Search Results - "LEUKEMIA"

Incidence, mortality, and survival associated with acute leukaemia subtypes by age group in China: a population-based cancer registry analysis and cohort study.

Authors: Yin W Yan X Cai J et al.

Corporate Authors: Yin W Yan X Cai J et al.

Source: The Lancet. Haematology [Lancet Haematol] 2025 Oct; Vol. 12 (10), pp. e808-e822.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101643584 Publication Model: Print Cited Medium: Internet ISSN: 2352-3026 (Electronic) Linking ISSN: 23523026 NLM ISO Abbreviation: Lancet Haematol Subsets: MEDLINE

MeSH Terms: Leukemia*/mortality , Leukemia*/epidemiology , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/epidemiology , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/mortality, Humans ; China/epidemiology ; Male ; Female ; Registries ; Incidence ; Child ; Adolescent ; Child, Preschool ; Infant ; Adult ; Middle Aged ; Infant, Newborn ; Young Adult ; Cohort Studies ; Aged ; Age Factors ; Leukemia, Myeloid, Acute/epidemiology ; Leukemia, Myeloid, Acute/mortality ; Survival Rate ; Survival Analysis

The promise of menin inhibitors: from approval to triplet regimens.

Authors: Thakur RK Wang ES

Source: Hematology. American Society of Hematology. Education Program [Hematology Am Soc Hematol Educ Program] 2025 Dec 05; Vol. 2025 (1), pp. 599-606.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 100890099 Publication Model: Print Cited Medium: Internet ISSN: 1520-4383 (Electronic) Linking ISSN: 15204383 NLM ISO Abbreviation: Hematology Am Soc Hematol Educ Program Subsets: MEDLINE

MeSH Terms: Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/genetics , Leukemia, Myeloid, Acute*/metabolism , Proto-Oncogene Proteins*/antagonists & inhibitors , Proto-Oncogene Proteins*/genetics , Proto-Oncogene Proteins*/metabolism, Humans ; Nucleophosmin ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Drug Approval ; Myeloid-Lymphoid Leukemia Protein/genetics ; Myeloid-Lymphoid Leukemia Protein/metabolism ; Mutation

[Use of Ommaya Reservoirs in the management of acute leukemias in children and adolescents: Guidelines from the French Society for Childhood and Adolescent Cancer and Leukemia (SFCE) Committee].

Transliterated Title: Utilisation des réservoirs d’Ommaya au cours du traitement des leucémies aiguës pédiatriques : recommandations du comité Leucémies de la Société française de lutte contre les cancers et leucémies de l’enfant et de l’adolescent (SFCE).

Authors: Rousseaux A Leglise C Goldwirt L et al.

Source: Bulletin du cancer [Bull Cancer] 2025 Dec; Vol. 112 (12), pp. 1438-1446. Date of Electronic Publication: 2025 Sep 17.

Publication Type: Journal Article; Practice Guideline; Multicenter Study; English Abstract

Journal Info: Publisher: Elsevier Country of Publication: France NLM ID: 0072416 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1769-6917 (Electronic) Linking ISSN: 00074551 NLM ISO Abbreviation: Bull Cancer Subsets: MEDLINE

MeSH Terms: Infusion Pumps, Implantable*/adverse effects , Leukemia*/drug therapy , Antineoplastic Agents*/administration & dosage, Humans ; Child ; Adolescent ; France ; Methotrexate/administration & dosage ; Methotrexate/pharmacokinetics ; Societies, Medical ; Cytarabine/administration & dosage ; Cytarabine/pharmacokinetics ; Surveys and Questionnaires ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Spinal Puncture ; Acute Disease

Effect of neutropenic diet with or without magnesium supplementation on inflammatory factors and outcomes of allogeneic hematopoietic stem cell transplantation in patients with acute leukemia: study protocol for a randomized clinical trial.

Authors: Abdolkarimi MJ Jowshan MR Parkhideh S et al.

Source: Trials [Trials] 2025 Oct 31; Vol. 26 (1), pp. 459. Date of Electronic Publication: 2025 Oct 31.

