Search Results - "Immunogenic Cell Death"

Immunogenic cell death unlocks the potential for combined radiation and immunotherapy.

Authors: Rauf S Smirnova A Chang A et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Dec 02; Vol. 122 (48), pp. e2509875122. Date of Electronic Publication: 2025 Nov 26.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH Terms: Immunotherapy*/methods , Immunogenic Cell Death*/immunology , Immunogenic Cell Death*/radiation effects , Neoplasms*/immunology , Neoplasms*/therapy, Animals ; Mice ; Combined Modality Therapy ; Humans ; Macrophages/immunology ; CD47 Antigen/immunology ; Phagocytosis

Expression of immunogenic cell death-related genes is correlated with the immune microenvironment and predicts prognosis in lung adenocarcinoma.

Authors: Gao F Liang Y Gong W

Source: Molecular immunology [Mol Immunol] 2025 Oct; Vol. 186, pp. 70-81. Date of Electronic Publication: 2025 Aug 16.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 7905289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9142 (Electronic) Linking ISSN: 01615890 NLM ISO Abbreviation: Mol Immunol Subsets: MEDLINE

MeSH Terms: Tumor Microenvironment*/immunology , Tumor Microenvironment*/genetics , Adenocarcinoma of Lung*/genetics , Adenocarcinoma of Lung*/immunology , Adenocarcinoma of Lung*/pathology , Lung Neoplasms*/genetics , Lung Neoplasms*/immunology , Lung Neoplasms*/pathology , Gene Expression Regulation, Neoplastic*/immunology , Immunogenic Cell Death*/genetics , Immunogenic Cell Death*/immunology, Humans ; Prognosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/immunology ; Male ; Female ; Gene Expression Profiling

Immunogenic cell death and bystander killing: expanding the therapeutic potential of modern antibody-drug conjugates.

Authors: Kepp O Kroemer G

Source: Oncoimmunology [Oncoimmunology] 2025 Dec; Vol. 14 (1), pp. 2533488. Date of Electronic Publication: 2025 Jul 15.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2162-402X (Electronic) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: MEDLINE

MeSH Terms: Bystander Effect*/drug effects , Bystander Effect*/immunology , Immunoconjugates*/pharmacology , Immunoconjugates*/therapeutic use , Immunogenic Cell Death*/drug effects , Immunogenic Cell Death*/immunology , Neoplasms*/immunology , Neoplasms*/drug therapy , Neoplasms*/pathology, Animals ; Humans ; Immunotherapy/methods

Colon Cancer Cells Treated with Lacticaseibacillus casei Undergo Apoptosis and Release DAMPs Indicative of Immunogenic Cell Death.

Authors: Aindelis G Glaros V Fragkoulis K et al.

Source: Probiotics and antimicrobial proteins [Probiotics Antimicrob Proteins] 2025 Dec; Vol. 17 (6), pp. 4156-4170. Date of Electronic Publication: 2024 Sep 16.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101484100 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1867-1314 (Electronic) Linking ISSN: 18671306 NLM ISO Abbreviation: Probiotics Antimicrob Proteins Subsets: MEDLINE

MeSH Terms: Apoptosis*/drug effects , Lacticaseibacillus casei*/physiology , Probiotics*/pharmacology , Colonic Neoplasms*/immunology , Colonic Neoplasms*/metabolism , Colonic Neoplasms*/drug therapy , Immunogenic Cell Death*/drug effects , Alarmins*/metabolism, Humans ; Cell Line, Tumor ; HMGB1 Protein/metabolism ; HMGB1 Protein/genetics

How has the field of immunogenic cell death in breast cancer evolved and impacted clinical practice over the past eleven years?

Authors: Deng YL Chi BT Lu SY et al.

Source: Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2025 Dec; Vol. 21 (1), pp. 2505349. Date of Electronic Publication: 2025 May 26.

