Suchergebnisse - "Isoenzymes/genetics"

Republication: Targeting PI3KC2β Impairs Proliferation and Survival in Acute Leukemia, Brain Tumours and Neuroendocrine Tumours

Autoren: Boller, Danielle Doepfner, Kathrin T Laurentiis, Angela D E et al.

Weitere Verfasser: Boller, Danielle Doepfner, Kathrin T Laurentiis, Angela D E et al.

Quelle: Anticancer research, vol. 42, no. 6, pp. 3217-3230

Schlagwörter: Lung Neoplasms, Brain Neoplasms, 610 Medicine & health, 3. Good health, Isoenzymes, Leukemia, Myeloid, Acute, Neuroendocrine Tumors, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, 0302 clinical medicine, 10036 Medical Clinic, Cell Line, Tumor, Acute Disease, Humans, 2730 Oncology, 1306 Cancer Research, Brain Neoplasms/drug therapy, Brain Neoplasms/genetics, Cell Proliferation, Cerebellar Neoplasms/drug therapy, Cerebellar Neoplasms/genetics, Isoenzymes/genetics, Isoenzymes/metabolism, Leukemia, Myeloid, Acute/drug therapy, Leukemia, Myeloid, Acute/genetics, Neuroendocrine Tumors/drug therapy, Neuroendocrine Tumors/genetics, Phosphatidylinositol 3-Kinases/metabolism, PI3KC2β, acute leukemia, brain tumours, cell proliferation, migration, neuroendocrine tumours, pharmacological inhibition, Cerebellar Neoplasms

Dateibeschreibung: application/pdf; 3217.full.pdf - application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/35641277
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_9296B74EEA421
https://serval.unil.ch/notice/serval:BIB_9296B74EEA42
https://serval.unil.ch/resource/serval:BIB_9296B74EEA42.P001/REF.pdf

Feedback activation of phospholipase C via intracellular mobilization and store-operated influx of Ca2+ in insulin-secreting β-cells

Autoren: Thore, Sophia Dyachok, Oleg Gylfe, Erik et al.

Quelle: Journal of Cell Science. 118(Pt 19):4463-4471

Schlagwörter: Animals, Boron Compounds/metabolism, Ca(2+)-Transporting ATPase/antagonists & inhibitors/metabolism, Calcium/*metabolism, Calcium Channel Blockers/metabolism, Calcium Channels/metabolism, Cells, Cultured, Diazoxide/metabolism, Enzyme Activation, Feedback, Biochemical, Green Fluorescent Proteins/genetics/metabolism, Inositol 1, 5-Trisphosphate/metabolism, Insulin/*metabolism, Insulin-Secreting Cells/cytology/*metabolism, Isoenzymes/genetics/*metabolism, Lanthanum/metabolism, Mice, Microscopy, Fluorescence/methods, Phospholipase C/genetics/*metabolism, Recombinant Fusion Proteins/genetics/metabolism, Research Support, Non-U.S. Gov't, Signal Transduction/*physiology, MEDICINE, Morphology, cell biology, pathology, Cell biology, MEDICIN, Morfologi, cellbiologi, patologi, Cellbiologi, medicinsk cellbiologi, Medical Cell Biology

Dateibeschreibung: electronic

Zugangs-URL: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-79778

The central role of mosquito cytochrome P450 CYP6Zs in insecticide detoxification revealed by functional expression and structural modelling.

Autoren: Chandor-Proust, A. Bibby, J. Régent-Kloeckner, M. et al.

