Suchergebnisse - "LACTATE dehydrogenase"

Synthesis, molecular modeling, biological and pharmacokinetic evaluation of hydroxy pyrimidinones and pyrimidinediones as novel LDHA inhibitors.

Autoren: Sharma H Elliott T Good A et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118156. Date of Electronic Publication: 2025 Sep 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Pyrimidinones*/pharmacology , Pyrimidinones*/chemical synthesis , Pyrimidinones*/chemistry , Pyrimidinones*/pharmacokinetics , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacokinetics , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacokinetics , L-Lactate Dehydrogenase*/antagonists & inhibitors , L-Lactate Dehydrogenase*/metabolism , Pyrimidines*/pharmacology , Pyrimidines*/chemistry , Pyrimidines*/chemical synthesis , Pyrimidines*/pharmacokinetics, Humans ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Models, Molecular ; Animals ; Cell Line, Tumor ; Lactate Dehydrogenase 5/antagonists & inhibitors ; Drug Screening Assays, Antitumor ; Apoptosis/drug effects ; Rats

Proteomic Profiling Unraveling the Role of Lactate Dehydrogenase a in Vascular Repair and Functional Recovery after Spinal Cord Injury.

Autoren: Chopra M Kumar S Singh N et al.

Quelle: ACS chemical neuroscience [ACS Chem Neurosci] 2025 Dec 03; Vol. 16 (23), pp. 4519-4530. Date of Electronic Publication: 2025 Nov 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

MeSH-Schlagworte: Spinal Cord Injuries*/metabolism , Spinal Cord Injuries*/enzymology , Spinal Cord Injuries*/pathology , Spinal Cord Injuries*/drug therapy , Recovery of Function*/physiology , Recovery of Function*/drug effects , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/antagonists & inhibitors, Animals ; Proteomics/methods ; Lactate Dehydrogenase 5/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Signal Transduction/physiology ; Signal Transduction/drug effects ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; Rats ; Rats, Sprague-Dawley ; Endothelial Cells/metabolism ; Endothelial Cells/drug effects ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Lactic Acid/pharmacology ; Isoenzymes/metabolism ; Spinal Cord/metabolism ; Female

C1QTNF1-AS1/miR-346 axis suppresses osteosarcoma progression via dual inhibition of LDHA/PDK1-mediated Warburg effect.

Autoren: Zhang Y Hou J Ding K et al.

Quelle: BMC cancer [BMC Cancer] 2025 Nov 04; Vol. 25 (1), pp. 1698. Date of Electronic Publication: 2025 Nov 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE

MeSH-Schlagworte: Osteosarcoma*/pathology , Osteosarcoma*/genetics , Osteosarcoma*/metabolism , MicroRNAs*/genetics , MicroRNAs*/metabolism , Pyruvate Dehydrogenase Acetyl-Transferring Kinase*/metabolism , Pyruvate Dehydrogenase Acetyl-Transferring Kinase*/genetics , Warburg Effect, Oncologic* , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Bone Neoplasms*/pathology , Bone Neoplasms*/genetics , Bone Neoplasms*/metabolism , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/genetics, Humans ; Cell Line, Tumor ; Mice ; Animals ; Lactate Dehydrogenase 5/metabolism ; Lactate Dehydrogenase 5/genetics ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Cell Movement ; Disease Progression ; Drug Resistance, Neoplasm/genetics ; Xenograft Model Antitumor Assays ; Mice, Nude

CDK1-mediated phosphorylation of LDHA fuels mitosis through LDHB-dependent lactate oxidation.

Autoren: Liu M Cheng A You W et al.

Quelle: EMBO reports [EMBO Rep] 2025 Oct; Vol. 26 (20), pp. 4923-4949. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE

MeSH-Schlagworte: Mitosis* , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/genetics , L-Lactate Dehydrogenase*/chemistry , CDC2 Protein Kinase*/metabolism , Lactic Acid*/metabolism, Humans ; Phosphorylation ; Isoenzymes/metabolism ; Isoenzymes/genetics ; Oxidation-Reduction ; NAD/metabolism ; Lactate Dehydrogenase 5 ; Cell Line, Tumor ; Adenosine Triphosphate/metabolism ; HeLa Cells ; Neoplasms/metabolism ; Neoplasms/pathology

Lactate Metabolic Reprogramming Mediated by CircRNA-LDHA Complex Facilitates Innate Immune Evasion of Liver Cancer.

