Výsledky vyhľadávania - "Locus coeruleus"

Locus coeruleus-entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein.

Autori: Patsyuk Y Van Egroo M Beckers E a ďalší

Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Dec; Vol. 21 (12), pp. e70915.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

Výrazy zo slovníka MeSH: tau Proteins*/blood , Locus Coeruleus*/diagnostic imaging , Locus Coeruleus*/pathology , Glial Fibrillary Acidic Protein*/blood , Entorhinal Cortex*/diagnostic imaging , Entorhinal Cortex*/pathology , Alzheimer Disease*/blood , Alzheimer Disease*/pathology, Humans ; Male ; Female ; Aged ; Biomarkers/blood ; Middle Aged ; Diffusion Magnetic Resonance Imaging ; Neural Pathways/diagnostic imaging ; Neural Pathways/pathology

Inverse Association of Locus Coeruleus MRI Integrity With Structural Volume and Its Impact on Individual's Inattentiveness.

Autori: Neal J Kim SH Katz B a ďalší

Zdroj: Human brain mapping [Hum Brain Mapp] 2025 Dec 01; Vol. 46 (17), pp. e70419.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley Country of Publication: United States NLM ID: 9419065 Publication Model: Print Cited Medium: Internet ISSN: 1097-0193 (Electronic) Linking ISSN: 10659471 NLM ISO Abbreviation: Hum Brain Mapp Subsets: MEDLINE

Výrazy zo slovníka MeSH: Locus Coeruleus*/diagnostic imaging , Locus Coeruleus*/anatomy & histology , Locus Coeruleus*/pathology , Locus Coeruleus*/metabolism , Attention*/physiology, Humans ; Male ; Female ; Magnetic Resonance Imaging ; Adult ; Melanins/metabolism ; Middle Aged ; Young Adult ; Adolescent ; Child

Propofol inhibits norepinephrine release in vivo at presynaptic varicosities of locus coeruleus neurones in zebrafish larvae.

Autori: Du W Hu Y Yang Y a ďalší

Zdroj: British journal of anaesthesia [Br J Anaesth] 2025 Dec; Vol. 135 (6), pp. 1704-1716. Date of Electronic Publication: 2025 Oct 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: England NLM ID: 0372541 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-6771 (Electronic) Linking ISSN: 00070912 NLM ISO Abbreviation: Br J Anaesth Subsets: MEDLINE

Výrazy zo slovníka MeSH: Locus Coeruleus*/drug effects , Locus Coeruleus*/metabolism , Norepinephrine*/metabolism , Propofol*/pharmacology , Neurons*/drug effects , Neurons*/metabolism , Presynaptic Terminals*/drug effects , Presynaptic Terminals*/metabolism , Anesthetics, Intravenous*/pharmacology, Animals ; Zebrafish ; Larva/drug effects ; Calcium/metabolism

Noradrenergic dysregulation in the locus coeruleus: Implications for neuropsychiatric disease pathophysiology- A systematic review.

Autori: Mir FA Jha SK Nehs CJ

Zdroj: Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2025 Dec; Vol. 179, pp. 106442. Date of Electronic Publication: 2025 Oct 28.

Spôsob vydávania: Journal Article; Systematic Review; Review

Informácie o časopise: Publisher: Pergamon Press Country of Publication: United States NLM ID: 7806090 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7528 (Electronic) Linking ISSN: 01497634 NLM ISO Abbreviation: Neurosci Biobehav Rev Subsets: MEDLINE

Výrazy zo slovníka MeSH: Locus Coeruleus*/physiopathology , Locus Coeruleus*/metabolism , Mental Disorders*/physiopathology , Mental Disorders*/metabolism , Norepinephrine*/metabolism , Adrenergic Neurons*/metabolism , Adrenergic Neurons*/physiology, Humans ; Animals

Neural Circuit Connections and Functions of Locus Coeruleus-Norepinephrine System.

Autori: Hao M Li F Duan JW a ďalší

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 19; Vol. 26 (22). Date of Electronic Publication: 2025 Nov 19.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Locus Coeruleus*/physiology , Locus Coeruleus*/metabolism , Norepinephrine*/metabolism , Neural Pathways*/physiology , Nerve Net*/physiology, Animals ; Humans ; Neurons/metabolism

Locus Coeruleus MR Measured Signal Intensity in Fibromyalgia Relative to Healthy Controls.

