Suchergebnisse - "Injury"

Multidrug Resistance-Associated Protein 1 Aberration-Incurred Glutathione Efflux Drives Renal Ferroptosis and Acute Kidney Injury-Chronic Kidney Disease Progression.

Autoren: Zhao J An H Zhou S et al.

Quelle: Journal of cellular physiology [J Cell Physiol] 2025 Oct; Vol. 240 (10), pp. e70105.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0050222 Publication Model: Print Cited Medium: Internet ISSN: 1097-4652 (Electronic) Linking ISSN: 00219541 NLM ISO Abbreviation: J Cell Physiol Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis*/drug effects , Acute Kidney Injury*/pathology , Acute Kidney Injury*/metabolism , Acute Kidney Injury*/genetics , Glutathione*/metabolism , Multidrug Resistance-Associated Proteins*/metabolism , Multidrug Resistance-Associated Proteins*/genetics , Renal Insufficiency, Chronic*/pathology , Renal Insufficiency, Chronic*/metabolism , Renal Insufficiency, Chronic*/genetics , Kidney*/pathology , Kidney*/metabolism, Animals ; Reperfusion Injury/pathology ; Reperfusion Injury/metabolism ; Reperfusion Injury/genetics ; Disease Progression ; Male ; Mice ; Disease Models, Animal ; Mice, Inbred C57BL ; Propionates/pharmacology ; Kidney Tubules/metabolism ; Kidney Tubules/pathology ; Quinolines

Organ Crosstalk During Injury: Mechanisms of Lung-Kidney Interaction in Critical Illness.

Autoren: Sullivan KM Liu KD Matthay MA

Quelle: Comprehensive Physiology [Compr Physiol] 2025 Dec; Vol. 15 (6), pp. e70069.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Country of Publication: United States NLM ID: 101574442 Publication Model: Print Cited Medium: Internet ISSN: 2040-4603 (Electronic) Linking ISSN: 20404603 NLM ISO Abbreviation: Compr Physiol Subsets: MEDLINE

MeSH-Schlagworte: Acute Kidney Injury*/physiopathology , Acute Kidney Injury*/metabolism , Respiratory Distress Syndrome*/physiopathology , Lung*/physiopathology , Kidney*/physiopathology, Humans ; Animals ; Critical Illness ; Acute Lung Injury/physiopathology

Evaluating the association between bronchoscopic severity of burns-related smoke inhalation injury and clinical outcomes: A systematic review and meta-analysis.

Autoren: Amarasekera NN Jha A Charles WN et al.

Quelle: Burns : journal of the International Society for Burn Injuries [Burns] 2025 Dec; Vol. 51 (9), pp. 107721. Date of Electronic Publication: 2025 Oct 01.

Publikationsart: Journal Article; Systematic Review; Meta-Analysis

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8913178 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1409 (Electronic) Linking ISSN: 03054179 NLM ISO Abbreviation: Burns Subsets: MEDLINE

MeSH-Schlagworte: Smoke Inhalation Injury*/complications , Smoke Inhalation Injury*/mortality , Smoke Inhalation Injury*/diagnosis , Bronchoscopy* , Respiratory Distress Syndrome*/epidemiology , Respiratory Distress Syndrome*/etiology , Pneumonia*/epidemiology , Pneumonia*/etiology , Burns*/complications , Burns*/mortality, Humans ; Intubation, Intratracheal/statistics & numerical data ; Abbreviated Injury Scale ; Severity of Illness Index

HIF-1α/A2BAR signalling pathway alleviates kidney fibrosis after ischemia-reperfusion injury by preventing macrophage-to-myofibroblast transition.

