Suchergebnisse - "LIPASES"

Deciphering the role of monoacylglycerol lipases (MAGL) under abiotic stress and lipid metabolism in soybean (Glycine max L.).

Autoren: Kumar V Mandlik R Kumawat S et al.

Quelle: Plant biotechnology journal [Plant Biotechnol J] 2025 Oct; Vol. 23 (10), pp. 4318-4335. Date of Electronic Publication: 2025 Jul 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley on behalf of the Society for Experimental Biology, Association of Applied Biologists Country of Publication: England NLM ID: 101201889 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1467-7652 (Electronic) Linking ISSN: 14677644 NLM ISO Abbreviation: Plant Biotechnol J Subsets: MEDLINE

MeSH-Schlagworte: Glycine max*/genetics , Glycine max*/enzymology , Glycine max*/metabolism , Glycine max*/physiology , Stress, Physiological*/genetics , Lipid Metabolism*/genetics , Monoacylglycerol Lipases*/metabolism , Monoacylglycerol Lipases*/genetics, Gene Expression Regulation, Plant ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Seeds/genetics ; Seeds/metabolism

MCH11, a new monoacylglycerol lipase inhibitor, reduces ethanol consumption and motivation to drink in mice, with sex-dependent differences.

Autoren: Torregrosa AB García-Gutiérrez MS Navarro D et al.

Quelle: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Nov; Vol. 192, pp. 118662. Date of Electronic Publication: 2025 Oct 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE

MeSH-Schlagworte: Monoacylglycerol Lipases*/antagonists & inhibitors , Monoacylglycerol Lipases*/metabolism , Alcohol Drinking*/drug therapy , Alcohol Drinking*/psychology , Alcohol Drinking*/prevention & control , Motivation*/drug effects , Enzyme Inhibitors*/pharmacology , Sex Characteristics*, Animals ; Male ; Female ; Mice, Inbred C57BL ; Mice ; Behavior, Animal/drug effects ; Ethanol/administration & dosage ; Self Administration ; Endocannabinoids/blood ; Dose-Response Relationship, Drug ; Ventral Tegmental Area/drug effects ; Ventral Tegmental Area/metabolism ; Impulsive Behavior/drug effects ; Sex Factors

Targeting MGLL: terazosin regulates glycerolipid metabolism to mitigate endothelial cell senescence.

Autoren: Huang J Yan J Wan Z et al.

Quelle: Journal of lipid research [J Lipid Res] 2025 Nov; Vol. 66 (11), pp. 100904. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0376606 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-7262 (Electronic) Linking ISSN: 00222275 NLM ISO Abbreviation: J Lipid Res Subsets: MEDLINE

MeSH-Schlagworte: Cellular Senescence*/drug effects , Prazosin*/analogs & derivatives , Prazosin*/pharmacology , Monoacylglycerol Lipases*/metabolism , Monoacylglycerol Lipases*/antagonists & inhibitors , Lipid Metabolism*/drug effects , Endothelial Cells*/drug effects , Endothelial Cells*/metabolism, Humans ; Animals ; Mice ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Male ; Mice, Inbred C57BL

Suppression of adipocyte ABHD6 favors anti-inflammatory and adipogenic programs to preserve adipose tissue fitness in obesity.

Autoren: Poursharifi P Attané C Chenier I et al.

Quelle: Molecular metabolism [Mol Metab] 2025 Nov; Vol. 101, pp. 102241. Date of Electronic Publication: 2025 Aug 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

MeSH-Schlagworte: Obesity*/metabolism , Adipogenesis*/physiology , Monoacylglycerol Lipases*/metabolism , Monoacylglycerol Lipases*/genetics , Adipocytes*/metabolism , Adipose Tissue*/metabolism, Animals ; Mice ; Female ; Mice, Knockout ; Humans ; Insulin Resistance ; Mice, Inbred C57BL ; Adipose Tissue, White/metabolism ; Diet, High-Fat/adverse effects ; Male ; Lipolysis ; Inflammation/metabolism ; Adult ; Energy Metabolism

Methods for Assessing MAGL Enzymatic Activity: An Extensive Review of Past and Emerging Approaches.