Autoren: Shen H Liu B He J et al.

Quelle: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Dec; Vol. 12 (45), pp. e09989. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH-Schlagworte: Liver Neoplasms*/immunology , Liver Neoplasms*/genetics , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , RNA, Circular*/genetics , RNA, Circular*/metabolism , Immunity, Innate*/genetics , Immunity, Innate*/immunology , Carcinoma, Hepatocellular*/immunology , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/metabolism , Lactic Acid*/metabolism , Lactate Dehydrogenase 5*/metabolism , Lactate Dehydrogenase 5*/genetics , Tumor Escape*/immunology, Humans ; Mice ; Animals ; Tumor Microenvironment/immunology ; Cell Line, Tumor ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Metabolic Reprogramming ; L-Lactate Dehydrogenase

CPSF6 loss mediates LDHA 3'UTR shortening to promote fibroblast glycolysis and pulmonary fibrosis.

Autoren: Yang H Han M Zhang L et al.

Quelle: Cellular signalling [Cell Signal] 2025 Dec; Vol. 136, pp. 112165. Date of Electronic Publication: 2025 Oct 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

MeSH-Schlagworte: Glycolysis*/genetics , Fibroblasts*/metabolism , Fibroblasts*/pathology , Pulmonary Fibrosis*/metabolism , Pulmonary Fibrosis*/genetics , Pulmonary Fibrosis*/pathology , 3' Untranslated Regions*/genetics , mRNA Cleavage and Polyadenylation Factors*/metabolism , mRNA Cleavage and Polyadenylation Factors*/genetics , L-Lactate Dehydrogenase*/genetics , L-Lactate Dehydrogenase*/metabolism, Animals ; Mice ; Humans ; Mice, Inbred C57BL ; MicroRNAs/metabolism ; MicroRNAs/genetics ; Lactate Dehydrogenase 5 ; Polyadenylation ; Male ; Cell Line

Neutrophil extracellular traps regulate LDHA expression to promote colorectal cancer liver metastasis.

Autoren: Li N Yang S Hu C et al.

Quelle: Journal of translational medicine [J Transl Med] 2025 Nov 03; Vol. 23 (1), pp. 1208. Date of Electronic Publication: 2025 Nov 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH-Schlagworte: Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/enzymology , Liver Neoplasms*/secondary , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics , Liver Neoplasms*/enzymology , Extracellular Traps*/metabolism , Gene Expression Regulation, Neoplastic* , Neutrophils*/metabolism , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/genetics, Humans ; Animals ; Cell Line, Tumor ; Cell Movement ; Epithelial-Mesenchymal Transition/genetics ; Mice, Nude ; Cell Proliferation ; Lactate Dehydrogenase 5/metabolism ; Neoplasm Invasiveness ; Mice ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Phosphatidylinositol 3-Kinases/metabolism ; Cell Communication ; Male

PSMD14-Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression.

Autoren: Lu RS Ren LK Fei XB et al.

Quelle: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Nov; Vol. 12 (44), pp. e05762. Date of Electronic Publication: 2025 Oct 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH-Schlagworte: Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/pathology , ATP Citrate (pro-S)-Lyase*/metabolism , ATP Citrate (pro-S)-Lyase*/genetics , Lactate Dehydrogenase 5*/metabolism , Lactate Dehydrogenase 5*/genetics , Proteasome Endopeptidase Complex*/metabolism , Proteasome Endopeptidase Complex*/genetics, Humans ; Mice ; Animals ; Ubiquitination ; Cell Line, Tumor ; Disease Progression ; Lipid Metabolism/genetics ; Mice, Nude ; L-Lactate Dehydrogenase

FAM111B enhances glycolysis and promotes metastasis of prostate cancer by upregulating LDHA.

Autoren: He Q Li H Cong Y et al.

