Suchergebnisse - "Jayaswamy PK"

Chronic oral administration of ibrutinib prevents long-term memory deficits and reduces AD pathology and neuroinflammatory responses in a mouse model of AD.

Autoren: Lee, Hyun-ju Kang, Sora Jeong, Yoo Joo et al.

Quelle: Molecular Brain; 7/21/2025, Vol. 18 Issue 1, p1-5, 5p

Plasma exosomal miR-30b-5p attenuates neuroinflammation in a rat model of autism spectrum disorder.

Autoren: Zheng, Zhen Wu, Qiuting Zhang, Xingliang

Quelle: Frontiers in Psychiatry; 2025, p1-12, 12p

Schlagwörter: MICRORNA, NEUROINFLAMMATION, INTRACELLULAR calcium, ANIMAL disease models, EXOSOMES, EPIDERMAL growth factor receptors, AUTISM spectrum disorders, MITOGEN-activated protein kinases

Hydroxychloroquine modulates the progression of experimentally induced benign prostatic hyperplasia in rats via targeting EGFR/ERK/STAT3 and AR/FOXO1/TRAIL pathways: computational and in vivo studies.

Autoren: El-Maadawy, Walaa H. Hafiz, Ehab Tadros, Samer A. et al.

Quelle: Scientific Reports; 6/20/2025, Vol. 15 Issue 1, p1-18, 18p

Schlagwörter: TRANSCRIPTION factors, BENIGN prostatic hyperplasia, ANDROGEN receptors, DEATH receptors, TRAIL protein

Identifying the mediating role of brain atrophy on the relationship between DNA damage repair pathway and Alzheimer's disease: A Mendelian randomization analysis and mediation analysis.

Autoren: Bao, Wei Bi, Haidi Chao, Lishuo et al.

Quelle: Journal of Alzheimer's Disease; Jun2025, Vol. 105 Issue 3, p1017-1029, 13p

Schlagwörter: MENDELIAN randomization, LOCUS (Genetics), GENOME-wide association studies, ALZHEIMER'S disease, CEREBRAL atrophy

Multi-Omics Analysis and Nephroseq Database of Genes Related to Kidney Function in Diabetic Nephropathy Patients to Predict Potential Target Drugs.

Autoren: Deng, Ling Yan, Feifan Feng, Changmei et al.

Quelle: Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy; Oct2025, Vol. 18, p3781-3794, 14p

Genome‐wide meta‐analysis identifies ancestry‐specific loci for Alzheimer's disease.

Autoren: Ge, Yi‐Jun Chen, Shi‐Dong Wu, Bang‐Sheng et al.

Quelle: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Sep2024, Vol. 20 Issue 9, p6243-6256, 14p

Role of tumor microenvironment in cancer promotion, development of drug resistance and cancer treatment.

Autoren: Fathah, Duaa e Ejaz, Samina

Quelle: Journal of the Egyptian National Cancer Institute; 9/15/2025, Vol. 37 Issue 1, p1-19, 19p

Schlagwörter: TUMOR microenvironment, DRUG resistance, HYPOXIA (Water), THERAPEUTICS, CANCER treatment, BIOLOGICAL crosstalk, CANCER invasiveness

A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosis.

Autoren: Wendt, Stefan Lin, Ada J. Ebert, Sarah N. et al.

Quelle: Journal of Neuroinflammation; 4/24/2025, Vol. 22 Issue 1, p1-38, 38p

Schlagwörter: CELL analysis, MEDICAL sciences, LIFE sciences, GENE expression profiling, ALZHEIMER'S disease, AMYLOID plaque

UHPLC-Q Exactive-Orbitrap-MS and network pharmacology analyses to investigate the mechanism by which Danggui-Shaoyao-San affects 27-OHC-induced cell damage in SH-SY5Y/C6 coculture.

Autoren: Huang, Yi Zhai, Yingying Zhao, Di et al.

Quelle: BMC Complementary Medicine & Therapies; 2/24/2025, Vol. 25 Issue 1, p1-20, 20p

Schlagwörter: LIPID metabolism, HIGH performance liquid chromatography, CHINESE medicine, IN vitro studies, GLUTATHIONE, ALZHEIMER'S disease, COMPUTER software, RESEARCH funding, PHARMACEUTICAL chemistry, HERBAL medicine, POLYMERASE chain reaction, OXYSTEROLS, CELLULAR signal transduction, DESCRIPTIVE statistics, CELL lines, RATS, CELL culture, REACTIVE oxygen species, BIOINFORMATICS, MASS spectrometry, ANIMAL experimentation, CYTOCHROME P-450, CHOLESTEROL, METABOLISM, CELL survival, ACIDS, INTERLEUKINS, TUMOR necrosis factors, TRANSFORMING growth factors-beta, DRUG dosage, DRUG administration

Insight into the Synthesis Approaches of Oxadiazole and its Derivatives, Focuses on their Pharmacological Activities.

