Suchergebnisse - "Immunology"

Peripheral blood T regulatory cell profiles in repeat-breeder Cattle: Differential responses to seminal components.

Autoren: Pandit A Umar SIU Shah SM et al.

Quelle: Theriogenology [Theriogenology] 2025 Dec; Vol. 248, pp. 117625. Date of Electronic Publication: 2025 Aug 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0421510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3231 (Electronic) Linking ISSN: 0093691X NLM ISO Abbreviation: Theriogenology Subsets: MEDLINE

MeSH-Schlagworte: Cattle*/immunology , T-Lymphocytes, Regulatory*/metabolism , Reproduction*/immunology , Reproduction*/physiology , Leukocytes, Mononuclear*/metabolism, Animals ; Breeding/methods ; Enzyme-Linked Immunosorbent Assay ; Biomarkers/metabolism ; Seminal Plasma Proteins/genetics ; Seminal Plasma Proteins/immunology ; Seminal Plasma Proteins/metabolism ; Semen/immunology ; Semen/metabolism ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Sperm Proteins/genetics ; Sperm Proteins/metabolism ; Allergy and Immunology

[Obesity at the crossroads: between immunity and cancer].

Transliterierter Titel: L’Obésité à la croisée des chemins - Entre immunité et cancer.

Autoren: Kaboré C Silva M Zellner A et al.

Quelle: Medecine sciences : M/S [Med Sci (Paris)] 2025 Oct; Vol. 41 (10), pp. 791-794. Date of Electronic Publication: 2025 Nov 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: EDK Country of Publication: France NLM ID: 8710980 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1958-5381 (Electronic) Linking ISSN: 07670974 NLM ISO Abbreviation: Med Sci (Paris) Subsets: MEDLINE

MeSH-Schlagworte: Immunity*/physiology , Immunity*/immunology , Neoplasms*/immunology , Neoplasms*/therapy , Neoplasms*/complications , Obesity*/immunology , Obesity*/complications , Obesity*/therapy , Obesity*/epidemiology, Humans ; Allergy and Immunology/education ; Allergy and Immunology/trends ; Immunotherapy/methods

Immunology as a guide to human relationships.

Autoren: Andrade BB Araújo-Pereira M

Quelle: Trends in immunology [Trends Immunol] 2025 Dec; Vol. 46 (12), pp. 758-761. Date of Electronic Publication: 2025 Oct 29.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 100966032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-4981 (Electronic) Linking ISSN: 14714906 NLM ISO Abbreviation: Trends Immunol Subsets: MEDLINE

MeSH-Schlagworte: Allergy and Immunology*, Humans ; Microbiota/immunology ; Cytokines/immunology ; Animals ; Immune Tolerance

From Histology to High-Resolution Mapping: The Rise of Spatial Omics in Immunology.

Autoren: De Giovanni M Inverso D Iannacone M

Quelle: European journal of immunology [Eur J Immunol] 2025 Oct; Vol. 55 (10), pp. e70073.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE

MeSH-Schlagworte: Allergy and Immunology* , Immune System*/immunology, Humans ; Animals ; Proteomics/methods ; Metabolomics/methods ; Transcriptome ; Signal Transduction/immunology ; Genomics/methods ; Lipidomics

How does Elie Metchnikoff relate to the investigator of today?

Autoren: Edwards CR Lipsky PE

Quelle: Annals of the rheumatic diseases [Ann Rheum Dis] 2025 Oct; Vol. 84 (10), pp. 1616-1620. Date of Electronic Publication: 2025 Aug 05.

Publikationsart: Historical Article; Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE

MeSH-Schlagworte: Allergy and Immunology*/history, History, 20th Century ; History, 19th Century ; Humans ; Ukraine ; Immunity, Innate ; Nobel Prize ; Phagocytosis/immunology

Comparative efficacy of Naringenin and Sinomenine in facilitating the differentiation of mouse hematopoietic stem cells into immature dendritic cells to promote transplantation immunological regulation.

