Suchergebnisse - "Letrozole"

Genetic variations in CYP2A6 predict efficacy of neoadjuvant letrozole concurrent with chemotherapy in locally advanced hormone receptor-positive breast cancer.

Autoren: Wu Y Wang Y Sheng X et al.

Quelle: Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2557510. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE

MeSH-Schlagworte: Letrozole*/therapeutic use , Letrozole*/administration & dosage , Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics , Breast Neoplasms*/mortality , Cytochrome P-450 CYP2A6*/genetics , Cytochrome P-450 CYP2A6*/metabolism , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use, Humans ; Female ; Neoadjuvant Therapy/methods ; Middle Aged ; Retrospective Studies ; Adult ; Polymorphism, Single Nucleotide ; Aged ; Prognosis ; Prospective Studies ; Genotype ; Treatment Outcome ; Receptors, Estrogen/metabolism ; Triazoles

Identification of related substances in letrozole using LC-Q-TOF/MS.

Autoren: Hu ZL Zou WY Hu PW et al.

Quelle: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2025 Nov 15; Vol. 265, pp. 117006. Date of Electronic Publication: 2025 Jun 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

MeSH-Schlagworte: Letrozole*/chemistry , Letrozole*/analysis , Aromatase Inhibitors*/chemistry , Aromatase Inhibitors*/analysis , Triazoles*/chemistry , Triazoles*/analysis , Nitriles*/chemistry, Chromatography, High Pressure Liquid/methods ; Tandem Mass Spectrometry/methods ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/analysis ; Drug Contamination/prevention & control ; Drug Stability

Masculinization and physiological responses of rosy barb, Pethia conchonius to combined hormonal treatment.

Autoren: Lal J Biswas P Singh SK et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 14; Vol. 15 (1), pp. 39897. Date of Electronic Publication: 2025 Nov 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Letrozole*/pharmacology , Letrozole*/administration & dosage , Methyltestosterone*/pharmacology , Methyltestosterone*/administration & dosage , Cyprinidae*/physiology , Masculinity*, Animals ; Male ; Female ; Aromatase Inhibitors/pharmacology ; Ovary/drug effects ; Antioxidants/metabolism ; Testis/drug effects

Comparative effects of streptozotocin, dehydroepiandrosterone and letrozole with high fat diet on ovarian injury induction and functional impairment.

Autoren: Yu L Peng Q Ma C et al.

Quelle: Scientific reports [Sci Rep] 2025 Oct 08; Vol. 15 (1), pp. 35054. Date of Electronic Publication: 2025 Oct 08.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Letrozole*/adverse effects , Letrozole*/toxicity , Dehydroepiandrosterone*/toxicity , Dehydroepiandrosterone*/adverse effects , Diet, High-Fat*/adverse effects , Ovary*/drug effects , Ovary*/metabolism , Ovary*/pathology , Ovary*/physiopathology , Streptozocin*/adverse effects , Streptozocin*/toxicity, Animals ; Female ; Mice ; Signal Transduction/drug effects ; Mice, Inbred ICR ; Phosphatidylinositol 3-Kinases/metabolism ; Disease Models, Animal ; Proto-Oncogene Proteins c-akt/metabolism

Comparison of Combined Letrozole and Clomiphene Citrate With Gonadotropin Microstimulation Protocols on Fertility Outcomes.

Autoren: Zhou N Xu J Liu L et al.

Quelle: Clinical therapeutics [Clin Ther] 2025 Oct; Vol. 47 (10), pp. 884-888. Date of Electronic Publication: 2025 Aug 27.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Excerpta Medica Country of Publication: United States NLM ID: 7706726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-114X (Electronic) Linking ISSN: 01492918 NLM ISO Abbreviation: Clin Ther Subsets: MEDLINE

MeSH-Schlagworte: Letrozole*/administration & dosage , Letrozole*/therapeutic use , Clomiphene*/administration & dosage , Clomiphene*/therapeutic use , Ovulation Induction*/methods , Gonadotropins*/administration & dosage , Fertility Agents, Female*/administration & dosage , Fertility Agents, Female*/therapeutic use , Infertility, Female*/therapy, Humans ; Female ; Pregnancy ; Retrospective Studies ; Adult ; Pregnancy Rate ; Pregnancy Outcome ; Live Birth/epidemiology ; Abortion, Spontaneous/epidemiology ; Birth Rate ; Fertility/drug effects ; Drug Therapy, Combination

Letrozole to prevent breast cancer in postmenopausal women with BRCA1/2 mutations (LIBER study).

Autoren: Pujol P Roca L Lortholary A et al.

