Výsledky vyhľadávania - "Insulin Secretion/drug effects"

A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion

Autori: Montaner, Mireia Denom, Jessica Simon, Vincent a ďalší

Zdroj: Montaner , M , Denom , J , Simon , V , Jiang , W , Holt , M K , Brierley , D I , Rouch , C , Foppen , E , Kassis , N , Jarriault , D , Khan , D , Eygret , L , Mifsud , F , Hodson , D J , Broichhagen , J , Van Oudenhove , L , Fioramonti , X , Gault , V , Cota , D , Reimann , F , Gribble , F M , Migrenne-Li , S , Trapp , S , Gurden , ....

Predmety: Animals, Glucagon-Like Peptide 1/metabolism, Male, Olfactory Bulb/metabolism, Insulin Secretion/drug effects, Glucagon-Like Peptide-1 Receptor/metabolism, Mice, Paraventricular Hypothalamic Nucleus/metabolism, Inbred C57BL, Insulin/metabolism, Obesity/metabolism, Sympathetic Nervous System/metabolism, Neurons/metabolism, Signal Transduction, Norepinephrine/metabolism, Glucose/metabolism

Popis súboru: application/pdf

Dostupnosť: https://pure.knaw.nl/portal/en/publications/b2f0d9f3-2a09-4abd-91f1-d3943e372549
https://doi.org/10.1038/s41467-024-51076-4
https://hdl.handle.net/20.500.11755/b2f0d9f3-2a09-4abd-91f1-d3943e372549
https://pure.knaw.nl/ws/files/1566090630/Montaner2024.pdf

The hepatokine fetuin-A disrupts functional maturation of pancreatic beta cells

Autori: Gerst F. Kemter E. Lorza-Gil E. a ďalší

Zdroj: Diabetologia
Diabetologia 64, 1358–1374 (2021)

Predmety: 0301 basic medicine, Swine, alpha-2-HS-Glycoprotein, Smad Proteins, Pancreatic beta cells, Article, Islets of Langerhans, 03 medical and health sciences, Phosphorylation/drug effects [MeSH], Islets of Langerhans/drug effects [MeSH], Swine [MeSH], Humans [MeSH], Insulin Secretion/drug effects [MeSH], Adaptive proliferation, FOXM1, Functional maturity, Glucose Intolerance/metabolism [MeSH], Animals [MeSH], Fetuin-A, Islets of Langerhans/metabolism [MeSH], TGFBR–SMAD2/3, Signal Transduction/drug effects [MeSH], Smad Proteins/metabolism [MeSH], Gene Expression Profiling [MeSH], Diabetes Mellitus, Type 2/metabolism [MeSH], Cell Proliferation/drug effects [MeSH], alpha-2-HS-Glycoprotein/pharmacology [MeSH], Insulin/metabolism [MeSH], Glucose Intolerance, Insulin Secretion, Animals, Humans, Insulin, Phosphorylation, Cell Proliferation, 0303 health sciences, Gene Expression Profiling, Adaptive Proliferation, Foxm1, Fetuin-a, Functional Maturity, Pancreatic Beta Cells, Tgfbr–smad2/3, Diabetes Mellitus, Type 2, Signal Transduction

Popis súboru: application/pdf

Prístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00125-021-05435-1.pdf
https://pubmed.ncbi.nlm.nih.gov/33765181
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099843
https://pubmed.ncbi.nlm.nih.gov/33765181/
http://pubmed.ncbi.nlm.nih.gov/33765181/
https://link.springer.com/article/10.1007/s00125-021-05435-1
https://link.springer.com/content/pdf/10.1007/s00125-021-05435-1.pdf
https://europepmc.org/article/PMC/PMC8099843
https://hdl.handle.net/20.500.11768/115647
https://doi.org/10.1007/s00125-021-05435-1
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=61684
https://repository.publisso.de/resource/frl:6451918

Pharmacological inhibition of thioredoxin reductase increases insulin secretion and diminishes beta cell viability

