemo-/immunotherapy in patients with non-small cell lung cancer

Autori: Uhlenbruch, Mark Krüger, Stefan

Zdroj: J Cancer Res Clin Oncol

Predmety: Male, Lung Neoplasms, Carcinoma, Non-Small-Cell Lung/metabolism [MeSH], Aged [MeSH], Progression-Free Survival [MeSH], TTF-1 expression, NSCLC, Immunotherapy/methods [MeSH], Carcinoma, Non-Small-Cell Lung/mortality [MeSH], Male [MeSH], Transcription Factors/metabolism [MeSH], Carcinoma, Non-Small-Cell Lung/pathology [MeSH], Female [MeSH], Lung Neoplasms/mortality [MeSH], Lung Neoplasms/therapy [MeSH], DNA-Binding Proteins [MeSH], Humans [MeSH], Prognostic factor for therapy, Retrospective Studies [MeSH], Middle Aged [MeSH], Chemo-/immunotherapy, Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MeSH], Immune Checkpoint Inhibitors/therapeutic use [MeSH], Biomarkers, Tumor/metabolism [MeSH], Research, Immunotherapy, Lung Neoplasms/pathology [MeSH], Lung Neoplasms/metabolism [MeSH], Carcinoma, Non-Small-Cell Lung/drug therapy [MeSH], Carcinoma, Non-Small-Cell Lung/therapy [MeSH], Lung Neoplasms/drug therapy [MeSH], Thyroid Nuclear Factor 1/metabolism [MeSH], Thyroid Nuclear Factor 1, Middle Aged, Progression-Free Survival, DNA-Binding Proteins, Carcinoma, Non-Small-Cell Lung, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Humans, Female, Immune Checkpoint Inhibitors, Aged, Retrospective Studies, Transcription Factors

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39172188
https://repository.publisso.de/resource/frl:6522587

Chemotherapy increases CDA expression and sensitizes malignant pleural mesothelioma cells to capecitabine treatment

Autori: Karatkevich D. Losmanova T. Zens P. a ďalší

Zdroj: Sci Rep
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Scientific reports, vol. 14, no. 1, pp. 18206
Karatkevich, Darya; Losmanová, Tereza; Zens, Philipp; Deng, Haibin; Dubey, Christelle; Zhang, Tuo; Casty, Corsin; Gao, Yanyun; Neppl, Christina; Berezowska, Sabina; Wang, Wenxiang; Peng, Ren-Wang; Schmid, Ralph Alexander; Dorn, Patrick; Marti, Thomas (2024). Chemotherapy increases CDA expression and sensitizes malignant pleural mesothelioma cells to capecitabine treatment. Scientific Reports, 14(18206) Nature Publishing Group 10.1038/s41598-024-69347-x <http://dx.doi.org/10.1038/s41598-024-69347-x>
Karatkevich, Darya; Losmanová, Tereza; Zens, Philipp; Deng, Haibin; Dubey, Christelle; Zhang, Tuo; Casty, Corsin; Gao, Yanyun; Neppl, Christina; Berezowska, Sabina; Wang, Wenxiang; Peng, Ren-Wang; Schmid, Ralph Alexander; Dorn, Patrick; Marti, Thomas (2024). Chemotherapy increases CDA expression and sensitizes malignant pleural mesothelioma cells to capecitabine treatment. Scientific Reports, 14(1), p. 18206. Nature Publishing Group 10.1038/s41598-024-69347-x <http://dx.doi.org/10.1038/s41598-024-69347-x>

