Suchergebnisse - "Intramolecular Oxidoreductases"

Potential Role of Tumor-derived MIF in B-Cell Antigen Presentation in Lung Adenocarcinoma: Single-cell and TCGA Analyses.

Autoren: Ahmed F Khan S

Quelle: Anticancer research [Anticancer Res] 2025 Dec; Vol. 45 (12), pp. 5369-5387.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE

MeSH-Schlagworte: Macrophage Migration-Inhibitory Factors*/genetics , Macrophage Migration-Inhibitory Factors*/metabolism , Macrophage Migration-Inhibitory Factors*/immunology , Adenocarcinoma of Lung*/immunology , Adenocarcinoma of Lung*/genetics , Adenocarcinoma of Lung*/pathology , Adenocarcinoma of Lung*/mortality , Intramolecular Oxidoreductases*/genetics , Intramolecular Oxidoreductases*/metabolism , Intramolecular Oxidoreductases*/immunology , Lung Neoplasms*/immunology , Lung Neoplasms*/genetics , Lung Neoplasms*/pathology , Lung Neoplasms*/mortality , B-Lymphocytes*/immunology , B-Lymphocytes*/metabolism , Antigen Presentation*/immunology, Humans ; Single-Cell Analysis ; Prognosis ; Tumor Microenvironment/immunology ; Antigens, Differentiation, B-Lymphocyte/metabolism ; Histocompatibility Antigens Class II/metabolism ; Female ; Male ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor

Discovery and characterization of novel hematopoietic prostaglandin D synthase inhibitors from traditional Chinese medicine: the bioactive potential of dihydroberberine in treatments of Duchenne muscular dystrophy and inflammation-related diseases.

Autoren: Li CH Tung MC Tsai CK et al.

Quelle: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2555624. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Intramolecular Oxidoreductases*/antagonists & inhibitors , Intramolecular Oxidoreductases*/metabolism , Inflammation*/drug therapy , Inflammation*/metabolism , Drug Discovery* , Muscular Dystrophy, Duchenne*/drug therapy , Muscular Dystrophy, Duchenne*/metabolism , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/isolation & purification , Lipocalins*/antagonists & inhibitors , Lipocalins*/metabolism , Medicine, Chinese Traditional* , Berberine*/pharmacology , Berberine*/chemistry , Berberine*/analogs & derivatives , Berberine*/chemical synthesis , Berberine*/isolation & purification, Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Molecular Dynamics Simulation

Spatial Profiling Identifies Tumor-Associated Stroma Enrichment and MIF as Potential Immunotherapy Targets in Primary Ewing Sarcomas.

Autoren: Kuo C Giannikou K Wang N et al.

Quelle: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2025 Dec 01; Vol. 31 (23), pp. 5051-5069.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

MeSH-Schlagworte: Sarcoma, Ewing*/pathology , Sarcoma, Ewing*/genetics , Sarcoma, Ewing*/immunology , Sarcoma, Ewing*/therapy , Sarcoma, Ewing*/metabolism , Macrophage Migration-Inhibitory Factors*/genetics , Macrophage Migration-Inhibitory Factors*/metabolism , Macrophage Migration-Inhibitory Factors*/antagonists & inhibitors , Stromal Cells*/metabolism , Stromal Cells*/pathology , Stromal Cells*/immunology , Intramolecular Oxidoreductases*/genetics , Intramolecular Oxidoreductases*/metabolism , Intramolecular Oxidoreductases*/antagonists & inhibitors , Bone Neoplasms*/pathology , Bone Neoplasms*/genetics , Bone Neoplasms*/immunology , Bone Neoplasms*/metabolism , Bone Neoplasms*/therapy, Humans ; Tumor Microenvironment/immunology ; Tumor Microenvironment/genetics ; Immunotherapy/methods ; Proteomics/methods ; Gene Expression Regulation, Neoplastic ; Histocompatibility Antigens Class II/genetics ; Histocompatibility Antigens Class II/metabolism ; Antigens, Differentiation, B-Lymphocyte/metabolism ; Antigens, Differentiation, B-Lymphocyte/genetics ; Gene Expression Profiling ; Biomarkers, Tumor ; Transcriptome

Identification of a novel and high affinity MIF inhibitor via structure-based pharmacophore modelling, molecular docking, molecular dynamics simulations, and biological evaluation.

Autoren: Zhu S Yang S Chen Y et al.