Autori: Dennis Brüning Kathrin Hatlapatka Verena Lier-Glaubitz a ďalší

Zdroj: Naunyn Schmiedebergs Arch Pharmacol

Predmety: 0301 basic medicine, 0303 health sciences, Thioredoxin-Disulfide Reductase, Time Factors, Dose-Response Relationship, Drug, Cell Survival, Apoptosis, Cell Line, Islets of Langerhans, Mice, 03 medical and health sciences, Glucose, Dose-Response Relationship, Drug [MeSH], Female [MeSH], Islets of Langerhans/drug effects [MeSH], Organogold Compounds/pharmacology [MeSH], NADPH, Cell Line [MeSH], Insulin Secretion/drug effects [MeSH], Apoptosis/drug effects [MeSH], Cell Survival/drug effects [MeSH], Cytosolic calcium concentration, Insulin-Secreting Cells/drug effects [MeSH], Animals [MeSH], Benzene Derivatives/pharmacology [MeSH], Time Factors [MeSH], Insulin secretion, Islets of Langerhans/metabolism [MeSH], Original Article, Thioredoxin-Disulfide Reductase/antagonists, Mice [MeSH], Thioredoxin-Disulfide Reductase/metabolism [MeSH], Thioredoxin, Glucose/metabolism [MeSH], Insulin-Secreting Cells/metabolism [MeSH], Insulin-Secreting Cells, Insulin Secretion, Benzene Derivatives, Animals, Female, Organogold Compounds

Prístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00210-020-02046-2.pdf
https://pubmed.ncbi.nlm.nih.gov/33464387
https://link.springer.com/content/pdf/10.1007/s00210-020-02046-2.pdf
https://europepmc.org/article/PMC/PMC8208932
https://www.ncbi.nlm.nih.gov/pubmed/33464387
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208932
https://link.springer.com/article/10.1007/s00210-020-02046-2
https://pubmed.ncbi.nlm.nih.gov/33464387/
https://repository.publisso.de/resource/frl:6448015

A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion

Autori: Montaner, Mireia Denom, Jessica Simon, Vincent a ďalší

Prispievatelia: Montaner, Mireia Denom, Jessica Simon, Vincent a ďalší

Zdroj: Nat Commun
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Predmety: Male, Sympathetic Nervous System, AFFERENT CONNECTIONS, Insulin/metabolism, Science, Norepinephrine/metabolism, Neurons/metabolism, Paraventricular Hypothalamic Nucleus/metabolism, Inbred C57BL, Article, Glucagon-Like Peptide-1 Receptor, Glucagon-Like Peptide-1 Receptor/metabolism, Mice, Norepinephrine, HORMONE, Glucagon-Like Peptide 1/metabolism, Olfactory Bulb/metabolism, Glucagon-Like Peptide 1, Obesity/metabolism, Insulin Secretion, Glucose/metabolism, Animals, Insulin, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Obesity, RELEASE, Neurons, Science & Technology, GLUCAGON-LIKE PEPTIDE-1, PARAVENTRICULAR NUCLEUS, Insulin Secretion/drug effects, Sympathetic Nervous System/metabolism, Olfactory Bulb, Multidisciplinary Sciences, Mice, Inbred C57BL, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Glucose, RECEPTOR-EXPRESSING CELLS, LATERAL HYPOTHALAMUS, PROJECTIONS, Science & Technology - Other Topics, RAT, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, SYSTEM, Paraventricular Hypothalamic Nucleus, Signal Transduction

Popis súboru: application/pdf; text/xml

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39138162
https://doaj.org/article/cb3515a89fa242b4a3b002d0b2c03c19
https://hdl.handle.net/20.500.11755/b2f0d9f3-2a09-4abd-91f1-d3943e372549
https://doi.org/10.1038/s41467-024-51076-4
https://pure.knaw.nl/portal/en/publications/b2f0d9f3-2a09-4abd-91f1-d3943e372549
https://pure.amsterdamumc.nl/en/publications/5216fe2e-2bca-4891-813d-d653cc65b248
https://doi.org/10.1038/s41467-024-51076-4
https://ora.ox.ac.uk/objects/uuid:4d50dc1d-9b19-489d-952b-5ffff08d927b
https://doi.org/10.1038/s41467-024-51076-4
https://hal.science/hal-04789309v1
https://hal.science/hal-04789309v1/document
https://doi.org/10.1038/s41467-024-51076-4
https://www.repository.cam.ac.uk/handle/1810/372739
https://doi.org/10.1038/s41467-024-51076-4

Integrin and autocrine IGF2 pathways control fasting insulin secretion in β-cells

Autori: Caroline Arous Maria Luisa Mizgier Katharina Rickenbach a ďalší

Zdroj: J Biol Chem
Journal of Biological Chemistry, Vol. 295, No 49 (2020) pp. 16510-16528

