Suchergebnisse - "L-Lactate Dehydrogenase"

Heterologous expression of L-lactate dehydrogenase in Chlorella pyrenoidosa: A beginning for poly(L-lactic acid) biosynthesis from CO 2 by eukaryotic microalgae.

Autoren: Zhang X Meng X Liang J et al.

Quelle: Journal of biotechnology [J Biotechnol] 2025 Oct; Vol. 406, pp. 136-146. Date of Electronic Publication: 2025 Jul 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8411927 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4863 (Electronic) Linking ISSN: 01681656 NLM ISO Abbreviation: J Biotechnol Subsets: MEDLINE

MeSH-Schlagworte: Chlorella*/genetics , Chlorella*/metabolism , Chlorella*/enzymology , Microalgae*/metabolism , Microalgae*/genetics , L-Lactate Dehydrogenase*/genetics , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/chemistry , Polyesters*/metabolism , Carbon Dioxide*/metabolism , Lactic Acid*/biosynthesis, Molecular Docking Simulation ; Animals

Synthesis, molecular modeling, biological and pharmacokinetic evaluation of hydroxy pyrimidinones and pyrimidinediones as novel LDHA inhibitors.

Autoren: Sharma H Elliott T Good A et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118156. Date of Electronic Publication: 2025 Sep 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Pyrimidinones*/pharmacology , Pyrimidinones*/chemical synthesis , Pyrimidinones*/chemistry , Pyrimidinones*/pharmacokinetics , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacokinetics , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacokinetics , L-Lactate Dehydrogenase*/antagonists & inhibitors , L-Lactate Dehydrogenase*/metabolism , Pyrimidines*/pharmacology , Pyrimidines*/chemistry , Pyrimidines*/chemical synthesis , Pyrimidines*/pharmacokinetics, Humans ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Models, Molecular ; Animals ; Cell Line, Tumor ; Lactate Dehydrogenase 5/antagonists & inhibitors ; Drug Screening Assays, Antitumor ; Apoptosis/drug effects ; Rats

Proteomic Profiling Unraveling the Role of Lactate Dehydrogenase a in Vascular Repair and Functional Recovery after Spinal Cord Injury.

Autoren: Chopra M Kumar S Singh N et al.

Quelle: ACS chemical neuroscience [ACS Chem Neurosci] 2025 Dec 03; Vol. 16 (23), pp. 4519-4530. Date of Electronic Publication: 2025 Nov 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

MeSH-Schlagworte: Spinal Cord Injuries*/metabolism , Spinal Cord Injuries*/enzymology , Spinal Cord Injuries*/pathology , Spinal Cord Injuries*/drug therapy , Recovery of Function*/physiology , Recovery of Function*/drug effects , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/antagonists & inhibitors, Animals ; Proteomics/methods ; Lactate Dehydrogenase 5/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Signal Transduction/physiology ; Signal Transduction/drug effects ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; Rats ; Rats, Sprague-Dawley ; Endothelial Cells/metabolism ; Endothelial Cells/drug effects ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Lactic Acid/pharmacology ; Isoenzymes/metabolism ; Spinal Cord/metabolism ; Female

Lactylation Genes LDHA and LDHC Alleviate Osteoarthritis by Reducing Specific B-Cell Expression: Mechanistic Exploration and Experimental Validation.

Autoren: Di J Guo Z Di Y et al.

Quelle: Journal of cellular and molecular medicine [J Cell Mol Med] 2025 Dec; Vol. 29 (23), pp. e70935.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE

MeSH-Schlagworte: B-Lymphocytes*/metabolism , B-Lymphocytes*/immunology , L-Lactate Dehydrogenase*/genetics , L-Lactate Dehydrogenase*/metabolism , Osteoarthritis, Knee*/genetics , Osteoarthritis, Knee*/pathology , Osteoarthritis, Knee*/metabolism , Lactate Dehydrogenase 5*/genetics , Lactate Dehydrogenase 5*/metabolism , Osteoarthritis*/genetics , Osteoarthritis*/pathology, Humans ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Cell Proliferation/genetics ; Cell Movement/genetics ; Gene Expression Regulation ; Genome-Wide Association Study ; Male

Unveiling the enzymatic activity of a dimeric LDH isoform and its implications for allosteric inhibition strategies.

Autoren: Nadal-Bufi F Van Gysel M Brustenga C et al.

Quelle: Protein science : a publication of the Protein Society [Protein Sci] 2025 Dec; Vol. 34 (12), pp. e70367.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

MeSH-Schlagworte: L-Lactate Dehydrogenase*/chemistry , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/antagonists & inhibitors , L-Lactate Dehydrogenase*/genetics , Protein Multimerization*/drug effects , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology, Humans ; Allosteric Regulation/drug effects ; Isoenzymes/chemistry ; Isoenzymes/metabolism ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/genetics ; NAD/metabolism ; NAD/chemistry ; Crystallography, X-Ray ; Models, Molecular

Disrupting bacterial metabolism by targeting LDH reverses aminoglycoside resistance in Streptococcus suis.