Autoren: Xu C Zhao X Niu Z et al.

Quelle: Transplant immunology [Transpl Immunol] 2025 Sep; Vol. 92, pp. 102260. Date of Electronic Publication: 2025 Jun 09.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9309923 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5492 (Electronic) Linking ISSN: 09663274 NLM ISO Abbreviation: Transpl Immunol Subsets: MEDLINE

MeSH-Schlagworte: Morphinans*/pharmacology , Flavanones*/pharmacology , Dendritic Cells*/immunology , Hematopoietic Stem Cells*/immunology , Skin Transplantation* , T-Lymphocytes, Regulatory*/immunology , Hematopoietic Stem Cell Transplantation*, Animals ; Mice ; Cell Differentiation/drug effects ; Mice, Inbred BALB C ; Graft Survival ; Cells, Cultured ; Apoptosis ; Mice, Inbred C57BL ; Cytokines/metabolism ; Transplantation Immunology

From Fleas to T Lymphocytes and Beyond: How did I Become an Immunologist, and What Has Resulted from It?

Autoren: Kisielow P; Professor Emeritus from the Ludwik Hirszfeld, Institute of Immunology and Experimental Therapy, Wrocław, Poland.

Quelle: Archivum immunologiae et therapiae experimentalis [Arch Immunol Ther Exp (Warsz)] 2025 Aug 22; Vol. 73 (1). Date of Electronic Publication: 2025 Aug 22 (Print Publication: 2025).

Publikationsart: Journal Article; Review; Historical Article

Info zur Zeitschrift: Publisher: Sciendo Country of Publication: Poland NLM ID: 0114365 Publication Model: eCollection Cited Medium: Internet ISSN: 1661-4917 (Electronic) Linking ISSN: 0004069X NLM ISO Abbreviation: Arch Immunol Ther Exp (Warsz) Subsets: MEDLINE

MeSH-Schlagworte: Allergy and Immunology*/history, Animals ; Humans ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/genetics ; Mice ; Mice, Transgenic ; History, 20th Century ; History, 21st Century

Eosinophilic esophagitis: An allergy and immunology perspective on the updated guidelines.

Autoren: McGowan EC Wright BL Ruffner MA et al.

Quelle: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2025 Aug; Vol. 156 (2), pp. 252-258. Date of Electronic Publication: 2025 May 06.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825 (Electronic) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol Subsets: MEDLINE

MeSH-Schlagworte: Eosinophilic Esophagitis*/diagnosis , Eosinophilic Esophagitis*/therapy , Eosinophilic Esophagitis*/immunology , Eosinophilic Esophagitis*/epidemiology, Humans ; Practice Guidelines as Topic ; Allergy and Immunology ; Hypersensitivity/therapy

Human CD4 T cells are a functional target for lipid nanoparticle-based mRNA vaccines.

Autoren: Kim SC Felgner J Soto MS et al.

Quelle: MBio [mBio] 2025 Nov 12; Vol. 16 (11), pp. e0225425. Date of Electronic Publication: 2025 Sep 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

MeSH-Schlagworte: CD4-Positive T-Lymphocytes*/immunology , COVID-19 Vaccines*/immunology , COVID-19 Vaccines*/administration & dosage , Nanoparticles*/chemistry , SARS-CoV-2*/immunology , SARS-CoV-2*/genetics , COVID-19*/prevention & control , COVID-19*/immunology , Lipids*, Humans ; Animals ; Mice ; mRNA Vaccines/immunology ; RNA, Messenger/immunology ; RNA, Messenger/genetics ; Antibodies, Viral/immunology ; Antibodies, Viral/blood ; Female ; Vaccines, Synthetic/immunology ; Mice, Inbred C57BL ; Liposomes

Myeloid cells mediate interferon-driven resistance to immunotherapy in advanced renal cell carcinoma.

