Suchergebnisse - "Immunoglobulin Fc Fragments"

Efficacy and safety of luspatercept in non-transfusion-dependent β-thalassemia: long-term results from the BEYOND study.

Autoren: Taher AT Viprakasit V Kattamis A et al.

Quelle: Blood advances [Blood Adv] 2025 Dec 09; Vol. 9 (23), pp. 6108-6119.

Publikationsart: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study

Info zur Zeitschrift: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE

MeSH-Schlagworte: beta-Thalassemia*/drug therapy , beta-Thalassemia*/blood , Immunoglobulin Fc Fragments*/therapeutic use , Immunoglobulin Fc Fragments*/adverse effects , Immunoglobulin Fc Fragments*/administration & dosage , Recombinant Fusion Proteins*/therapeutic use , Recombinant Fusion Proteins*/adverse effects , Recombinant Fusion Proteins*/administration & dosage , Activin Receptors, Type II*/therapeutic use , Activin Receptors, Type II*/administration & dosage, Humans ; Male ; Female ; Adult ; Treatment Outcome ; Adolescent ; Young Adult ; Middle Aged ; Double-Blind Method ; Child

Cardiovascular Effectiveness of Semaglutide Versus Dulaglutide in Type 2 Diabetes.

Autoren: Bonnesen K Heide-Jørgensen U Christensen DH et al.

Quelle: Pharmacoepidemiology and drug safety [Pharmacoepidemiol Drug Saf] 2025 Dec; Vol. 34 (12), pp. e70276.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 9208369 Publication Model: Print Cited Medium: Internet ISSN: 1099-1557 (Electronic) Linking ISSN: 10538569 NLM ISO Abbreviation: Pharmacoepidemiol Drug Saf Subsets: MEDLINE

MeSH-Schlagworte: Glucagon-Like Peptides*/analogs & derivatives , Glucagon-Like Peptides*/administration & dosage , Glucagon-Like Peptides*/therapeutic use , Glucagon-Like Peptides*/adverse effects , Diabetes Mellitus, Type 2*/drug therapy , Recombinant Fusion Proteins*/administration & dosage , Recombinant Fusion Proteins*/therapeutic use , Recombinant Fusion Proteins*/adverse effects , Immunoglobulin Fc Fragments*/administration & dosage , Immunoglobulin Fc Fragments*/therapeutic use , Immunoglobulin Fc Fragments*/adverse effects , Hypoglycemic Agents*/administration & dosage , Hypoglycemic Agents*/adverse effects , Hypoglycemic Agents*/therapeutic use , Cardiovascular Diseases*/epidemiology , Cardiovascular Diseases*/prevention & control , Cardiovascular Diseases*/etiology, Humans ; Female ; Male ; Middle Aged ; Aged ; Denmark/epidemiology ; Cohort Studies ; Glycated Hemoglobin/analysis ; Treatment Outcome ; Injections, Subcutaneous ; Glucagon-Like Peptide 1

Identification of engineered IMGT Fc variants in IMGT/mAb-DB, a database of therapeutic antibodies and fusion proteins.

Autoren: Manso T Sanou G Nousias C et al.

Quelle: MAbs [MAbs] 2025 Dec; Vol. 17 (1), pp. 2594260. Date of Electronic Publication: 2025 Nov 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

MeSH-Schlagworte: Antibodies, Monoclonal*/genetics , Antibodies, Monoclonal*/therapeutic use , Antibodies, Monoclonal*/chemistry , Antibodies, Monoclonal*/immunology , Immunoglobulin Fc Fragments*/genetics , Immunoglobulin Fc Fragments*/immunology , Immunoglobulin Fc Fragments*/chemistry , Protein Engineering*/methods , Recombinant Fusion Proteins*/genetics , Recombinant Fusion Proteins*/chemistry , Recombinant Fusion Proteins*/therapeutic use , Recombinant Fusion Proteins*/immunology , Databases, Protein*, Humans

Design of bispecific antibody Fc region employing a shark-human chimeric and asymmetric format.