Schlagwörter: Aedes/drug effects, Aedes/enzymology, Animals, Anopheles gambiae/drug effects, Anopheles gambiae/enzymology, Benzaldehydes/chemistry, Benzaldehydes/metabolism, Benzoates/metabolism, Cytochrome P-450 Enzyme System/chemistry, Cytochrome P-450 Enzyme System/genetics, Escherichia coli/enzymology, Escherichia coli/genetics, Genetic Engineering, Insect Proteins/chemistry, Insect Proteins/genetics, Insect Vectors/drug effects, Insect Vectors/enzymology, Insecticide Resistance/drug effects, Insecticide Resistance/genetics, Insecticides/chemistry, Insecticides/metabolism, Isoenzymes/chemistry, Isoenzymes/genetics, Metabolic Detoxication, Drug, Molecular Docking Simulation, NADPH-Ferrihemoprotein Reductase/chemistry, NADPH-Ferrihemoprotein Reductase/genetics, Oxidation-Reduction, Pyrethrins/chemistry

Dateibeschreibung: application/pdf

Relation: Biochemical Journal; https://iris.unil.ch/handle/iris/97827; serval:BIB_3BD092DD43F6; 000329843200008

Verfügbarkeit: https://iris.unil.ch/handle/iris/97827
https://doi.org/10.1042/BJ20130577

Different Effects of BORIS/CTCFL on Stemness Gene Expression, Sphere Formation and Cell Survival in Epithelial Cancer Stem Cells.

Autoren: Alberti, L. Losi, L. Leyvraz, S. et al.

Schlagwörter: ATP-Binding Cassette Transporters/genetics, ATP-Binding Cassette Transporters/metabolism, Antigens, CD44/genetics, CD44/metabolism, Biomarkers, Tumor/genetics, Tumor/metabolism, Cell Line, Tumor, Cell Movement, Cell Proliferation, DNA-Binding Proteins/antagonists & inhibitors, DNA-Binding Proteins/genetics, Epithelial Cells/metabolism, Epithelial Cells/pathology, Epithelial-Mesenchymal Transition/genetics, Gene Expression Regulation, Neoplastic, Homeodomain Proteins/genetics, Homeodomain Proteins/metabolism, Humans, Isoenzymes/genetics, Isoenzymes/metabolism, Neoplasm Proteins/genetics, Neoplasm Proteins/metabolism, Neoplastic Stem Cells/metabolism, Neoplastic Stem Cells/pathology, Octamer Transcription Factor-3/genetics, Octamer Transcription Factor-3/metabolism

Dateibeschreibung: application/pdf

Relation: PLoS ONE; https://iris.unil.ch/handle/iris/87738; serval:BIB_127E6A07B81B; 000358198700081

Verfügbarkeit: https://iris.unil.ch/handle/iris/87738
https://doi.org/10.1371/journal.pone.0132977

Heterogeneity within the alkane-inducible cytochrome P450 gene family of the yeast Candida tropicalis

Autoren: Sanglard, D. Fiechter, A.

Schlagwörter: Alkanes/*pharmacology Blotting, Southern Candida/drug effects/*genetics Cloning, Molecular Cytochrome P-450 Enzyme System/*genetics/isolation & purification DNA/isolation & purification Enzyme Induction/drug effects *Genes, Fungal Isoenzymes/*genetics Molecular Sequence Data Nucleic Acid Hybridization Plasmids Sequence Homology, Nucleic Acid

Relation: FEBS Letters; https://iris.unil.ch/handle/iris/67837; serval:BIB_0283D3DCC267; A1989AW22200027; 2806542

Verfügbarkeit: https://iris.unil.ch/handle/iris/67837
https://doi.org/10.1016/0014-5793(89)81732-6

Cysteine-rich regions of protein kinase Cdelta are functionally non-equivalent. Differences between cysteine-rich regions of non-calcium-dependent protein kinase Cdelta and calcium-dependent protein kinase Cgamma.

Autoren: Hunn, M. Quest, A.F.