Autoren: Sharma, Sadhana Majee, Chandana Mazumder, Rupa et al.

Quelle: Indian Journal of Pharmaceutical Education & Research; 2025 Supplement, Vol. 59, p25-45, 21p

Schlagwörter: DOSAGE forms of drugs, PLANT protection, ORGANIC compounds, DRUG development, RESEARCH personnel

Bioinformatics analysis of the potential mechanisms of Alzheimer's disease induced by exposure to combined triazine herbicides.

Autoren: Li, Jianan Qi, Ling Chen, Yuxin et al.

Quelle: Annals of Human Biology; Feb2023, Vol. 50 Issue 1, p442-451, 10p

Schlagwörter: ATRAZINE, HERBICIDES, ALZHEIMER'S disease, MOLECULAR docking, CELLULAR aging, CELLULAR signal transduction, MOLECULAR dynamics

Serum NfL and EGFR/NfL ratio mRNAs as biomarkers for phenotype and disease severity of myelin oligodendrocyte glycoprotein IgG-associated disease.

Autoren: Xin Wang Yi Qu Jiayu Fan et al.

Quelle: Frontiers in Immunology; 2024, p01-09, 9p

Schlagwörter: MYELIN oligodendrocyte glycoprotein, EPIDERMAL growth factor receptors, ENDOTHELIAL growth factors, PHENOTYPES, CHILD patients

Geografische Kategorien: HEBEI Sheng (China)

Mechanisms of endothelial activation, hypercoagulation and thrombosis in COVID-19: a link with diabetes mellitus.

Autoren: Valencia, Inés Lumpuy-Castillo, Jairo Magalhaes, Giselle et al.

Quelle: Cardiovascular Diabetology; 2/20/2024, Vol. 23 Issue 1, p1-18, 18p

Schlagwörter: POST-acute COVID-19 syndrome, DIABETES, COVID-19, VON Willebrand factor, THROMBOSIS, VON Willebrand disease, ENDOTHELIUM diseases

Pro-inflammatory regulation of EGFR-Annexin A2 synergy by sodium butyrate: An upstream target to reduce articular inflammation and cartilage destruction in rheumatoid arthritis.

Autoren: Jayaswamy PK Haridas V Vijaykrishnaraj M et al.

Quelle: Cytokine [Cytokine] 2025 Oct; Vol. 194, pp. 157008. Date of Electronic Publication: 2025 Aug 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005353 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0023 (Electronic) Linking ISSN: 10434666 NLM ISO Abbreviation: Cytokine Subsets: MEDLINE

MeSH-Schlagworte: Arthritis, Rheumatoid*/metabolism , Arthritis, Rheumatoid*/drug therapy , Arthritis, Rheumatoid*/pathology , ErbB Receptors*/metabolism , Butyric Acid*/pharmacology , Inflammation*/metabolism , Inflammation*/pathology , Inflammation*/drug therapy , Annexin A2*/metabolism , Cartilage, Articular*/pathology , Cartilage, Articular*/metabolism , Cartilage, Articular*/drug effects, Animals ; Humans ; Mice ; Arthritis, Experimental/metabolism ; Arthritis, Experimental/pathology ; Arthritis, Experimental/drug therapy ; Fibroblasts/metabolism ; Fibroblasts/drug effects ; Mice, Inbred DBA ; Annexin A1/metabolism ; Male ; Synovial Membrane/pathology ; Synovial Membrane/metabolism ; Tumor Necrosis Factor-alpha/metabolism

AnxA2-EGFR pro-inflammatory signaling potentiates EMT-induced fibrotic stress and its modulation by short-chain fatty acid butyrate in idiopathic pulmonary fibrosis.

Autoren: Sangamesh VC Jayaswamy PK Krishnaraj VM et al.

Quelle: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2025 Jun; Vol. 499, pp. 117342. Date of Electronic Publication: 2025 Apr 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Idiopathic Pulmonary Fibrosis*/drug therapy , Idiopathic Pulmonary Fibrosis*/pathology , Idiopathic Pulmonary Fibrosis*/metabolism , Epithelial-Mesenchymal Transition*/drug effects , Epithelial-Mesenchymal Transition*/physiology , ErbB Receptors*/metabolism , Annexin A2*/metabolism , Annexin A2*/genetics , Butyrates*/pharmacology , Lung*/drug effects , Lung*/pathology , Lung*/metabolism, Signal Transduction/drug effects ; Humans ; Animals ; Galectin 3/metabolism ; Mice ; Male

Targeting AnxA2-EGFR signaling: hydroxychloroquine as a therapeutic strategy for bleomycin-induced pulmonary fibrosis.

