Suchergebnisse - "Kaczmarek, Isabell"

Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity.

Autoren: Dietzsch, André Nguyen Al-Hasani, Hadi Altschmied, Joachim et al.

Quelle: Signal Transduction & Targeted Therapy; 4/26/2024, Vol. 9 Issue 1, p1-14, 14p

A Pathophysiologically Hypertrophic 3T3-L1 Cell Model—An Alternative to Primary Cells Isolated from DIO Mice.

Autoren: Kaczmarek, Isabell Schüßler, Kristiana Lindhorst, Andreas et al.

Quelle: Cells (2073-4409); Jun2025, Vol. 14 Issue 11, p837, 20p

Schlagwörter: FAT cells, CELL size, ADIPOSE tissues, LIPOLYTIC enzymes, FREE fatty acids, ADIPOGENESIS

Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue

Autoren: Georgiadi, Anastasia Lopez-Salazar, Valeria El-Merahbi, Rabih et al.

Weitere Verfasser: Georgiadi, Anastasia Lopez-Salazar, Valeria El-Merahbi, Rabih et al.

Schlagwörter: GLUT4 TRANSLOCATION, PROTEIN, FAT, RESISTANCE, OBESITY, 3T3-L1, MOUSE, EXPRESSION, RECEPTORS, CELLS, Biomedicine

Dateibeschreibung: application/pdf

Relation: We thank Dr. Brad St. Croix (Tumor Angiogenesis Section, MCGP, NCI at Frederick, NIH, Frederick, MD 21702, USA) for generously providing the GPR116KO and GPR116flox/flox mice. The authors would like to thank Venetia Bazioti, Thomas Malmborg, Dr. Donna Maretta Ariestanti, Hikaru Ando, Malin Elven, Sabine Hartig, Andrea Takacs, and Elena Sophie Vogl for technical assistance with experiments. We also thank Dr. David Brodin for support with the preparation, analysis and submission of the Affymetrix microarrays data. This work was supported by grants of the Deutsche Forschungsgemeinschaft, Obesity Mechanisms (SFB 1052, B01 to M.Bluher), Karolinska Institute derived funds (ERC 309596), the Helmholtz Association (Cross-Program Topic AMPro to S. Herzig), the DFG TRR 152 and DFG TRR 296 to Timo D.Muller. The NUGAT study was funded by the German Federal Ministry of Education and Research (BMBF; grant no. 0315424) to A.F.H.P. The Rubicon Netherlands Organization for Scientific research (NWO)-mobility grant and the EFSD grant supported A. Georgiadi.; http://hdl.handle.net/10138/333042; 000658758500001

Verfügbarkeit: http://hdl.handle.net/10138/333042

The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development.

Autoren: Röthe, Juliane Kraft, Robert Ricken, Albert et al.

Quelle: Communications Biology; 1/16/2024, Vol. 7 Issue 1, p1-14, 14p

Schlagwörter: ISLANDS of Langerhans, PANCREATIC beta cells, SOMATOSTATIN receptors, SOMATOSTATIN, G protein coupled receptors, KNOCKOUT mice, PULMONARY surfactant, SECRETION

Evaluating the feasibility of Cas9 overexpression in 3T3-L1 cells for generation of genetic knock-out adipocyte cell lines.

Autoren: Suchý, Tomás Kaczmarek, Isabell Maricic, Tomislav et al.

Quelle: Adipocyte; Dec 2021, Vol. 10 Issue 1, p631-645, 15p

Schlagwörter: GENE transfection, CELL lines, FAT cells, G protein coupled receptors, ADIPOKINES, GENETIC overexpression, INSULIN sensitivity

The relevance of adhesion G protein-coupled receptors in metabolic functions.

Autoren: Kaczmarek, Isabell Suchý, Tomáš Prömel, Simone et al.

Quelle: Biological Chemistry; 2022, Vol. 403 Issue 2, p195-209, 15p

Schlagwörter: G protein coupled receptors, ISLANDS of Langerhans, ADIPOSE tissues, CENTRAL nervous system, METABOLIC disorders, DRUG target