Quelle: Neoplasia (New York, N.Y.) [Neoplasia] 2025 Nov; Vol. 69, pp. 101227. Date of Electronic Publication: 2025 Sep 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5586 (Electronic) Linking ISSN: 14765586 NLM ISO Abbreviation: Neoplasia Subsets: MEDLINE

MeSH-Schlagworte: Glycolysis*/genetics , Prostatic Neoplasms*/pathology , Prostatic Neoplasms*/metabolism , Prostatic Neoplasms*/genetics , Lactate Dehydrogenase 5*/genetics , Lactate Dehydrogenase 5*/metabolism, Male ; Humans ; Animals ; Mice ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Neoplasm Metastasis ; Up-Regulation ; Cell Proliferation ; L-Lactate Dehydrogenase

Mogroside V restores glycolytic function via LDHA promoter demethylation independent of alternative splicing in PCOS granulosa cells.

Autoren: Li S Wu J Lu R et al.

Quelle: The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2025 Nov; Vol. 254, pp. 106839. Date of Electronic Publication: 2025 Jul 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Country of Publication: England NLM ID: 9015483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1220 (Electronic) Linking ISSN: 09600760 NLM ISO Abbreviation: J Steroid Biochem Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: Alternative Splicing*/drug effects , Promoter Regions, Genetic*/drug effects , Glycolysis*/drug effects , Polycystic Ovary Syndrome*/metabolism , Polycystic Ovary Syndrome*/genetics , Polycystic Ovary Syndrome*/drug therapy , Polycystic Ovary Syndrome*/pathology , Granulosa Cells*/metabolism , Granulosa Cells*/drug effects , Granulosa Cells*/pathology , Triterpenes*/pharmacology , L-Lactate Dehydrogenase*/genetics , L-Lactate Dehydrogenase*/metabolism, Female ; Humans ; DNA Methylation/drug effects ; Demethylation/drug effects ; Lactate Dehydrogenase 5

Integrated multi-omics analysis reveals a glycolytic signature that predicts pan-cancer immune checkpoint inhibitor response and LDHA as a combinatorial target in fumarate hydratase-deficient renal cell carcinoma.

Autoren: Liu S Yuan Y He J et al.

Quelle: Frontiers in immunology [Front Immunol] 2025 Oct 03; Vol. 16, pp. 1666121. Date of Electronic Publication: 2025 Oct 03 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Renal Cell*/drug therapy , Carcinoma, Renal Cell*/genetics , Carcinoma, Renal Cell*/metabolism , Carcinoma, Renal Cell*/immunology , Kidney Neoplasms*/drug therapy , Kidney Neoplasms*/genetics , Kidney Neoplasms*/metabolism , Kidney Neoplasms*/immunology , Immune Checkpoint Inhibitors*/therapeutic use , Immune Checkpoint Inhibitors*/pharmacology , Glycolysis* , Fumarate Hydratase*/deficiency , Fumarate Hydratase*/genetics , Lactate Dehydrogenase 5*/genetics , Lactate Dehydrogenase 5*/metabolism, Humans ; Biomarkers, Tumor/genetics ; Multiomics ; L-Lactate Dehydrogenase

Decreased Glycolysis Due to Lactate Dehydrogenase A N ⁶ -Methyladenosine Methylation in Endometrium of Endometriosis Impairs Its Decidualization and Contributes to Related Infertility.

Autoren: Weng R Liu Y Xiong W

Quelle: The American journal of pathology [Am J Pathol] 2025 Dec; Vol. 195 (12), pp. 2431-2450. Date of Electronic Publication: 2025 Sep 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0370502 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-2191 (Electronic) Linking ISSN: 00029440 NLM ISO Abbreviation: Am J Pathol Subsets: MEDLINE

MeSH-Schlagworte: Endometriosis*/metabolism , Endometriosis*/pathology , Endometriosis*/complications , Adenosine*/analogs & derivatives , Adenosine*/metabolism , Glycolysis*/physiology , Endometrium*/metabolism , Endometrium*/pathology , Infertility, Female*/pathology , Infertility, Female*/metabolism , Infertility, Female*/etiology , L-Lactate Dehydrogenase*/metabolism , Decidua*/pathology , Decidua*/metabolism, Female ; Humans ; Animals ; Mice ; Lactate Dehydrogenase 5/metabolism ; Methylation ; Adult ; AlkB Homolog 5, RNA Demethylase/metabolism ; Apoptosis ; Stromal Cells/metabolism ; Stromal Cells/pathology

Selective Sensing of Lactate Dehydrogenase A by Naphthalene Diimide-Based AIEgen as a Diagnostic Probe toward Cancer Cells.