Autoren: Munetomo R Inoue A Onitsuka M

Quelle: Journal of bioscience and bioengineering [J Biosci Bioeng] 2025 Dec; Vol. 140 (6), pp. 368-377. Date of Electronic Publication: 2025 Oct 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Society for Biotechnology, Japan Country of Publication: Japan NLM ID: 100888800 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1347-4421 (Electronic) Linking ISSN: 13474421 NLM ISO Abbreviation: J Biosci Bioeng Subsets: MEDLINE

MeSH-Schlagworte: Antibodies, Bispecific*/genetics , Antibodies, Bispecific*/chemistry , Antibodies, Bispecific*/immunology , Sharks*/immunology , Sharks*/genetics , Immunoglobulin Fc Fragments*/genetics , Immunoglobulin Fc Fragments*/chemistry , Immunoglobulin Fc Fragments*/immunology , Protein Engineering*/methods , Recombinant Fusion Proteins*/genetics , Recombinant Fusion Proteins*/chemistry, Humans ; Animals ; Glycosylation ; Chromatography, Affinity

Development and characterization of AD-214, an anti-CXCR4 i-body-Fc fusion for the treatment of idiopathic pulmonary fibrosis.

Autoren: Lynch JP Organ L Tomusange K et al.

Quelle: MAbs [MAbs] 2025 Dec; Vol. 17 (1), pp. 2505090. Date of Electronic Publication: 2025 May 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

MeSH-Schlagworte: Idiopathic Pulmonary Fibrosis*/drug therapy , Idiopathic Pulmonary Fibrosis*/immunology , Idiopathic Pulmonary Fibrosis*/pathology , Receptors, CXCR4*/immunology , Receptors, CXCR4*/antagonists & inhibitors , Recombinant Fusion Proteins*/pharmacology , Recombinant Fusion Proteins*/genetics , Recombinant Fusion Proteins*/immunology , Recombinant Fusion Proteins*/therapeutic use , Immunoglobulin Fc Fragments*/genetics , Immunoglobulin Fc Fragments*/immunology, Humans ; Animals ; Mice ; Cell Movement/drug effects

Glycemic, renal, and graft outcomes with dulaglutide versus multiple daily insulin therapy after kidney transplantation in type 2 diabetes.

Autoren: Kim MJ Kim HS Cho YK et al.

Quelle: Diabetes research and clinical practice [Diabetes Res Clin Pract] 2025 Dec; Vol. 230, pp. 112978. Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8508335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8227 (Electronic) Linking ISSN: 01688227 NLM ISO Abbreviation: Diabetes Res Clin Pract Subsets: MEDLINE

MeSH-Schlagworte: Kidney Transplantation* , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/blood , Recombinant Fusion Proteins*/therapeutic use , Recombinant Fusion Proteins*/administration & dosage , Glucagon-Like Peptides*/analogs & derivatives , Glucagon-Like Peptides*/therapeutic use , Glucagon-Like Peptides*/administration & dosage , Immunoglobulin Fc Fragments*/therapeutic use , Immunoglobulin Fc Fragments*/administration & dosage , Hypoglycemic Agents*/therapeutic use , Hypoglycemic Agents*/administration & dosage , Insulin*/administration & dosage , Insulin*/therapeutic use, Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Blood Glucose/drug effects ; Blood Glucose/analysis ; Glycated Hemoglobin/analysis ; Aged ; Treatment Outcome ; Adult

Appetite, eating attitudes, and eating behaviours during treatment with retatrutide in adults with type 2 diabetes: Results of a phase 2 study.

Autoren: Kanu C Boye KS Poon JL et al.

Quelle: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2025 Dec; Vol. 27 (12), pp. 6988-6998. Date of Electronic Publication: 2025 Sep 08.

Publikationsart: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE

MeSH-Schlagworte: Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/psychology , Glucagon-Like Peptides*/analogs & derivatives , Glucagon-Like Peptides*/therapeutic use , Glucagon-Like Peptides*/administration & dosage , Appetite*/drug effects , Immunoglobulin Fc Fragments*/therapeutic use , Immunoglobulin Fc Fragments*/administration & dosage , Recombinant Fusion Proteins*/therapeutic use , Recombinant Fusion Proteins*/administration & dosage , Hypoglycemic Agents*/therapeutic use , Hypoglycemic Agents*/administration & dosage , Feeding Behavior*/drug effects, Humans ; Female ; Male ; Middle Aged ; Aged ; Adult ; Weight Loss/drug effects ; Double-Blind Method ; Fatty Acids ; Peptides

Luspatercept for the treatment of lower-risk myelodysplastic syndrome with SF3B1 mutation: a real-world single-center research in China.

Autoren: Liang W Kang R Zhao Y et al.