Autori: DeMayo MM Cassidy CM McCreary C a ďalší

Zdroj: European journal of pain (London, England) [Eur J Pain] 2025 Nov; Vol. 29 (10), pp. e70173.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley Country of Publication: England NLM ID: 9801774 Publication Model: Print Cited Medium: Internet ISSN: 1532-2149 (Electronic) Linking ISSN: 10903801 NLM ISO Abbreviation: Eur J Pain Subsets: MEDLINE

Výrazy zo slovníka MeSH: Fibromyalgia*/diagnostic imaging , Fibromyalgia*/physiopathology , Fibromyalgia*/metabolism , Locus Coeruleus*/diagnostic imaging , Locus Coeruleus*/metabolism, Humans ; Female ; Middle Aged ; Magnetic Resonance Imaging/methods ; Adult ; Male ; Cross-Sectional Studies ; Norepinephrine/metabolism ; Anxiety ; Case-Control Studies ; Melanins

Dysfunctional locus coeruleus-cerebellum-cortex pathways in chronic low back pain: A resting-state functional magnetic resonance imaging and machine learning study.

Autori: Zhang B Guo M Chai M a ďalší

Zdroj: Brain research bulletin [Brain Res Bull] 2025 Nov; Vol. 232, pp. 111580. Date of Electronic Publication: 2025 Oct 13.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2747 (Electronic) Linking ISSN: 03619230 NLM ISO Abbreviation: Brain Res Bull Subsets: MEDLINE

Výrazy zo slovníka MeSH: Locus Coeruleus*/physiopathology , Locus Coeruleus*/diagnostic imaging , Low Back Pain*/physiopathology , Low Back Pain*/diagnostic imaging , Cerebellum*/physiopathology , Cerebellum*/diagnostic imaging , Chronic Pain*/physiopathology , Chronic Pain*/diagnostic imaging , Cerebral Cortex*/physiopathology , Cerebral Cortex*/diagnostic imaging, Humans ; Male ; Female ; Magnetic Resonance Imaging/methods ; Adult ; Middle Aged ; Machine Learning ; Neural Pathways/physiopathology ; Neural Pathways/diagnostic imaging ; Support Vector Machine ; Brain Mapping/methods

Blood oxygenation level-dependent responses in neuromodulatory nuclei and their associations with attention and memory across age groups.

Autori: Riley E Cicero N Swallow K a ďalší

Zdroj: Neurobiology of aging [Neurobiol Aging] 2025 Nov; Vol. 155, pp. 24-34. Date of Electronic Publication: 2025 Jul 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 8100437 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-1497 (Electronic) Linking ISSN: 01974580 NLM ISO Abbreviation: Neurobiol Aging Subsets: MEDLINE

Výrazy zo slovníka MeSH: Attention*/physiology , Aging*/psychology , Aging*/physiology , Memory*/physiology , Oxygen*/blood , Ventral Tegmental Area*/physiology , Ventral Tegmental Area*/metabolism , Basal Nucleus of Meynert*/physiology , Basal Nucleus of Meynert*/metabolism , Locus Coeruleus*/physiology , Locus Coeruleus*/metabolism, Humans ; Aged ; Middle Aged ; Male ; Adult ; Female ; Aged, 80 and over ; Young Adult ; Norepinephrine/metabolism ; Norepinephrine/physiology ; Dopamine/metabolism ; Dopamine/physiology ; Acetylcholine/metabolism ; Alzheimer Disease/psychology ; Alzheimer Disease/etiology ; Magnetic Resonance Imaging

Modulation of the Neurovascular Unit by the Locus Coeruleus-Norepinephrine System: From Physiological Mechanisms to Therapeutic Applications.

Autori: Pan Z Jia Z Jiang T a ďalší

Zdroj: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Oct 31; Vol. 39 (20), pp. e71127.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

Výrazy zo slovníka MeSH: Locus Coeruleus*/physiology , Locus Coeruleus*/metabolism , Norepinephrine*/metabolism , Neurovascular Coupling*/physiology, Humans ; Animals ; Neurons/metabolism ; Neurons/physiology ; Brain/metabolism

Propofol regulates arousal by enhancing inhibitory synaptic transmission of noradrenergic neurons in the locus coeruleus of adult male mice.

Autori: Abe T Kurabe M Nakamura Y a ďalší

Zdroj: Scientific reports [Sci Rep] 2025 Oct 28; Vol. 15 (1), pp. 37725. Date of Electronic Publication: 2025 Oct 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Propofol*/pharmacology , Locus Coeruleus*/drug effects , Locus Coeruleus*/physiology , Locus Coeruleus*/cytology , Synaptic Transmission*/drug effects , Adrenergic Neurons*/drug effects , Adrenergic Neurons*/physiology , Adrenergic Neurons*/metabolism , Arousal*/drug effects, Animals ; Male ; Mice ; Receptors, GABA-A/metabolism ; Action Potentials/drug effects ; Bicuculline/pharmacology ; Anesthetics, Intravenous/pharmacology ; Inhibitory Postsynaptic Potentials/drug effects

Circuit-selective pharmacological targeting of prefrontal cortex-projecting locus coeruleus neurons drives antinociception.