Autoren: Yang Y Tao T Huang J et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 2), pp. 117358. Date of Electronic Publication: 2025 Sep 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Reperfusion Injury*/metabolism , Reperfusion Injury*/pathology , Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/genetics , Macrophages*/metabolism , Macrophages*/pathology , Macrophages*/drug effects , Receptor, Adenosine A2B*/metabolism , Receptor, Adenosine A2B*/genetics , Myofibroblasts*/metabolism , Myofibroblasts*/pathology , Myofibroblasts*/drug effects , Kidney*/pathology , Kidney*/metabolism, Animals ; Fibrosis/metabolism ; Signal Transduction/physiology ; Signal Transduction/drug effects ; Mice ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Acute Kidney Injury/metabolism ; Acute Kidney Injury/pathology

Splenectomy modulates intrarenal B cell differentiation and impairs repair of post-ischemic kidney.

Autoren: Lee K Jeon H Lee KS et al.

Quelle: Frontiers in immunology [Front Immunol] 2025 Nov 19; Vol. 16, pp. 1684731. Date of Electronic Publication: 2025 Nov 19 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Splenectomy*/adverse effects , Reperfusion Injury*/immunology , Reperfusion Injury*/pathology , B-Lymphocytes*/immunology , B-Lymphocytes*/metabolism , Cell Differentiation*/immunology , Kidney*/immunology , Kidney*/pathology, Animals ; Mice ; Mice, Inbred C57BL ; Male ; Disease Models, Animal ; Cytokines/metabolism ; Acute Kidney Injury/immunology

Targeting UBE2B-mediated U2AF1 degradation to alleviate endothelial dysfunction in renal ischemia-reperfusion injury: therapeutic potential of semaglutide.

Autoren: Wang Q Ren S Jiao L et al.

Quelle: Molecular biology reports [Mol Biol Rep] 2025 Nov 04; Vol. 53 (1), pp. 44. Date of Electronic Publication: 2025 Nov 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

MeSH-Schlagworte: Reperfusion Injury*/metabolism , Reperfusion Injury*/drug therapy , Ubiquitin-Conjugating Enzymes*/metabolism , Ubiquitin-Conjugating Enzymes*/genetics , Glucagon-Like Peptides*/pharmacology , Glucagon-Like Peptides*/metabolism, Humans ; Animals ; Apoptosis/drug effects ; Signal Transduction/drug effects ; Acute Kidney Injury/metabolism ; Acute Kidney Injury/drug therapy ; Kidney/metabolism ; Kidney/pathology ; Male ; Oxidative Stress/drug effects ; Endothelial Cells/metabolism ; Endothelial Cells/drug effects ; Cell Proliferation/drug effects ; Ubiquitination/drug effects ; Human Umbilical Vein Endothelial Cells ; Glucagon-Like Peptide 1

Dexmedetomidine alleviates renal ischemia reperfusion injury via suppressing SLC2A1-mediated glycolysis.

Autoren: Ding W Xie L Wang L et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Nov; Vol. 241, pp. 117166. Date of Electronic Publication: 2025 Jul 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Dexmedetomidine*/pharmacology , Dexmedetomidine*/therapeutic use , Reperfusion Injury*/metabolism , Reperfusion Injury*/drug therapy , Reperfusion Injury*/prevention & control , Glycolysis*/drug effects , Glycolysis*/physiology , Glucose Transporter Type 1*/metabolism , Glucose Transporter Type 1*/antagonists & inhibitors , Kidney*/drug effects , Kidney*/metabolism , Kidney*/pathology, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Humans ; Cell Line ; Acute Kidney Injury/metabolism ; Acute Kidney Injury/drug therapy

Integrated spatial and functional metabolic profiling identified the thick ascending limb as a mitochondrial vulnerability hub in acute kidney injury.

Autoren: Arnoux G Serre J Verissimo T et al.

Quelle: Kidney international [Kidney Int] 2025 Nov; Vol. 108 (5), pp. 866-882. Date of Electronic Publication: 2025 Aug 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0323470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1755 (Electronic) Linking ISSN: 00852538 NLM ISO Abbreviation: Kidney Int Subsets: MEDLINE

MeSH-Schlagworte: Acute Kidney Injury*/metabolism , Acute Kidney Injury*/pathology , Acute Kidney Injury*/etiology , Mitochondria*/metabolism , Mitochondria*/drug effects , Mitochondria*/pathology , Loop of Henle*/metabolism , Loop of Henle*/pathology , Loop of Henle*/drug effects, Animals ; Humans ; Mice ; Kidney Transplantation/adverse effects ; Male ; Oxidative Phosphorylation/drug effects ; Disease Models, Animal ; Mice, Inbred C57BL ; Female ; Energy Metabolism/drug effects ; Reperfusion Injury/pathology ; Reperfusion Injury/metabolism ; Glycolysis/drug effects ; Single-Cell Analysis

Comprehensive evaluation of high dose methotrexate therapy: a retrospective observational trial.