Quelle: Hematology (Amsterdam, Netherlands) [Hematology] 2025 Dec; Vol. 30 (1), pp. 2506858. Date of Electronic Publication: 2025 Jun 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9708388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-8454 (Electronic) Linking ISSN: 10245332 NLM ISO Abbreviation: Hematology Subsets: MEDLINE

MeSH-Schlagworte: Myelodysplastic Syndromes*/drug therapy , Myelodysplastic Syndromes*/genetics , RNA Splicing Factors*/genetics , Immunoglobulin Fc Fragments*/therapeutic use , Immunoglobulin Fc Fragments*/administration & dosage , Immunoglobulin Fc Fragments*/adverse effects , Recombinant Fusion Proteins*/therapeutic use , Recombinant Fusion Proteins*/adverse effects , Recombinant Fusion Proteins*/administration & dosage , Mutation* , Activin Receptors, Type II*/therapeutic use , Activin Receptors, Type II*/administration & dosage, Humans ; Male ; Female ; Middle Aged ; Aged ; China ; Retrospective Studies ; Treatment Outcome ; Phosphoproteins

Impact of antibody Fc engineering on translational pharmacology, and safety: insights from industry case studies.

Autoren: Brennan FR Polli JR Sathish J et al.

Quelle: MAbs [MAbs] 2025 Dec; Vol. 17 (1), pp. 2505092. Date of Electronic Publication: 2025 Jul 07.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

MeSH-Schlagworte: Protein Engineering*/methods , Antibodies, Monoclonal*/adverse effects , Antibodies, Monoclonal*/pharmacology , Antibodies, Monoclonal*/immunology , Antibodies, Monoclonal*/therapeutic use , Antibodies, Monoclonal*/genetics , Immunoglobulin Fc Fragments*/genetics , Immunoglobulin Fc Fragments*/immunology, Humans ; Animals ; Receptors, Fc/immunology ; Receptors, Fc/metabolism ; Antibody-Dependent Cell Cytotoxicity ; Translational Research, Biomedical ; Drug Development ; Drug Industry

Combinatorial Fc modifications for complementary antibody functionality.

Autoren: Bartsch YC Webb NE Burgess E et al.

Quelle: MAbs [MAbs] 2025 Dec; Vol. 17 (1), pp. 2465391. Date of Electronic Publication: 2025 Feb 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

MeSH-Schlagworte: Immunoglobulin Fc Fragments*/genetics , Immunoglobulin Fc Fragments*/immunology , Immunoglobulin Fc Fragments*/chemistry , Protein Engineering*/methods , Antibodies, Monoclonal*/genetics , Antibodies, Monoclonal*/immunology , HIV-1*/immunology , HIV Antibodies*/immunology , HIV Antibodies*/genetics, Humans ; Immunoglobulin Fab Fragments/immunology ; Immunoglobulin Fab Fragments/genetics

Healthcare resource utilization of patients with lower-risk myelodysplastic syndromes treated with luspatercept versus erythropoiesis-stimulating agents: a United States healthcare claims database study.

Autoren: Ball BJ Song R Zanardo E et al.

Quelle: Journal of medical economics [J Med Econ] 2025 Dec; Vol. 28 (1), pp. 719-725. Date of Electronic Publication: 2025 May 21.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9892255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-837X (Electronic) Linking ISSN: 13696998 NLM ISO Abbreviation: J Med Econ Subsets: MEDLINE

MeSH-Schlagworte: Myelodysplastic Syndromes*/drug therapy , Hematinics*/therapeutic use , Hematinics*/economics , Recombinant Fusion Proteins*/therapeutic use , Recombinant Fusion Proteins*/economics , Patient Acceptance of Health Care*/statistics & numerical data , Immunoglobulin Fc Fragments*/therapeutic use , Immunoglobulin Fc Fragments*/economics, Humans ; Male ; Female ; Retrospective Studies ; United States ; Aged ; Insurance Claim Review ; Middle Aged ; Aged, 80 and over ; Health Resources/statistics & numerical data ; Databases, Factual ; Activin Receptors, Type II

Prediction of human pharmacokinetics of Fc-engineered therapeutic monoclonal antibodies using human FcRn transgenic mice.

Autoren: Haraya K Ichikawa T Murao N et al.