Quelle: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2501378. Date of Electronic Publication: 2025 Jun 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Macrophage Migration-Inhibitory Factors*/antagonists & inhibitors , Macrophage Migration-Inhibitory Factors*/metabolism , Molecular Docking Simulation* , Molecular Dynamics Simulation* , Intramolecular Oxidoreductases*/antagonists & inhibitors , Intramolecular Oxidoreductases*/metabolism, Structure-Activity Relationship ; Molecular Structure ; Humans ; Dose-Response Relationship, Drug ; Mice ; Animals ; Cytokines/metabolism ; Cytokines/antagonists & inhibitors ; Pharmacophore

MIF downregulation attenuates neuroinflammation via TLR4/MyD88/TRAF6/NF-κB pathway to protect dopaminergic neurons in Parkinson's disease model.

Autoren: Huang Y Zhou C Qu S

Quelle: Communications biology [Commun Biol] 2025 Nov 18; Vol. 8 (1), pp. 1595. Date of Electronic Publication: 2025 Nov 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

MeSH-Schlagworte: Macrophage Migration-Inhibitory Factors*/metabolism , Macrophage Migration-Inhibitory Factors*/genetics , Toll-Like Receptor 4*/metabolism , Toll-Like Receptor 4*/genetics , Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/genetics , Dopaminergic Neurons*/metabolism , Dopaminergic Neurons*/pathology , Parkinson Disease*/metabolism , Parkinson Disease*/genetics , Parkinson Disease*/pathology , Neuroinflammatory Diseases*/metabolism , Intramolecular Oxidoreductases*/metabolism , Intramolecular Oxidoreductases*/genetics, Animals ; Mice ; TNF Receptor-Associated Factor 6/metabolism ; TNF Receptor-Associated Factor 6/genetics ; NF-kappa B/metabolism ; Signal Transduction ; Disease Models, Animal ; Down-Regulation ; Mice, Inbred C57BL ; Male ; Microglia/metabolism

Galectin-9 inhibition of the MIF-CD74/CD44 pathway suppresses chronic arthritis.

Autoren: Li M Nam MK Kim JG et al.

Quelle: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Nov 05; Vol. 33 (11), pp. 5760-5774. Date of Electronic Publication: 2025 Aug 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

MeSH-Schlagworte: Macrophage Migration-Inhibitory Factors*/metabolism , Macrophage Migration-Inhibitory Factors*/genetics , Galectins*/pharmacology , Galectins*/metabolism , Galectins*/genetics , Hyaluronan Receptors*/metabolism , Hyaluronan Receptors*/genetics , Signal Transduction*/drug effects , Arthritis, Rheumatoid*/metabolism , Arthritis, Rheumatoid*/pathology , Arthritis, Rheumatoid*/drug therapy , Intramolecular Oxidoreductases*/metabolism , Intramolecular Oxidoreductases*/genetics , Antigens, Differentiation, B-Lymphocyte*/metabolism , Antigens, Differentiation, B-Lymphocyte*/genetics, Animals ; Humans ; Mice ; Synoviocytes/metabolism ; Synoviocytes/drug effects ; Cell Proliferation/drug effects ; Disease Models, Animal ; Cell Movement/drug effects ; Arthritis, Experimental/metabolism ; Arthritis, Experimental/pathology ; Histocompatibility Antigens Class II

Atomistic modulation of MIF-2 structure, catalysis, and biological signaling via cysteine residues and a small molecule, Ebselen.

Autoren: Widjaja V D'Orazio SM Das P et al.

Quelle: Protein science : a publication of the Protein Society [Protein Sci] 2025 Nov; Vol. 34 (11), pp. e70344.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

MeSH-Schlagworte: Organoselenium Compounds*/chemistry , Organoselenium Compounds*/metabolism , Azoles*/chemistry , Azoles*/metabolism , Macrophage Migration-Inhibitory Factors*/chemistry , Macrophage Migration-Inhibitory Factors*/metabolism , Macrophage Migration-Inhibitory Factors*/genetics , Intramolecular Oxidoreductases*/chemistry , Intramolecular Oxidoreductases*/metabolism , Intramolecular Oxidoreductases*/genetics , Cysteine*/chemistry , Cysteine*/metabolism, Isoindoles ; Signal Transduction ; Humans ; Models, Molecular ; Molecular Dynamics Simulation

GPX2 induces macrophage M2 polarization through the MIF signaling pathway to promote colorectal cancer progression.