Autoren: Bi K Kashima S Camp SY et al.

Quelle: Immunity [Immunity] 2025 Nov 11; Vol. 58 (11), pp. 2814-2829.e9. Date of Electronic Publication: 2025 Oct 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Renal Cell*/immunology , Carcinoma, Renal Cell*/therapy , Carcinoma, Renal Cell*/pathology , Carcinoma, Renal Cell*/drug therapy , Kidney Neoplasms*/immunology , Kidney Neoplasms*/therapy , Kidney Neoplasms*/pathology , Myeloid Cells*/immunology , Myeloid Cells*/metabolism , Immunotherapy*/methods , Drug Resistance, Neoplasm*/immunology , Interferon-gamma*/metabolism , Interferons*/metabolism, Humans ; Tumor Microenvironment/immunology ; Cell Line, Tumor ; Immune Checkpoint Inhibitors/therapeutic use ; Immune Checkpoint Inhibitors/pharmacology ; Signal Transduction ; Macrophages/immunology

Correlation patterns among house dust mite allergens in allergic rhinitis: A molecular sensitization study in Mallorca.

Autoren: Chugo S Pons J Escobar D et al.

Quelle: Allergologia et immunopathologia [Allergol Immunopathol (Madr)] 2025 Nov 01; Vol. 53 (6), pp. 73-85. Date of Electronic Publication: 2025 Nov 01 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Codon Publications Country of Publication: Singapore NLM ID: 0370073 Publication Model: eCollection Cited Medium: Internet ISSN: 1578-1267 (Electronic) Linking ISSN: 03010546 NLM ISO Abbreviation: Allergol Immunopathol (Madr) Subsets: MEDLINE

MeSH-Schlagworte: Antigens, Dermatophagoides*/immunology , Rhinitis, Allergic*/immunology , Rhinitis, Allergic*/epidemiology , Dermatophagoides pteronyssinus*/immunology , Arthropod Proteins*/immunology , Pyroglyphidae*/immunology , Allergens*/immunology, Humans ; Animals ; Male ; Female ; Adult ; Immunoglobulin E/blood ; Immunoglobulin E/immunology ; Middle Aged ; Young Adult ; Adolescent ; Cysteine Endopeptidases/immunology ; Immunization ; Child ; Aged

Innate immuno-response to nanoparticle uptake in liver and spleen mimics pathogen infection.

Autoren: Brodin BA Saladino GM Hertz HM et al.

Quelle: Nanomedicine (London, England) [Nanomedicine (Lond)] 2025 Nov; Vol. 20 (22), pp. 2721-2731. Date of Electronic Publication: 2025 Oct 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101278111 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-6963 (Electronic) Linking ISSN: 17435889 NLM ISO Abbreviation: Nanomedicine (Lond) Subsets: MEDLINE

MeSH-Schlagworte: Liver*/immunology , Liver*/metabolism , Liver*/drug effects , Immunity, Innate*/drug effects , Spleen*/immunology , Spleen*/metabolism , Spleen*/drug effects , Nanoparticles*/chemistry , Nanoparticles*/administration & dosage, Animals ; Mice ; Macrophages/immunology ; Macrophages/drug effects ; Macrophages/metabolism ; Kupffer Cells/immunology ; Kupffer Cells/drug effects ; Mice, Inbred C57BL ; Killer Cells, Natural/immunology ; Killer Cells, Natural/drug effects ; Lung/immunology ; Lung/metabolism ; Oxidative Stress/drug effects

Immunology in corneal transplantation-From homeostasis to graft rejection.