Autoren: Gao S Quan Y Song S et al.

Quelle: International journal of antimicrobial agents [Int J Antimicrob Agents] 2025 Dec; Vol. 66 (6), pp. 107599. Date of Electronic Publication: 2025 Aug 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 9111860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7913 (Electronic) Linking ISSN: 09248579 NLM ISO Abbreviation: Int J Antimicrob Agents Subsets: MEDLINE

MeSH-Schlagworte: Streptococcus suis*/drug effects , Streptococcus suis*/metabolism , Streptococcus suis*/enzymology , Anti-Bacterial Agents*/pharmacology , Aminoglycosides*/pharmacology , Drug Resistance, Bacterial*/drug effects , L-Lactate Dehydrogenase*/antagonists & inhibitors , L-Lactate Dehydrogenase*/metabolism, Animals ; Streptococcal Infections/drug therapy ; Streptococcal Infections/microbiology ; Microbial Sensitivity Tests ; Disease Models, Animal ; Drug Synergism ; Metabolic Networks and Pathways/drug effects

Lactate dehydrogenase B A Hypoxia and lactylation relative-gene as potential biomarkers for alcoholic liver disease: Integration of single-cell, bulk RNA-sequencing and experimental validation.

Autoren: Zhang W Wang YN Sun H

Quelle: Computational biology and chemistry [Comput Biol Chem] 2025 Dec; Vol. 119, pp. 108566. Date of Electronic Publication: 2025 Jun 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 101157394 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-928X (Electronic) Linking ISSN: 14769271 NLM ISO Abbreviation: Comput Biol Chem Subsets: MEDLINE

MeSH-Schlagworte: Liver Diseases, Alcoholic*/genetics , Liver Diseases, Alcoholic*/metabolism , Liver Diseases, Alcoholic*/diagnosis , L-Lactate Dehydrogenase*/genetics , L-Lactate Dehydrogenase*/metabolism, Humans ; Biomarkers/metabolism ; Biomarkers/analysis ; Animals ; Mice ; Sequence Analysis, RNA ; Single-Cell Analysis ; Male ; Mice, Inbred C57BL

CPSF6 loss mediates LDHA 3'UTR shortening to promote fibroblast glycolysis and pulmonary fibrosis.

Autoren: Yang H Han M Zhang L et al.

Quelle: Cellular signalling [Cell Signal] 2025 Dec; Vol. 136, pp. 112165. Date of Electronic Publication: 2025 Oct 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

MeSH-Schlagworte: Glycolysis*/genetics , Fibroblasts*/metabolism , Fibroblasts*/pathology , Pulmonary Fibrosis*/metabolism , Pulmonary Fibrosis*/genetics , Pulmonary Fibrosis*/pathology , 3' Untranslated Regions*/genetics , mRNA Cleavage and Polyadenylation Factors*/metabolism , mRNA Cleavage and Polyadenylation Factors*/genetics , L-Lactate Dehydrogenase*/genetics , L-Lactate Dehydrogenase*/metabolism, Animals ; Mice ; Humans ; Mice, Inbred C57BL ; MicroRNAs/metabolism ; MicroRNAs/genetics ; Lactate Dehydrogenase 5 ; Polyadenylation ; Male ; Cell Line

LDHA associated with telomerase-related genes promotes tumorigenesis and progression of lung adenocarcinoma.

Autoren: Pan D Zou B Wang Y et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 24; Vol. 15 (1), pp. 41677. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Adenocarcinoma of Lung*/genetics , Adenocarcinoma of Lung*/pathology , Telomerase*/genetics , Telomerase*/metabolism , Lung Neoplasms*/genetics , Lung Neoplasms*/pathology , Lactate Dehydrogenase 5*/genetics , Carcinogenesis*/genetics , L-Lactate Dehydrogenase*/genetics , L-Lactate Dehydrogenase*/metabolism, Humans ; Tumor Microenvironment/genetics ; Disease Progression ; Cell Proliferation/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Cell Movement/genetics ; Prognosis

C1QTNF1-AS1/miR-346 axis suppresses osteosarcoma progression via dual inhibition of LDHA/PDK1-mediated Warburg effect.

Autoren: Zhang Y Hou J Ding K et al.