Predmety: Proto-Oncogene Proteins c-akt/antagonists & inhibitors/genetics/metabolism, 0301 basic medicine, Integrins, Insulin/metabolism, Small Interfering/metabolism, Integrins/metabolism, Focal Adhesion Kinase 1/metabolism, Mice, 03 medical and health sciences, Insulin-Like Growth Factor II, Signal Transduction/drug effects, Tyrphostins/pharmacology, Insulin-Secreting Cells, Insulin Secretion, Cell Adhesion, Animals, Cell Adhesion/drug effects, RNA, Small Interfering, ddc:612, Rho-Associated Kinases/metabolism, rho-Associated Kinases, Insulin Secretion/drug effects, Cell Biology, Tyrphostins, Glucose/pharmacology, RhoA GTP-Binding Protein/metabolism, Actins, Receptor, Insulin, Rats, Insulin-Like Growth Factor II/metabolism, Autocrine Communication, Glucose, Actins/metabolism, Focal Adhesion Kinase 1, Insulin-Secreting Cells/cytology/metabolism, RNA, RNA Interference, rhoA GTP-Binding Protein, Proto-Oncogene Proteins c-akt, Receptor, Signal Transduction

Popis súboru: application/pdf

Prístupová URL adresa: http://www.jbc.org/article/S002192581750472X/pdf
https://pubmed.ncbi.nlm.nih.gov/32934005
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864053
https://archive-ouverte.unige.ch/unige:153888
https://pubmed.ncbi.nlm.nih.gov/32934005/
http://pubmed.ncbi.nlm.nih.gov/33453891/
https://www.jbc.org/content/295/49/16510.short
https://www.ncbi.nlm.nih.gov/pubmed/32934005
https://archive-ouverte.unige.ch/unige:153888

In vitro models to study insulin and glucocorticoids modulation of trimethyltin (TMT)-induced neuroinflammation and neurodegeneration, and in vivo validation in db/db mice.

Autori: Sandström, J. Kratschmar, D.V. Broyer, A. a ďalší

Predmety: 11-beta-Hydroxysteroid Dehydrogenase Type 1/biosynthesis, 11-beta-Hydroxysteroid Dehydrogenase Type 1/drug effects, Animals, Cell Line, Cells, Cultured, Cytokines/biosynthesis, Glucocorticoids/metabolism, In Vitro Techniques, Inflammation/chemically induced, Inflammation/metabolism, Insulin Secretion/drug effects, Metabolic Syndrome/metabolism, Mice, Inbred Strains, Nerve Degeneration/chemically induced, Nerve Degeneration/metabolism, Neuroglia/drug effects, Neurons/drug effects, Rats, Sprague-Dawley, Receptors, Glucocorticoid/drug effects, Reproducibility of Results, Trimethyltin Compounds/toxicity, 11β-Hydroxysteroid dehydrogenase (11β-hsd1), Astrocyte, Glucocorticoid, Insulin, Interleukin-6 (IL-6)

Relation: Archives of Toxicology; https://iris.unil.ch/handle/iris/162606; serval:BIB_D7E0994E9422; 000475702100014

Dostupnosť: https://iris.unil.ch/handle/iris/162606
https://doi.org/10.1007/s00204-019-02455-0

Decrement in Cellular Iron and Reactive Oxygen Species, and Improvement of Insulin Secretion in a Pancreatic Cell Line Using Green Tea Extract

Autori: Koonyosying, Pimpisid Uthaipibull, Chairat Fucharoen, Suthat a ďalší

Zdroj: Pancreas

Predmety: 0301 basic medicine, insulin, Diabetes Complications/metabolism, Insulin/metabolism, green tea, Iron, Catechin, Cell Line, Diabetes Complications, 03 medical and health sciences, Reactive Oxygen Species/metabolism, Cell Line, Tumor, Insulin-Secreting Cells, Insulin Secretion, Animals, Insulin, iron overload, beta-Thalassemia/complications, Catechin/analogs & derivatives, 0303 health sciences, Tumor, Tea, Plant Extracts, Plant Extracts/pharmacology, Tea/chemistry, beta-Thalassemia, Insulin Secretion/drug effects, Original Articles, Phytotherapy/methods, Rats, 3. Good health, Insulin-Secreting Cells/drug effects, pancreatic cell, Reactive Oxygen Species, Iron/metabolism, EGCG, RINm5F, Phytotherapy

Prístupová URL adresa: http://links.lww.com/MPA/A721
https://pubmed.ncbi.nlm.nih.gov/31091209
https://pubmed.ncbi.nlm.nih.gov/31091209/
https://www.ncbi.nlm.nih.gov/pubmed/31091209
https://europepmc.org/article/MED/31091209
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553981
https://discovery-pp.ucl.ac.uk/id/eprint/10076888/

Growth differentiation factor-15 prevents glucotoxicity and connexin-36 downregulation in pancreatic beta-cells

Autori: Asrih, Mohamed Dusaulcy, Rodolphe Gosmain, Yvan a ďalší

Zdroj: ISSN: 0303-7207 ; Molecular and cellular endocrinology, vol. 541 (2022) 111503.