Predmety: Mesothelioma, Lung Neoplasms, Epithelial-Mesenchymal Transition, Science, Pleural Neoplasms, 610 Medicine & health, Humans, Capecitabine/pharmacology, Animals, Cell Line, Tumor, Mesothelioma, Malignant/drug therapy, Mesothelioma, Malignant/metabolism, Mesothelioma, Malignant/pathology, Cytidine Deaminase/metabolism, Cytidine Deaminase/genetics, Mice, Pemetrexed/pharmacology, Pleural Neoplasms/drug therapy, Pleural Neoplasms/metabolism, Pleural Neoplasms/pathology, Xenograft Model Antitumor Assays, Cisplatin/pharmacology, Cisplatin/therapeutic use, Lung Neoplasms/drug therapy, Lung Neoplasms/metabolism, Lung Neoplasms/pathology, Epithelial-Mesenchymal Transition/drug effects, Mesothelioma/drug therapy, Mesothelioma/metabolism, Mesothelioma/pathology, Female, Antineoplastic Combined Chemotherapy Protocols/pharmacology, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Gene Expression Regulation, Neoplastic/drug effects, Capecitabine, Chemotherapy, Cisplatin, Cytidine deaminase, Pemetrexed, Article, Cytidine Deaminase, Antineoplastic Combined Chemotherapy Protocols, Mesothelioma, Malignant, 3. Good health, Gene Expression Regulation, Neoplastic, 570 Life sciences, biology, Medicine

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39107509
https://doaj.org/article/b97b92bc2b4847fca5438e0799a61a42
https://serval.unil.ch/resource/serval:BIB_4EC8964DB10E.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_4EC8964DB10E1
https://serval.unil.ch/notice/serval:BIB_4EC8964DB10E
https://boris.unibe.ch/199547/

Fibroblast growth factor receptor (FGFR) inhibitor rogaratinib in patients with advanced pretreated squamous-cell non-small cell lung cancer over-expressing FGFR mRNA: The SAKK 19/18 phase II study

Autori: Addeo, Alfredo Rothschild, Sacha I Holer, Lisa a ďalší

Zdroj: Addeo, Alfredo; Rothschild, Sacha I; Holer, Lisa; Schneider, Martina; Waibel, Christine; Haefliger, Simon; Mark, Michael; Fernandez, Eugenio; Mach, Nicolas; Mauti, Laetitia; Jermann, Philip M; Alborelli, Ilaria; Calgua, Byron; Savic-Prince, Spasenija; Joerger, Markus; Früh, Martin (2022). Fibroblast growth factor receptor (FGFR) inhibitor rogaratinib in patients with advanced pretreated squamous-cell non-small cell lung cancer over-expressing FGFR mRNA: The SAKK 19/18 phase II study. Lung cancer, 172, pp. 154-159. Elsevier 10.1016/j.lungcan.2022.08.016 <http://dx.doi.org/10.1016/j.lungcan.2022.08.016>

Predmety: 0301 basic medicine, Lung Neoplasms, RNA, Messenger / metabolism, 610 Medicine & health, Thiophenes, Lung Neoplasms / drug therapy, Piperazines, 03 medical and health sciences, Carcinoma, Non-Small-Cell Lung, SQCLC, Carcinoma, Non-Small-Cell Lung / genetics, Carcinoma, Squamous Cell / drug therapy, Humans, Pyrroles, RNA, Messenger, Protein Kinase Inhibitors / therapeutic use, Protein Kinase Inhibitors, Lung Neoplasms / genetics, 0303 health sciences, RNA, Messenger / genetics, FGFR inhibitor, Lung Neoplasms / metabolism, 3. Good health, Carcinoma, Non-Small-Cell Lung / metabolism, Carcinoma, Squamous Cell, Carcinoma, Non-Small-Cell Lung / drug therapy

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/36099710
https://boris.unibe.ch/172862/

Molecular classification and biomarkers of outcome with immunotherapy in extensive-stage small-cell lung cancer: analyses of the CASPIAN phase 3 study

Autori: Xie, Mingchao Vuko, Miljenka Rodriguez-Canales, Jaime a ďalší

Zdroj: Mol Cancer
Molecular Cancer, Vol 23, Iss 1, Pp 1-17 (2024)