Autoren: Bononi G Landucci E Di Stefano M et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 09; Vol. 26 (19). Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Monoacylglycerol Lipases*/metabolism , Monoacylglycerol Lipases*/antagonists & inhibitors , Enzyme Assays*/methods, Humans ; Animals ; Enzyme Inhibitors/pharmacology ; Neoplasms/drug therapy ; Lipid Metabolism

Tritium-Labeled Compounds in PET Tracer Discovery? A Case Study from Roche's Internal Monoacylglycerol Lipase Program.

Autoren: Edelmann MR Gobbi LC Schmalzbauer S et al.

Quelle: ACS chemical neuroscience [ACS Chem Neurosci] 2025 Oct 01; Vol. 16 (19), pp. 3834-3850. Date of Electronic Publication: 2025 Sep 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

MeSH-Schlagworte: Positron-Emission Tomography*/methods , Tritium*/chemistry , Radiopharmaceuticals*/chemistry , Radiopharmaceuticals*/chemical synthesis , Monoacylglycerol Lipases*/metabolism , Monoacylglycerol Lipases*/antagonists & inhibitors, Animals ; Humans ; Brain/diagnostic imaging ; Brain/metabolism

Optimization of a naphthyl amide class identifies potent and selective reversible monoacylglycerol lipase (MAGL) inhibitors.

Autoren: Song C Yang N Deng H et al.

Quelle: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Oct 01; Vol. 128, pp. 118237. Date of Electronic Publication: 2025 May 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Monoacylglycerol Lipases*/antagonists & inhibitors , Monoacylglycerol Lipases*/metabolism , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Amides*/chemistry , Amides*/pharmacology , Amides*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Naphthalenes*/chemistry , Naphthalenes*/pharmacology , Naphthalenes*/chemical synthesis, Humans ; Animals ; Mice ; Structure-Activity Relationship ; Cell Proliferation/drug effects ; Molecular Structure ; Dose-Response Relationship, Drug ; Apoptosis/drug effects ; Cell Movement/drug effects

A novel approach for modeling in vivo enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase.

Autoren: Volpi T Holden D Gallezot JD et al.

Quelle: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2025 Oct; Vol. 45 (10), pp. 1947-1960. Date of Electronic Publication: 2025 May 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: SAGE Publications Country of Publication: United States NLM ID: 8112566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-7016 (Electronic) Linking ISSN: 0271678X NLM ISO Abbreviation: J Cereb Blood Flow Metab Subsets: MEDLINE

MeSH-Schlagworte: Positron-Emission Tomography*/methods , Brain*/diagnostic imaging , Brain*/enzymology , Brain*/metabolism , Brain*/drug effects , Monoacylglycerol Lipases*/metabolism , Monoacylglycerol Lipases*/antagonists & inhibitors , Enzyme Inhibitors*/pharmacology , Models, Biological*, Animals ; Proof of Concept Study ; Male

[ ³ H]T-401 binding to monoacylglycerol lipase (MAGL) in the brains of patients and mice with temporal lobe epilepsy.

Autoren: Aripaka SS Pazarlar BA Pinborg LH et al.

Quelle: Neuroscience [Neuroscience] 2025 Oct 01; Vol. 584, pp. 240-249. Date of Electronic Publication: 2025 Aug 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE

MeSH-Schlagworte: Epilepsy, Temporal Lobe*/metabolism , Epilepsy, Temporal Lobe*/enzymology , Epilepsy, Temporal Lobe*/pathology , Monoacylglycerol Lipases*/metabolism , Brain*/metabolism , Brain*/enzymology, Animals ; Humans ; Male ; Adult ; Female ; Middle Aged ; Mice ; Autoradiography ; Young Adult ; Tritium ; Mice, Inbred C57BL ; Temporal Lobe/metabolism ; Hippocampus/metabolism ; Aged

ABHD6 suppression attenuates pro-inflammatory responses in mice and promotes anti-inflammatory polarization of macrophages during endotoxin stress.

