Suchergebnisse - "INTRANASAL administration"

Ex vivo and in vivo evaluation of an in situ nanogel composite loaded with carmustine: implications for efficient nose-to-brain delivery.

Autoren: Akilo, Olufemi D. Kumar, Pradeep du Toit, Lisa C. et al.

Quelle: Pharmaceutical Development & Technology. Oct2025, Vol. 30 Issue 8, p1198-1213. 16p.

Schlagwörter: NANOGELS, INTRANASAL administration, RESPONSIVE gels, IN vivo studies, TARGETED drug delivery, DRUG therapy

Functionalized liposomes for intranasal levodopa delivery to the brain.

Autoren: Gordeeva, Daria S. Tameloucht, Achraf Sym Semina, Irina I. et al.

Quelle: Drug Development & Industrial Pharmacy. Jul2025, Vol. 51 Issue 7, p758-770. 13p.

Schlagwörter: INTRANASAL administration, INTRANASAL medication, FICK'S laws of diffusion, POLYETHYLENE glycol, LIPOSOMES

Reversal of Fentanyl‐Induced Respiratory Depression in Healthy Subjects by Intramuscular Nalmefene Administered by Auto‐Injector Versus Intranasal Naloxone.

Autoren: Cipriano, Alessandra He, Ellie Shet, Manjunath et al.

Quelle: Journal of Clinical Pharmacology. Dec2025, Vol. 65 Issue 12, p1661-1675. 15p.

Schlagwörter: *INTRANASAL administration, *RESEARCH funding, *INTRAMUSCULAR injections, *RESPIRATORY diseases, *DRUG delivery systems, *DESCRIPTIVE statistics, *NALOXONE, *CONFIDENCE intervals, *FENTANYL, *NARCOTIC antagonists

Efficacy of intranasal delivery of VEGFR inhibitors to cervical lymph nodes for inhibiting tongue cancer metastasis in mice.

Autoren: Furubayashi, Tomoyuki Kobayashi, Minori Hamada, Nao et al.

Quelle: Journal of Drug Targeting. Dec2025, Vol. 33 Issue 10, p1932-1941. 10p.

Schlagwörter: *INTRANASAL administration, *VASCULAR endothelial growth factor antagonists, *METASTASIS, *TONGUE cancer, *MINIMALLY invasive procedures, *LYMPH nodes, *TREATMENT effectiveness, *PHARMACOKINETICS

Intranasal phage therapy overcomes antibody neutralization challenges in pulmonary Pseudomonas aeruginosa infections.

Autoren: Wannigama, Dhammika Leshan Shao, Jingping Sun, Hongya et al.

Quelle: Archives of Microbiology. Dec2025, Vol. 207 Issue 12, p1-11. 11p.

Schlagwörter: *PSEUDOMONAS aeruginosa, *INTRANASAL administration, *TREATMENT effectiveness, *IMMUNE response, *ANTIBODY formation, *BACTERIOPHAGES, *INFECTION prevention, *LUNG infections

A Single‐Molecule Pleuripotent Scaffold for Combinational Therapy of Alzheimer's Disease via Intranasal Administration.

Autoren: Gao, Jian‐Mei Li, Wen‐Bo Chen, Na‐Na et al.

Quelle: Advanced Science. 11/20/2025, Vol. 12 Issue 43, p1-15. 15p.

Schlagwörter: *ALZHEIMER'S disease, *INTRANASAL administration, *COGNITION disorders, *TREATMENT effectiveness, *NEUROPROTECTIVE agents, *BLOOD-brain barrier, *BIOCOMPATIBILITY

First-in-human intranasal [¹³N]oxytocin PET: evaluation of feasibility, biodistribution, and radiation dosimetry.

Autoren: Winterdahl, Michael Nielsen, Erik Nguyen Hansen, Søren B. et al.

Quelle: EJNMMI Research. 11/18/2025, Vol. 15 Issue 1, p1-12. 12p.