Autoren: Roy K Biswas S Basu D et al.

Quelle: Analytical chemistry [Anal Chem] 2025 Aug 19; Vol. 97 (32), pp. 17650-17658. Date of Electronic Publication: 2025 Aug 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE

MeSH-Schlagworte: Naphthalenes*/chemistry , Fluorescent Dyes*/chemistry , Fluorescent Dyes*/chemical synthesis , Imides*/chemistry , L-Lactate Dehydrogenase*/analysis , L-Lactate Dehydrogenase*/metabolism , Neoplasms*/diagnosis, Humans ; Lactate Dehydrogenase 5/analysis ; Nanoparticles/chemistry ; MCF-7 Cells ; Isoenzymes/analysis ; Isoenzymes/metabolism ; Cell Line, Tumor ; Spectrometry, Fluorescence

α-Hederin inhibited pancreatic cancer cell malignant progression by inhibiting LDHA-mediated glycolysis.

Autoren: Li J Liu J Wu Y et al.

Quelle: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Aug; Vol. 398 (8), pp. 10285-10294. Date of Electronic Publication: 2025 Feb 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/metabolism , Saponins*/pharmacology , Glycolysis*/drug effects , Oleanolic Acid*/analogs & derivatives , Oleanolic Acid*/pharmacology , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/antagonists & inhibitors , Antineoplastic Agents, Phytogenic*/pharmacology, Humans ; Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Apoptosis/drug effects ; Molecular Docking Simulation ; Lactate Dehydrogenase 5/metabolism ; Cell Movement/drug effects ; Mice, Nude ; Mice ; Mice, Inbred BALB C ; Xenograft Model Antitumor Assays

HIF-1α stabilization in osteoclasts induces the expression of aerobic glycolysis-related proteins GLUT1, LDHA, and MCT4.

Autoren: Nishioku T Nakao S Anzai R et al.

Quelle: Journal of pharmacological sciences [J Pharmacol Sci] 2025 Aug; Vol. 158 (4), pp. 336-342. Date of Electronic Publication: 2025 May 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Japanese Pharmacological Society Country of Publication: Japan NLM ID: 101167001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1347-8648 (Electronic) Linking ISSN: 13478613 NLM ISO Abbreviation: J Pharmacol Sci Subsets: MEDLINE

MeSH-Schlagworte: Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/physiology , Osteoclasts*/metabolism , Osteoclasts*/cytology , Monocarboxylic Acid Transporters*/metabolism , Monocarboxylic Acid Transporters*/genetics , Glycolysis*/genetics , Glucose Transporter Type 1*/genetics , Glucose Transporter Type 1*/metabolism , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/genetics , Muscle Proteins*/metabolism , Muscle Proteins*/genetics , Gene Expression*/drug effects , Gene Expression*/genetics, Animals ; Cell Differentiation/genetics ; Cell Differentiation/drug effects ; Lactate Dehydrogenase 5 ; Echinomycin/pharmacology ; Mice ; Cells, Cultured ; Protein Stability ; Bone Resorption

Metabolic alterations driven by LDHA in CD8 + T cells promote immune evasion and therapy resistance in NSCLC.

Autoren: Wen H Zhang P Zhao J et al.