Predmety: PD-L1, Male, Adult, 0301 basic medicine, Medical Sciences, Lung Neoplasms, Bioinformatics, Antibodies, Monoclonal, Humanized, Antibodies, Biomedical Informatics, 03 medical and health sciences, Monoclonal, Antineoplastic Combined Chemotherapy Protocols, Medical Specialties, Medicine and Health Sciences, Biomarkers, Tumor, Humans, Humanized, Biomarkers, CTLA-4, Aged [MeSH], Antibodies, Monoclonal/therapeutic use [MeSH], T-cell inflamed signature, Lung Neoplasms/genetics [MeSH], Small Cell Lung Carcinoma/mortality [MeSH], Small-cell lung cancer, Neoplasm Staging [MeSH], Immunotherapy/methods [MeSH], SCLC subtypes, Small Cell Lung Carcinoma/drug therapy [MeSH], Male [MeSH], Small Cell Lung Carcinoma/genetics [MeSH], Lung Neoplasms/immunology [MeSH], Small Cell Lung Carcinoma/pathology [MeSH], Biomarkers, Tumor [MeSH], Molecular subtyping, Female [MeSH], Lung Neoplasms/mortality [MeSH], Lung Neoplasms/therapy [MeSH], Adult [MeSH], Humans [MeSH], Small Cell Lung Carcinoma/metabolism [MeSH], Treatment Outcome [MeSH], Gene expression profiling, Middle Aged [MeSH], Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MeSH], Small Cell Lung Carcinoma/therapy [MeSH], Antigen presentation machinery, Research, Antibodies, Monoclonal, Humanized/therapeutic use [MeSH], Prognosis [MeSH], Lung Neoplasms/pathology [MeSH], Lung Neoplasms/metabolism [MeSH], Small Cell Lung Carcinoma/immunology [MeSH], Lung Neoplasms/drug therapy [MeSH], RC254-282, Aged, Neoplasm Staging, 0303 health sciences, Tumor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Antibodies, Monoclonal, Middle Aged, Prognosis, Small Cell Lung Carcinoma, 3. Good health, Treatment Outcome, Oncology, Female, Immunotherapy

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38811992
https://doaj.org/article/dac90161c2bf43f78841723ad0ac6b3b
https://repository.publisso.de/resource/frl:6509269

EDI3 knockdown in ER-HER2+ breast cancer cells reduces tumor burden and improves survival in two mouse models of experimental metastasis

Autori: Glotzbach, Annika Rohlf, Katharina Gonscharow, Anastasia a ďalší

Zdroj: Breast Cancer Res
Breast Cancer Research, Vol 26, Iss 1, Pp 1-20 (2024)

Predmety: Glycerophospholipid metabolism, 0301 basic medicine, Lung Neoplasms, Receptor, ErbB-2, Cell Line, Tumor [MeSH], Receptor, ErbB-2/metabolism [MeSH], Lung Neoplasms/genetics [MeSH], Metastasis, Breast cancer, Cell Movement [MeSH], Receptor, ErbB-2/genetics [MeSH], Tumor Burden [MeSH], Disease Models, Animal [MeSH], HER2 positive breast cancer, Breast Neoplasms/pathology [MeSH], Anoikis, Female [MeSH], Cell Proliferation [MeSH], Phospholipases/genetics [MeSH], Receptors, Estrogen/metabolism [MeSH], Humans [MeSH], Neoplasm Metastasis [MeSH], Breast Neoplasms/genetics [MeSH], Gene Knockdown Techniques [MeSH], Breast Neoplasms/metabolism [MeSH], Animals [MeSH], GPCPD1, Mice [MeSH], Phospholipases/metabolism [MeSH], Research, Lung Neoplasms/pathology [MeSH], Lung Neoplasms/metabolism [MeSH], Choline metabolism, Lung Neoplasms/secondary [MeSH], Breast Neoplasms, Mice, 03 medical and health sciences, Cell Movement, Cell Line, Tumor, Animals, Humans, Neoplasm Metastasis, RC254-282, Cell Proliferation, 0303 health sciences, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Tumor Burden, 3. Good health, Disease Models, Animal, Receptors, Estrogen, Phospholipases, Gene Knockdown Techniques, Female

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38816770
https://doaj.org/article/f5f898d38fee442c8efa7d5ee8240227
https://repository.publisso.de/resource/frl:6524446

Smoking-associated gene expression alterations in nasal epithelium reveal immune impairment linked to lung cancer risk