Schlagwörter: *OXYTOCIN, *INTRANASAL administration, *BIOAVAILABILITY, *RADIATION dosimetry, *TRIGEMINAL nerve, *POSITRON emission tomography, *NEUROBEHAVIORAL disorders

Esketamine monotherapy efficacious in treatment‐resistant depression.

Quelle: Brown University Psychopharmacology Update. Nov2025, Vol. 36 Issue 11, p1-6. 6p.

Schlagwörter: *INTRANASAL administration, *DRUG side effects, *SUICIDAL ideation, *AEROSOLS, *DIZZINESS, *HEADACHE, *TREATMENT effectiveness, *DISEASE remission, *ANTIDEPRESSANTS, *DRUG approval, *QUALITY assurance, *MENTAL depression, *DRUG resistance, *NAUSEA

Firma/Körperschaft: UNITED States. Food & Drug Administration

Evaluating the Use of Nasal Epinephrine in Anaphylaxis: Current Status.

Autoren: Bekis Bozkurt, Hayrunnisa Pençe, İlknur

Quelle: Turkish Archives of Pediatrics. Nov2025, Vol. 60 Issue 6, p572-576. 5p.

Schlagwörter: *DRUG allergy, *INTRANASAL administration, *PATIENT safety, *ADRENALINE, *TREATMENT effectiveness, *RHINITIS, *HEART beat, *DRUG efficacy, *ANAPHYLAXIS, *DRUG development, *BLOOD pressure

First‐in‐Human Study of Merotocin, a Short‐Acting Peptidic Oxytocin Receptor Agonist for Lactation Support.

Autoren: Bagger, Yu Holmqvist, Carina Jonker, Daniël M. et al.

Quelle: Clinical Pharmacology in Drug Development. Nov2025, Vol. 14 Issue 11, p879-888. 10p.

Schlagwörter: *LACTATION, *INTRANASAL administration, *OXYTOCIN receptors, *BREASTFEEDING, *PHARMACOKINETICS, *PHARMACOLOGY, *CLINICAL trials

Effect of perioperative intranasal insulin on postoperative delirium in elderly hip fracture patients undergoing general anesthesia: a randomized controlled study.

Autoren: Wang, Jianpeng Dai, Chenxu Li, Huihui et al.

Quelle: BMC Anesthesiology. 10/27/2025, Vol. 25 Issue 1, p1-10. 10p.

Schlagwörter: *INSULIN therapy, *INTRANASAL administration, *HIP fractures, *RESEARCH funding, *T-test (Statistics), *STATISTICAL sampling, *BLIND experiment, *VISUAL analog scale, *FISHER exact test, *TREATMENT effectiveness, *RANDOMIZED controlled trials, *HOSPITALS, *DESCRIPTIVE statistics, *MANN Whitney U Test, *SURGICAL complications, *DELIRIUM, *NEUROPSYCHOLOGICAL tests, *GENERAL anesthesia, *DATA analysis software, *PERIOPERATIVE care, *EVALUATION, *OLD age

Geografische Kategorien: CHINA

Thermosensitive transniosomal in situ gel of hesperetin for intranasal administration: novel approach for Parkinson’s therapy.

Autoren: Tabassum, Nazreen Sultana, Niha Ali, Asad et al.

Quelle: Journal of Drug Targeting. Oct2025, p1-18. 18p. 14 Illustrations.

Schlagwörter: *INTRANASAL administration, *PARKINSON'S disease, *NANOPARTICLES, *DRUG delivery systems, *HESPERIDIN, *BIOAVAILABILITY, *THERMOREVERSIBLE gels

Intranasal nanoparticle therapy for arsenic-induced neurotoxicity: Restoring IGF-1 signaling and advancing translational neuroprotection.

Autoren: Elsayed, Nourhan Foo, Jhi Biau

Quelle: Neuroscience. Oct2025, Vol. 585, p107-124. 18p.

Schlagwörter: *INTRANASAL administration, *DRUG delivery systems, *NANOPARTICLES, *CENTRAL nervous system, *OXIDATIVE stress, *COGNITIVE neuroscience, *NANOMEDICINE, *NEUROSCIENCES

Intranasally Delivered Echinacoside Micelles Modulate Mitochondrial Fusion Against Postoperative Cognitive Dysfunction.

