Výsledky vyhľadávania - "JAK-STAT pathway"

The African swine fever virus B125R protein antagonizes JAK-STAT signalling by promoting the degradation of IFNAR2.

Autori: Fan, Jun-Hao Zhao, Yan-Yan Ma, Yu-He a ďalší

Zdroj: Veterinary Research. 4/23/2025, Vol. 56 Issue 1, p1-15. 15p.

Predmet: African swine fever virus, JAK-STAT pathway, Life sciences, Cellular signal transduction, Viral proteins, African swine fever

The long non-coding RNA lncRNA-DRNR enhances infectious bronchitis virus replication by targeting chicken JMJD6 and modulating interferon-stimulated genes expression via the JAK-STAT signalling pathway.

Autori: Yan, Wenjun Fu, Xue Li, Hao a ďalší

Zdroj: Veterinary Research. 11/5/2024, Vol. 55 Issue 1, p1-14. 14p.

Predmet: LincRNA, JAK-STAT pathway, Avian infectious bronchitis virus, Gene expression, Chickens

Pseudorabies Virus UL41 Hijacks IFN Response via JAK/STAT Pathway While Cellular TRIM21 Blocks it Through K48 Ubiquitination.

Autori: Li, Xue Zheng, Jiawei Zhang, Guoqing a ďalší

Zdroj: Transboundary & Emerging Diseases. 11/25/2025, Vol. 2025, p1-20. 20p.

Predmety: *JAK-STAT pathway, *UBIQUITINATION, *ANTIVIRAL agents, *AUJESZKY'S disease virus, *VIRAL proteins, *HOST-parasite relationships, *UBIQUITIN ligases

Th17/IL‐17A Drives Alveolar Bone Loss via the JAK/STAT3‐RANKL Axis in the Periodontal Ligament.

Autori: Lv, Die Zhang, Jiuge Zhang, Yixin a ďalší

Zdroj: Oral Diseases. Nov2025, p1. 13p. 6 Illustrations.

Predmety: *INTERLEUKIN-17, *JAK-STAT pathway, *OSTEOCLAST inhibition, *T helper cells, *PERIODONTAL ligament, *BONE resorption, *CYTOKINES, *ANTI-inflammatory agents

Weifuchun alleviates MNNG-induced chronic atrophic gastritis by improving the gastric and intestinal microbiota homeostasis.

Autori: Chen, Yingying Feng, Ping Lou, Xiaoqin a ďalší

Zdroj: PLoS ONE. 11/24/2025, Vol. 20 Issue 11, p1-24. 24p.

Predmety: *GUT microbiota, *JAK-STAT pathway, *INFLAMMATORY mediators, *STOMACH cancer, *CHEMICAL mutagenesis, *HERBAL medicine, *ATROPHIC gastritis

Perindopril and/or α‑pinene mitigate acetic acid-induced ulcerative colitis via regulation of JAK/STAT3/SOCS3 axis and miR-98-5p expression in rats.

Autori: Mohamed, Basma M. A. El Fattah, Mai A. Abd El Wakeel, Sara A.

Zdroj: Future Journal of Pharmaceutical Sciences. 11/17/2025, Vol. 11 Issue 1, p1-16. 16p.

Predmety: *ULCERATIVE colitis, *JAK-STAT pathway, *INFLAMMATORY bowel diseases, *OXIDATIVE stress, *ANTI-inflammatory agents, *ANTIHYPERTENSIVE agents, *MICRORNA, *TERPENES

SHP1 overexpression ameliorates renal fibrosis via inhibition of STAT3 signaling and glycolysis reprogramming.

Autori: Tian, Hongzhe Liu, Bo Liu, Wei a ďalší

Zdroj: Scientific Reports. 11/18/2025, Vol. 15 Issue 1, p1-15. 15p.

Predmety: *RENAL fibrosis, *JAK-STAT pathway, *PROTEIN-tyrosine phosphatase, *CELL proliferation, *EXTRACELLULAR matrix, *GLYCOLYSIS, *FIBROSIS

Effects of miR-210-3p/SDF2 and miR-31-5p/FGF7 from hypoxic endometrial exosomes on UCB-MSC proliferation, migration, and differentiation.

Autori: Liu, Simiao Zhang, Wanyu Deng, Chengyan a ďalší

Zdroj: Stem Cell Research & Therapy. 11/3/2025, Vol. 16 Issue 1, p1-17. 17p.

Predmety: *MESENCHYMAL stem cells, *JAK-STAT pathway, *GROWTH factors, *HUMAN growth, *MICRORNA, *FIBROBLAST growth factors

Targeting hypercoagulability in ischemic stroke modulates fibrin-driven microglial polarization via JAK-STAT pathway.

Autori: Guan, Siyu Lu, Taoyuan Li, Lei a ďalší

Zdroj: Journal of Neuroinflammation. 11/4/2025, Vol. 22 Issue 1, p1-21. 21p.

Predmety: *ISCHEMIC stroke, *JAK-STAT pathway, *BLOOD coagulation, *BLOOD coagulation disorders, *BLOOD-brain barrier, *NEUROINFLAMMATION, *THERAPEUTICS, *MICROGLIA

Ficus pandurata as a Functional Phytotherapeutic: Inhibiting JAK2/STAT3 Signaling and Activating Mitochondrial Apoptosis in Hepatocellular Carcinoma.

Autori: Majid, Muhammad Tang, Bing Lai, Yingyao a ďalší

Zdroj: Food Science & Nutrition. Nov2025, Vol. 13 Issue 11, p1-16. 16p.

