Výsledky vyhľadávania - "Katayama, Shintaro"

Signs of immune dysregulation in second-trimester maternal blood RNA profiles in late-onset preeclampsia.

Autori: Gunaydin, Gamze Yazgeldi Ezer, Sini Wedenoja, Juho a ďalší

Zdroj: Scientific Reports; 11/26/2025, Vol. 15 Issue 1, p1-11, 11p

Oxygen level alters energy metabolism in bovine preimplantation embryos.

Autori: Boskovic, Nina Ivask, Marilin Yazgeldi Gunaydin, Gamze a ďalší

Zdroj: Scientific Reports; 4/3/2025, Vol. 15 Issue 1, p1-13, 13p

RNA sequencing of mRNA 5'-ends reveals regulators of bovine embryonic genome activation.

Autori: Yaşar, Barış Boskovic, Nina Org, Tõnis a ďalší

Zdroj: BMC Genomics; 10/14/2025, Vol. 26 Issue 1, p1-15, 15p

Predmety: RNA sequencing, TRANSCRIPTION factors, HOMEOBOX genes, EMBRYOLOGY, MESSENGER RNA, GENETIC regulation

The functional role of CST1 and CCL26 in asthma development

Autori: Hoyer, Angela Chakraborty, Sandip Lilienthal, Ingrid a ďalší

Prispievatelia: Hoyer, Angela Chakraborty, Sandip Lilienthal, Ingrid a ďalší

Predmety: A549, Ccl26, Cst1, Olink, RNA sequencing, Allergic asthma, General medicine, internal medicine and other clinical medicine

Popis súboru: application/pdf

Relation: The authors acknowledge the support from the National Genomics Infrastructure in Stockholm funded by Science for Life Laboratory, the Knut and Alice Wallenberg Foundation and the Swedish Research Council, and SNIC/Uppsala Multidisciplinary Center for Advanced Computational Science for assistance with massively parallel sequencing and access to the UPPMAX computational infrastructure. Support by NBIS (National Bioinformatics Infrastructure Sweden) is gratefully acknowledged. The authors would also like to thank the Affinity Proteomics-Stockholm Facility at SciLifeLab for conducting the Olink proximity extension assay analyses.; Hoyer , A , Chakraborty , S , Lilienthal , I , Konradsen , J R , Katayama , S & Söderhäll , C 2024 , ' The functional role of CST1 and CCL26 in asthma development ' , Immunity, Inflammation and Disease , vol. 12 , no. 1 , e1162 . https://doi.org/10.1002/iid3.1162; http://hdl.handle.net/10138/570773; 85182678301; 001145553600001

Dostupnosť: http://hdl.handle.net/10138/570773

Molecular cloning of PRD-like homeobox genes expressed in bovine oocytes and early IVF embryos.

Autori: Yaşar, Barış Boskovic, Nina Ivask, Marilin a ďalší

Zdroj: BMC Genomics; 11/7/2024, Vol. 25 Issue 1, p1-16, 16p

Predmety: HOMEOBOX genes, SINGLE nucleotide polymorphisms, MOLECULAR cloning, CATTLE, EMBRYOLOGY

B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors.

Autori: Kaemena, Daniel F. Yoshihara, Masahito Beniazza, Meryam a ďalší

Zdroj: Nature Communications; 1/30/2023, Vol. 14 Issue 1, p1-16, 16p

Human endometrial cell-type-specific RNA sequencing provides new insights into the embryo–endometrium interplay.

Autori: Koel, Mariann Krjutškov, Kaarel Saare, Merli a ďalší

Zdroj: Human Reproduction Open; 2022, Vol. 2022 Issue 4, p1-15, 15p

Predmety: RNA sequencing, ENDOMETRIUM, GALECTINS

The effect of type 1 diabetes protection and susceptibility associated HLA class II genotypes on DNA methylation in immune cells.

Autori: Pahkuri, Sirpa Katayama, Shintaro Valta, Milla a ďalší

Zdroj: HLA: Immune Response Genetics; Jun2024, Vol. 103 Issue 6, p1-12, 12p

Predmety: TYPE 1 diabetes, DNA methylation, GENOTYPES, DNA microarrays, EPIGENOMICS, ANTIGEN presentation

Revealing myopathy spectrum: integrating transcriptional and clinical features of human skeletal muscles with varying health conditions.

Autori: Zhong, Huahua Sian, Veronica Johari, Mridul a ďalší

Zdroj: Communications Biology; 4/10/2024, Vol. 7 Issue 1, p1-9, 9p

Predmety: INCLUSION body myositis, NEMALINE myopathy, MUSCLE diseases, TRINUCLEOTIDE repeats, SKELETAL muscle, MAGNETIC resonance imaging, POLYMERASE chain reaction

Effects of exercise on whole‐blood transcriptome profile in children with overweight/obesity.