Autoren: Poursharifi P Schmitt C Chenier I et al.

Quelle: Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2026 Jan; Vol. 1871 (1), pp. 159694. Date of Electronic Publication: 2025 Oct 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731727 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2618 (Electronic) Linking ISSN: 13881981 NLM ISO Abbreviation: Biochim Biophys Acta Mol Cell Biol Lipids Subsets: MEDLINE

MeSH-Schlagworte: Macrophages*/metabolism , Macrophages*/drug effects , Monoacylglycerol Lipases*/antagonists & inhibitors , Monoacylglycerol Lipases*/genetics , Monoacylglycerol Lipases*/metabolism , Inflammation*/metabolism , Inflammation*/chemically induced , Endotoxemia*/metabolism , Endotoxemia*/chemically induced, Animals ; Mice ; Lipopolysaccharides/toxicity ; RAW 264.7 Cells ; Mice, Knockout ; Male ; Mice, Inbred C57BL ; Anti-Inflammatory Agents/pharmacology

Genetic suppression features ABHD18 as a Barth syndrome therapeutic target.

Autoren: Masud SN Srivastava A Mero P et al.

Quelle: Nature [Nature] 2025 Sep; Vol. 645 (8082), pp. 1029-1038. Date of Electronic Publication: 2025 Sep 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

MeSH-Schlagworte: Barth Syndrome*/genetics , Barth Syndrome*/drug therapy , Barth Syndrome*/enzymology , Barth Syndrome*/pathology , Barth Syndrome*/metabolism , Cardiolipins*/biosynthesis , Cardiolipins*/metabolism , Molecular Targeted Therapy* , Monoacylglycerol Lipases*/antagonists & inhibitors , Monoacylglycerol Lipases*/metabolism , Monoacylglycerol Lipases*/genetics, Humans ; Animals ; Mice ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondria/drug effects ; Zebrafish/genetics ; Zebrafish/embryology ; Lysophospholipids/biosynthesis ; Lysophospholipids/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription Factors/deficiency ; Fibroblasts/metabolism ; Fibroblasts/drug effects ; Female ; Male ; Mutation ; Disease Models, Animal ; Phenotype ; Acyltransferases

Cistanoside F acts as a Monoacylglycerol Lipase inhibitor that synergizes the anti-tumor effect of 2-Arachidonoyl Glycerol on Bladder cancer.

Autoren: Tan YJ Ren YS Lv JL et al.

Quelle: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Sep; Vol. 145, pp. 157046. Date of Electronic Publication: 2025 Jul 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH-Schlagworte: Monoacylglycerol Lipases*/antagonists & inhibitors , Monoacylglycerol Lipases*/metabolism , Urinary Bladder Neoplasms*/drug therapy , Urinary Bladder Neoplasms*/pathology , Glycerides*/pharmacology , Arachidonic Acids*/pharmacology , Endocannabinoids*/pharmacology , Antineoplastic Agents, Phytogenic*/pharmacology, Humans ; Animals ; Cell Line, Tumor ; Drug Synergism ; Protein Serine-Threonine Kinases/metabolism ; Mice ; Cell Proliferation/drug effects ; AMP-Activated Protein Kinase Kinases ; Mice, Nude ; Cell Movement/drug effects ; Mice, Inbred BALB C ; Xenograft Model Antitumor Assays ; Cell Survival/drug effects ; TOR Serine-Threonine Kinases/metabolism ; Enzyme Inhibitors/pharmacology

Neurochemical in vivo microdialysis and postmortem tissue analysis of amygdala endocannabinoid levels after MAGL- and FAAH-inhibition in rodents.

Autoren: Heins MS Ferger MD Voehringer P et al.