Autori: Kuo CC McCall JG

Zdroj: Cell reports [Cell Rep] 2025 Oct 28; Vol. 44 (10), pp. 116294. Date of Electronic Publication: 2025 Sep 18.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Locus Coeruleus*/drug effects , Locus Coeruleus*/physiology , Locus Coeruleus*/metabolism , Prefrontal Cortex*/drug effects , Prefrontal Cortex*/physiology , Prefrontal Cortex*/metabolism , Neurons*/drug effects , Neurons*/metabolism , Neurons*/physiology , Analgesics*/pharmacology , Nociception*/drug effects, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Optogenetics ; Receptors, G-Protein-Coupled/metabolism ; Receptors, G-Protein-Coupled/agonists ; Action Potentials/drug effects

Catecholaminergic nucleus integrity and Alzheimer's pathology, symptoms, and progression.

Autori: David MCB Kolanko MA Parker TD a ďalší

Korporácia: David MCB Kolanko MA Parker TD a ďalší

Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Oct; Vol. 21 (10), pp. e70749.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

Výrazy zo slovníka MeSH: Alzheimer Disease*/pathology , Alzheimer Disease*/diagnostic imaging , Locus Coeruleus*/pathology , Locus Coeruleus*/diagnostic imaging , Locus Coeruleus*/metabolism , Substantia Nigra*/pathology , Substantia Nigra*/diagnostic imaging, Humans ; Female ; Male ; Disease Progression ; Aged ; Magnetic Resonance Imaging ; Cognitive Dysfunction/pathology ; Neuropsychological Tests ; Atrophy/pathology ; Melanins/metabolism ; tau Proteins/blood ; Aged, 80 and over

Trigeminal influences and Locus Coeruleus: Tips for countermeasures, therapies and precocious diagnosis in dementia.

Autori: De Cicco V Tramonti Fantozzi MP Ligori S a ďalší

Zdroj: Brain research bulletin [Brain Res Bull] 2025 Oct 01; Vol. 230, pp. 111528. Date of Electronic Publication: 2025 Aug 27.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2747 (Electronic) Linking ISSN: 03619230 NLM ISO Abbreviation: Brain Res Bull Subsets: MEDLINE

Výrazy zo slovníka MeSH: Locus Coeruleus*/physiopathology , Locus Coeruleus*/physiology , Dementia*/physiopathology , Dementia*/diagnosis , Dementia*/therapy , Trigeminal Nerve*/physiopathology , Trigeminal Nerve*/physiology, Humans ; Alzheimer Disease/physiopathology ; Alzheimer Disease/diagnosis ; Mastication/physiology ; Pupil/physiology ; Cognition/physiology

Dexmedetomidine elicits a prolonged anxiolytic effect by inhibiting adrenergic neurons in the locus coeruleus in mice.

Autori: Jiang L Zhao J Xia M a ďalší

Zdroj: Translational psychiatry [Transl Psychiatry] 2025 Nov 18; Vol. 15 (1), pp. 487. Date of Electronic Publication: 2025 Nov 18.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE

Výrazy zo slovníka MeSH: Dexmedetomidine*/pharmacology , Dexmedetomidine*/administration & dosage , Locus Coeruleus*/drug effects , Locus Coeruleus*/metabolism , Adrenergic Neurons*/drug effects , Adrenergic Neurons*/metabolism , Anti-Anxiety Agents*/pharmacology , Anti-Anxiety Agents*/administration & dosage , Adrenergic alpha-2 Receptor Agonists*/pharmacology , Anxiety*/drug therapy , Anxiety*/metabolism, Animals ; Mice ; Male ; Disease Models, Animal ; Norepinephrine/metabolism ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism ; Receptors, Adrenergic, alpha-2/genetics ; Receptors, Adrenergic, alpha-2/metabolism ; Mice, Inbred C57BL ; Behavior, Animal/drug effects ; Stress, Psychological/drug therapy

Maternal separation disrupts noradrenergic control of adult coping behaviors.

Autori: Vazquez CR Becker LJ Kuo CC a ďalší

Zdroj: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2025 Nov; Vol. 50 (12), pp. 1795-1806. Date of Electronic Publication: 2025 Aug 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE

Výrazy zo slovníka MeSH: Maternal Deprivation* , Locus Coeruleus*/metabolism , Locus Coeruleus*/physiopathology , Adaptation, Psychological*/physiology , Norepinephrine*/metabolism , Stress, Psychological*/physiopathology , Stress, Psychological*/metabolism, Animals ; Mice ; Male ; Female ; Dopamine beta-Hydroxylase/metabolism ; Dopamine beta-Hydroxylase/genetics ; Mice, Inbred C57BL ; Receptors, Adrenergic, alpha-2/metabolism ; Receptors, Adrenergic, alpha-2/genetics ; Coping Skills

The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation.