Quelle: BMC cancer [BMC Cancer] 2025 Nov 04; Vol. 25 (1), pp. 1698. Date of Electronic Publication: 2025 Nov 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE

MeSH-Schlagworte: Osteosarcoma*/pathology , Osteosarcoma*/genetics , Osteosarcoma*/metabolism , MicroRNAs*/genetics , MicroRNAs*/metabolism , Pyruvate Dehydrogenase Acetyl-Transferring Kinase*/metabolism , Pyruvate Dehydrogenase Acetyl-Transferring Kinase*/genetics , Warburg Effect, Oncologic* , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Bone Neoplasms*/pathology , Bone Neoplasms*/genetics , Bone Neoplasms*/metabolism , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/genetics, Humans ; Cell Line, Tumor ; Mice ; Animals ; Lactate Dehydrogenase 5/metabolism ; Lactate Dehydrogenase 5/genetics ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Cell Movement ; Disease Progression ; Drug Resistance, Neoplasm/genetics ; Xenograft Model Antitumor Assays ; Mice, Nude

Neutrophil extracellular traps regulate LDHA expression to promote colorectal cancer liver metastasis.

Autoren: Li N Yang S Hu C et al.

Quelle: Journal of translational medicine [J Transl Med] 2025 Nov 03; Vol. 23 (1), pp. 1208. Date of Electronic Publication: 2025 Nov 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH-Schlagworte: Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/enzymology , Liver Neoplasms*/secondary , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics , Liver Neoplasms*/enzymology , Extracellular Traps*/metabolism , Gene Expression Regulation, Neoplastic* , Neutrophils*/metabolism , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/genetics, Humans ; Animals ; Cell Line, Tumor ; Cell Movement ; Epithelial-Mesenchymal Transition/genetics ; Mice, Nude ; Cell Proliferation ; Lactate Dehydrogenase 5/metabolism ; Neoplasm Invasiveness ; Mice ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Phosphatidylinositol 3-Kinases/metabolism ; Cell Communication ; Male

POU2F1 facilitates the malignant phenotypes and aerobic glycolysis of pituitary adenoma by activating LDHA transcription.

Autoren: Wang H Zhang F Li L et al.

Quelle: Brain research [Brain Res] 2025 Nov 01; Vol. 1866, pp. 149870. Date of Electronic Publication: 2025 Aug 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE

MeSH-Schlagworte: Pituitary Neoplasms*/metabolism , Pituitary Neoplasms*/genetics , Pituitary Neoplasms*/pathology , Lactate Dehydrogenase 5*/metabolism , Lactate Dehydrogenase 5*/genetics , Adenoma*/metabolism , Adenoma*/genetics , Adenoma*/pathology , Transcription Factor Pit-1*/metabolism , Transcription Factor Pit-1*/genetics , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/genetics, Humans ; Glycolysis/physiology ; Animals ; Cell Line, Tumor ; Mice ; Cell Proliferation/physiology ; Mice, Nude ; Apoptosis ; Gene Expression Regulation, Neoplastic ; Phenotype ; Cell Movement/physiology ; Mice, Inbred BALB C ; Neoplasm Invasiveness ; Male

Mogroside V restores glycolytic function via LDHA promoter demethylation independent of alternative splicing in PCOS granulosa cells.

Autoren: Li S Wu J Lu R et al.

Quelle: The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2025 Nov; Vol. 254, pp. 106839. Date of Electronic Publication: 2025 Jul 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Country of Publication: England NLM ID: 9015483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1220 (Electronic) Linking ISSN: 09600760 NLM ISO Abbreviation: J Steroid Biochem Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: Alternative Splicing*/drug effects , Promoter Regions, Genetic*/drug effects , Glycolysis*/drug effects , Polycystic Ovary Syndrome*/metabolism , Polycystic Ovary Syndrome*/genetics , Polycystic Ovary Syndrome*/drug therapy , Polycystic Ovary Syndrome*/pathology , Granulosa Cells*/metabolism , Granulosa Cells*/drug effects , Granulosa Cells*/pathology , Triterpenes*/pharmacology , L-Lactate Dehydrogenase*/genetics , L-Lactate Dehydrogenase*/metabolism, Female ; Humans ; DNA Methylation/drug effects ; Demethylation/drug effects ; Lactate Dehydrogenase 5

Engineering of Clostridium thermocellum lactate dehydrogenase: Effects on enzyme catalytic properties and bacterial metabolism.

Autoren: Ponsetto P Sasal EM Catucci G et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 329 (Pt 2), pp. 147883. Date of Electronic Publication: 2025 Sep 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Clostridium thermocellum*/enzymology , Clostridium thermocellum*/genetics , Clostridium thermocellum*/metabolism , L-Lactate Dehydrogenase*/genetics , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/chemistry , Biocatalysis* , Protein Engineering*, NAD/metabolism ; Lactic Acid/biosynthesis ; Mutation

Inhibition Profiling of Rhodiola crenulata on Lactate Dehydrogenase Isoenzymes.

Autoren: Wei YX Asgari M Zhao QF et al.