Quelle: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2025 Dec 09; Vol. 231, pp. 116101. Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE

MeSH-Schlagworte: Breast Neoplasms*/genetics , Breast Neoplasms*/prevention & control , Letrozole*/therapeutic use , Aromatase Inhibitors*/therapeutic use , Aromatase Inhibitors*/adverse effects , BRCA2 Protein*/genetics , BRCA1 Protein*/genetics, Humans ; Female ; Postmenopause ; Middle Aged ; Double-Blind Method ; Aged ; Adult ; Germ-Line Mutation ; Quality of Life ; Genes, BRCA2 ; Genetic Predisposition to Disease ; Mutation ; Treatment Outcome

Effect of letrozole doses on clinical pregnancy rates in polycystic ovary syndrome: a systematic review and network meta-analysis.

Autoren: Sun Y Wang J Chen G

Quelle: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2025 Dec; Vol. 41 (1), pp. 2504977. Date of Electronic Publication: 2025 May 26.

Publikationsart: Journal Article; Systematic Review; Network Meta-Analysis

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8807913 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-0766 (Electronic) Linking ISSN: 09513590 NLM ISO Abbreviation: Gynecol Endocrinol Subsets: MEDLINE

MeSH-Schlagworte: Letrozole*/administration & dosage , Polycystic Ovary Syndrome*/drug therapy , Aromatase Inhibitors*/administration & dosage , Infertility, Female*/etiology , Infertility, Female*/drug therapy, Humans ; Female ; Pregnancy ; Pregnancy Rate ; Ovulation Induction/methods ; Pregnancy Outcome

Invasive disease-free and overall survival after (neo)adjuvant chemotherapy in postmenopausal patients with hormone receptor-positive, HER2-negative early breast cancer treated with upfront letrozole: Experiences from the phase IV PreFace trial.

Autoren: Beierlein M Häberle L Nabieva N et al.

Quelle: International journal of cancer [Int J Cancer] 2025 Dec 01; Vol. 157 (11), pp. 2363-2373. Date of Electronic Publication: 2025 Jul 11.

Publikationsart: Journal Article; Clinical Trial, Phase IV

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE

MeSH-Schlagworte: Letrozole*/therapeutic use , Letrozole*/administration & dosage , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/mortality , Breast Neoplasms*/metabolism, Humans ; Female ; Postmenopause ; Middle Aged ; Receptor, ErbB-2/metabolism ; Chemotherapy, Adjuvant ; Neoadjuvant Therapy/methods ; Receptors, Estrogen/metabolism ; Aged ; Retrospective Studies ; Receptors, Progesterone/metabolism ; Disease-Free Survival ; Prognosis ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Adult ; Triazoles/therapeutic use

Computational analysis on the influence of pressure and temperature on drug solubility in supercritical CO 2 with machine learning and optimizer.

Autoren: Obaidullah AJ Mahdi WA Alhowyan A

Quelle: Scientific reports [Sci Rep] 2025 Nov 17; Vol. 15 (1), pp. 40234. Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Machine Learning* , Carbon Dioxide*/chemistry , Letrozole*/chemistry, Solubility ; Pressure ; Temperature

Ongoing pregnancy rate is associated with trigger-day progesterone level in letrozole/clomiphene intrauterine insemination cycles.

Autoren: Malcom CA Flannagan K Romanski PA et al.

Quelle: Journal of assisted reproduction and genetics [J Assist Reprod Genet] 2025 Nov; Vol. 42 (11), pp. 3947-3956. Date of Electronic Publication: 2025 Sep 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Netherlands NLM ID: 9206495 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7330 (Electronic) Linking ISSN: 10580468 NLM ISO Abbreviation: J Assist Reprod Genet Subsets: MEDLINE

MeSH-Schlagworte: Letrozole*/administration & dosage , Progesterone*/blood , Ovulation Induction*/methods , Insemination, Artificial*/methods , Clomiphene*/administration & dosage, Humans ; Female ; Pregnancy ; Adult ; Pregnancy Rate ; Fertilization in Vitro/methods ; Retrospective Studies ; Embryo Transfer/methods

Considerations for emulations of randomized controlled trials using real-world data: learnings from an emulation of MONALEESA-2.

Autoren: Kong AM Andrean D Khan S et al.

Quelle: Journal of comparative effectiveness research [J Comp Eff Res] 2025 Nov; Vol. 14 (11), pp. e250026. Date of Electronic Publication: 2025 Oct 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Becaris Publishing Country of Publication: England NLM ID: 101577308 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2042-6313 (Electronic) Linking ISSN: 20426305 NLM ISO Abbreviation: J Comp Eff Res Subsets: MEDLINE

MeSH-Schlagworte: Letrozole*/therapeutic use , Letrozole*/administration & dosage , Breast Neoplasms*/drug therapy , Breast Neoplasms*/mortality , Breast Neoplasms*/pathology , Randomized Controlled Trials as Topic* , Aminopyridines*/therapeutic use , Aminopyridines*/administration & dosage , Purines*/therapeutic use , Purines*/administration & dosage , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use, Humans ; Female ; Middle Aged ; Aged ; Antineoplastic Agents/therapeutic use ; Proportional Hazards Models

Effects of co administration of gonadotropins and letrozole during the ovarian stimulation on IVF outcome for poor responders: a systematic review and meta-analysis of randomized controlled trials.

