Suchergebnisse - "Immunoglobulin G"

Biomaterial surface-induced immunoglobulin G unfolding enhances phagocytosis of Staphylococcus Aureus by macrophages.

Autoren: Alemie MN Le TN Nguyen NH et al.

Quelle: Acta biomaterialia [Acta Biomater] 2025 Dec; Vol. 208, pp. 226-243. Date of Electronic Publication: 2025 Oct 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE

MeSH-Schlagworte: Phagocytosis*/drug effects , Staphylococcus aureus*/immunology , Immunoglobulin G*/chemistry , Immunoglobulin G*/pharmacology , Macrophages*/metabolism , Macrophages*/immunology , Macrophages*/microbiology , Biocompatible Materials*/pharmacology , Biocompatible Materials*/chemistry , Protein Unfolding*/drug effects, Animals ; Mice ; Surface Properties ; Reactive Oxygen Species/metabolism ; Humans

IgG expressed by renal tubular epithelial cells in epithelial mesenchymal transformation and interstitial fibrosis in diabetic kidney disease.

Autoren: Wang X Deng Z Wang Y

Quelle: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2458764. Date of Electronic Publication: 2025 Feb 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

MeSH-Schlagworte: Epithelial-Mesenchymal Transition* , Diabetic Nephropathies*/pathology , Diabetic Nephropathies*/metabolism , Kidney Tubules*/pathology , Kidney Tubules*/metabolism , Kidney Tubules*/cytology , Epithelial Cells*/metabolism , Epithelial Cells*/pathology , Immunoglobulin G*/metabolism , Immunoglobulin G*/genetics, Humans ; Fibrosis ; Animals ; Mice ; Male ; Transforming Growth Factor beta1/metabolism ; Female ; Middle Aged ; Fibronectins/metabolism ; Actins/metabolism

IgG subclass-specific N-glycosylation differentiates HRCT subtypes in idiopathic inflammatory myopathies-associated ILD.

Autoren: Wu T Li Y Ling Y et al.

Quelle: Frontiers in immunology [Front Immunol] 2025 Nov 03; Vol. 16, pp. 1696126. Date of Electronic Publication: 2025 Nov 03 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Immunoglobulin G*/immunology , Immunoglobulin G*/blood , Immunoglobulin G*/metabolism , Tomography, X-Ray Computed*/methods , Myositis*/complications , Myositis*/immunology , Lung Diseases, Interstitial*/diagnostic imaging , Lung Diseases, Interstitial*/immunology , Lung Diseases, Interstitial*/etiology , Lung Diseases, Interstitial*/diagnosis , Lung Diseases, Interstitial*/blood, Humans ; Female ; Male ; Glycosylation ; Middle Aged ; Aged ; Glycopeptides/blood ; Adult ; Biomarkers/blood

Neonatal ischemic stroke potentially associated with transplacental passage of maternal anti-cardiolipin immunoglobulin G antibodies: A case report.

Autoren: Oiwa H Hawaka H Fujieda Y et al.

Quelle: Lupus [Lupus] 2025 Nov; Vol. 34 (13), pp. 1413-1416. Date of Electronic Publication: 2025 Sep 29.

Publikationsart: Case Reports; Journal Article

Info zur Zeitschrift: Publisher: SAGE Publications Country of Publication: England NLM ID: 9204265 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0962 (Electronic) Linking ISSN: 09612033 NLM ISO Abbreviation: Lupus Subsets: MEDLINE

MeSH-Schlagworte: Ischemic Stroke*/immunology , Ischemic Stroke*/etiology , Antibodies, Anticardiolipin*/blood , Antibodies, Anticardiolipin*/immunology , Immunoglobulin G*/blood , Immunoglobulin G*/immunology , Maternal-Fetal Exchange*/immunology , Antibodies, Antiphospholipid*/blood, Humans ; Female ; Adult ; Pregnancy ; Infant, Newborn

Association between immunoglobulin G N-glycosylation, inflammatory factors, and ankylosing spondylitis: A case-control study.