Publication Type: Journal Article; Clinical Trial Protocol

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE

MeSH Terms: Dietary Supplements* , Hematopoietic Stem Cell Transplantation*/adverse effects , Inflammation Mediators*/blood , Graft vs Host Disease*/prevention & control , Graft vs Host Disease*/etiology , Neutropenia*/diet therapy , Neutropenia*/etiology , Leukemia*/therapy , Leukemia*/blood , Magnesium*/administration & dosage, Humans ; Double-Blind Method ; Randomized Controlled Trials as Topic ; Iran ; Treatment Outcome ; Adult ; Female ; Male ; Adolescent ; Young Adult ; Middle Aged ; Biomarkers/blood ; Leukemia, Myeloid, Acute

NKX6-3 in B-Cell Progenitor Differentiation and Leukemia.

Authors: Nagel S Meyer C Pommerenke C

Source: Genes [Genes (Basel)] 2025 Oct 14; Vol. 16 (10). Date of Electronic Publication: 2025 Oct 14.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE

MeSH Terms: Homeodomain Proteins*/genetics , Homeodomain Proteins*/metabolism , Transcription Factors*/genetics , Transcription Factors*/metabolism , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/genetics , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/pathology , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/metabolism, Humans ; Cell Differentiation/genetics ; Cell Line, Tumor ; Gene Regulatory Networks ; Gene Expression Regulation, Leukemic ; Pre-B-Cell Leukemia Transcription Factor 1/genetics ; Pre-B-Cell Leukemia Transcription Factor 1/metabolism ; B-Lymphocytes/metabolism ; Basic Helix-Loop-Helix Transcription Factors

Identification of a novel PML exon 6 splice variant in atypical PML::RARα transcripts in acute promyelocytic leukemia.

Authors: Chen H Chen M Yang Z et al.

Source: Annals of hematology [Ann Hematol] 2025 Oct; Vol. 104 (10), pp. 5077-5084. Date of Electronic Publication: 2025 Sep 26.

Publication Type: Case Reports; Journal Article

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE

MeSH Terms: Alternative Splicing* , Exons*/genetics , Leukemia, Promyelocytic, Acute*/genetics , Leukemia, Promyelocytic, Acute*/diagnosis , Oncogene Proteins, Fusion*/genetics, Humans ; Neoplasm, Residual/genetics ; Promyelocytic Leukemia Protein/genetics ; Retinoic Acid Receptor alpha ; Translocation, Genetic

Endogenous T cell responses to fusion-derived neoantigens in pediatric acute leukemias.

Authors: Tirtakusuma R Ghonim MA Schattgen S et al.

Source: Leukemia [Leukemia] 2025 Oct; Vol. 39 (10), pp. 2419-2431. Date of Electronic Publication: 2025 Jul 24.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE

MeSH Terms: T-Lymphocytes*/immunology , Antigens, Neoplasm*/immunology , Antigens, Neoplasm*/genetics , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/immunology , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/therapy , Oncogene Proteins, Fusion*/immunology , Oncogene Proteins, Fusion*/genetics , Leukemia, Myeloid, Acute*/immunology , Leukemia, Myeloid, Acute*/therapy, Humans ; Child ; Child, Preschool ; Adolescent ; Male ; Female ; Immunotherapy, Adoptive/methods ; Myeloid-Lymphoid Leukemia Protein/genetics ; Infant ; Histone-Lysine N-Methyltransferase/genetics

Rational combination of homoharringtonine to selectively target FLT3-ITD acute myeloid leukemia through synthetic lethality.

Authors: Li Y Gao X Zhang H et al.

Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Oct; Vol. 146, pp. 157124. Date of Electronic Publication: 2025 Jul 29.

Publication Type: Journal Article

Journal Info: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH Terms: Homoharringtonine*/pharmacology , fms-Like Tyrosine Kinase 3*/antagonists & inhibitors , fms-Like Tyrosine Kinase 3*/genetics , fms-Like Tyrosine Kinase 3*/metabolism , Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/genetics , Harringtonines*/pharmacology , Antineoplastic Agents, Phytogenic*/pharmacology, Humans ; Animals ; Cell Line, Tumor ; Apoptosis/drug effects ; Sulfonamides/pharmacology ; Phenylurea Compounds/pharmacology ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Mice ; Xenograft Model Antitumor Assays ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Benzothiazoles/pharmacology ; Female ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; bcl-2-Associated X Protein/metabolism ; Mutation ; Aniline Compounds/pharmacology ; Staurosporine/analogs & derivatives ; Staurosporine/pharmacology ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Pyrazines

Overcoming venetoclax resistance through heme-mediated NOXA/cyclin D1/Mcl-1 axis with a novel artemisinin conjugate.

Authors: Zhang J Zhang Z Liu J et al.