Quelle: Scientific reports [Sci Rep] 2025 Jul 08; Vol. 15 (1), pp. 24440. Date of Electronic Publication: 2025 Jul 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Non-Small-Cell Lung*/immunology , Carcinoma, Non-Small-Cell Lung*/metabolism , Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/genetics , Carcinoma, Non-Small-Cell Lung*/therapy , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , Lung Neoplasms*/immunology , Lung Neoplasms*/metabolism , Lung Neoplasms*/pathology , Lung Neoplasms*/genetics , Lactate Dehydrogenase 5*/metabolism , Drug Resistance, Neoplasm* , Immune Evasion* , Tumor Escape*, Humans ; Tumor Microenvironment/immunology ; Glycolysis ; Prognosis ; Gene Expression Regulation, Neoplastic ; L-Lactate Dehydrogenase

Investigation of the inhibitory peptide effect as novel strategy in cancer treatment: Targeting the tetramerization of lactate dehydrogenase A.

Autoren: Jafary F Moradi A Ganjalikhany MR et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 May; Vol. 306 (Pt 1), pp. 140878. Date of Electronic Publication: 2025 Feb 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Peptides*/pharmacology , Peptides*/chemistry , L-Lactate Dehydrogenase*/antagonists & inhibitors , L-Lactate Dehydrogenase*/chemistry , L-Lactate Dehydrogenase*/metabolism , Neoplasms*/drug therapy , Neoplasms*/pathology , Neoplasms*/enzymology , Protein Multimerization*/drug effects , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry, Humans ; Animals ; Mice ; Cell Line, Tumor ; Apoptosis/drug effects ; Lactate Dehydrogenase 5/antagonists & inhibitors ; Lactate Dehydrogenase 5/chemistry ; Mice, Inbred BALB C

Role of lactate dehydrogenase A in the regulation of podocyte metabolism and glucose uptake under hyperglycemic conditions.

Autoren: Irena A Klaudia G Maria S et al.

Quelle: Scientific reports [Sci Rep] 2025 Apr 23; Vol. 15 (1), pp. 14162. Date of Electronic Publication: 2025 Apr 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Podocytes*/metabolism , Podocytes*/pathology , Glucose*/metabolism , Hyperglycemia*/metabolism , Hyperglycemia*/pathology , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/genetics, Animals ; Glycolysis ; Mice ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/pathology ; Humans ; Lactate Dehydrogenase 5/metabolism ; Isoenzymes/metabolism

Oxamate, an LDHA Inhibitor, Inhibits Stemness, Including EMT and High DNA Repair Ability, Induces Senescence, and Exhibits Radiosensitizing Effects in Glioblastoma Cells.

Autoren: Hashimoto T Ushikubo G Arao N et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Jun 14; Vol. 26 (12). Date of Electronic Publication: 2025 Jun 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Glioblastoma*/metabolism , Glioblastoma*/pathology , Glioblastoma*/drug therapy , Cellular Senescence*/drug effects , DNA Repair*/drug effects , Epithelial-Mesenchymal Transition*/drug effects , Radiation-Sensitizing Agents*/pharmacology , Neoplastic Stem Cells*/drug effects , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/radiation effects , Oxamic Acid*/pharmacology , L-Lactate Dehydrogenase*/antagonists & inhibitors , L-Lactate Dehydrogenase*/metabolism, Humans ; Cell Line, Tumor ; Radiation Tolerance/drug effects ; Apoptosis/drug effects ; Lactate Dehydrogenase 5 ; Isoenzymes/antagonists & inhibitors

Stallion spermatozoa express LDH isoforms A, B, and C, with LDHC playing a crucial role in sustaining sperm viability.

Autoren: Becerro-Rey L Martín-Cano FE Silva-Rodríguez A et al.

Quelle: Reproduction (Cambridge, England) [Reproduction] 2025 Jun 05; Vol. 170 (1). Date of Electronic Publication: 2025 Jun 05 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Published for the Society for Reproduction and Fertility by BioScientifica Country of Publication: England NLM ID: 100966036 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1741-7899 (Electronic) Linking ISSN: 14701626 NLM ISO Abbreviation: Reproduction Subsets: MEDLINE

MeSH-Schlagworte: Spermatozoa*/enzymology , Spermatozoa*/physiology , Spermatozoa*/metabolism , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/genetics, Male ; Animals ; Horses/metabolism ; Cell Survival ; Isoenzymes/metabolism ; Glycolysis ; Sperm Motility ; Mitochondria/enzymology ; Mitochondria/metabolism ; NAD/metabolism ; Lactate Dehydrogenase 5