Autoren: Yin J Yin X Tao L et al.

Quelle: Clinical rheumatology [Clin Rheumatol] 2025 Nov; Vol. 44 (11), pp. 4517-4528. Date of Electronic Publication: 2025 Sep 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Germany NLM ID: 8211469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1434-9949 (Electronic) Linking ISSN: 07703198 NLM ISO Abbreviation: Clin Rheumatol Subsets: MEDLINE

MeSH-Schlagworte: Spondylitis, Ankylosing*/blood , Spondylitis, Ankylosing*/immunology , Spondylitis, Ankylosing*/diagnosis , Immunoglobulin G*/blood , Immunoglobulin G*/metabolism, Humans ; Glycosylation ; Case-Control Studies ; Male ; Female ; Adult ; Middle Aged ; Biomarkers/blood ; Polysaccharides/blood ; C-Reactive Protein/metabolism ; Inflammation ; Glycoproteins

Seroprevalence of Anti-Mpox Virus IgG Antibody and Awareness of Mpox Disease in Ibadan, Southwest Nigeria.

Autoren: Olayiwola J Akagbosu A Samson O et al.

Quelle: Voprosy virusologii [Vopr Virusol] 2025 Oct 30; Vol. 70 (5), pp. 463-470. Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: FBUN T︠S︡NII Ėpidemiologii Rospotrebnadzora Country of Publication: Russia (Federation) NLM ID: 0417337 Publication Model: Electronic Cited Medium: Internet ISSN: 2411-2097 (Electronic) Linking ISSN: 05074088 NLM ISO Abbreviation: Vopr Virusol Subsets: MEDLINE

MeSH-Schlagworte: Immunoglobulin G*/blood , Immunoglobulin G*/immunology , Antibodies, Viral*/blood , Antibodies, Viral*/immunology , Health Knowledge, Attitudes, Practice* , Mpox, Monkeypox*/epidemiology , Mpox, Monkeypox*/virology , Mpox, Monkeypox*/blood , Mpox, Monkeypox*/immunology , Mpox, Monkeypox*/prevention & control , Monkeypox virus*/immunology , Monkeypox virus*/pathogenicity, Humans ; Female ; Male ; Nigeria/epidemiology ; Middle Aged ; Adult ; Seroepidemiologic Studies ; Adolescent ; Cross-Sectional Studies ; Aged ; Young Adult ; Child

Immunoglobulin G N-glycosylation predicts long-term risk of ischemic stroke: a nested case-control study.

Autoren: Sun S Hao J Yu C et al.

Quelle: Journal of translational medicine [J Transl Med] 2025 Oct 27; Vol. 23 (1), pp. 1175. Date of Electronic Publication: 2025 Oct 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH-Schlagworte: Immunoglobulin G*/metabolism , Immunoglobulin G*/blood , Ischemic Stroke*/blood , Ischemic Stroke*/immunology, Humans ; Male ; Female ; Case-Control Studies ; Middle Aged ; Glycosylation ; Risk Factors ; Aged ; Polysaccharides ; Biomarkers/blood ; ROC Curve ; Glycoproteins

Immunoglobulin G Subclass-Specific Glycosylation Changes in Rheumatoid Arthritis.

Autoren: Szabó D Gyebrovszki B Szarka E et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 02; Vol. 26 (19). Date of Electronic Publication: 2025 Oct 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Arthritis, Rheumatoid*/immunology , Arthritis, Rheumatoid*/blood , Arthritis, Rheumatoid*/metabolism , Immunoglobulin G*/blood , Immunoglobulin G*/metabolism , Immunoglobulin G*/immunology , Anti-Citrullinated Protein Antibodies*/blood , Anti-Citrullinated Protein Antibodies*/immunology, Humans ; Glycosylation ; Middle Aged ; Female ; Male ; Adult ; Biomarkers/blood ; Aged ; C-Reactive Protein/metabolism ; Glycoproteins

Proximity-based site-specific labeling of a native IgG Fab fragment by a fusion microbial transglutaminase-protein G variant.