Autori: Altmäe, Signe Plaza‐Florido, Abel Esteban, Francisco J. a ďalší

Zdroj: American Journal of Human Biology; Feb2024, Vol. 36 Issue 2, p1-16, 16p

Predmety: OVERWEIGHT children, CHILDHOOD obesity, T cell receptors, EXERCISE therapy, TRANSCRIPTOMES, GENE expression profiling

Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells.

Autori: Wagner, Magdalena Yoshihara, Masahito Douagi, Iyadh a ďalší

Zdroj: Nature Communications; 3/2/2020, Vol. 11 Issue 1, p1-15, 15p

Predmety: STEM cells, CELL populations, CELL surface antigens, OVARIAN reserve, HUMAN stem cells, OVUM, OVARIAN follicle

Dielectric Property of a Large‐Scale Transferred Single‐Crystal BaTiO3 Film Prepared Using a Water‐Soluble Sacrificial Buffering Layer.

Autori: Yasuhara, Sou Kikuchi, Taisei Katayama, Tsukasa a ďalší

Zdroj: Advanced Materials Interfaces; 11/22/2025, Vol. 12 Issue 22, p1-6, 6p

Predmety: BARIUM titanate, THIN films, SINGLE crystals, CRYSTALLINITY, BUFFER layers, FLEXIBLE electronics, DIELECTRIC properties

The Continued Absence of Functional Germline Stem Cells in Adult Ovaries.

Autori: Yoshihara, Masahito Wagner, Magdalena Damdimopoulos, Anastasios a ďalší

Zdroj: Stem Cells; Feb2023, Vol. 41 Issue 2, p105-110, 6p

Predmety: STEM cells, OVARIES, GERM cells, CELL analysis, ADULTS, REPRODUCTION

Viral infection‐related gene upregulation in monocytes in children with signs of β‐cell autoimmunity.

Autori: Valta, Milla Yoshihara, Masahito Einarsdottir, Elisabet a ďalší

Zdroj: Pediatric Diabetes; Sep2022, Vol. 23 Issue 6, p703-713, 11p

Predmety: GENETICS of virus diseases, AUTOANTIBODIES, TYPE 1 diabetes, CASE-control method, ISLANDS of Langerhans, LYMPHOCYTES, VIRUS diseases, GENE expression profiling, IMMUNITY, SYMPTOMS, DESCRIPTIVE statistics, MONOCYTES, CHILDREN

Geografický termín: FINLAND

Transient DUX4 expression in human embryonic stem cells induces blastomere-like expression program that is marked by SLC34A2

Autori: Yoshihara, Masahito Kirjanov, Ida Nykänen, Sonja a ďalší

Prispievatelia: Yoshihara, Masahito Kirjanov, Ida Nykänen, Sonja a ďalší

Predmety: Biochemistry, cell and molecular biology, Zygotic genome activation, Transcription factors, Gene, Naive

Popis súboru: application/pdf

Relation: The authors thank Dr. Gerd Ritter (Ludwig Institute for Cancer Research, New York City, USA) for kindly providing anti-NaPi2b monoclonal antibody (MX35). The STRT whole-culture RNA-seq and scRNA-seq were carried out at the Biomedicum Functional Genomics Unit (FuGU), University of Helsinki and FIMM Single-Cell Analytics unit supported by HiLIFE and Biocenter Finland, respectively. The flow cytometry analyses and FACS were performed at the HiLIFE Flow Cytometry Unit, and the confocal imaging was performed at the HiLIFE Biomedicum Imaging Unit, both at the University of Helsinki. The live-cell imaging was performed at the Biomedicum Stem Cell Center, the University of Helsinki, supported by HiLIFE and Biocenter Finland. Most of the computations for this work were performed on resources provided by the Swedish National Infrastructure for Computing (SNIC) through the Uppsala Multidisciplinary Center for Advanced Computational Science (UPPMAX) under project SNIC 2017/7-317. M.Y. was supported by Scandinavia-Japan Sasakawa Foundation, Japan Eye Bank Association, Astellas Foundation for Research on Metabolic Disorders, and Japan Society for the Promotion of Science (JSPS) Overseas Research Fellowships. S.N. was supported by the University of Helsinki Doctoral Program in Biomedicine. S.V. lab was supported by the research project grants from the Sigrid Juse ' lius Foundation and the University of Helsinki. Work in the J.K. lab was supported by Jane and Aatos Erkko Foundation, Sigrid Juse ' lius Foundation, Swedish Research Council, the Finnish Medical Society Finska Lakaresallskapet, and Foreningen Livoch Halsa. Work in the T.O. lab was supported by Jane and Aatos Erkko Foundation and Helsinki University Hospital funds. J.W. was supported by Sigrid Juse ' lius Foundation and Paivikki and Sakari Sohlberg Foundation. S.K. was supported by Jane and Aatos Erkko Foundation. The preprint of this work was first deposited on bioRxiv (https://doi. org/10.1101/2021.08.25.457357) on August 27, 2021.; http://hdl.handle.net/10138/346605; 000827592600001