Quelle: Molecules (Basel, Switzerland) [Molecules] 2025 Oct 27; Vol. 30 (21). Date of Electronic Publication: 2025 Oct 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

MeSH-Schlagworte: L-Lactate Dehydrogenase*/antagonists & inhibitors , L-Lactate Dehydrogenase*/chemistry , L-Lactate Dehydrogenase*/metabolism , Rhodiola*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry, Molecular Docking Simulation ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/chemistry ; Cell Survival/drug effects ; Cell Line, Tumor ; Kaempferols/chemistry ; Kaempferols/pharmacology

Temperature adaptation in structure and function in lactate dehydrogenase-A reflects convergent evolution in a few key protein regions.

Autoren: Zhu XL Liao ML Ma LX et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Oct 21; Vol. 122 (42), pp. e2517759122. Date of Electronic Publication: 2025 Oct 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: L-Lactate Dehydrogenase*/genetics , L-Lactate Dehydrogenase*/chemistry , L-Lactate Dehydrogenase*/metabolism , Evolution, Molecular* , Adaptation, Physiological*/genetics, Animals ; Zebrafish/genetics ; Temperature ; Isoenzymes/genetics ; Isoenzymes/chemistry ; Isoenzymes/metabolism ; Amino Acid Substitution ; Amino Acid Sequence ; Mutagenesis, Site-Directed

Metabolic Engineering of Lactococcus lactis for the Enhanced Production of Lactate by Manipulating Pyruvate Dehydrogenase Complex E2 and Lactate Dehydrogenase.

Autoren: Zhang X Montalbán-López M Li X et al.

Quelle: Journal of agricultural and food chemistry [J Agric Food Chem] 2025 Oct 08; Vol. 73 (40), pp. 25549-25561. Date of Electronic Publication: 2025 Sep 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Lactococcus lactis*/genetics , Lactococcus lactis*/metabolism , Lactococcus lactis*/enzymology , Lactic Acid*/biosynthesis , Lactic Acid*/metabolism , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/genetics , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Pyruvate Dehydrogenase Complex*/metabolism , Pyruvate Dehydrogenase Complex*/genetics, Metabolic Engineering

The Shaping of Enzymatic Free Energy Barriers through the Creation of Rate-Promoting Vibrations via Inter-Residue Cross-Talk on Multiple Time Scales.

Autoren: Roy RK Antoniou D Schwartz SD

Quelle: The journal of physical chemistry. B [J Phys Chem B] 2025 Oct 02; Vol. 129 (39), pp. 9973-9982. Date of Electronic Publication: 2025 Sep 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101157530 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5207 (Electronic) Linking ISSN: 15205207 NLM ISO Abbreviation: J Phys Chem B Subsets: MEDLINE

MeSH-Schlagworte: L-Lactate Dehydrogenase*/chemistry , L-Lactate Dehydrogenase*/metabolism, Vibration ; Thermodynamics ; Pyruvic Acid/metabolism ; Pyruvic Acid/chemistry ; Molecular Dynamics Simulation

Tumor-Derived Lactate Drives Malignant Progression of Refractory Papillary Thyroid Carcinoma via the H3K18la-STAT1-LDHA Axis.

Autoren: Zhou Z He C Wang X et al.

Quelle: International journal of biological sciences [Int J Biol Sci] 2025 Oct 01; Vol. 21 (14), pp. 6373-6388. Date of Electronic Publication: 2025 Oct 01 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE

MeSH-Schlagworte: Thyroid Cancer, Papillary*/metabolism , Thyroid Cancer, Papillary*/pathology , Thyroid Cancer, Papillary*/genetics , Lactic Acid*/metabolism , Histones*/metabolism , Thyroid Neoplasms*/metabolism , Thyroid Neoplasms*/pathology , STAT1 Transcription Factor*/metabolism , STAT1 Transcription Factor*/genetics , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/genetics, Humans ; Cell Line, Tumor ; Disease Progression ; Female ; Male

CDK1-mediated phosphorylation of LDHA fuels mitosis through LDHB-dependent lactate oxidation.

Autoren: Liu M Cheng A You W et al.

Quelle: EMBO reports [EMBO Rep] 2025 Oct; Vol. 26 (20), pp. 4923-4949. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE

MeSH-Schlagworte: Mitosis* , L-Lactate Dehydrogenase*/metabolism , L-Lactate Dehydrogenase*/genetics , L-Lactate Dehydrogenase*/chemistry , CDC2 Protein Kinase*/metabolism , Lactic Acid*/metabolism, Humans ; Phosphorylation ; Isoenzymes/metabolism ; Isoenzymes/genetics ; Oxidation-Reduction ; NAD/metabolism ; Lactate Dehydrogenase 5 ; Cell Line, Tumor ; Adenosine Triphosphate/metabolism ; HeLa Cells ; Neoplasms/metabolism ; Neoplasms/pathology