Publication Type: Journal Article; Review

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-554X (Electronic) Linking ISSN: 21645515 NLM ISO Abbreviation: Hum Vaccin Immunother Subsets: MEDLINE

MeSH Terms: Immunotherapy*/methods , Breast Neoplasms*/therapy , Breast Neoplasms*/immunology , Immunogenic Cell Death*, Humans ; Female ; Tumor Microenvironment/immunology ; Photochemotherapy/methods ; Triple Negative Breast Neoplasms/therapy ; Triple Negative Breast Neoplasms/immunology ; Bibliometrics ; Nanomedicine

Glycyrrhetinic acid orchestrates ERS-pyroptosis crosstalk to elicit immunogenic cell death in hepatocellular carcinoma.

Authors: Bian M Ji J Lian N et al.

Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Nov 25; Vol. 148, pp. 157309. Date of Electronic Publication: 2025 Sep 25.

Publication Type: Journal Article

Journal Info: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

MeSH Terms: Glycyrrhetinic Acid*/pharmacology , Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/pathology , Liver Neoplasms*/drug therapy , Liver Neoplasms*/pathology , Endoplasmic Reticulum Stress*/drug effects , Immunogenic Cell Death*/drug effects , Pyroptosis*/drug effects, Animals ; Humans ; Mice ; Cell Line, Tumor ; Mice, Inbred BALB C ; Tumor Microenvironment/drug effects ; Male ; Xenograft Model Antitumor Assays ; Mice, Nude

Development of a prognostic model based on immunogenic cell death/ferroptosis-related genes and the study of TREX1 effects on prostate cancer cells.

Authors: Wen Y Zhan S Chen J et al.

Source: Frontiers in immunology [Front Immunol] 2025 Nov 19; Vol. 16, pp. 1708437. Date of Electronic Publication: 2025 Nov 19 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/pathology , Prostatic Neoplasms*/mortality , Prostatic Neoplasms*/immunology , Prostatic Neoplasms*/metabolism , Exodeoxyribonucleases*/genetics , Exodeoxyribonucleases*/metabolism , Phosphoproteins*/genetics , Phosphoproteins*/metabolism , Ferroptosis*/genetics , Immunogenic Cell Death*/genetics , Biomarkers, Tumor*/genetics, Humans ; Male ; Prognosis ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cell Movement/genetics

Tumor-Targeted Bacterial Vaccine Induces In Situ Immunogenic Cell Death for Cancer Immunotherapy.

Authors: Wu Y Wu N Xu Y et al.

Source: Nano letters [Nano Lett] 2025 Nov 19; Vol. 25 (46), pp. 16346-16355. Date of Electronic Publication: 2025 Nov 06.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101088070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6992 (Electronic) Linking ISSN: 15306984 NLM ISO Abbreviation: Nano Lett Subsets: MEDLINE

MeSH Terms: Cancer Vaccines*/immunology , Cancer Vaccines*/therapeutic use , Immunogenic Cell Death*/immunology , Immunotherapy*/methods , Neoplasms*/therapy , Neoplasms*/immunology , Bacterial Vaccines*/immunology, Animals ; Mice ; Humans ; Tumor Microenvironment/immunology ; Antigens, Neoplasm/immunology ; Cell Line, Tumor ; Mice, Inbred C57BL ; Salmonella/immunology ; Female

Planar conjugate donor engineering enhanced photodynamic immunogenic cell death stimulator for efficient Triple-Negative breast cancer immunotherapy.

Authors: Yan P Li F Qin S et al.

Source: Journal of colloid and interface science [J Colloid Interface Sci] 2025 Nov 15; Vol. 698, pp. 138085. Date of Electronic Publication: 2025 Jun 03.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0043125 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-7103 (Electronic) Linking ISSN: 00219797 NLM ISO Abbreviation: J Colloid Interface Sci Subsets: MEDLINE

MeSH Terms: Triple Negative Breast Neoplasms*/therapy , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/immunology , Triple Negative Breast Neoplasms*/drug therapy , Immunogenic Cell Death*/drug effects , Immunotherapy* , Photochemotherapy* , Photosensitizing Agents*/pharmacology , Photosensitizing Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis, Animals ; Female ; Humans ; Mice ; Reactive Oxygen Species/metabolism ; Tumor Microenvironment/drug effects ; Mice, Inbred BALB C ; Cell Line, Tumor ; Endoplasmic Reticulum Stress/drug effects ; Drug Screening Assays, Antitumor ; Cell Proliferation/drug effects

Dual-Targeted Biomimetic Nanoparticles for Enhanced Delivery of Polyphyllin B Synergistically Induce Ferroptosis and Immunogenic Cell Death in Gastric Cancer.