Dostupnosť: http://hdl.handle.net/10138/346605

Generation of RNA sequencing libraries for transcriptome analysis of globin-rich tissues of the domestic dog

Autori: DoGA consortium Ezer, Sini Yoshihara, Masahito a ďalší

Prispievatelia: DoGA consortium Ezer, Sini Yoshihara, Masahito a ďalší

Predmety: Biomedicine, Genetics, developmental biology, physiology, Veterinary science

Popis súboru: application/pdf

Relation: All funding sources; The Academy of Finland , HiLife , Jane and Aatos Erkko Foundation , Sigrid Jusélius Foundation , Scandinavia–Japan Sasakawa Foundation , Japan Eye Bank Association , Astellas Foundation for Research on Metabolic Disorders , Japan Society for the Promotion of Science (JSPS) Overseas Research Fellowships. All funding sources; The Academy of Finland, HiLife, Jane and Aatos Erkko Foundation, Sigrid Jus?lius Foundation, Scandinavia?Japan Sasakawa Foundation, Japan Eye Bank Association, Astellas Foundation for Research on Metabolic Disorders, Japan Society for the Promotion of Science (JSPS) Overseas Research Fellowships. We thank Auli Saarinen and Mari Tervaniemi for technical assistance and Biomedicum Functional Genomics Unit (FuGU), University of Helsinki, for library sequencing services. Part of the computations were performed on resources provided by SNIC through Uppsala Multidisciplinary Center for Advanced Computational Science (UPPMAX) under Project SNIC 2017/7-317. S.E. prepared the libraries and wrote the manuscript. K.K. developed the protocol. M.Y. and S.K. developed and performed the data analysis. J.K. C.D. and H.L. conceived and designed the project and directed the work. DOGA consortium collected and prepared the animal tissues. The authors declare no competing interests.; http://hdl.handle.net/10138/341385; 001052294000001

Dostupnosť: http://hdl.handle.net/10138/341385

SkewC : Identifying cells with skewed gene body coverage in single-cell RNA sequencing data

Autori: Abugessaisa, Imad Hasegawa, Akira Noguchi, Shuhei a ďalší

Prispievatelia: Abugessaisa, Imad Hasegawa, Akira Noguchi, Shuhei a ďalší

Predmety: EXPRESSION, HETEROGENEITY, PROGRAMS, NOISE, FATE, Biomedicine

Popis súboru: application/pdf

Relation: We greatly appreciate the efforts of Nobuyu Takeda, Teruaki Kitakura, and Akira Furukawa in providing technical support and the IT infrastructure. We are thankful for the English proofreading by Scott Walker. The authors would like to thank Dr Cody Kime from RIKEN Center for Biosystems Dynamics Research for testing SkewC at the early stage of development and for the feedback and discussion. This work was supported by research grants for the RIKEN Center for Life Science Technologies, RIKEN Center for Integrative Medical Sciences, and RIKEN Open Life Science Platform project from MEXT, Japan. SK was supported by Jane and Aatos Erkko Foundation (Finland) . JK was supported in part by Knut and Alice Wallenberg Foundation (KAW2015.0096) (Sweden) , Swedish Research Council, Jane and Aatos Erkko Foundation (Finland) , and Sigrid Juselius Foundation (Finland) . This work was initiated when JK was a Japan Society for the Promotion of Science Fellow (Japan) at RIKEN Center for Integrative Medical Sciences.; http://hdl.handle.net/10138/342576; 000760398900009

Dostupnosť: http://hdl.handle.net/10138/342576

Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes.

Autori: Sjögren, Rasmus J. O. Rizo-Roca, David Chibalin, Alexander V. a ďalší

Zdroj: Diabetologia; Sep2021, Vol. 64 Issue 9, p2077-2091, 15p

Distinct whole-blood transcriptome profile of children with metabolic healthy overweight/obesity compared to metabolic unhealthy overweight/obesity.

Autori: Plaza-Florido, Abel Altmäe, Signe Esteban, Francisco J. a ďalší

Zdroj: Pediatric Research; Jun2021, Vol. 89 Issue 7, p1687-1694, 8p

Motor Function Deficits in the Estrogen Receptor Beta Knockout Mouse: Role on Excitatory Neurotransmission and Myelination in the Motor Cortex.

Autori: Varshney, Mukesh Kumar Yu, Nancy Yiu-Lin Katayama, Shintaro a ďalší

Zdroj: Neuroendocrinology; 2021, Vol. 111 Issue 1/2, p27-44, 18p

Predmety: MOTOR cortex, ESTROGEN receptors, KNOCKOUT mice, MYELINATION, NEURAL transmission