Predmety: *HEPATOCELLULAR carcinoma, *JAK-STAT pathway, *ANTI-inflammatory agents, *FICUS (Plants), *FUNCTIONAL foods, *APOPTOSIS, *TUMOR growth, *PHYTOTHERAPY

Antagonism between JAK/STAT downstream targets controls stem cell proliferation, cell fate conversion and tumorigenesis.

Autori: Hanfei Zhao Min Wei Ruiyan Kong a ďalší

Zdroj: Development (09501991). Nov2025, Vol. 152 Issue 21, p1-20. 20p.

Predmety: *CELL proliferation, *JAK-STAT pathway, *NEOPLASTIC cell transformation, *DROSOPHILA, *PROTEOLYSIS, *UBIQUITIN ligases, *CELL differentiation

Inhibition of miR-4284 could reduce apoptosis and neuroinflammation by targeting APBA1/JAK1/STAT3 signaling in Alzheimer's disease.

Autori: Choi, Jiyun Hwang, Jinsu Kim, Dohee a ďalší

Zdroj: Cell & Bioscience. 10/31/2025, Vol. 15 Issue 1, p1-18. 18p.

Predmety: *ALZHEIMER'S disease, *JAK-STAT pathway, *NEUROINFLAMMATION, *APOPTOSIS, *DRUG target, *AMYLOID beta-protein precursor, *COGNITIVE ability, *MICRORNA

SPP1⁺ macrophages promote colorectal cancer progression by activating JAK2/STAT3 signaling pathway.

Autori: Yang, Shaohui Ma, Chenyang Zhao, Yibin

Zdroj: Scientific Reports. 10/27/2025, Vol. 15 Issue 1, p1-11. 11p.

Predmety: *COLORECTAL cancer, *JAK-STAT pathway, *RNA sequencing, *CHEMOKINES, *EPITHELIAL-mesenchymal transition, *CELL populations, *MACROPHAGES

Luteolin alleviates CUMS-induced depressive-like behavioral deficits in mice through blocking the JAK2/STAT3 pathway.

Autori: Wu, Hai-hong Chen, Shang-yue Yuan, Dong-liang a ďalší

Zdroj: PLoS ONE. 10/24/2025, Vol. 20 Issue 10, p1-12. 12p.

Predmety: *LUTEOLIN, *JAK-STAT pathway, *MENTAL depression, *PSYCHOLOGICAL stress, *ANTI-inflammatory agents, *NEUROINFLAMMATION, *ANTIOXIDANTS

Effective treatment of pretibial myxoedema with tofacitinib: a case report and analysis of immunopathogenesis.

Autori: Zhao, Chen-xi Zhao, Ming-dan Li, Xin

Zdroj: Thyroid Research. 10/21/2025, Vol. 18 Issue 1, p1-6. 6p.

Predmety: *GRAVES' disease, *JAK-STAT pathway, *CONNECTIVE tissue cells, *THERAPEUTICS, *IMMUNOMODULATORS, *IMMUNOPATHOLOGY

Knockdown of CLEC4D alleviates myoblast dysfunction and inflammation in sarcopenia by inhibiting the JAK/STAT pathway.

Autori: Ma, Ke Feng, Mei Qiao, Aichun a ďalší

Zdroj: BMC Musculoskeletal Disorders. 10/21/2025, Vol. 26 Issue 1, p1-17. 17p.

Predmety: *SARCOPENIA, *JAK-STAT pathway, *THERAPEUTICS, *MUSCULAR atrophy, *CELL receptors, *OLDER people, *INFLAMMATION

JAK–STAT inhibitory effect of IN‐115314, a novel small molecule inhibitor, and pharmacokinetic/pharmacodynamic study in canine.

Autori: Ahn, Jae‐Hun Kim, Joohwan Kwak, Jina a ďalší

Zdroj: British Journal of Pharmacology. Oct2025, Vol. 182 Issue 20, p5071-5082. 12p.

Predmety: *JAK-STAT pathway, *PHARMACOKINETICS, *VETERINARY medicine, *DRUG target, *PHARMACODYNAMICS, *CHEMICAL inhibitors, *INTERLEUKIN-6

Efficacy and safety of OB756 (a novel selective JAK2 inhibitor) for essential thrombocythemia in patients intolerant of or resistant to hydroxyurea or intolerant of interferon: A phase 2, open‐label, multicenter study.

Autori: Huang, Jian Li, Rumeng Gong, Tiejun a ďalší

Zdroj: Cancer (0008543X). Oct2025, Vol. 131 Issue 20, p1-11. 11p.

Predmety: *JAK-STAT pathway, *DRUG resistance, *THROMBOCYTOSIS, *CLINICAL trials, *JANUS kinases, *PATIENT safety, *INTERFERON gamma

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy.

Autori: Wang, Jiayu He, Pengzhan Liu, Cheng a ďalší

Zdroj: Advanced Science. 10/13/2025, Vol. 12 Issue 38, p1-18. 18p.

Predmety: *OVARIAN cancer, *JAK-STAT pathway, *DRUG resistance in cancer cells, *TUMOR growth, *CISPLATIN, *NATURAL products, *METASTASIS, *SAPONINS

Flavonoids from aging tangerine peel alleviate OVA-induced allergic asthma through JAK/STAT signaling pathway in balb/c mice.

Autori: Sun, Xiaoming Liu, Kunyi yu, Le a ďalší

Zdroj: European Food Research & Technology. Oct2025, Vol. 251 Issue 10, p3071-3086. 16p.

Predmety: *FLAVONOIDS, *JAK-STAT pathway, *ASTHMA, *LABORATORY mice, *LUNG infections, *THERAPEUTICS, *FRUIT skins, *MANDARIN orange

Geografický termín: CHINA