Schlagwörter: Binding Sites, Calcium/pharmacology, Cysteine, Dose-Response Relationship, Drug, Glutathione Transferase/genetics, Isoenzymes/genetics, Isoenzymes/isolation & purification, Micelles, Phorbol 12,13-Dibutyrate/metabolism, Phosphatidylserines/metabolism, Protein Kinase C/genetics, Protein Kinase C/isolation & purification, Protein Kinase C-delta, Recombinant Fusion Proteins/genetics, Recombinant Fusion Proteins/isolation & purification, Structure-Activity Relationship

Relation: FEBS Letters; https://iris.unil.ch/handle/iris/66443; serval:BIB_372; A1997WC87600019; 9001403

Verfügbarkeit: https://iris.unil.ch/handle/iris/66443
https://doi.org/10.1016/S0014-5793(96)01395-6

Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.

Autoren: Burki, F. Kaessmann, H.

Schlagwörter: Animals, Brain/enzymology, Evolution, Molecular, Gene Duplication, Glutamate Dehydrogenase/genetics, Glutamate Dehydrogenase/metabolism, Hominidae/genetics, Hominidae/metabolism, Humans, Isoenzymes/genetics, Isoenzymes/metabolism, Neurotransmitter Agents/metabolism, Phylogeny, Retroelements, Selection, Genetic, Time Factors

Relation: Nature Genetics; 1061-4036[print], 1061-4036[linking]; https://iris.unil.ch/handle/iris/54082; serval:BIB_51AB4869F8C0; 000224156500013

Verfügbarkeit: https://iris.unil.ch/handle/iris/54082
https://doi.org/10.1038/ng1431

ATP2A2 mutations in Darier's disease: variant cutaneous phenotypes are associated with missense mutations, but neuropsychiatric features are independent of mutation class

Autoren: Ruiz-Perez, V. L. Carter, S. A. Healy, E. et al.

Schlagwörter: Calcium-Transporting ATPases/*genetics Cells, Cultured DNA Mutational Analysis DNA Primers Europe Humans Immunohistochemistry Isoenzymes/genetics Keratosis Follicularis/*genetics/pathology/psychology *Mutation Phenotype Polymorphism, Single-Stranded Conformational Skin/metabolism/*pathology

Dateibeschreibung: application/pdf

Relation: Human Molecular Genetics; https://iris.unil.ch/handle/iris/43189; serval:BIB_51444699F855; 000082600300004

Verfügbarkeit: https://iris.unil.ch/handle/iris/43189
https://doi.org/10.1093/hmg/8.9.1621

Differential regulation of Na-K-ATPase isoform gene expression by T3 during rat brain development.

Autoren: Corthésy-Theulaz, I. Mérillat, A.M. Honegger, P. et al.

Schlagwörter: Animals, Blotting, Northern, Cells, Cultured, Gene Expression Regulation, Enzymologic, Immunoblotting, Isoenzymes/biosynthesis, Isoenzymes/genetics, Kinetics, RNA, Messenger/analysis, Rats, Sodium-Potassium-Exchanging ATPase/biosynthesis, Sodium-Potassium-Exchanging ATPase/genetics, Telencephalon/embryology, Telencephalon/enzymology, Transcription, Genetic, Triiodothyronine/physiology

Relation: American Journal of Physiology: Cell Physiology; https://iris.unil.ch/handle/iris/229246; serval:BIB_C699C5580A10; A1991FY35600016; 1650137

Verfügbarkeit: https://iris.unil.ch/handle/iris/229246

Pre-existing astrocytes form functional perisynaptic processes on neurons generated in the adult hippocampus.

Autoren: Krzisch, M. Temprana, S.G. Mongiat, L.A. et al.