Autori: Maria Stella de Biase Florian Massip Tzu-Ting Wei a ďalší

Prispievatelia: Maria Stella de Biase Florian Massip Tzu-Ting Wei a ďalší

Zdroj: Genome Med
Genome Medicine, Vol 16, Iss 1, Pp 1-19 (2024)

Predmety: Cancer Research, Lung Neoplasms, [SDV]Life Sciences [q-bio], Research, Smoking, Tobacco Products, QH426-470, Smoking/genetics [MeSH], Tobacco Products [MeSH], Nasal Mucosa/metabolism [MeSH], Humans [MeSH], Lung Neoplasms/genetics [MeSH], Transcriptome [MeSH], Lung Neoplasms/metabolism [MeSH], Lung/metabolism [MeSH], Smoking/adverse effects [MeSH], 3. Good health, Nasal Mucosa, Genetics, Medicine, Humans, Technology Platforms, Genes, Cells and Cell-Based Medicine [Topic 1], Transcriptome, Lung, Lung Cancer, Genomics, Transcriptomics

Popis súboru: application/pdf; text/xml; application/zip

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38589970
https://doaj.org/article/1477c061531644cca19787d9aa30b28b
https://edoc.mdc-berlin.de/id/eprint/24282/1/24282oa.pdf
https://repository.publisso.de/resource/frl:6523368

Differential prognostic effect of systemic inflammation in patients with non–small cell lung cancer treated with immunotherapy or chemotherapy: A post hoc analysis of the phase 3OAKtrial

Autori: Cortellini, Alessio Ricciuti, Biagio Borghaei, Hossein a ďalší

Prispievatelia: Cortellini, Alessio Ricciuti, Biagio Borghaei, Hossein a ďalší

Zdroj: Cancer

Predmety: atezolizumab, Male, Lung Neoplasms, NF-E2-Related Factor 2, immune checkpoint inhibitor, Non-small cell lung cancer (NSCLC), Docetaxel, Lung Neoplasms / drug therapy, B7-H1 Antigen, Proto-Oncogene Proteins p21(ras), Immune checkpoint inhibitors, 03 medical and health sciences, ErbB Receptors / metabolism, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, non–small cell lung cancer (NSCLC), Carcinoma, Non-Small-Cell Lung / genetics, Humans, Immunologic Factors, Atezolizumab, Lung Neoplasms / genetics, Inflammation, Kelch-Like ECH-Associated Protein 1, Neutrophil to lymphocyte ratio (NLR), DNA Helicases, Nuclear Proteins, Original Articles, neutrophil to lymphocyte ratio (NLR), Prognosis, Lung Neoplasms / metabolism, 3. Good health, ErbB Receptors, lung cancer, B7-H1 Antigen / metabolism, inflammation, immunotherapy, Carcinoma, Non-Small-Cell Lung / drug therapy, Immunotherapy, Lung cancer, Cell-Free Nucleic Acids, Transcription Factors

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/35727053
https://archive-ouverte.unige.ch/unige:167313
https://doi.org/10.1002/cncr.34348

MicroRNA-143 act as a tumor suppressor microRNA in human lung cancer cells by inhibiting cell proliferation, invasion, and migration

Autori: Asghariazar, Vahid Mansoori, Behzad Kadkhodayi, Mahtab a ďalší

Zdroj: Molecular Biology Reports. 49:7637-7647

Predmety: 0301 basic medicine, Lung Neoplasms, Apoptosis, Replacement therapy, NSCLC, Metastasis, Cell Line, Cell Proliferation/genetics, 03 medical and health sciences, Invasion, Cell Movement, Apoptosis/genetics, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Cell Movement/genetics, MicroRNAs/metabolism, Humans, MicroRNA-143, Cell Proliferation, Non-Small-Cell Lung/genetics, 0303 health sciences, Tumor, Signaling pathway, Carcinoma, MicroRNA, Neoplastic/genetics, 3. Good health, Gene Expression Regulation, Neoplastic, MicroRNAs, Gene Expression Regulation, A549 Cells, Lung Neoplasms/metabolism

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/35717476
https://portal.findresearcher.sdu.dk/da/publications/b33f81f8-7600-43cd-9895-95a60ed4978b
https://doi.org/10.1007/s11033-022-07580-1