Autori: Anuncibay Soto B Ma Y Nollet M a ďalší

Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Oct 14; Vol. 122 (41), pp. e2422878122. Date of Electronic Publication: 2025 Oct 07.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Výrazy zo slovníka MeSH: Dexmedetomidine*/pharmacology , Dexmedetomidine*/adverse effects , Locus Coeruleus*/drug effects , Locus Coeruleus*/physiology , Locus Coeruleus*/metabolism , Hypothermia*/chemically induced , Hypothermia*/prevention & control , Hypothermia*/metabolism , Hypothermia*/physiopathology , Body Temperature*/drug effects , Hypnotics and Sedatives*/pharmacology , Hypnotics and Sedatives*/adverse effects, Animals ; Mice ; Receptors, Adrenergic, alpha-2/metabolism ; Receptors, Adrenergic, alpha-2/genetics ; Male ; Norepinephrine/metabolism ; Adrenergic alpha-2 Receptor Agonists/pharmacology ; Neurons/metabolism ; Neurons/drug effects ; Sleep/drug effects ; Preoptic Area/drug effects ; Preoptic Area/metabolism ; Mice, Inbred C57BL ; Body Temperature Regulation/drug effects

Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity.

Autori: Toyoda H Kim D Koh BG a ďalší

Zdroj: ELife [Elife] 2025 Oct 09; Vol. 14. Date of Electronic Publication: 2025 Oct 09.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

Výrazy zo slovníka MeSH: Locus Coeruleus* , Neurons*/physiology , Neurons*/enzymology , Neurons*/metabolism , Cysteine Endopeptidases*/metabolism , Stress, Physiological*, Animals ; Mice ; Male ; Monoamine Oxidase/metabolism ; Norepinephrine/metabolism ; Mice, Inbred C57BL ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/metabolism

A central CeA-LC-PVH circuit mediates stress-induced osteopenia via skeletal sympathetic nerves in male mice.

Autori: Zhao WJ Lu YX Fan GD a ďalší

Zdroj: Science advances [Sci Adv] 2025 Dec 05; Vol. 11 (49), pp. eadz9329. Date of Electronic Publication: 2025 Dec 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

Výrazy zo slovníka MeSH: Bone Diseases, Metabolic*/etiology , Bone Diseases, Metabolic*/metabolism , Bone Diseases, Metabolic*/physiopathology , Sympathetic Nervous System*/metabolism , Paraventricular Hypothalamic Nucleus*/metabolism , Locus Coeruleus*/metabolism , Stress, Psychological*/complications , Stress, Psychological*/metabolism , Amygdala*/metabolism, Animals ; Mice ; Male ; Corticotropin-Releasing Hormone/metabolism ; Disease Models, Animal ; Adrenergic Neurons/metabolism

Eye movement evidence for locus coeruleus-noradrenaline system contributions to age differences in attention.

Autori: Kim AJ Nguyen K Tian Y a ďalší

Zdroj: Psychology and aging [Psychol Aging] 2025 Dec; Vol. 40 (8), pp. 929-944. Date of Electronic Publication: 2025 Aug 07.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Psychological Association Country of Publication: United States NLM ID: 8904079 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-1498 (Electronic) Linking ISSN: 08827974 NLM ISO Abbreviation: Psychol Aging Subsets: MEDLINE

Výrazy zo slovníka MeSH: Attention*/physiology , Locus Coeruleus*/physiology , Eye Movements*/physiology , Aging*/physiology , Norepinephrine*/physiology , Norepinephrine*/metabolism, Humans ; Male ; Female ; Adult ; Aged ; Young Adult ; Arousal/physiology ; Middle Aged ; Pupil/physiology ; Eye Movement Measurements ; Age Factors

Abdominal Vagus Nerve Stimulation Increases Firing in the Rat Locus Coeruleus.

Autori: Hyakumura T Payne SC Matarazzo JV a ďalší

Zdroj: Neuromodulation : journal of the International Neuromodulation Society [Neuromodulation] 2025 Dec; Vol. 28 (8), pp. 1239-1247. Date of Electronic Publication: 2025 Jun 20.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 9804159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-1403 (Electronic) Linking ISSN: 10947159 NLM ISO Abbreviation: Neuromodulation Subsets: MEDLINE

Výrazy zo slovníka MeSH: Locus Coeruleus*/physiology , Vagus Nerve Stimulation*/methods , Action Potentials*/physiology , Abdomen*/innervation , Neurons*/physiology , Vagus Nerve*/physiology, Animals ; Rats, Sprague-Dawley ; Male ; Rats ; Heart Rate/physiology