Autoren: Ehab Barakat H Ashraf El Bahy K Victor Labib S et al.

Quelle: Journal of the Egyptian National Cancer Institute [J Egypt Natl Canc Inst] 2025 Oct 20; Vol. 37 (1), pp. 69. Date of Electronic Publication: 2025 Oct 20.

Publikationsart: Journal Article; Observational Study

Info zur Zeitschrift: Publisher: SpringerOpen Country of Publication: England NLM ID: 9424566 Publication Model: Electronic Cited Medium: Internet ISSN: 2589-0409 (Electronic) Linking ISSN: 11100362 NLM ISO Abbreviation: J Egypt Natl Canc Inst Subsets: MEDLINE

MeSH-Schlagworte: Methotrexate*/adverse effects , Methotrexate*/administration & dosage , Methotrexate*/blood , Neoplasms*/drug therapy , Neoplasms*/mortality , Chemical and Drug Induced Liver Injury*/etiology , Chemical and Drug Induced Liver Injury*/epidemiology , Antimetabolites, Antineoplastic*/adverse effects , Antimetabolites, Antineoplastic*/administration & dosage, Humans ; Male ; Retrospective Studies ; Female ; Middle Aged ; Adult ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/epidemiology ; Length of Stay/statistics & numerical data ; Aged

15-lipoxygenase blockade switches off pan-organ ischaemia-reperfusion injury by inhibiting pyroptosis.

Autoren: Li J Zhang H Dai M et al.

Quelle: Molecular biomedicine [Mol Biomed] 2025 Oct 10; Vol. 6 (1), pp. 77. Date of Electronic Publication: 2025 Oct 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE

MeSH-Schlagworte: Arachidonate 15-Lipoxygenase*/metabolism , Arachidonate 15-Lipoxygenase*/genetics , Pyroptosis*/drug effects , Reperfusion Injury*/pathology , Reperfusion Injury*/metabolism , Reperfusion Injury*/drug therapy , Lipoxygenase Inhibitors*/pharmacology, Animals ; Reactive Oxygen Species/metabolism ; Mice ; Mitochondria/metabolism ; Mitochondria/drug effects ; Mice, Inbred C57BL ; Male ; Myocardial Reperfusion Injury/pathology ; Myocardial Reperfusion Injury/metabolism ; Arachidonate 12-Lipoxygenase

Augmenter of liver regeneration (ALR) can regulate iron homeostasis through the INOS/NO/SLC39A14 pathway to reduce ferroptosis in acute kidney injury.

Autoren: Tan F Cao D Huang L et al.

Quelle: The FEBS journal [FEBS J] 2025 Oct; Vol. 292 (19), pp. 5130-5150. Date of Electronic Publication: 2025 Apr 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-4658 (Electronic) Linking ISSN: 1742464X NLM ISO Abbreviation: FEBS J Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis*/genetics , Acute Kidney Injury*/metabolism , Acute Kidney Injury*/pathology , Acute Kidney Injury*/genetics , Iron*/metabolism , Nitric Oxide Synthase Type II*/metabolism , Nitric Oxide Synthase Type II*/genetics , Nitric Oxide*/metabolism , Nitric Oxide*/genetics , Cation Transport Proteins*/metabolism , Cation Transport Proteins*/genetics , Coenzyme A Ligases*/genetics , Coenzyme A Ligases*/metabolism, Animals ; Mice ; Humans ; Homeostasis ; Mice, Knockout ; Male ; Disease Models, Animal ; Mice, Inbred C57BL ; Reperfusion Injury/pathology ; Reperfusion Injury/genetics ; Reperfusion Injury/metabolism ; Signal Transduction

Targeting WNT5A noncanonical signaling attenuates renal fibrosis progression in acute kidney injury.