Autoren: Qiu M Lan C Xia Z et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 331 (Pt 1), pp. 148341. Date of Electronic Publication: 2025 Oct 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Macrophage Migration-Inhibitory Factors*/metabolism , Macrophage Migration-Inhibitory Factors*/genetics , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/immunology , Signal Transduction* , Macrophages*/metabolism , Macrophages*/immunology , Macrophages*/pathology , Intramolecular Oxidoreductases*/metabolism , Intramolecular Oxidoreductases*/genetics , Glutathione Peroxidase*/metabolism , Glutathione Peroxidase*/genetics, Humans ; Animals ; Disease Progression ; Mice ; Cell Line, Tumor ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Cell Movement/genetics ; Tumor Microenvironment

Improving immunotherapy responses by dual inhibition of macrophage migration inhibitory factor and PD-1.

Autoren: Tran TT Sánchez-Zuno GA Osmani L et al.

Quelle: JCI insight [JCI Insight] 2025 Oct 22; Vol. 10 (20). Date of Electronic Publication: 2025 Oct 22 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

MeSH-Schlagworte: Macrophage Migration-Inhibitory Factors*/antagonists & inhibitors , Macrophage Migration-Inhibitory Factors*/genetics , Macrophage Migration-Inhibitory Factors*/immunology , Macrophage Migration-Inhibitory Factors*/metabolism , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Programmed Cell Death 1 Receptor*/immunology , Immunotherapy*/methods , Melanoma*/immunology , Melanoma*/genetics , Melanoma*/drug therapy , Melanoma*/therapy , Melanoma*/pathology , Colorectal Neoplasms*/immunology , Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/genetics , Immune Checkpoint Inhibitors*/pharmacology , Intramolecular Oxidoreductases*/genetics , Intramolecular Oxidoreductases*/antagonists & inhibitors , Intramolecular Oxidoreductases*/immunology , Intramolecular Oxidoreductases*/metabolism, Animals ; Mice ; Humans ; Mice, Knockout ; Female ; Cell Line, Tumor ; Disease Models, Animal

MIF Promotes Phenotypic Switching of VSMCs via AKT/mTOR-Mediated Autophagy Regulation in Aortic Dissection.

Autoren: Pu Y Zhou Y Guo T et al.

Quelle: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Oct 15; Vol. 39 (19), pp. e71079.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH-Schlagworte: Macrophage Migration-Inhibitory Factors*/metabolism , Macrophage Migration-Inhibitory Factors*/genetics , TOR Serine-Threonine Kinases*/metabolism , TOR Serine-Threonine Kinases*/genetics , Autophagy*/physiology , Proto-Oncogene Proteins c-akt*/metabolism , Proto-Oncogene Proteins c-akt*/genetics , Aortic Dissection*/metabolism , Aortic Dissection*/pathology , Intramolecular Oxidoreductases*/metabolism , Intramolecular Oxidoreductases*/genetics , Muscle, Smooth, Vascular*/metabolism , Muscle, Smooth, Vascular*/pathology , Myocytes, Smooth Muscle*/metabolism , Myocytes, Smooth Muscle*/pathology, Animals ; Mice ; Humans ; Mice, Knockout ; Signal Transduction ; Male ; Mice, Inbred C57BL ; Phenotype ; Cells, Cultured

Macrophage migration inhibitory factor (MIF) and the tumor ecosystem: a tale of inflammation, immune escape, and tumor growth.

Autoren: Youness RA Elemam NM Abdelhamid AM et al.

Quelle: Frontiers in immunology [Front Immunol] 2025 Oct 13; Vol. 16, pp. 1636839. Date of Electronic Publication: 2025 Oct 13 (Print Publication: 2025).

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Macrophage Migration-Inhibitory Factors*/metabolism , Macrophage Migration-Inhibitory Factors*/immunology , Neoplasms*/pathology , Neoplasms*/immunology , Neoplasms*/metabolism , Neoplasms*/etiology , Tumor Microenvironment*/immunology , Inflammation*/immunology , Inflammation*/metabolism , Tumor Escape* , Intramolecular Oxidoreductases*/metabolism , Intramolecular Oxidoreductases*/immunology, Humans ; Animals ; Signal Transduction

Targeting PTGDS inhibits pro-inflammatory fibroblasts associated with skin fibrosis in systemic sclerosis.

Autoren: Fang D Yuan X Yi J et al.