Quelle: MAbs [MAbs] 2025 Dec; Vol. 17 (1), pp. 2484443. Date of Electronic Publication: 2025 Mar 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Fc*/genetics , Receptors, Fc*/immunology , Histocompatibility Antigens Class I*/genetics , Histocompatibility Antigens Class I*/immunology , Antibodies, Monoclonal*/pharmacokinetics , Antibodies, Monoclonal*/genetics , Immunoglobulin Fc Fragments*/genetics , Immunoglobulin Fc Fragments*/immunology, Animals ; Humans ; Mice, Transgenic ; Mice ; Protein Engineering/methods ; Immunoglobulins, Intravenous

An Fc-Engineered Glycomodified Antibody Supports Proinflammatory Activation of Immune Effector Cells and Restricts Progression of Breast Cancer.

Autoren: Chenoweth AM Cheung A Chauhan J et al.

Quelle: Cancer research [Cancer Res] 2025 Nov 14; Vol. 85 (22), pp. 4521-4540.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

MeSH-Schlagworte: Immunoglobulin Fc Fragments*/immunology , Immunoglobulin Fc Fragments*/genetics , Triple Negative Breast Neoplasms*/immunology , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/drug therapy , Antineoplastic Agents, Immunological*/pharmacology, Humans ; Animals ; Female ; Mice ; Receptors, IgG/metabolism ; Receptors, IgG/immunology ; Receptor, ErbB-2/immunology ; Receptor, ErbB-2/antagonists & inhibitors ; Receptor, ErbB-2/metabolism ; Killer Cells, Natural/immunology ; Tumor Microenvironment/immunology ; Xenograft Model Antitumor Assays ; Macrophages/immunology ; Cell Line, Tumor ; Disease Progression ; Protein Engineering ; Folate Receptor 1/metabolism ; Folate Receptor 1/immunology

Quantitative Targeted Analysis of Antibody Fc Glycosylation by Glyco-MRM.

Autoren: Ma Y Song Y Luo J et al.

Quelle: Journal of proteome research [J Proteome Res] 2025 Nov 07; Vol. 24 (11), pp. 5793-5802. Date of Electronic Publication: 2025 Oct 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101128775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3907 (Electronic) Linking ISSN: 15353893 NLM ISO Abbreviation: J Proteome Res Subsets: MEDLINE

MeSH-Schlagworte: Immunoglobulin G*/metabolism , Immunoglobulin G*/chemistry , Immunoglobulin G*/immunology , Immunoglobulin Fc Fragments*/metabolism , Immunoglobulin Fc Fragments*/chemistry, Glycosylation ; Humans ; Chromatography, Liquid/methods ; Mass Spectrometry/methods ; COVID-19/immunology ; SARS-CoV-2/immunology ; Glycopeptides/analysis ; Influenza, Human/immunology

Immunoglobulin G Fc engineering for localized therapy: Eliminating neonatal Fc receptor interactions and ensuring purification using protein A.

Autoren: Kato A Toshima A Takekawa G et al.

Quelle: Protein science : a publication of the Protein Society [Protein Sci] 2025 Nov; Vol. 34 (11), pp. e70351.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Fc*/genetics , Receptors, Fc*/metabolism , Receptors, Fc*/chemistry , Histocompatibility Antigens Class I*/genetics , Histocompatibility Antigens Class I*/metabolism , Histocompatibility Antigens Class I*/chemistry , Immunoglobulin G*/genetics , Immunoglobulin G*/chemistry , Immunoglobulin G*/metabolism , Protein Engineering* , Staphylococcal Protein A*/chemistry , Staphylococcal Protein A*/metabolism , Immunoglobulin Fc Fragments*/genetics , Immunoglobulin Fc Fragments*/chemistry , Immunoglobulin Fc Fragments*/metabolism, Animals ; Humans ; Mice ; Mice, Transgenic ; Amino Acid Substitution ; Protein Binding

Multiple analysis based on dual-mode anion-exchange chromatography strategy reveals significant impact of charge heterogeneity on structure and function of dulaglutide.

Autoren: Gong F Shen Z Sun B et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 329 (Pt 1), pp. 147808. Date of Electronic Publication: 2025 Sep 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Immunoglobulin Fc Fragments*/chemistry , Immunoglobulin Fc Fragments*/pharmacology , Immunoglobulin Fc Fragments*/isolation & purification , Glucagon-Like Peptides*/analogs & derivatives , Glucagon-Like Peptides*/chemistry , Glucagon-Like Peptides*/pharmacology , Recombinant Fusion Proteins*/chemistry , Recombinant Fusion Proteins*/pharmacology , Recombinant Fusion Proteins*/isolation & purification, Chromatography, Ion Exchange/methods ; Humans ; Structure-Activity Relationship ; Protein Processing, Post-Translational

Engineered B7-H3-targeted VHH-Fc fusion antibody demonstrates rapid tumor accumulation for infrared imaging in pancreatic cancer xenograft model.