Autoren: Gu S Feng H Li X et al.

Quelle: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Oct 01; Vol. 33 (10), pp. 5248-5262. Date of Electronic Publication: 2025 Jun 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

MeSH-Schlagworte: Acute Kidney Injury*/metabolism , Acute Kidney Injury*/pathology , Acute Kidney Injury*/genetics , Acute Kidney Injury*/etiology , Wnt-5a Protein*/metabolism , Wnt-5a Protein*/genetics , Renal Insufficiency, Chronic*/metabolism , Renal Insufficiency, Chronic*/pathology , Renal Insufficiency, Chronic*/etiology , Renal Insufficiency, Chronic*/genetics , Signal Transduction*, Animals ; Humans ; Mice ; Fibrosis ; Disease Progression ; Male ; Disease Models, Animal ; CD146 Antigen/metabolism ; CD146 Antigen/genetics ; Snail Family Transcription Factors/genetics ; Snail Family Transcription Factors/metabolism ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology ; Cell Line ; Kidney/pathology ; Kidney/metabolism

Renoprotective Effects of MIT-001 in Ischemia-Reperfusion Injury: Modulation of Ferroptosis, ROS and Fibrotic Markers.

Autoren: Shin JA Hwang Y Park H et al.

Quelle: Journal of cellular and molecular medicine [J Cell Mol Med] 2025 Oct; Vol. 29 (20), pp. e70914.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis*/drug effects , Reperfusion Injury*/drug therapy , Reperfusion Injury*/metabolism , Reperfusion Injury*/pathology , Reactive Oxygen Species*/metabolism , Protective Agents*/pharmacology, Animals ; Fibrosis ; Mice ; Humans ; Oxidative Stress/drug effects ; Male ; Acute Kidney Injury/pathology ; Acute Kidney Injury/metabolism ; Acute Kidney Injury/drug therapy ; Biomarkers/metabolism ; NF-E2-Related Factor 2/metabolism ; Cell Line ; Mice, Inbred C57BL ; Signal Transduction/drug effects ; Disease Models, Animal ; Kidney/pathology ; Kidney/drug effects ; Kidney/metabolism

The molecular mechanisms and therapeutic potential of p53 in kidney injury repair: a perspective on the p53alpha/delta133p53alpha signaling axis.

Autoren: Fan J Guo Y Cui G et al.

Quelle: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2586388. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

MeSH-Schlagworte: Tumor Suppressor Protein p53*/metabolism , Tumor Suppressor Protein p53*/genetics , Acute Kidney Injury*/metabolism , Acute Kidney Injury*/drug therapy, Humans ; Signal Transduction ; Protein Isoforms/metabolism ; Apoptosis ; Animals ; Reperfusion Injury ; Autophagy

Galectin-3/CD146 interaction promotes renal damage and systemic inflammation after acute kidney injury.

Autoren: Boutin L Figueroa SM Roger E et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 24; Vol. 15 (1), pp. 41575. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Galectin 3*/metabolism , Galectin 3*/genetics , Acute Kidney Injury*/metabolism , Acute Kidney Injury*/pathology , Inflammation*/metabolism , Inflammation*/pathology , CD146 Antigen*/metabolism , Kidney*/pathology , Kidney*/metabolism, Animals ; Mice ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology ; Male ; Mice, Knockout ; Mice, Inbred C57BL ; Disease Models, Animal

Prediction of primary blast lung injury outcomes in goats using CT and injury factors.

Autoren: Yang B Feng L Wang H et al.