Authors: Zu D Yao J Li X et al.

Source: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2025 Nov 12; Vol. 17 (45), pp. 61676-61694. Date of Electronic Publication: 2025 Oct 29.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , Stomach Neoplasms*/drug therapy , Stomach Neoplasms*/pathology , Stomach Neoplasms*/metabolism , Nanoparticles*/chemistry , Immunogenic Cell Death*/drug effects , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Biomimetic Materials*/chemistry , Biomimetic Materials*/pharmacology, Humans ; Animals ; Mice ; Cell Line, Tumor ; Mice, Inbred BALB C ; Hyaluronic Acid/chemistry ; Mice, Nude

Near-Infrared Light-Responsive Copper Selenide Nanoparticle-Loaded Calcium Silicate Cement Induces Immunogenic Cell Death in Osteosarcoma.

Authors: Liu R Sun R Xue Y et al.

Source: International journal of nanomedicine [Int J Nanomedicine] 2025 Nov 11; Vol. 20, pp. 13587-13607. Date of Electronic Publication: 2025 Nov 11 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101263847 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-2013 (Electronic) Linking ISSN: 11769114 NLM ISO Abbreviation: Int J Nanomedicine Subsets: MEDLINE

MeSH Terms: Osteosarcoma*/drug therapy , Osteosarcoma*/pathology , Osteosarcoma*/therapy , Silicates*/chemistry , Silicates*/pharmacology , Calcium Compounds*/chemistry , Calcium Compounds*/pharmacology , Copper*/chemistry , Copper*/pharmacology , Nanoparticles*/chemistry , Bone Neoplasms*/therapy , Bone Neoplasms*/pathology , Bone Neoplasms*/drug therapy , Bone Cements*/chemistry , Bone Cements*/pharmacology , Immunogenic Cell Death*/drug effects, Animals ; Cell Line, Tumor ; Infrared Rays ; Mice ; Humans ; Photothermal Therapy/methods ; Compressive Strength

Nano co-inducer of immunogenic cell death and ferroptosis for anti-tumor immunotherapy.

Authors: Guo G Ding W Li F et al.

Source: Journal of colloid and interface science [J Colloid Interface Sci] 2025 Nov; Vol. 697, pp. 137980. Date of Electronic Publication: 2025 May 24.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0043125 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-7103 (Electronic) Linking ISSN: 00219797 NLM ISO Abbreviation: J Colloid Interface Sci Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , Immunotherapy* , Immunogenic Cell Death*/drug effects , Photosensitizing Agents*/pharmacology , Photosensitizing Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Nanoparticles*/chemistry , Neoplasms*/therapy , Neoplasms*/immunology, Humans ; Animals ; Tumor Microenvironment/drug effects ; Iron/chemistry ; Iron/pharmacology ; Reactive Oxygen Species/metabolism ; Calcium/chemistry ; Calcium/pharmacology ; Mice ; Cell Line, Tumor

Astragalin induces immunogenic cell death in liver cancer by targeting NQO2 to promote ROS-mediated endoplasmic reticulum stress pathway.

Authors: Zheng L Zhao Z Chen L et al.

Source: Free radical biology & medicine [Free Radic Biol Med] 2025 Nov; Vol. 239, pp. 317-335. Date of Electronic Publication: 2025 Jul 30.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH Terms: Endoplasmic Reticulum Stress*/drug effects , Kaempferols*/pharmacology , Liver Neoplasms*/drug therapy , Liver Neoplasms*/pathology , Liver Neoplasms*/immunology , Liver Neoplasms*/metabolism , Liver Neoplasms*/genetics , Immunogenic Cell Death*/drug effects , Saponins*/pharmacology, Humans ; Reactive Oxygen Species/metabolism ; Animals ; Mice ; Endoplasmic Reticulum Chaperone BiP ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Apoptosis/drug effects ; B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/genetics ; Signal Transduction/drug effects ; Membrane Potential, Mitochondrial/drug effects

Construction and evaluation of pH-sensitive nanoparticles with resveratrol release to trigger the immunogenic cell death in colon cancer cellsin vitro.