Schlagwörter: Animals, Astrocytes/physiology, Astrocytes/ultrastructure, Bromodeoxyuridine/metabolism, Dendritic Spines/drug effects, Dendritic Spines/metabolism, Excitatory Postsynaptic Potentials/drug effects, Excitatory Postsynaptic Potentials/genetics, Gene Expression Regulation/genetics, Glial Fibrillary Acidic Protein/genetics, Glial Fibrillary Acidic Protein/metabolism, Green Fluorescent Proteins/genetics, Green Fluorescent Proteins/metabolism, Hippocampus/cytology, Isoenzymes/genetics, Isoenzymes/metabolism, Kainic Acid/analogs & derivatives, Kainic Acid/pharmacology, Mice, Inbred C57BL, Transgenic, Microscopy, Confocal, Immunoelectron, Neurogenesis/drug effects, Neurogenesis/genetics, Neurons/cytology, Neurons/drug effects, Patch-Clamp Techniques, Phosphopyruvate Hydratase/metabolism

Dateibeschreibung: application/pdf

Relation: Brain Structure and Function; https://iris.unil.ch/handle/iris/207396; serval:BIB_8B2A2B0863C3; 000356874700011

Verfügbarkeit: https://iris.unil.ch/handle/iris/207396
https://doi.org/10.1007/s00429-014-0768-y

Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha.

Autoren: Mouta-Bellum, C. Kirov, A. Miceli-Libby, L. et al.

Schlagwörter: Animals, Newborn/anatomy & histology, Newborn/physiology, Gene Targeting, Isoenzymes/genetics, Isoenzymes/metabolism, Lymphangiectasis/pathology, Lymphangiectasis/physiopathology, Lymphangiogenesis/physiology, Lymphatic Vessels/abnormalities, Lymphatic Vessels/anatomy & histology, Mice, Knockout, Phosphatidylinositol 3-Kinases/genetics, Phosphatidylinositol 3-Kinases/metabolism, Protein Subunits/genetics, Protein Subunits/metabolism, Signal Transduction/physiology

Dateibeschreibung: application/pdf

Relation: Developmental Dynamics; https://iris.unil.ch/handle/iris/205691; serval:BIB_EA5F5070E865; 000270769300021

Verfügbarkeit: https://iris.unil.ch/handle/iris/205691
https://doi.org/10.1002/dvdy.22078

Localization of alpha-isoforms of Na(+)-K(+)-ATPase in rat kidney by in situ hybridization

Autoren: Farman, N. Corthesy-Theulaz, I. Bonvalet, J. P. et al.

Schlagwörter: Animals Antisense Elements (Genetics) Blotting, Northern Brain/enzymology DNA/*analysis/genetics Female Isoenzymes/*genetics Kidney/cytology/*enzymology Kidney Cortex/enzymology Kidney Glomerulus/enzymology Kidney Medulla/enzymology Kidney Tubules/enzymology Nucleic Acid Hybridization RNA Probes Rats Rats, Inbred Strains Sodium-Potassium-Exchanging ATPase/*genetics

Relation: American Journal of Physiology: Cell Physiology; https://iris.unil.ch/handle/iris/189150; serval:BIB_72B177EEFC2F; A1991FC25000011; 1848400

Verfügbarkeit: https://iris.unil.ch/handle/iris/189150

Analysis of active site residues of the antiviral protein from summer leaves from Phytolacca americana by site-directed mutagenesis.

Autoren: Poyet, J.L. Hoeveler, A. Jongeneel, C.V.

Schlagwörter: Amino Acid Sequence, Animals, Antiviral Agents/chemistry, Antiviral Agents/metabolism, Catalytic Domain/genetics, Cell-Free System, Dose-Response Relationship, Drug, Isoenzymes/genetics, Isoenzymes/metabolism, Models, Molecular, Molecular Sequence Data, Mutagenesis, Site-Directed, N-Glycosyl Hydrolases/chemistry, N-Glycosyl Hydrolases/genetics, Plant Proteins/chemistry, Plant Proteins/genetics, Protein Biosynthesis/drug effects, Rabbits, Reticulocytes, Ribosome Inactivating Proteins, Type 1, Seasons, Sequence Homology, Amino Acid

Relation: Biochemical and Biophysical Research Communications; 0006-291X[print], 0006-291X[linking]; https://iris.unil.ch/handle/iris/171843; serval:BIB_A743D714F369; 000077846900007; 9918771

Verfügbarkeit: https://iris.unil.ch/handle/iris/171843
https://doi.org/10.1006/bbrc.1998.9815

Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice.