Autoren: Zakerinasab F Khalili M AbdollahyBiroon F et al.

Quelle: BMC pregnancy and childbirth [BMC Pregnancy Childbirth] 2025 Oct 08; Vol. 25 (1), pp. 1046. Date of Electronic Publication: 2025 Oct 08.

Publikationsart: Journal Article; Systematic Review; Meta-Analysis

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 100967799 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2393 (Electronic) Linking ISSN: 14712393 NLM ISO Abbreviation: BMC Pregnancy Childbirth Subsets: MEDLINE

MeSH-Schlagworte: Letrozole*/administration & dosage , Ovulation Induction*/methods , Gonadotropins*/administration & dosage , Fertilization in Vitro*/methods , Aromatase Inhibitors*/administration & dosage , Nitriles*/administration & dosage , Triazoles*/administration & dosage, Humans ; Female ; Pregnancy ; Randomized Controlled Trials as Topic ; Pregnancy Rate ; Pregnancy Outcome

Amlodipine with letrozole as maintenance post-chemotherapy: targeting calcium calcineurin calmodulin pathway and aromatase inhibitor in disseminated endometrioid adenocarcinoma of the endometrium-a case report.

Autoren: Gharote MA Deshpande AA Kale AS

Quelle: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Oct; Vol. 398 (10), pp. 13903-13906. Date of Electronic Publication: 2025 Apr 15.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Amlodipine*/administration & dosage , Amlodipine*/therapeutic use , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Carcinoma, Endometrioid*/drug therapy , Carcinoma, Endometrioid*/pathology , Carcinoma, Endometrioid*/metabolism , Endometrial Neoplasms*/drug therapy , Endometrial Neoplasms*/pathology , Endometrial Neoplasms*/metabolism , Letrozole*/administration & dosage , Letrozole*/therapeutic use, Female ; Humans ; Aromatase Inhibitors/therapeutic use ; Aromatase Inhibitors/administration & dosage ; Calcium Channel Blockers/therapeutic use ; Calcium Channel Blockers/administration & dosage ; Calmodulin/metabolism ; Aged

Treatment of luteal phase mares with the aromatase inhibitor letrozole does not change characteristics of the estrous cycle, ovarian function, and embryo characteristics.

Autoren: Khan Y Gautier C Aurich C et al.

Quelle: Research in veterinary science [Res Vet Sci] 2025 Dec; Vol. 197, pp. 105935. Date of Electronic Publication: 2025 Oct 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: British Veterinary Association Country of Publication: England NLM ID: 0401300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2661 (Electronic) Linking ISSN: 00345288 NLM ISO Abbreviation: Res Vet Sci Subsets: MEDLINE

MeSH-Schlagworte: Letrozole*/pharmacology , Aromatase Inhibitors*/pharmacology , Estrous Cycle*/drug effects , Luteal Phase*/drug effects , Ovary*/drug effects , Ovary*/physiology , Embryo, Mammalian*/drug effects , Embryo, Mammalian*/physiology, Animals ; Female ; Horses/physiology ; Horses/embryology ; Pregnancy ; Progesterone/blood ; Estradiol/blood

Betaine alleviates letrozole-induced polycystic ovarian syndrome in rats by regulating oxidative stress and inflammation and restoring the proliferation-apoptosis balance.

Autoren: Babaeenezhad E Farzane Yegane D Yarahmadi S et al.

Quelle: Journal of ovarian research [J Ovarian Res] 2025 Nov 14; Vol. 18 (1), pp. 261. Date of Electronic Publication: 2025 Nov 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101474849 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-2215 (Electronic) Linking ISSN: 17572215 NLM ISO Abbreviation: J Ovarian Res Subsets: MEDLINE

MeSH-Schlagworte: Polycystic Ovary Syndrome*/drug therapy , Polycystic Ovary Syndrome*/chemically induced , Polycystic Ovary Syndrome*/pathology , Polycystic Ovary Syndrome*/metabolism , Oxidative Stress*/drug effects , Letrozole*/adverse effects , Betaine*/pharmacology , Betaine*/therapeutic use , Inflammation*/drug therapy , Inflammation*/metabolism, Animals ; Female ; Rats ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Disease Models, Animal ; Ovary/pathology ; Ovary/drug effects

A Novel Letrozole Stair-Step Duration Regimen for Ovulation Induction in Women with Polycystic Ovary Syndrome and Letrozole Resistance.

Autoren: Zhu X Lang J Zhi Y et al.