Authors: Li W Fu Y Yan S et al.

Source: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2025 Nov; Vol. 255, pp. 114895. Date of Electronic Publication: 2025 Jun 18.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE

MeSH Terms: Resveratrol*/pharmacology , Resveratrol*/chemistry , Colonic Neoplasms*/pathology , Colonic Neoplasms*/drug therapy , Colonic Neoplasms*/immunology , Nanoparticles*/chemistry , Immunogenic Cell Death*/drug effects , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry, Hydrogen-Ion Concentration ; Humans ; Drug Liberation ; Cell Proliferation/drug effects ; Particle Size ; Mice ; Cell Line, Tumor ; Animals ; Drug Screening Assays, Antitumor ; Cell Survival/drug effects ; Surface Properties ; Drug Carriers/chemistry

IFN-γ enhances Poly(I:C)-induced necroptosis and immunogenic cell death via TLR3 upregulation in cholangiocarcinoma cells.

Authors: Sae-Fung A Lomphithak T Duangthim N et al.

Source: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2025 Nov 01; Vol. 214, pp. 107274. Date of Electronic Publication: 2025 Sep 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE

MeSH Terms: Cholangiocarcinoma*/metabolism , Cholangiocarcinoma*/drug therapy , Cholangiocarcinoma*/genetics , Cholangiocarcinoma*/immunology , Cholangiocarcinoma*/pathology , Toll-Like Receptor 3*/metabolism , Toll-Like Receptor 3*/genetics , Poly I-C*/pharmacology , Necroptosis*/drug effects , Interferon-gamma*/pharmacology , Interferon-gamma*/metabolism , Bile Duct Neoplasms*/drug therapy , Bile Duct Neoplasms*/metabolism , Bile Duct Neoplasms*/immunology , Bile Duct Neoplasms*/genetics , Bile Duct Neoplasms*/pathology , Immunogenic Cell Death*/drug effects, Humans ; Cell Line, Tumor ; Up-Regulation/drug effects ; Interferon Regulatory Factor-1/metabolism ; Interferon Regulatory Factor-1/genetics

Targeting FUT1-mediated EGFR fucosylation and COX-2 reverses gemcitabine resistance by activating immunogenic cell death in hepatocellular carcinoma.

Authors: Li N Hu B Liu C et al.

Source: Bioorganic chemistry [Bioorg Chem] 2025 Nov; Vol. 166, pp. 109111. Date of Electronic Publication: 2025 Oct 20.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH Terms: Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Deoxycytidine*/analogs & derivatives , Deoxycytidine*/pharmacology , Deoxycytidine*/chemistry , Liver Neoplasms*/drug therapy , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Drug Resistance, Neoplasm*/drug effects , Cyclooxygenase 2*/metabolism , Fucosyltransferases*/metabolism , Fucosyltransferases*/antagonists & inhibitors , Immunogenic Cell Death*/drug effects , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Antimetabolites, Antineoplastic*/pharmacology , Antimetabolites, Antineoplastic*/chemistry, Gemcitabine ; Humans ; ErbB Receptors/metabolism ; ErbB Receptors/antagonists & inhibitors ; Animals ; Mice ; Glycosylation/drug effects ; Dose-Response Relationship, Drug ; Structure-Activity Relationship ; Molecular Structure ; Drug Screening Assays, Antitumor ; Galactoside 2-alpha-L-fucosyltransferase ; Cell Line, Tumor ; Cell Proliferation/drug effects

Therapeutic targeting of cell death-immune crosstalk in cancer to rewire the tumor immune microenvironment.

Authors: Zhang H Li S Liu S et al.