Autoren: Yang, Z.Z. Tschopp, O. Di-Poï, N. et al.

Schlagwörter: Animals, Newborn, Cardiovascular System/embryology, Cardiovascular System/enzymology, Cells, Cultured, Embryo Loss, Embryo, Mammalian/abnormalities, Mammalian/embryology, Embryonic Development, Female, Gene Expression Regulation, Developmental, Enzymologic, Isoenzymes/deficiency, Isoenzymes/genetics, Male, Mice, Knockout, Mutation/genetics, Neurons/enzymology, Organ Specificity, Proto-Oncogene Proteins c-akt/deficiency, Proto-Oncogene Proteins c-akt/genetics, Skin/embryology, Skin/enzymology, Survival Rate, Thymus Gland/embryology, Thymus Gland/enzymology

Relation: Molecular and Cellular Biology; 0270-7306[print], 0270-7306[linking]; https://iris.unil.ch/handle/iris/150912; serval:BIB_8DC81DF45098; 000233452600016

Verfügbarkeit: https://iris.unil.ch/handle/iris/150912
https://doi.org/10.1128/MCB.25.23.10407-10418.2005

Regulation of alpha 1-beta 3-NA(+)-K(+)-ATPase isozyme during meiotic maturation of Xenopus laevis oocytes

Autoren: Pralong-Zamofing, D. Yi, Q. H. Schmalzing, G. et al.

Schlagwörter: Animals Cell Membrane/enzymology Embryo, Nonmammalian/*physiology Endocytosis Female Fertilization Isoenzymes/genetics/*metabolism Male Meiosis/physiology Microsomes/enzymology Na(+)-K(+)-Exchanging ATPase/genetics/*metabolism Oocytes/cytology/drug effects/*physiology Ouabain/metabolism Progesterone/*pharmacology Protein Binding RNA/genetics/metabolism Subcellular Fractions/enzymology Xenopus laevis

Relation: American journal of physiology; https://iris.unil.ch/handle/iris/135335; serval:BIB_B73C2768CDF8; A1992JC37600025; 1377448

Verfügbarkeit: https://iris.unil.ch/handle/iris/135335

GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex

Autoren: Chattopadhyaya, B. Di Cristo, G. Wu, C. Z. et al.

Schlagwörter: Animals Axons/physiology Glutamate Decarboxylase/genetics/*physiology Green Fluorescent Proteins/metabolism Isoenzymes/genetics/*physiology Mice Mice, Transgenic Neural Inhibition/*physiology Neurons/classification/cytology/physiology Organ Culture Techniques Parvalbumins/metabolism Phosphopyruvate Hydratase/metabolism Signal Transduction/*physiology Synapses/*physiology Time Factors Transfection/methods Visual Cortex/*cytology/metabolism Visual Pathways/cytology/physiology gamma-Aminobutyric Acid/*metabolism

Dateibeschreibung: application/pdf

Relation: Neuron; https://iris.unil.ch/handle/iris/134702; serval:BIB_9B100739FF7B; 000247645600009

Verfügbarkeit: https://iris.unil.ch/handle/iris/134702
https://doi.org/10.1016/j.neuron.2007.05.015

Arabidopsis lox3 lox4 double mutants are male sterile and defective in global proliferative arrest.

Autoren: Caldelari, D. Wang, G. Farmer, E.E. et al.