Autoren: Sangamesh VC Alagundagi DB Jayaswamy PK et al.

Quelle: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Feb; Vol. 398 (2), pp. 2015-2026. Date of Electronic Publication: 2024 Sep 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Hydroxychloroquine*/pharmacology , Hydroxychloroquine*/therapeutic use , ErbB Receptors*/metabolism , ErbB Receptors*/antagonists & inhibitors , Annexin A2*/metabolism , Pulmonary Fibrosis*/chemically induced , Pulmonary Fibrosis*/drug therapy , Pulmonary Fibrosis*/metabolism , Idiopathic Pulmonary Fibrosis*/drug therapy , Idiopathic Pulmonary Fibrosis*/chemically induced , Idiopathic Pulmonary Fibrosis*/metabolism , Idiopathic Pulmonary Fibrosis*/pathology , Antifibrotic Agents*/pharmacology , Antifibrotic Agents*/therapeutic use, Animals ; Bleomycin ; Signal Transduction/drug effects ; Mice ; Male ; Mice, Inbred C57BL ; Lung/drug effects ; Lung/pathology ; Lung/metabolism ; Disease Models, Animal ; Indoles/pharmacology

Vetting of New 2,5-Bis (2,2,2-trifluoroethoxy) Phenyl-Linked 1,3-Thiazolidine-4-one Derivatives as AURKA and VEGFR-2 Inhibitor Antiglioma Agents Assisted with In Vitro and In Silico Studies.

Autoren: D Shankara S Isloor AM Jayaswamy PK et al.

Quelle: ACS omega [ACS Omega] 2023 Nov 10; Vol. 8 (46), pp. 43596-43609. Date of Electronic Publication: 2023 Nov 10 (Print Publication: 2023).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE

Tissue plasminogen activator receptor ANXA2 and its complementary regulator anti-inflammatory ANXA1 as prognostic indicators of inflammatory response in COVID-19 pathogenesis.

Autoren: Shenoy RD Nithin Kuriakose Vijaykrishnaraj M et al.

Quelle: Immunobiology [Immunobiology] 2023 Sep; Vol. 228 (5), pp. 152728. Date of Electronic Publication: 2023 Aug 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8002742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3279 (Electronic) Linking ISSN: 01712985 NLM ISO Abbreviation: Immunobiology Subsets: MEDLINE

MeSH-Schlagworte: Annexin A2* , COVID-19*, Humans ; Anti-Inflammatory Agents ; Biomarkers ; Interleukin-6 ; Prognosis ; Tissue Plasminogen Activator ; Tumor Necrosis Factor-alpha

Implicative role of epidermal growth factor receptor and its associated signaling partners in the pathogenesis of Alzheimer's disease.

Autoren: Jayaswamy PK Vijaykrishnaraj M Patil P et al.

Quelle: Ageing research reviews [Ageing Res Rev] 2023 Jan; Vol. 83, pp. 101791. Date of Electronic Publication: 2022 Nov 17.

Publikationsart: Journal Article; Review; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE

MeSH-Schlagworte: Alzheimer Disease*/metabolism, Humans ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; ErbB Receptors/metabolism ; Signal Transduction/physiology

Single-cell transcriptomic analysis reveals metastatic and immunosuppressive characteristics in meningioma brain-tumor interface.

Autoren: Huang B Liang J Tang X et al.

Quelle: Journal of translational medicine [J Transl Med] 2025 Aug 18; Vol. 23 (1), pp. 930. Date of Electronic Publication: 2025 Aug 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH-Schlagworte: Meningioma*/genetics , Meningioma*/pathology , Meningioma*/immunology , Single-Cell Analysis* , Gene Expression Profiling* , Brain Neoplasms*/genetics , Brain Neoplasms*/pathology , Brain Neoplasms*/immunology , Transcriptome*/genetics , Meningeal Neoplasms*/pathology , Meningeal Neoplasms*/genetics , Meningeal Neoplasms*/immunology , Immune Tolerance*/genetics , Immunosuppression Therapy*, Humans ; Neoplasm Metastasis ; Tumor Microenvironment/genetics ; Gene Expression Regulation, Neoplastic ; Epithelial-Mesenchymal Transition/genetics ; Biomarkers, Tumor/metabolism ; Neoplasm Invasiveness