Predmety: info:eu-repo/classification/ddc/616, Connexin-36, GDF15, Glucotoxicity, INS-1E, Pancreatic beta-cell dysfunction, Animals, Cell Survival / drug effects, Cell Survival / genetics, Cells, Cultured, Connexins / genetics, Connexins / metabolism, Cytoprotection / genetics, Down-Regulation / drug effects, Down-Regulation / genetics, Glucose / adverse effects, Glucose / metabolism, Growth Differentiation Factor 15 / genetics, Growth Differentiation Factor 15 / physiology, Insulin / metabolism, Insulin Secretion / drug effects, Insulin Secretion / genetics, Insulin-Secreting Cells / drug effects, Insulin-Secreting Cells / metabolism, Insulin-Secreting Cells / physiology, Male, Mice, Inbred C57BL, Transgenic

Relation: info:eu-repo/semantics/altIdentifier/pmid/34763008; unige:169219

Dostupnosť: https://archive-ouverte.unige.ch/unige:169219

Neprilysin inhibition in mouse islets enhances insulin secretion in a GLP-1 receptor dependent manner

Autori: Nathalie Esser Breanne M. Barrow Edwina Choung a ďalší

Zdroj: Islets. 10:175-180

Predmety: Blood Glucose, insulin secretion, Dipeptidyl Peptidase 4, Diabetes Mellitus, Type 2/drug therapy/metabolism, Insulin Secretion/drug effects/physiology, Sciences de la santé humaine, Glucagon-Like Peptide-1 Receptor, neprilysin, Diabetes Mellitus, Experimental, Glucagon-Like Peptide-1 Receptor/metabolism, Islets of Langerhans, Mice, 03 medical and health sciences, 0302 clinical medicine, DPP-4, Endocrinology, metabolism & nutrition, Insulin Secretion, Animals, Human health sciences, Enzyme Inhibitors, Enzyme Inhibitors/pharmacology, Mice, Knockout, Dipeptidyl-Peptidase IV Inhibitors, Blood Glucose/metabolism, islet, Treatment Outcome, Diabetes Mellitus, Type 2, Dipeptidyl-Peptidase IV Inhibitors/pharmacology, Neprilysin/antagonists & inhibitors/metabolism, Neprilysin, Islets of Langerhans/metabolism, GLP-1, Dipeptidyl Peptidase 4/metabolism, Endocrinologie, métabolisme & nutrition

Prístupová URL adresa: https://www.tandfonline.com/doi/pdf/10.1080/19382014.2018.1502521?needAccess=true
https://pubmed.ncbi.nlm.nih.gov/30142012
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284476
https://www.tandfonline.com/doi/full/10.1080/19382014.2018.1502521
https://europepmc.org/article/MED/30142012
https://pubmed.ncbi.nlm.nih.gov/30142012/
https://www.tandfonline.com/doi/pdf/10.1080/19382014.2018.1502521
https://hdl.handle.net/2268/267272
https://doi.org/10.1080/19382014.2018.1502521

Integrin and autocrine IGF2 pathways control fasting insulin secretion in β-cells

Autori: Arous, Caroline Mizgier, Maria Luisa Rickenbach, Katharina a ďalší

Zdroj: ISSN: 0021-9258 ; Journal of Biological Chemistry, vol. 295, no. 49 (2020) p. 16510-16528.