Schlagwörter: Arabidopsis/genetics, Arabidopsis/growth & development, Arabidopsis Proteins/genetics, Arabidopsis Proteins/metabolism, Cell Proliferation, Cyclopentanes/metabolism, Flowers/genetics, Flowers/growth & development, Genetic Complementation Test, Isoenzymes/genetics, Isoenzymes/metabolism, Lipoxygenase/genetics, Lipoxygenase/metabolism, Mutation, Oxylipins/metabolism, Plant Infertility/genetics, Pollen/cytology, Pollen/metabolism

Dateibeschreibung: application/pdf

Relation: Plant Molecular Biology; https://iris.unil.ch/handle/iris/133715; serval:BIB_9074DD3E3C5A; 000285928100003

Verfügbarkeit: https://iris.unil.ch/handle/iris/133715
https://doi.org/10.1007/s11103-010-9701-9

Evolution of C(4) phosphoenolpyruvate carboxykinase in grasses, from genotype to phenotype.

Autoren: Christin, P.A. Petitpierre, B. Salamin, N. et al.

Schlagwörter: Evolution, Molecular, Isoenzymes/genetics, Phosphoenolpyruvate Carboxylase/genetics, Phylogeny, Plant Proteins/genetics, Poaceae/classification, Poaceae/enzymology

Relation: Molecular Biology and Evolution; https://iris.unil.ch/handle/iris/122165; serval:BIB_37EBFB47DFC6; 000262525700011

Verfügbarkeit: https://iris.unil.ch/handle/iris/122165
https://doi.org/10.1093/molbev/msn255

Primary sequence and functional expression of a novel ouabain-resistant Na,K-ATPase. The beta subunit modulates potassium activation of the Na,K-pump.

Autoren: Jaisser, F. Canessa, C.M. Horisberger, J.D. et al.

Schlagwörter: Amino Acid Sequence, Animals, Base Sequence, Blotting, Northern, Bufo marinus, Cell Line, Cloning, Molecular, Female, Gene Library, Humans, Isoenzymes/genetics, Isoenzymes/metabolism, Macromolecular Substances, Molecular Sequence Data, Oligodeoxyribonucleotides, Oligonucleotides, Antisense, Oocytes/cytology, Ouabain/pharmacology, Potassium/pharmacology, RNA/genetics, RNA/isolation & purification, Recombinant Proteins/metabolism, Sequence Homology, Nucleic Acid, Sodium-Potassium-Exchanging ATPase/drug effects, Sodium-Potassium-Exchanging ATPase/genetics, Transcription

Relation: Journal of Biological Chemistry; https://iris.unil.ch/handle/iris/117041; serval:BIB_4418E55F7437; A1992JL05300029; 1380956

Verfügbarkeit: https://iris.unil.ch/handle/iris/117041

Molecular cloning and characterization of porcine Na⁺/K⁺-ATPase isoform α4

Autoren: Knud Larsen Carina Henriksen Kaja Kjær Kristensen et al.

Quelle: Larsen, K, Henriksen, C, Kristensen, K K, Momeni, J & Farajzadeh, L 2019, 'Molecular cloning and characterization of porcine Na⁺/K⁺-ATPase isoform α4', Biochimie, vol. 158, pp. 149-155. https://doi.org/10.1016/j.biochi.2019.01.003

Schlagwörter: Male, 0301 basic medicine, Pig, Sodium-Potassium-Exchanging ATPase/genetics, 0303 health sciences, Swine, Mutation, Missense, Na⁺/K⁺-ATPase, SNP, Exons, Methylation, Polymorphism, Single Nucleotide, Introns, Isoenzymes, 03 medical and health sciences, Amino Acid Substitution, Testis, ATP1A4, Animals, Cloning, Molecular, Sodium-Potassium-Exchanging ATPase, Isoenzymes/genetics, Phylogeny

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/30633937
https://pubmed.ncbi.nlm.nih.gov/30633937/
https://europepmc.org/article/MED/30633937
https://www.ncbi.nlm.nih.gov/pubmed/30633937
https://www.sciencedirect.com/science/article/pii/S0300908419300033
https://pure.au.dk/portal/en/publications/a57057e9-e1eb-4310-9d83-97854417ff41
https://doi.org/10.1016/j.biochi.2019.01.003