Source: Blood advances [Blood Adv] 2025 Nov 11; Vol. 9 (21), pp. 5473-5488.

Publication Type: Journal Article

Journal Info: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE

MeSH Terms: Artemisinins*/pharmacology , Artemisinins*/chemistry , Artemisinins*/therapeutic use , Drug Resistance, Neoplasm*/drug effects , Sulfonamides*/pharmacology , Sulfonamides*/therapeutic use , Sulfonamides*/chemistry , Myeloid Cell Leukemia Sequence 1 Protein*/metabolism , Bridged Bicyclo Compounds, Heterocyclic*/pharmacology , Bridged Bicyclo Compounds, Heterocyclic*/therapeutic use , Proto-Oncogene Proteins c-bcl-2*/metabolism , Cyclin D1*/metabolism , Heme*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use, Humans ; Animals ; Mice ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Cell Line, Tumor ; Xenograft Model Antitumor Assays

The impact of social determinants of health on outcomes of brexucabtagene autoleucel in adults with relapsed/refractory B-cell acute lymphoblastic leukemia.

Authors: O'Connor TE Lin C Roloff GW et al.

Source: Bone marrow transplantation [Bone Marrow Transplant] 2025 Nov; Vol. 60 (11), pp. 1465-1471. Date of Electronic Publication: 2025 Aug 23.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8702459 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5365 (Electronic) Linking ISSN: 02683369 NLM ISO Abbreviation: Bone Marrow Transplant Subsets: MEDLINE

MeSH Terms: Social Determinants of Health* , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/therapy , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/mortality , Immunotherapy, Adoptive*/methods, Humans ; Male ; Female ; Adult ; Middle Aged ; Retrospective Studies ; Aged ; Recurrence ; Young Adult ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Adolescent

PML::RARα+ myeloid cells display metabolic alterations that can be targeted to treat resistant/relapse acute promyelocytic leukemias.

Authors: Zaza A Zardo G Banella C et al.

Source: Leukemia [Leukemia] 2025 Nov; Vol. 39 (11), pp. 2708-2720. Date of Electronic Publication: 2025 Sep 10.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE

MeSH Terms: Leukemia, Promyelocytic, Acute*/metabolism , Leukemia, Promyelocytic, Acute*/drug therapy , Leukemia, Promyelocytic, Acute*/pathology , Oncogene Proteins, Fusion*/metabolism , Oncogene Proteins, Fusion*/genetics , Drug Resistance, Neoplasm* , Myeloid Cells*/metabolism , Myeloid Cells*/drug effects , Myeloid Cells*/pathology , Retinoic Acid Receptor alpha*/metabolism, Humans ; Arsenic Trioxide ; Glycolysis/drug effects ; Tretinoin/pharmacology ; Oxidative Phosphorylation/drug effects ; Promyelocytic Leukemia Protein/metabolism ; Citric Acid Cycle ; Oxides/pharmacology ; Cell Line, Tumor ; Arsenicals/pharmacology

[A Clinical Study of Children with SIL-TAL1 -Positive Acute T-Lymphoblastic Leukemia].

Authors: Xue YJ Wang Y Zhang LP et al.

Source: Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2025 Oct; Vol. 33 (5), pp. 1262-1268.

Publication Type: English Abstract; Journal Article

Journal Info: Publisher: Zhongguo shi yan xue za zhi she Country of Publication: China NLM ID: 101084424 Publication Model: Print Cited Medium: Print ISSN: 1009-2137 (Print) Linking ISSN: 10092137 NLM ISO Abbreviation: Zhongguo Shi Yan Xue Ye Xue Za Zhi Subsets: MEDLINE

MeSH Terms: Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/diagnosis , Oncogene Proteins, Fusion*, Humans ; Prognosis ; Child ; Male ; Female ; Survival Rate ; T-Cell Acute Lymphocytic Leukemia Protein 1 ; Child, Preschool ; Leukocyte Count

Features of KRAS-mutated patients with chronic myelomonocytic leukemia with and without blast transformation in a national (ABCMML) and international cohort (BIOPORTAL).

Transliterated Title: Eigenschaften von Patienten mit KRAS-Mutation und chronischer myelomonozytärer Leukämie mit und ohne Blastentransformation in einer nationalen (ABCMML) und internationalen Kohorte (BIOPORTAL).

Authors: Weissenbacher M Geissler K

Source: Wiener medizinische Wochenschrift (1946) [Wien Med Wochenschr] 2025 Sep; Vol. 175 (11-12), pp. 274-281. Date of Electronic Publication: 2025 Jul 22.