Autoren: Qi, Fuwei Liao, Yinsheng Ge, Chenglong et al.

Quelle: Advanced Functional Materials. 10/8/2025, Vol. 35 Issue 41, p1-11. 11p.

Schlagwörter: *MITOCHONDRIAL dynamics, *INTRANASAL administration, *REACTIVE oxygen species, *NEUROPROTECTIVE agents, *MICELLES, *COGNITION disorders

Comparison between Oral Midazolam and Intranasal Midazolam for Sedative Premedication in Paediatric Patients: A Randomised Clinical Study.

Autoren: HASNAIN, SHAHBAZ KHATIB, REEM BARKAT JENA, SUBHASHREE

Quelle: Journal of Clinical & Diagnostic Research. Oct2025, Vol. 19 Issue 10, p12-18. 7p.

Schlagwörter: *MIDAZOLAM, *INTRANASAL administration, *SURGICAL complications, *CHILD patients, *ANXIETY, *ORAL drug administration, *CONSCIOUS sedation, *CLINICAL trials

Design of Polycation-Functionalized Resveratrol Nanocrystals for Intranasal Administration.

Autoren: Bonaccorso, Angela Zingale, Elide Caruso, Giuseppe et al.

Quelle: Pharmaceutics. Oct2025, Vol. 17 Issue 10, p1346. 27p.

Schlagwörter: *RESVERATROL, *INTRANASAL administration, *NEUROPROTECTIVE agents, *NANOPARTICLES, *DRUG delivery systems, *BIOPOLYMERS, *NANOCRYSTALS

Advances in Nasal Biopharmaceutics to Support Product Development and Therapeutic Needs.

Autoren: Forbes, Ben Goodacre, Lucy Lansley, Alison B. et al.

Quelle: Pharmaceutics. Oct2025, Vol. 17 Issue 10, p1321. 21p.

Schlagwörter: *INTRANASAL administration, *NEW product development, *DRUG absorption, *PHYSIOLOGICAL models, *TREATMENT effectiveness, *DRUG delivery systems

Safety, pharmacokinetics, and pharmacodynamics of Dexmedetomidine two-phase flow atomization in healthy subjects: a randomized, parallel study.

Autoren: Lian, Yujun Luo, Huanqi Yang, Zhijing et al.

Quelle: BMC Anesthesiology. 10/1/2025, Vol. 25 Issue 1, p1-9. 9p.

Schlagwörter: *PATIENT safety, *INTRANASAL administration, *T-test (Statistics), *RESEARCH funding, *BLIND experiment, *STATISTICAL sampling, *DRUG delivery systems, *RANDOMIZED controlled trials, *LONGITUDINAL method, *SYSTOLIC blood pressure, *DATA analysis software, *IMIDAZOLES, *ANESTHESIA, *PHARMACODYNAMICS

Nose-to-Brain Delivery of Dolutegravir via Thermoresponsive Nanostructured Lipid Carriers: Cytocompatibility and Fluorescent Biodistribution Studies.

Autoren: Taher, Salam Shanta Al-Kinani, Khalid Kadhem

Quelle: Journal of Nanostructures. Autumn2025, Vol. 15 Issue 4, p2227-2236. 10p.

Schlagwörter: *DOLUTEGRAVIR, *INTRANASAL administration, *CYTOCOMPATIBILITY, *NANOCARRIERS, *BLOOD-brain barrier, *NEUROLOGICAL disorders, *FLUOROPHORES

Intranasal insulin administration improves anxiety- and depressive-like behaviors in PTSD-exposed rats.

Autoren: Karimzadeh, Arezoo Nabavifard, Samaneh Beirami, Elmira et al.

Quelle: Journal of Psychiatric Research. Oct2025, Vol. 190, p84-91. 8p.

Schlagwörter: *INTRANASAL administration, *INSULIN therapy, *CENTRAL nervous system, *MENTAL illness, *LONG-term memory, *POST-traumatic stress disorder