Source: Molecular cancer [Mol Cancer] 2025 Oct 31; Vol. 24 (1), pp. 277. Date of Electronic Publication: 2025 Oct 31.

Publication Type: Journal Article; Review

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE

MeSH Terms: Tumor Microenvironment*/immunology , Tumor Microenvironment*/drug effects , Neoplasms*/immunology , Neoplasms*/pathology , Neoplasms*/metabolism , Neoplasms*/therapy , Neoplasms*/etiology , Immunogenic Cell Death*/immunology , Immunogenic Cell Death*/drug effects, Humans ; Animals ; Immunotherapy/methods ; Cell Death ; Signal Transduction

Identification of immunogenic cell death signature genes in hepatocellular carcinoma: from single-cell transcriptomics to in vitro mechanistic validation and comprehensive prognostic modeling with hundreds of machine learning algorithms.

Authors: Liu H Sun Z Wang X et al.

Source: Frontiers in immunology [Front Immunol] 2025 Oct 22; Vol. 16, pp. 1649618. Date of Electronic Publication: 2025 Oct 22 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/immunology , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/mortality , Liver Neoplasms*/genetics , Liver Neoplasms*/immunology , Liver Neoplasms*/pathology , Liver Neoplasms*/mortality , Machine Learning* , Transcriptome* , Immunogenic Cell Death*/genetics , Biomarkers, Tumor*/genetics, Humans ; Single-Cell Analysis ; Prognosis ; Tumor Microenvironment/immunology ; Tumor Microenvironment/genetics ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Hep G2 Cells

Hypofractionated radiotherapy followed by rhGM-CSF enhances immunogenic cell death in a murine model of pancreatic cancer.

Authors: Tang J Chen F Xia H et al.

Source: Acta cirurgica brasileira [Acta Cir Bras] 2025 Oct 17; Vol. 40, pp. e407625. Date of Electronic Publication: 2025 Oct 17 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Sociedade Brasileira Para O Desenvolvimento Da Pesquisa Em Cirurgia Curso De Pos-Graduacao Em Tecnica Operatoria E Cirurgia Experimental Escola Paulista De Medicina Country of Publication: Brazil NLM ID: 9103983 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-2674 (Electronic) Linking ISSN: 01028650 NLM ISO Abbreviation: Acta Cir Bras Subsets: MEDLINE

MeSH Terms: Pancreatic Neoplasms*/radiotherapy , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/immunology , Pancreatic Neoplasms*/therapy , Granulocyte-Macrophage Colony-Stimulating Factor*/therapeutic use , Granulocyte-Macrophage Colony-Stimulating Factor*/pharmacology , Immunogenic Cell Death*/drug effects , Immunogenic Cell Death*/radiation effects , Radiation Dose Hypofractionation*, Animals ; Disease Models, Animal ; Mice ; HMGB1 Protein ; Combined Modality Therapy/methods ; Enzyme-Linked Immunosorbent Assay ; Cell Line, Tumor ; Immunohistochemistry ; Cytokines ; Mice, Inbred BALB C ; Male ; Treatment Outcome

A light-controlled dextran nano-immunomodulator amplifies immunogenic cell death for cancer immunotherapy.

Authors: Xu D Ju J Chen W et al.

Source: Carbohydrate polymers [Carbohydr Polym] 2025 Oct 15; Vol. 366, pp. 123885. Date of Electronic Publication: 2025 Jun 11.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8307156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1344 (Electronic) Linking ISSN: 01448617 NLM ISO Abbreviation: Carbohydr Polym Subsets: MEDLINE

MeSH Terms: Immunotherapy*/methods , Immunogenic Cell Death*/drug effects , Dextrans*/chemistry , Dextrans*/pharmacology , Nanoparticles*/chemistry , Camptothecin*/pharmacology , Camptothecin*/chemistry , Immunologic Factors*/chemistry , Immunologic Factors*/pharmacology, Animals ; Mice ; Cell Line, Tumor ; Female ; Light ; Mice, Inbred BALB C ; Calreticulin/metabolism ; Apoptosis/drug effects ; HMGB1 Protein/metabolism ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Drug Liberation