Quelle: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2025 Oct 01; Vol. 64 (10), pp. 5551-5561.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 100883501 Publication Model: Print Cited Medium: Internet ISSN: 1462-0332 (Electronic) Linking ISSN: 14620324 NLM ISO Abbreviation: Rheumatology (Oxford) Subsets: MEDLINE

MeSH-Schlagworte: Scleroderma, Systemic*/pathology , Scleroderma, Systemic*/metabolism , Fibroblasts*/metabolism , Fibroblasts*/pathology , Fibroblasts*/drug effects , Skin*/pathology , Skin*/metabolism , Intramolecular Oxidoreductases*/antagonists & inhibitors , Intramolecular Oxidoreductases*/metabolism , Intramolecular Oxidoreductases*/genetics, Humans ; Fibrosis ; Animals ; Mice ; Female ; Disease Models, Animal ; Male ; Middle Aged ; Bleomycin ; Cells, Cultured

Generation of a human iPSC line, INMi007-A, carrying compound heterozygous DCT variants associated with oculocutaneous albinism type 8.

Autoren: Mamaeva D Erkilic N Vaché C et al.

Quelle: Stem cell research [Stem Cell Res] 2025 Oct; Vol. 88, pp. 103810. Date of Electronic Publication: 2025 Aug 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 101316957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7753 (Electronic) Linking ISSN: 18735061 NLM ISO Abbreviation: Stem Cell Res Subsets: MEDLINE

MeSH-Schlagworte: Albinism, Oculocutaneous*/genetics , Albinism, Oculocutaneous*/pathology , Induced Pluripotent Stem Cells*/metabolism , Induced Pluripotent Stem Cells*/cytology , Intramolecular Oxidoreductases*/genetics , Intramolecular Oxidoreductases*/metabolism, Humans ; Heterozygote ; Cell Line

Palmitate-induced downregulation of lipocalin prostaglandin D 2 synthase accompanies hepatic lipid accumulation in HepG2 cells.

Autoren: Khairnar R Islam MA Shetty DK et al.

Quelle: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2025 Oct 01; Vol. 608, pp. 112615. Date of Electronic Publication: 2025 Jul 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: North Holland Publishing Country of Publication: Ireland NLM ID: 7500844 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8057 (Electronic) Linking ISSN: 03037207 NLM ISO Abbreviation: Mol Cell Endocrinol Subsets: MEDLINE

MeSH-Schlagworte: Lipocalins*/metabolism , Lipocalins*/genetics , Intramolecular Oxidoreductases*/metabolism , Intramolecular Oxidoreductases*/genetics , Down-Regulation*/drug effects , Lipid Metabolism*/drug effects , Liver*/metabolism , Liver*/drug effects , Liver*/pathology , Palmitates*/pharmacology, Humans ; Hep G2 Cells ; Animals ; Mice ; Autophagy/drug effects ; Mice, Inbred C57BL ; Fatty Liver/metabolism ; Fatty Liver/pathology

Differential expression of haematopoietic prostaglandin D synthase by POU2F3‑positive tuft cells in conventional bilayered oncocytic and metaplastic epithelia of Warthin tumours.

Autoren: Hosomi K Sato A Ishida M et al.

Quelle: Molecular medicine reports [Mol Med Rep] 2025 Oct; Vol. 32 (4). Date of Electronic Publication: 2025 Jul 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-3004 (Electronic) Linking ISSN: 17912997 NLM ISO Abbreviation: Mol Med Rep Subsets: MEDLINE

MeSH-Schlagworte: Adenolymphoma*/pathology , Adenolymphoma*/metabolism , Adenolymphoma*/genetics , Intramolecular Oxidoreductases*/metabolism , Intramolecular Oxidoreductases*/genetics , Octamer Transcription Factor-3*/metabolism, Humans ; Male ; Middle Aged ; Aged ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Aged, 80 and over ; Adult ; Immunohistochemistry ; Metaplasia ; Female ; Epithelium/pathology ; Epithelium/metabolism ; Tuft Cells ; Lipocalins

D-Dopachrome Tautomerase-Driven Astrocytic CCL7 Aggravates Neuropathology by Recruitment of Microglia Following Spinal Cord Injury.

Autoren: Song H Fu T Geng Y et al.

Quelle: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Nov 30; Vol. 39 (22), pp. e71248.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH-Schlagworte: Spinal Cord Injuries*/metabolism , Spinal Cord Injuries*/pathology , Microglia*/metabolism , Microglia*/pathology , Astrocytes*/metabolism , Astrocytes*/pathology , Intramolecular Oxidoreductases*/metabolism , Chemokine CCL7*/metabolism , Chemokine CCL7*/genetics, Animals ; Mice ; Mice, Inbred C57BL ; Macrophages/metabolism ; Cell Movement ; Signal Transduction ; Antigens, Differentiation, B-Lymphocyte ; Histocompatibility Antigens Class II

Metformin protects against cyclophosphamide-induced ovarian fibrosis by MIF/CD74-mediated macrophage polarization.