Publication Type: Journal Article

Journal Info: Publisher: Springer Verlag Country of Publication: Austria NLM ID: 8708475 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1563-258X (Electronic) Linking ISSN: 00435341 NLM ISO Abbreviation: Wien Med Wochenschr Subsets: MEDLINE

MeSH Terms: Leukemia, Myelomonocytic, Chronic*/genetics , Leukemia, Myelomonocytic, Chronic*/mortality , Leukemia, Myelomonocytic, Chronic*/pathology , Proto-Oncogene Proteins p21(ras)*/genetics , Blast Crisis*/genetics , Blast Crisis*/mortality , Blast Crisis*/pathology , Mutation*/genetics, Humans ; Male ; Female ; Aged ; Cohort Studies ; Austria ; Aged, 80 and over ; Middle Aged ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/mortality ; Prognosis

Blood- and bone marrow-based mature T-cell and natural killer cell leukemias and lymphomas: a summary in the series of the 2023 SH/EAHP Workshop.

Authors: Wang W Czader M Wang SA

Source: American journal of clinical pathology [Am J Clin Pathol] 2025 Jul 11; Vol. 164 (1), pp. 7-25.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0370470 Publication Model: Print Cited Medium: Internet ISSN: 1943-7722 (Electronic) Linking ISSN: 00029173 NLM ISO Abbreviation: Am J Clin Pathol Subsets: MEDLINE

MeSH Terms: Killer Cells, Natural*/pathology , Bone Marrow*/pathology , Lymphoma, T-Cell*/pathology , Lymphoma, T-Cell*/diagnosis , Leukemia, T-Cell*/pathology , Leukemia, T-Cell*/diagnosis, Humans ; Leukemia, Large Granular Lymphocytic/pathology ; Leukemia, Large Granular Lymphocytic/diagnosis

Risk of early death after acute leukemia diagnosis among adolescents and young adults.

Authors: Berkman AM Andersen CR Puthenpura V et al.

Source: JNCI cancer spectrum [JNCI Cancer Spectr] 2025 Jul 01; Vol. 9 (4).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101721827 Publication Model: Print Cited Medium: Internet ISSN: 2515-5091 (Electronic) Linking ISSN: 25155091 NLM ISO Abbreviation: JNCI Cancer Spectr Subsets: MEDLINE

MeSH Terms: Precursor Cell Lymphoblastic Leukemia-Lymphoma*/mortality , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/diagnosis , Leukemia, Myeloid, Acute*/mortality , Leukemia, Myeloid, Acute*/diagnosis , Leukemia*/mortality, Humans ; Adolescent ; Male ; Young Adult ; Female ; SEER Program ; Risk Factors ; United States/epidemiology ; Age Factors ; Leukemia, Promyelocytic, Acute/mortality ; Leukemia, Promyelocytic, Acute/diagnosis ; Adult ; Logistic Models ; Sex Factors ; Incidence ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/mortality ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis

Leukemia inhibitory factor (LIF) in acute graft-versus-host disease: A hypothesis-generating review.

Authors: Meshkin A Zare F Abbasi ME et al.

Source: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2026 Jan; Vol. 282, pp. 110640. Date of Electronic Publication: 2025 Nov 13.

Publication Type: Journal Article; Review

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 100883537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-7035 (Electronic) Linking ISSN: 15216616 NLM ISO Abbreviation: Clin Immunol Subsets: MEDLINE

MeSH Terms: Graft vs Host Disease*/immunology , Leukemia Inhibitory Factor*/therapeutic use , Leukemia Inhibitory Factor*/immunology, Humans ; Animals ; Hematopoietic Stem Cell Transplantation/adverse effects ; Graft vs Leukemia Effect/immunology ; Acute Disease

Platelet Recovery and Its Impact on Outcomes After Allogeneic Hematopoietic Stem Cell Transplantation: A Japanese Nationwide Retrospective Study.

Authors: Kurita N Maruo K Kimura F et al.

Corporate Authors: Kurita N Maruo K Kimura F et al.

Source: American journal of hematology [Am J Hematol] 2026 Jan; Vol. 101 (1), pp. 193-197. Date of Electronic Publication: 2025 Oct 29.