Quelle: Drug design, development and therapy [Drug Des Devel Ther] 2025 Sep 29; Vol. 19, pp. 8793-8803. Date of Electronic Publication: 2025 Sep 29 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE

MeSH-Schlagworte: Letrozole*/administration & dosage , Letrozole*/pharmacology , Polycystic Ovary Syndrome*/drug therapy , Ovulation Induction*/methods , Drug Resistance*/drug effects, Humans ; Female ; Adult ; Retrospective Studies ; Pregnancy ; Aromatase Inhibitors/administration & dosage ; Pregnancy Rate ; Ovulation/drug effects ; Young Adult

A novel therapeutic approach: The effect of letrozole-assisted synchronization on reproductive performance in suckling ewes during the non-breeding season.

Autoren: Uyanık G Abay M Gözer A et al.

Quelle: Theriogenology [Theriogenology] 2026 Feb 01; Vol. 251, pp. 117751. Date of Electronic Publication: 2025 Nov 10.

Publikationsart: Journal Article; Randomized Controlled Trial, Veterinary

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0421510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3231 (Electronic) Linking ISSN: 0093691X NLM ISO Abbreviation: Theriogenology Subsets: MEDLINE

MeSH-Schlagworte: Letrozole*/pharmacology , Estrus Synchronization*/methods , Estrus Synchronization*/drug effects , Aromatase Inhibitors*/pharmacology , Reproduction*/drug effects, Animals ; Female ; Sheep/physiology ; Pregnancy ; Animals, Suckling ; Progesterone/blood

Letrozole or tamoxifen co-administration during fertility preservation for patients affected by breast cancer.

Autoren: Lifshitz D Ben-Haroush A Meirow D et al.

Quelle: Reproductive biomedicine online [Reprod Biomed Online] 2025 Sep; Vol. 51 (3), pp. 104878. Date of Electronic Publication: 2025 Feb 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101122473 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-6491 (Electronic) Linking ISSN: 14726483 NLM ISO Abbreviation: Reprod Biomed Online Subsets: MEDLINE

MeSH-Schlagworte: Letrozole*/administration & dosage , Letrozole*/therapeutic use , Fertility Preservation*/methods , Tamoxifen*/administration & dosage , Tamoxifen*/therapeutic use , Breast Neoplasms*/drug therapy, Humans ; Female ; Retrospective Studies ; Adult ; Cryopreservation ; Follicle Stimulating Hormone/administration & dosage ; Follicle Stimulating Hormone/therapeutic use ; Oocytes/drug effects ; Ovulation Induction

Reproductive outcomes after letrozole stimulated versus artificial frozen-thawed embryo transfer cycles in women with PCOS and/or oligo-anovulation: a systematic review and meta-analysis.

Autoren: Bülow NS Wissing ML Macklon N et al.

Quelle: Human reproduction update [Hum Reprod Update] 2025 Sep 01; Vol. 31 (5), pp. 445-463.

Publikationsart: Journal Article; Systematic Review; Meta-Analysis

Info zur Zeitschrift: Publisher: Published for the European Society of Human Reproduction and Embryology by Oxford University Press Country of Publication: England NLM ID: 9507614 Publication Model: Print Cited Medium: Internet ISSN: 1460-2369 (Electronic) Linking ISSN: 13554786 NLM ISO Abbreviation: Hum Reprod Update Subsets: MEDLINE

MeSH-Schlagworte: Letrozole*/therapeutic use , Letrozole*/pharmacology , Polycystic Ovary Syndrome*/complications , Embryo Transfer*/methods , Ovulation Induction*/methods , Anovulation*/therapy, Humans ; Female ; Pregnancy ; Pregnancy Rate ; Pregnancy Outcome ; Cryopreservation

Considering its mechanism of action it may be logical to choose letrozole as an initial option for endometrium preparation before vitrified-warmed embryo transfer.

Autoren: Aydin G Aslan K Arac M et al.

Quelle: The journal of obstetrics and gynaecology research [J Obstet Gynaecol Res] 2025 Aug; Vol. 51 (8), pp. e70048.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley on behalf of the Japan Society of Obstetrics and Gynecology] Country of Publication: Australia NLM ID: 9612761 Publication Model: Print Cited Medium: Internet ISSN: 1447-0756 (Electronic) Linking ISSN: 13418076 NLM ISO Abbreviation: J Obstet Gynaecol Res Subsets: MEDLINE

MeSH-Schlagworte: Letrozole*/pharmacology , Letrozole*/administration & dosage , Embryo Transfer*/methods , Aromatase Inhibitors*/pharmacology , Aromatase Inhibitors*/administration & dosage , Endometrium*/drug effects , Hormone Replacement Therapy*/methods, Humans ; Female ; Pregnancy ; Adult ; Retrospective Studies ; Pregnancy Rate ; Fertilization in Vitro/methods ; Vitrification