Autoren: Murozono K Nishioka R Kawaguchi Y et al.

Quelle: New biotechnology [N Biotechnol] 2025 Dec 25; Vol. 90, pp. 56-64. Date of Electronic Publication: 2025 Aug 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101465345 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-4347 (Electronic) Linking ISSN: 18716784 NLM ISO Abbreviation: N Biotechnol Subsets: MEDLINE

MeSH-Schlagworte: Immunoglobulin Fab Fragments*/chemistry , Immunoglobulin Fab Fragments*/metabolism , Transglutaminases*/metabolism , Transglutaminases*/chemistry , Immunoglobulin G*/chemistry , Immunoglobulin G*/metabolism , Recombinant Fusion Proteins*/metabolism , Recombinant Fusion Proteins*/chemistry , Staining and Labeling* , Bacterial Proteins*/metabolism, Humans ; Cell Line, Tumor ; Trastuzumab/chemistry

GD3 antibody subtyping reveals central-peripheral dichotomy in autoimmune neurological disorders.

Autoren: Zhang Z Chen K Qiu H et al.

Quelle: Journal of neuroimmunology [J Neuroimmunol] 2025 Dec 15; Vol. 409, pp. 578771. Date of Electronic Publication: 2025 Oct 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8421 (Electronic) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE

MeSH-Schlagworte: Gangliosides*/immunology , Autoantibodies*/blood , Autoantibodies*/immunology , Autoantibodies*/classification , Neuromyelitis Optica*/immunology , Neuromyelitis Optica*/blood , Neuromyelitis Optica*/diagnosis , Guillain-Barre Syndrome*/immunology , Guillain-Barre Syndrome*/blood , Guillain-Barre Syndrome*/diagnosis , Immunoglobulin G*/blood , Immunoglobulin G*/immunology , Immunoglobulin M*/blood , Immunoglobulin M*/immunology, Humans ; Female ; Male ; Middle Aged ; Adult ; Retrospective Studies ; Aged ; Young Adult

Live MOG-IgG cell-based assay: Comparison across flow cytometers and diagnostic validation on high-sensitivity full spectrum flow cytometry.

Autoren: Siwan E Tungpoomjaruswong A Merheb V et al.

Quelle: Journal of neuroimmunology [J Neuroimmunol] 2025 Dec 15; Vol. 409, pp. 578760. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article; Comparative Study; Validation Study

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8421 (Electronic) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE

MeSH-Schlagworte: Flow Cytometry*/methods , Flow Cytometry*/standards , Flow Cytometry*/instrumentation , Myelin-Oligodendrocyte Glycoprotein*/immunology , Immunoglobulin G*/blood , Immunoglobulin G*/immunology , Autoantibodies*/blood , Neuromyelitis Optica*/diagnosis , Neuromyelitis Optica*/blood , Neuromyelitis Optica*/immunology, Humans ; Reproducibility of Results ; Female ; Male ; Adult

Treatment strategy for myasthenia gravis with GAD65-IgG associated neurological disorders: A case report.

Autoren: Xu XN Luo WJ Li HN et al.

Quelle: Journal of neuroimmunology [J Neuroimmunol] 2025 Dec 15; Vol. 409, pp. 578741. Date of Electronic Publication: 2025 Aug 31.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8421 (Electronic) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE

MeSH-Schlagworte: Myasthenia Gravis*/complications , Myasthenia Gravis*/immunology , Myasthenia Gravis*/therapy , Myasthenia Gravis*/blood , Myasthenia Gravis*/drug therapy , Glutamate Decarboxylase*/immunology , Autoantibodies*/blood , Autoantibodies*/immunology , Immunoglobulin G*/blood , Immunoglobulin G*/immunology , Nervous System Diseases*/immunology , Nervous System Diseases*/complications , Nervous System Diseases*/therapy, Humans ; Female ; Middle Aged ; Immunotherapy/methods

Real-time and label-free monitoring of monoclonal antibody secretion rates using a PC-TIR biosensor.