Quelle: Neurochemistry international [Neurochem Int] 2025 Sep; Vol. 188, pp. 106006. Date of Electronic Publication: 2025 Jun 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 8006959 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9754 (Electronic) Linking ISSN: 01970186 NLM ISO Abbreviation: Neurochem Int Subsets: MEDLINE

MeSH-Schlagworte: Endocannabinoids*/metabolism , Endocannabinoids*/analysis , Amidohydrolases*/antagonists & inhibitors , Amidohydrolases*/metabolism , Amygdala*/metabolism , Amygdala*/drug effects , Monoacylglycerol Lipases*/antagonists & inhibitors , Monoacylglycerol Lipases*/metabolism, Animals ; Microdialysis/methods ; Male ; Rats ; Carbamates/pharmacology ; Mice ; Arachidonic Acids/metabolism ; Rats, Sprague-Dawley ; Enzyme Inhibitors/pharmacology ; Polyunsaturated Alkamides/metabolism ; Biphenyl Compounds/pharmacology ; Mice, Inbred C57BL

Discovery of reversible monoacylglycerol lipase (MAGL) inhibitors based on ortho-hydroxyanilide scaffold.

Autoren: Bononi G Gado F Masoni S et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Aug; Vol. 163, pp. 108698. Date of Electronic Publication: 2025 Jun 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Drug Discovery* , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Monoacylglycerol Lipases*/antagonists & inhibitors , Monoacylglycerol Lipases*/metabolism, Humans ; Dose-Response Relationship, Drug ; Molecular Structure ; Structure-Activity Relationship

Genome-wide characterization of monoacylglycerol lipase (MAGL) gene family in soybean and functional analysis of GmMAGLs in storage lipid metabolism and drought resistance.

Autoren: Jing H Sun Y Wang B et al.

Quelle: BMC genomics [BMC Genomics] 2025 Jul 01; Vol. 26 (1), pp. 625. Date of Electronic Publication: 2025 Jul 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 100965258 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2164 (Electronic) Linking ISSN: 14712164 NLM ISO Abbreviation: BMC Genomics Subsets: MEDLINE

MeSH-Schlagworte: Monoacylglycerol Lipases*/genetics , Monoacylglycerol Lipases*/metabolism , Monoacylglycerol Lipases*/chemistry , Glycine max*/genetics , Glycine max*/enzymology , Glycine max*/metabolism , Glycine max*/physiology , Droughts* , Lipid Metabolism*/genetics , Multigene Family* , Plant Proteins*/genetics , Plant Proteins*/metabolism , Plant Proteins*/chemistry, Phylogeny ; Gene Expression Regulation, Plant ; Stress, Physiological/genetics ; Drought Resistance

Discovery of new covalent inhibitors of monoacylglycerol lipase with the nitrile warhead via SCARdock.

Autoren: Wang J Shi X Zheng Q et al.

Quelle: Bioorganic chemistry [Bioorg Chem] 2025 Jun 01; Vol. 159, pp. 108378. Date of Electronic Publication: 2025 Mar 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH-Schlagworte: Monoacylglycerol Lipases*/antagonists & inhibitors , Monoacylglycerol Lipases*/metabolism , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Nitriles*/chemistry , Nitriles*/pharmacology , Nitriles*/chemical synthesis , Drug Discovery*, Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Molecular Docking Simulation

Identifying a novel class of lead compounds for monoacylglycerol lipase inhibition: an integrated computational study.

Autoren: Azam F; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy,Qassim University, Buraydah 51452, Saudi Arabia. f.azam@qu.edu.sa.