Publication Type: Journal Article; Letter

Journal Info: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 7610369 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-8652 (Electronic) Linking ISSN: 03618609 NLM ISO Abbreviation: Am J Hematol Subsets: MEDLINE

MeSH Terms: Hematopoietic Stem Cell Transplantation* , Blood Platelets* , Leukemia*/therapy , Leukemia*/mortality , Leukemia*/blood, Humans ; Retrospective Studies ; Adult ; Male ; Middle Aged ; Japan/epidemiology ; Female ; Transplantation, Homologous ; Aged ; Platelet Count ; Thrombocytopenia/etiology ; Thrombocytopenia/therapy ; Thrombocytopenia/blood ; Registries ; Adolescent ; Cord Blood Stem Cell Transplantation ; Young Adult ; Treatment Outcome ; Allografts ; Leukemia, Myeloid, Acute/therapy ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/blood ; East Asian People

Early Palliative Care, Goals of Care Conversations and Quality EOL Care in Acute Leukemia and HR-MDS.

Authors: Potenza L Giusti D Borelli E et al.

Source: Journal of pain and symptom management [J Pain Symptom Manage] 2025 Aug; Vol. 70 (2), pp. 121-130.e3. Date of Electronic Publication: 2025 Apr 03.

Publication Type: Journal Article; Observational Study

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 8605836 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6513 (Electronic) Linking ISSN: 08853924 NLM ISO Abbreviation: J Pain Symptom Manage Subsets: MEDLINE

MeSH Terms: Leukemia, Myeloid, Acute*/pathology , Leukemia, Myeloid, Acute*/therapy , Myelodysplastic Syndromes*/pathology , Myelodysplastic Syndromes*/therapy , Palliative Care*/standards , Palliative Care*/statistics & numerical data , Patient Care Planning*/standards , Patient Care Planning*/statistics & numerical data , Terminal Care*/standards , Terminal Care*/statistics & numerical data , Quality of Health Care*/statistics & numerical data, Retrospective Studies ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Odds Ratio ; Humans ; Male ; Female ; Adult ; Middle Aged ; Aged ; Multivariate Analysis ; Communication

Use of integrated spatial transcriptomics and histopathological analysis in adamantinomatous craniopharyngiomas to identify stromal cells as a new cellular source of leukemia inhibitory factor.

Authors: Hu W Zhao C Zheng W et al.

Source: Journal of neurosurgery [J Neurosurg] 2025 Aug 01; Vol. 143 (5), pp. 1336-1349. Date of Electronic Publication: 2025 Aug 01 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: American Association of Neurological Surgeons Country of Publication: United States NLM ID: 0253357 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1933-0693 (Electronic) Linking ISSN: 00223085 NLM ISO Abbreviation: J Neurosurg Subsets: MEDLINE

MeSH Terms: Leukemia Inhibitory Factor*/metabolism , Leukemia Inhibitory Factor*/genetics , Craniopharyngioma*/pathology , Craniopharyngioma*/genetics , Craniopharyngioma*/metabolism , Stromal Cells*/metabolism , Stromal Cells*/pathology , Pituitary Neoplasms*/pathology , Pituitary Neoplasms*/genetics , Pituitary Neoplasms*/metabolism , Transcriptome*, Humans ; Female ; Male ; Adult ; Adolescent ; Child ; Gene Expression Profiling ; Middle Aged ; Leukemia Inhibitory Factor Receptor alpha Subunit/metabolism ; Leukemia Inhibitory Factor Receptor alpha Subunit/genetics ; Young Adult ; Single-Cell Analysis

Hexosamine biosynthesis dysfunction-induced LIFR N-glycosylation deficiency exacerbates steatotic liver ischemia/reperfusion injury.

Authors: Liu R Wang G Qian Y et al.

Source: Metabolism: clinical and experimental [Metabolism] 2025 Jul; Vol. 168, pp. 156258. Date of Electronic Publication: 2025 Apr 02.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE

MeSH Terms: Reperfusion Injury*/metabolism , Reperfusion Injury*/pathology , Hexosamines*/biosynthesis , Liver*/metabolism , Liver*/pathology , Leukemia Inhibitory Factor Receptor alpha Subunit*/metabolism , Leukemia Inhibitory Factor Receptor alpha Subunit*/genetics , Leukemia Inhibitory Factor Receptor alpha Subunit*/deficiency , Fatty Liver*/metabolism, Animals ; Glycosylation ; Mice ; Mice, Knockout ; Leukemia Inhibitory Factor/metabolism ; Leukemia Inhibitory Factor/genetics ; Male ; Hepatocytes/metabolism ; Mice, Inbred C57BL