Autoren: Mo X Xu Y Han F et al.

Quelle: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Nov 01; Vol. 129, pp. 118319. Date of Electronic Publication: 2025 Jul 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH-Schlagworte: B7 Antigens*/immunology , B7 Antigens*/antagonists & inhibitors , B7 Antigens*/metabolism , Single-Domain Antibodies*/chemistry , Single-Domain Antibodies*/immunology , Pancreatic Neoplasms*/diagnostic imaging , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/metabolism , Immunoglobulin Fc Fragments*/chemistry , Immunoglobulin Fc Fragments*/immunology, Humans ; Animals ; Mice ; Cell Line, Tumor ; Optical Imaging ; Infrared Rays ; Recombinant Fusion Proteins/chemistry ; Protein Engineering ; Mice, Nude

Efficient eukaryotic expression and potent antiviral activity of a long-acting recombinant feline interferon-ω2-Fc fusion protein against major feline viruses.

Autoren: Yang Y Song H Zhang K et al.

Quelle: Antiviral research [Antiviral Res] 2025 Nov; Vol. 243, pp. 106272. Date of Electronic Publication: 2025 Sep 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE

MeSH-Schlagworte: Antiviral Agents*/pharmacology , Antiviral Agents*/pharmacokinetics , Interferon Type I*/genetics , Interferon Type I*/pharmacology , Interferon Type I*/pharmacokinetics , Recombinant Fusion Proteins*/pharmacology , Recombinant Fusion Proteins*/genetics , Recombinant Fusion Proteins*/pharmacokinetics , Immunoglobulin Fc Fragments*/genetics , Immunoglobulin Fc Fragments*/pharmacology, Animals ; Cats ; Cricetulus ; CHO Cells ; Calicivirus, Feline/drug effects ; Cat Diseases/drug therapy ; Cat Diseases/virology ; Varicellovirus/drug effects ; Cricetinae

Engineering of an Fc-specific monovalent protein G for the light-controlled affinity purification of antibodies.

Autoren: Mayrhofer P Skerra A

Quelle: Scientific reports [Sci Rep] 2025 Oct 31; Vol. 15 (1), pp. 38111. Date of Electronic Publication: 2025 Oct 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Immunoglobulin Fc Fragments*/chemistry , Immunoglobulin Fc Fragments*/metabolism , Immunoglobulin Fc Fragments*/genetics , Antibodies, Monoclonal*/isolation & purification , Antibodies, Monoclonal*/chemistry , Protein Engineering*/methods , Chromatography, Affinity*/methods , Bacterial Proteins*/genetics , Bacterial Proteins*/chemistry , Bacterial Proteins*/metabolism, Humans ; Light ; Protein Binding

Blood pressure changes during smoking cessation in a randomized, double-blind, placebo-controlled trial of dulaglutide treatment.

Autoren: Beck J Hasenböhler F Werlen L et al.

Quelle: European journal of preventive cardiology [Eur J Prev Cardiol] 2025 Oct 10; Vol. 32 (14), pp. 1394-1402.

Publikationsart: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 101564430 Publication Model: Print Cited Medium: Internet ISSN: 2047-4881 (Electronic) Linking ISSN: 20474873 NLM ISO Abbreviation: Eur J Prev Cardiol Subsets: MEDLINE

MeSH-Schlagworte: Blood Pressure*/drug effects , Glucagon-Like Peptides*/administration & dosage , Glucagon-Like Peptides*/adverse effects , Glucagon-Like Peptides*/analogs & derivatives , Glucagon-Like Peptides*/analogs & derivatives , Immunoglobulin Fc Fragments*/administration & dosage , Immunoglobulin Fc Fragments*/adverse effects , Recombinant Fusion Proteins*/administration & dosage , Recombinant Fusion Proteins*/adverse effects , Smoking Cessation*/methods, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Double-Blind Method ; Glucagon-Like Peptide-1 Receptor Agonists/administration & dosage ; Glucagon-Like Peptide-1 Receptor Agonists/adverse effects ; Time Factors ; Treatment Outcome ; Weight Gain/drug effects