Quelle: European journal of trauma and emergency surgery : official publication of the European Trauma Society [Eur J Trauma Emerg Surg] 2025 Nov 14; Vol. 51 (1), pp. 327. Date of Electronic Publication: 2025 Nov 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Heidelberg Country of Publication: Germany NLM ID: 101313350 Publication Model: Electronic Cited Medium: Internet ISSN: 1863-9941 (Electronic) Linking ISSN: 18639933 NLM ISO Abbreviation: Eur J Trauma Emerg Surg Subsets: MEDLINE

MeSH-Schlagworte: Blast Injuries*/diagnostic imaging , Blast Injuries*/mortality , Blast Injuries*/pathology , Lung Injury*/diagnostic imaging , Lung Injury*/mortality , Lung Injury*/pathology , Lung Injury*/etiology , Tomography, X-Ray Computed*, Animals ; Goats ; Disease Models, Animal ; Injury Severity Score ; Altitude ; Blood Gas Analysis ; ROC Curve ; Nomograms

Novel small molecule inhibitor of GPR68 attenuates endothelial dysfunction and lung injury caused by bacterial lipopolysaccharide.

Autoren: Karki P Ke Y Zhang CO et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 05; Vol. 15 (1), pp. 38669. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Receptors, G-Protein-Coupled*/antagonists & inhibitors , Receptors, G-Protein-Coupled*/metabolism , Lipopolysaccharides*/toxicity , Endothelial Cells*/drug effects , Endothelial Cells*/metabolism , Endothelial Cells*/pathology , Lung Injury*/drug therapy , Lung Injury*/metabolism , Lung Injury*/chemically induced , Lung Injury*/pathology , Endothelium, Vascular*/drug effects , Endothelium, Vascular*/metabolism, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Lung/drug effects ; Lung/pathology ; NF-kappa B/metabolism ; Acute Lung Injury ; Disease Models, Animal ; Signal Transduction/drug effects ; Humans

Advances in therapeutic strategies for acute kidney injury.

Autoren: Song S Su W Wang H et al.

Quelle: Life sciences [Life Sci] 2025 Nov 01; Vol. 380, pp. 123943. Date of Electronic Publication: 2025 Sep 01.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE

MeSH-Schlagworte: Acute Kidney Injury*/therapy, Humans ; Animals ; Drug Delivery Systems/methods ; Contrast Media/adverse effects ; Nanomedicine/methods ; Sepsis/complications ; Reperfusion Injury/complications

DNA-Guided Multivalent Antibody Display Boosts the Targeting Performance of Therapeutic Nanovesicles.

Autoren: Wu J Liu X Ye T et al.

Quelle: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2025 Oct 01; Vol. 17 (39), pp. 54484-54495. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE

MeSH-Schlagworte: DNA*/chemistry , Acute Lung Injury*/drug therapy , Acute Lung Injury*/pathology , Acute Lung Injury*/metabolism , Antibodies*/chemistry , Nanoparticles*/chemistry, Humans ; Animals ; Mice ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/pathology ; Mesenchymal Stem Cells/metabolism ; Extracellular Vesicles/chemistry

Angiopoietin-like 4 exacerbates renal tubular epithelial cell pyroptosis in acute kidney injury via integrin β5/FAK signaling pathway.

Autoren: Shen X Wang H Weng C et al.

Quelle: Kidney international [Kidney Int] 2025 Dec; Vol. 108 (6), pp. 1073-1087. Date of Electronic Publication: 2025 Aug 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0323470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1755 (Electronic) Linking ISSN: 00852538 NLM ISO Abbreviation: Kidney Int Subsets: MEDLINE

MeSH-Schlagworte: Pyroptosis* , Angiopoietin-Like Protein 4*/metabolism , Angiopoietin-Like Protein 4*/genetics , Acute Kidney Injury*/pathology , Acute Kidney Injury*/metabolism , Epithelial Cells*/pathology , Epithelial Cells*/metabolism , Kidney Tubules*/pathology , Kidney Tubules*/cytology , Focal Adhesion Kinase 1*/metabolism, Animals ; Humans ; Signal Transduction ; Mice ; Disease Models, Animal ; Mice, Knockout ; Male ; Cell Line ; Mice, Inbred C57BL ; Up-Regulation ; Reperfusion Injury/pathology