Predmety: info:eu-repo/classification/ddc/612, Actins/metabolism, Animals, Autocrine Communication, Cell Adhesion/drug effects, Focal Adhesion Kinase 1/metabolism, Glucose/pharmacology, Insulin Secretion/drug effects, Insulin-Like Growth Factor II/metabolism, Insulin-Secreting Cells/cytology/metabolism, Integrins/metabolism, Mice, Proto-Oncogene Proteins c-akt/antagonists & inhibitors/genetics/metabolism, RNA Interference, RNA, Small Interfering/metabolism, Rats, Receptor, Insulin/metabolism, Signal Transduction/drug effects, Tyrphostins/pharmacology, Rho-Associated Kinases/metabolism, RhoA GTP-Binding Protein/metabolism

Relation: info:eu-repo/semantics/altIdentifier/pmid/32934005; unige:153888

Dostupnosť: https://archive-ouverte.unige.ch/unige:153888

Differential sensitivity of human islets from obese versus lean donors to chronic high glucose or palmitate

Autori: Castex, Françoise Leroy, Jeremy Broca, Christophe a ďalší

Prispievatelia: Castex, Françoise Leroy, Jeremy Broca, Christophe a ďalší

Zdroj: ISSN: 1753-0407 ; Journal of Diabetes ; https://hal.umontpellier.fr/hal-02964168 ; Journal of Diabetes, 2020, 12 (7), pp.532-541. ⟨10.1111/1753-0407.13026⟩.

Predmety: Human islets, Insulin secretion, Islet transplantation, Nitric oxide synthase, Obesity, MESH: Aged Glucose / pharmacology, Humans, Insulin Secretion / drug effects, Islets of Langerhans / drug effect, MESH: Islets of Langerhans / metabolism, Male, Middle Aged, Obesity / metabolism, Palmitates / pharmacology, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences

Dostupnosť: https://hal.umontpellier.fr/hal-02964168
https://hal.umontpellier.fr/hal-02964168v1/document
https://hal.umontpellier.fr/hal-02964168v1/file/Journal%20of%20Diabetes%20-%202020%20-%20Castex%20-%20Differential%20sensitivity%20of%20human%20islets%20from%20obese%20versus%20lean%20donors%20to%20chronic.pdf
https://doi.org/10.1111/1753-0407.13026

Growth differentiation factor-15 prevents glucotoxicity and connexin-36 downregulation in pancreatic beta-cells

Autori: Karim Gariani Min Jeong Choi Rodolphe Dusaulcy a ďalší

Zdroj: Molecular and Cellular Endocrinology. 541:111503

Predmety: Connexins / genetics, Male, 0301 basic medicine, Cell Survival / drug effects, Growth Differentiation Factor 15, Cell Survival, INS-1E, Down-Regulation, Insulin-Secreting Cells / drug effects, Mice, Transgenic, Pancreatic beta-cell dysfunction, Insulin-Secreting Cells / physiology, Down-Regulation / drug effects, Connexins, Connexins / metabolism, Mice, 03 medical and health sciences, Down-Regulation / genetics, Insulin Secretion / genetics, Growth Differentiation Factor 15 / physiology, Insulin-Secreting Cells, Insulin Secretion, Cytoprotection / genetics, Animals, Insulin, Insulin Secretion / drug effects, Glucotoxicity, Growth Differentiation Factor 15 / genetics, Cells, Cultured, Insulin-Secreting Cells / metabolism, Glucose / metabolism, Gap Junction delta-2 Protein, 0303 health sciences, Connexin-36, Cell Survival / genetics, Glucose / adverse effects, 3. Good health, Mice, Inbred C57BL, GDF15, Glucose, Cytoprotection, Insulin / metabolism

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/34763008
https://www.sciencedirect.com/science/article/pii/S0303720721003476
https://archive-ouverte.unige.ch/unige:169219
https://doi.org/10.1016/j.mce.2021.111503

Neprilysin inhibition in mouse islets enhances insulin secretion in a GLP-1 receptor dependent manner.

Autori: Esser, Nathalie Barrow, Breanne M. Choung, Edwina a ďalší

Zdroj: Islets, 10 (5), 175-180 (2018)

Predmety: Animals, Blood Glucose/metabolism, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2/drug therapy/metabolism, Dipeptidyl Peptidase 4/metabolism, Dipeptidyl-Peptidase IV Inhibitors/pharmacology, Enzyme Inhibitors/pharmacology, Glucagon-Like Peptide-1 Receptor/metabolism, Insulin Secretion/drug effects/physiology, Islets of Langerhans/metabolism, Mice, Mice, Knockout, Neprilysin/antagonists & inhibitors/metabolism, Treatment Outcome, DPP-4, GLP-1, insulin secretion, islet, neprilysin, Human health sciences, Endocrinology, metabolism & nutrition, Sciences de la santé humaine, Endocrinologie, métabolisme & nutrition

Relation: urn:issn:1938-2014; urn:issn:1938-2022

Prístupová URL adresa: https://orbi.uliege.be/handle/2268/267272