Autoren: Lee S Dohlman TH Dana R

Quelle: Transplantation reviews (Orlando, Fla.) [Transplant Rev (Orlando)] 2025 Apr; Vol. 39 (2), pp. 100909. Date of Electronic Publication: 2025 Jan 09.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 8804364 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-9816 (Electronic) Linking ISSN: 0955470X NLM ISO Abbreviation: Transplant Rev (Orlando) Subsets: MEDLINE

MeSH-Schlagworte: Graft Rejection*/immunology , Graft Rejection*/prevention & control , Corneal Transplantation* , Homeostasis*/immunology , Transplantation Immunology*/immunology, Humans ; Animals ; Transplantation, Heterologous ; Immune Tolerance/immunology ; Graft Survival/immunology

Unrestrained MyD88 Signaling in A20-Deficient Keratinocytes Triggers T-Cell-Dependent Psoriatic Arthritis-Like Disease.

Autoren: Tobias R Kumar S Liu J et al.

Quelle: The Journal of investigative dermatology [J Invest Dermatol] 2025 Dec; Vol. 145 (12), pp. 2998-3010.e3. Date of Electronic Publication: 2025 Apr 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1747 (Electronic) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE

MeSH-Schlagworte: Keratinocytes*/immunology , Keratinocytes*/metabolism , Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/genetics , Arthritis, Psoriatic*/immunology , Arthritis, Psoriatic*/pathology , Arthritis, Psoriatic*/genetics , T-Lymphocytes*/immunology , Tumor Necrosis Factor alpha-Induced Protein 3*/genetics , Tumor Necrosis Factor alpha-Induced Protein 3*/metabolism , Tumor Necrosis Factor alpha-Induced Protein 3*/deficiency, Animals ; Mice ; Signal Transduction/immunology ; Humans ; Disease Models, Animal ; Mice, Knockout ; Psoriasis/immunology ; Cells, Cultured ; Mice, Inbred C57BL

Identification of TTLL8, POTEE, and PKMYT1 as immunogenic cancer-associated antigens and potential immunotherapy targets in ovarian cancer.

Autoren: Bassoy EY Raja R Rubino TE Jr et al.

Quelle: Oncoimmunology [Oncoimmunology] 2025 Dec; Vol. 14 (1), pp. 2460276. Date of Electronic Publication: 2025 Jan 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2162-402X (Electronic) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: MEDLINE

MeSH-Schlagworte: Ovarian Neoplasms*/immunology , Ovarian Neoplasms*/therapy , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/metabolism , Ovarian Neoplasms*/mortality , Antigens, Neoplasm*/immunology , Antigens, Neoplasm*/metabolism, Humans ; Female ; Immunotherapy/methods ; Cell Line, Tumor ; CD8-Positive T-Lymphocytes/immunology ; Prognosis ; Lymphocytes, Tumor-Infiltrating/immunology ; Middle Aged

Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations.

Autoren: Dreyer FA Schneider C Kovaltsuk A et al.

Quelle: MAbs [MAbs] 2025 Dec; Vol. 17 (1), pp. 2511220. Date of Electronic Publication: 2025 Jun 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

MeSH-Schlagworte: SARS-CoV-2*/immunology , SARS-CoV-2*/genetics , Antibodies, Viral*/immunology , Antibodies, Viral*/genetics , Antibodies, Viral*/chemistry , Antibodies, Viral*/therapeutic use , Antibodies, Monoclonal*/therapeutic use , Antibodies, Monoclonal*/genetics , Antibodies, Monoclonal*/immunology , Antibodies, Monoclonal*/chemistry , Antibodies, Neutralizing*/immunology , Antibodies, Neutralizing*/genetics , Antibodies, Neutralizing*/chemistry , Drug Design*, Humans ; COVID-19/immunology ; COVID-19/virology ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Mutation ; Epitopes/immunology ; Epitopes/genetics ; COVID-19 Drug Treatment

SCR Organism: SARS-CoV-2 variants

Antibody-dependent enhancement of SARS-CoV-2, the impact of variants and vaccination.

Autoren: Thomas S Smatti MK Mohammad AlKhatib HA et al.