Autoren: Khorsandi D Yang JW Trabucco L et al.

Quelle: Biosensors & bioelectronics [Biosens Bioelectron] 2025 Dec 15; Vol. 290, pp. 117979. Date of Electronic Publication: 2025 Sep 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Advanced Technology Country of Publication: England NLM ID: 9001289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4235 (Electronic) Linking ISSN: 09565663 NLM ISO Abbreviation: Biosens Bioelectron Subsets: MEDLINE

MeSH-Schlagworte: Biosensing Techniques*/instrumentation , Antibodies, Monoclonal*/metabolism , Antibodies, Monoclonal*/analysis , Immunoglobulin G*/analysis , Immunoglobulin G*/metabolism, Animals ; Hybridomas/metabolism ; Equipment Design ; Mice ; Humans

Ultra-high concentration low-viscosity subcutaneous antibody formulations using ionic liquids.

Autoren: Ramesh A Erdi M Zhang S et al.

Quelle: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Dec 10; Vol. 388 (Pt 1), pp. 114295. Date of Electronic Publication: 2025 Oct 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH-Schlagworte: Ionic Liquids*/chemistry , Ionic Liquids*/administration & dosage , Antibodies, Monoclonal*/administration & dosage , Antibodies, Monoclonal*/chemistry , Antibodies, Monoclonal*/pharmacokinetics , Immunoglobulin G*/administration & dosage , Immunoglobulin G*/chemistry, Viscosity ; Injections, Subcutaneous ; Animals ; Mice ; Humans ; Drug Stability ; Female ; Biological Availability

Antibody translocation into the cytosol: Mechanisms and engineering of endosomal escape.

Autoren: Kim DS Kim YS

Quelle: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Dec 10; Vol. 388 (Pt 2), pp. 114386. Date of Electronic Publication: 2025 Nov 03.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH-Schlagworte: Endosomes*/metabolism , Cytosol*/metabolism , Immunoglobulin G*/administration & dosage , Immunoglobulin G*/metabolism, Humans ; Animals ; Protein Transport ; Protein Engineering ; Drug Delivery Systems

Spinal cord lesions in relapsing-remitting multiple sclerosis: Prognostic value of intrathecal production of immunoglobulins.

Autoren: Kreiter D Franken N Bouweriks D et al.

Quelle: PloS one [PLoS One] 2025 Dec 05; Vol. 20 (12), pp. e0337515. Date of Electronic Publication: 2025 Dec 05 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH-Schlagworte: Spinal Cord*/pathology , Spinal Cord*/immunology , Immunoglobulin M*/cerebrospinal fluid , Immunoglobulin M*/blood , Multiple Sclerosis, Relapsing-Remitting*/pathology , Multiple Sclerosis, Relapsing-Remitting*/immunology , Multiple Sclerosis, Relapsing-Remitting*/cerebrospinal fluid , Multiple Sclerosis, Relapsing-Remitting*/diagnosis , Immunoglobulin G*/cerebrospinal fluid , Immunoglobulin G*/blood, Humans ; Female ; Male ; Adult ; Prognosis ; Magnetic Resonance Imaging ; Middle Aged ; Retrospective Studies ; Cross-Sectional Studies ; Biomarkers/cerebrospinal fluid ; Biomarkers/blood

Rapid Glass Wool Enrichment of Glycopeptides for MALDI-MS Analysis of Immunoglobulin G Glycosylation in COVID-19 Samples.

Autoren: Zhou Y Karlahag F Weiss SS et al.