Autoren: Nie P Yao B Zhang Z et al.

Quelle: Journal of translational medicine [J Transl Med] 2025 Nov 12; Vol. 23 (1), pp. 1273. Date of Electronic Publication: 2025 Nov 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH-Schlagworte: Macrophage Migration-Inhibitory Factors*/metabolism , Macrophages*/drug effects , Macrophages*/metabolism , Macrophages*/pathology , Antigens, Differentiation, B-Lymphocyte*/metabolism , Metformin*/pharmacology , Metformin*/therapeutic use , Histocompatibility Antigens Class II*/metabolism , Cyclophosphamide*/adverse effects , Intramolecular Oxidoreductases*/metabolism , Ovary*/pathology , Ovary*/drug effects , Protective Agents*/pharmacology , Protective Agents*/therapeutic use , Cell Polarity*/drug effects, Animals ; Female ; Fibrosis ; Signal Transduction/drug effects ; Mice ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Mice, Inbred C57BL ; Extracellular Matrix/metabolism ; Extracellular Matrix/drug effects ; Coculture Techniques ; Humans ; NF-kappa B/metabolism

Macrophage migration inhibitory factor (MIF): a Janus-faced cytokine in viral pathogenesis and host defense.

Autoren: Saadh MJ Muhammad FA Shareef A et al.

Quelle: Immunologic research [Immunol Res] 2025 Nov 10; Vol. 73 (1), pp. 160. Date of Electronic Publication: 2025 Nov 10.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8611087 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-0755 (Electronic) Linking ISSN: 0257277X NLM ISO Abbreviation: Immunol Res Subsets: MEDLINE

MeSH-Schlagworte: Macrophage Migration-Inhibitory Factors*/metabolism , Macrophage Migration-Inhibitory Factors*/immunology , Macrophage Migration-Inhibitory Factors*/genetics , Virus Diseases*/immunology , Virus Diseases*/metabolism , Viruses*/immunology , Intramolecular Oxidoreductases*/metabolism, Humans ; Animals ; Host-Pathogen Interactions/immunology ; Signal Transduction ; Cytokines/metabolism

Single-Cell Transcriptome Analysis Reveals the Effect of MIF on Myeloid-Derived Suppressor Cells in Multiple Myeloma.

Autoren: Zhao X Zhou J Yao J et al.

Quelle: International journal of laboratory hematology [Int J Lab Hematol] 2025 Oct; Vol. 47 (5), pp. 849-858. Date of Electronic Publication: 2025 Apr 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 101300213 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1751-553X (Electronic) Linking ISSN: 17515521 NLM ISO Abbreviation: Int J Lab Hematol Subsets: MEDLINE

MeSH-Schlagworte: Macrophage Migration-Inhibitory Factors*/genetics , Macrophage Migration-Inhibitory Factors*/metabolism , Multiple Myeloma*/genetics , Multiple Myeloma*/pathology , Multiple Myeloma*/metabolism , Myeloid-Derived Suppressor Cells*/metabolism , Myeloid-Derived Suppressor Cells*/pathology , Single-Cell Analysis* , Intramolecular Oxidoreductases*/genetics , Gene Expression Profiling* , Transcriptome*, Humans ; Tumor Microenvironment ; Gene Expression Regulation, Neoplastic ; Single-Cell Gene Expression Analysis

MIF Facilitates Resistance to Androgen Deprivation Therapy by Regulating AMPD2 Expression in Prostate Cancer Cells.

Autoren: Li C He C Pan J et al.

Quelle: The Prostate [Prostate] 2026 Jan; Vol. 86 (1), pp. 53-64. Date of Electronic Publication: 2025 Sep 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8101368 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0045 (Electronic) Linking ISSN: 02704137 NLM ISO Abbreviation: Prostate Subsets: MEDLINE

MeSH-Schlagworte: Macrophage Migration-Inhibitory Factors*/genetics , Macrophage Migration-Inhibitory Factors*/metabolism , Macrophage Migration-Inhibitory Factors*/biosynthesis , Androgen Antagonists*/pharmacology , Androgen Antagonists*/therapeutic use , Drug Resistance, Neoplasm*/genetics , Prostatic Neoplasms*/drug therapy , Prostatic Neoplasms*/metabolism , Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/pathology , Intramolecular Oxidoreductases*/genetics , Intramolecular Oxidoreductases*/biosynthesis , Intramolecular Oxidoreductases*/metabolism, Male ; Humans ; Receptors, Androgen/metabolism ; Receptors, Androgen/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/drug effects ; Cell Proliferation/drug effects ; Up-Regulation