Quelle: Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2025 Dec; Vol. 21 (1), pp. 2505356. Date of Electronic Publication: 2025 May 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-554X (Electronic) Linking ISSN: 21645515 NLM ISO Abbreviation: Hum Vaccin Immunother Subsets: MEDLINE

MeSH-Schlagworte: SARS-CoV-2*/immunology , SARS-CoV-2*/genetics , Antibodies, Viral*/blood , Antibodies, Viral*/immunology , COVID-19 Vaccines*/immunology , COVID-19 Vaccines*/administration & dosage , COVID-19*/immunology , COVID-19*/prevention & control , COVID-19*/virology , Antibody-Dependent Enhancement*/immunology, Humans ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Middle Aged ; Adult ; Male ; Female ; Vaccination ; Aged ; Complement Activation ; Neutralization Tests ; Young Adult ; Middle East Respiratory Syndrome Coronavirus/immunology ; mRNA Vaccines/immunology

SCR Organism: SARS-CoV-2 variants

Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance.

Autoren: Zhang Y Guo Y Liu Z et al.

Quelle: Cell [Cell] 2025 Nov 26; Vol. 188 (24), pp. 6754-6773.e29. Date of Electronic Publication: 2025 Oct 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

MeSH-Schlagworte: Immunologic Surveillance* , Head and Neck Neoplasms*/immunology , Head and Neck Neoplasms*/pathology , Squamous Cell Carcinoma of Head and Neck*/immunology , Squamous Cell Carcinoma of Head and Neck*/pathology , Neuroimmunomodulation* , Tumor Escape*, Animals ; Mice ; Humans ; Calcitonin Gene-Related Peptide/metabolism ; Nociceptors/metabolism ; Nociceptors/immunology ; Activating Transcription Factor 4/metabolism ; Mice, Inbred C57BL ; Nerve Tissue Proteins/metabolism ; Lymph Nodes/immunology ; Cell Line, Tumor ; Female ; Male ; Chemokine CCL5/metabolism ; Tumor-Associated Macrophages/immunology ; Tumor-Associated Macrophages/metabolism ; Immune Checkpoint Inhibitors/therapeutic use ; Immune Checkpoint Inhibitors/pharmacology

Mechanism for evolution of diverse autologous antibodies upon broadly neutralizing antibody therapy of people with HIV.

Autoren: Kannan D Wang E Deeks SG et al.

Quelle: Cell reports [Cell Rep] 2025 Nov 25; Vol. 44 (11), pp. 116545. Date of Electronic Publication: 2025 Nov 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH-Schlagworte: HIV Infections*/immunology , HIV Infections*/drug therapy , HIV Infections*/therapy , HIV Infections*/virology , Antibodies, Neutralizing*/immunology , Antibodies, Neutralizing*/therapeutic use , HIV Antibodies*/immunology , HIV Antibodies*/therapeutic use , HIV-1*/immunology , Broadly Neutralizing Antibodies*/immunology , Broadly Neutralizing Antibodies*/therapeutic use, Humans ; Epitopes/immunology

CD94/NKG2A-Qa-1 ^b axis as a key modulator of vaccine responsiveness in aging populations.

Autoren: Chen L Bai Z Wan D et al.

Quelle: Cell reports [Cell Rep] 2025 Nov 25; Vol. 44 (11), pp. 116514. Date of Electronic Publication: 2025 Nov 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH-Schlagworte: NK Cell Lectin-Like Receptor Subfamily C*/metabolism , NK Cell Lectin-Like Receptor Subfamily C*/immunology , Aging*/immunology , NK Cell Lectin-Like Receptor Subfamily D*/metabolism , NK Cell Lectin-Like Receptor Subfamily D*/immunology , Histocompatibility Antigens Class I*/metabolism , Histocompatibility Antigens Class I*/immunology , Vaccines*/immunology, Humans ; Monocytes/immunology ; Monocytes/metabolism ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Female ; Adult ; Aged ; Male ; Middle Aged ; T-Lymphocytes/immunology