Quelle: Journal of the American Society for Mass Spectrometry [J Am Soc Mass Spectrom] 2025 Dec 03; Vol. 36 (12), pp. 2615-2622. Date of Electronic Publication: 2025 Oct 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: ACS Publications Country of Publication: United States NLM ID: 9010412 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1123 (Electronic) Linking ISSN: 10440305 NLM ISO Abbreviation: J Am Soc Mass Spectrom Subsets: MEDLINE

MeSH-Schlagworte: Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization*/methods , COVID-19*/blood , Glycopeptides*/blood , Glycopeptides*/chemistry , Glycopeptides*/analysis , Glycopeptides*/isolation & purification , Immunoglobulin G*/blood , Immunoglobulin G*/chemistry , Immunoglobulin G*/metabolism, Humans ; Glycosylation ; SARS-CoV-2 ; Glass

Lower total serum Immunoglobulin G is associated with impaired patient-reported health-related quality of life in systemic sclerosis: a prospective cross-sectional study.

Autoren: Trefler J Pasierb A Lech L et al.

Quelle: Rheumatology international [Rheumatol Int] 2025 Dec 02; Vol. 46 (1), pp. 3. Date of Electronic Publication: 2025 Dec 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer International Country of Publication: Germany NLM ID: 8206885 Publication Model: Electronic Cited Medium: Internet ISSN: 1437-160X (Electronic) Linking ISSN: 01728172 NLM ISO Abbreviation: Rheumatol Int Subsets: MEDLINE

MeSH-Schlagworte: Quality of Life* , Scleroderma, Systemic*/blood , Scleroderma, Systemic*/immunology , Scleroderma, Systemic*/psychology , Scleroderma, Systemic*/physiopathology , Scleroderma, Systemic*/diagnosis , Immunoglobulin G*/blood, Humans ; Cross-Sectional Studies ; Female ; Male ; Prospective Studies ; Middle Aged ; Patient Reported Outcome Measures ; Adult ; Aged ; Severity of Illness Index ; Disability Evaluation ; Biomarkers/blood

Yupingfeng Formula Exerts Antiviral Property by Promoting IFN-I Production and IgG1 Antibody Response.

Autoren: Chen C Zhu M Li Y et al.

Quelle: Journal of medical virology [J Med Virol] 2025 Dec; Vol. 97 (12), pp. e70723.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE

MeSH-Schlagworte: Antiviral Agents*/pharmacology , Antiviral Agents*/administration & dosage , Immunoglobulin G*/immunology , Immunoglobulin G*/blood , Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/administration & dosage , Orthomyxoviridae Infections*/drug therapy , Orthomyxoviridae Infections*/immunology , Orthomyxoviridae Infections*/virology , Interferon Type I*/biosynthesis , Antibody Formation*/drug effects , Antibodies, Viral*/blood, Animals ; Mice ; Disease Models, Animal ; Viral Load/drug effects ; Mice, Inbred BALB C ; Humans ; Female

Clinicopathological features differentiating Castleman Disease from IgG4-related ophthalmic disease, a 10 years retrospective study.

Autoren: Wang H Zhao J Wang W et al.

Quelle: Indian journal of ophthalmology [Indian J Ophthalmol] 2025 Dec 01; Vol. 73 (12), pp. 1840-1846. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Medknow Publications Country of Publication: India NLM ID: 0405376 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1998-3689 (Electronic) Linking ISSN: 03014738 NLM ISO Abbreviation: Indian J Ophthalmol Subsets: MEDLINE

MeSH-Schlagworte: Immunoglobulin G4-Related Disease*/diagnosis , Immunoglobulin G4-Related Disease*/immunology , Castleman Disease*/diagnosis , Castleman Disease*/immunology , Immunoglobulin G*/immunology , Immunoglobulin G*/blood , Lacrimal Apparatus*/pathology , Lacrimal Apparatus*/diagnostic imaging , Lacrimal Apparatus Diseases*/diagnosis , Lacrimal Apparatus Diseases*/immunology, Humans ; Retrospective Studies ; Male ; Female ; Middle Aged ; Diagnosis, Differential ; Adult ; Aged ; Follow-Up Studies ; Biopsy ; Time Factors