Quelle: Cellular and molecular biology (Noisy-le-Grand, France) [Cell Mol Biol (Noisy-le-grand)] 2025 May 26; Vol. 71 (5), pp. 103-111. Date of Electronic Publication: 2025 May 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: C.M.B. Association Country of Publication: France NLM ID: 9216789 Publication Model: Electronic Cited Medium: Internet ISSN: 1165-158X (Electronic) Linking ISSN: 01455680 NLM ISO Abbreviation: Cell Mol Biol (Noisy-le-grand) Subsets: MEDLINE

MeSH-Schlagworte: Monoacylglycerol Lipases*/antagonists & inhibitors , Monoacylglycerol Lipases*/chemistry , Monoacylglycerol Lipases*/metabolism , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology, Molecular Docking Simulation ; Humans ; Molecular Dynamics Simulation ; Crystallography, X-Ray

Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU-005 reduces ex vivo cortical spreading depression.

Autoren: Brugia F Ivanov K Aroviita A et al.

Quelle: The journal of headache and pain [J Headache Pain] 2025 Apr 23; Vol. 26 (1), pp. 85. Date of Electronic Publication: 2025 Apr 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 100940562 Publication Model: Electronic Cited Medium: Internet ISSN: 1129-2377 (Electronic) Linking ISSN: 11292369 NLM ISO Abbreviation: J Headache Pain Subsets: MEDLINE

MeSH-Schlagworte: Monoacylglycerol Lipases*/antagonists & inhibitors , Monoacylglycerol Lipases*/metabolism , Amidohydrolases*/antagonists & inhibitors , Amidohydrolases*/metabolism , Cortical Spreading Depression*/drug effects , Cerebral Cortex*/drug effects, Animals ; Humans ; Mice ; Rats ; Rats, Wistar ; Mice, Inbred C57BL ; Male ; Endocannabinoids/metabolism ; HEK293 Cells ; Carbamates/pharmacology ; Enzyme Inhibitors/pharmacology ; Lipoprotein Lipase

Enhancement of the endocannabinoid system through monoacylglycerol lipase inhibition relieves migraine-associated pain in mice.

Autoren: Mangutov E Awad-Igbaria Y Siegersma K et al.

Quelle: The journal of headache and pain [J Headache Pain] 2025 Apr 18; Vol. 26 (1), pp. 84. Date of Electronic Publication: 2025 Apr 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 100940562 Publication Model: Electronic Cited Medium: Internet ISSN: 1129-2377 (Electronic) Linking ISSN: 11292369 NLM ISO Abbreviation: J Headache Pain Subsets: MEDLINE

MeSH-Schlagworte: Monoacylglycerol Lipases*/antagonists & inhibitors , Monoacylglycerol Lipases*/metabolism , Migraine Disorders*/drug therapy , Migraine Disorders*/complications , Migraine Disorders*/chemically induced , Migraine Disorders*/metabolism , Endocannabinoids*/metabolism , Enzyme Inhibitors*/pharmacology, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Female ; Disease Models, Animal ; Receptor, Cannabinoid, CB1/metabolism ; Hyperalgesia/drug therapy ; Nitroglycerin ; Trigeminal Ganglion/drug effects ; Trigeminal Ganglion/metabolism

Bioinformatics Analysis Identifies Sequence Determinants of Enzymatic Activity for the PHARC-Associated Lipase ABHD12.

Autoren: Chakraborty A Devarajan A Kumar K et al.

Quelle: Biochemistry [Biochemistry] 2025 Apr 15; Vol. 64 (8), pp. 1852-1863. Date of Electronic Publication: 2025 Mar 26.

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

MeSH-Schlagworte: Monoacylglycerol Lipases*/genetics , Monoacylglycerol Lipases*/metabolism , Monoacylglycerol Lipases*/chemistry , Retinitis Pigmentosa*/genetics , Retinitis Pigmentosa*/enzymology , Retinitis Pigmentosa*/metabolism , Polyneuropathies*/genetics , Polyneuropathies*/enzymology , Polyneuropathies*/metabolism, Animals ; Humans ; Computational Biology ; Mice ; Amino Acid Sequence ; Mutation ; Drosophila melanogaster ; Models, Molecular ; Ataxia ; Cataract

SCR Disease Name: Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract