Search Results - "INTESTINAL absorption"

Investigating the influence of mucus layer, bile acids, and pharmaceutical excipients on the intestinal permeability of solifenacin using PermeaPad™ plate.

Authors: Hagiwara Y Yoshinari K

Source: Journal of pharmaceutical sciences [J Pharm Sci] 2025 Oct; Vol. 114 (10), pp. 103976. Date of Electronic Publication: 2025 Aug 28.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

MeSH Terms: Excipients*/chemistry , Solifenacin Succinate*/pharmacokinetics , Solifenacin Succinate*/chemistry , Solifenacin Succinate*/metabolism , Bile Acids and Salts*/metabolism , Bile Acids and Salts*/chemistry , Intestinal Absorption*/drug effects , Intestinal Absorption*/physiology , Mucus*/metabolism , Intestinal Mucosa*/metabolism, Permeability/drug effects ; Taurocholic Acid/chemistry ; Taurocholic Acid/metabolism ; Hydrophobic and Hydrophilic Interactions ; Humans ; Intestinal Barrier Function

High-salt diets provoke phosphorus absorption from the small intestine in mice.

Authors: Yang M You H Ni L et al.

Source: Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2025 Dec; Vol. 47 (1), pp. 2472066. Date of Electronic Publication: 2025 Feb 25.

Publication Type: Journal Article

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9305929 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6006 (Electronic) Linking ISSN: 10641963 NLM ISO Abbreviation: Clin Exp Hypertens Subsets: MEDLINE

MeSH Terms: Intestinal Absorption*/drug effects , Intestinal Absorption*/physiology , Intestine, Small*/metabolism , Intestine, Small*/drug effects , Phosphorus*/metabolism , Sodium Chloride, Dietary*/pharmacology, Animals ; Male ; Mice, Inbred C57BL ; Mice ; Fibroblast Growth Factor-23 ; Sodium-Hydrogen Exchanger 3/metabolism ; Fibroblast Growth Factors/metabolism ; Kidney/metabolism ; Sodium-Phosphate Cotransporter Proteins, Type IIb/metabolism ; Sodium-Phosphate Cotransporter Proteins, Type IIb/genetics ; Blood Pressure/drug effects

In Vitro and Ex Vivo Models to Study Molecular Trafficking Across the Human Intestinal Barrier.

Authors: Galvan A Guidorizzi E Carton F et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 29; Vol. 26 (21). Date of Electronic Publication: 2025 Oct 29.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Intestinal Mucosa*/metabolism , Models, Biological* , Intestinal Absorption*, Humans ; Biological Transport

Enhancement in the intestinal absorption of ginsenoside Re by ginseng polysaccharides and its mechanisms.

Authors: Zhu Y Yue J Yan R et al.

Source: Food chemistry [Food Chem] 2025 Oct 01; Vol. 488, pp. 144914. Date of Electronic Publication: 2025 May 24.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH Terms: Ginsenosides*/chemistry , Ginsenosides*/metabolism , Ginsenosides*/pharmacokinetics , Ginsenosides*/administration & dosage , Panax*/chemistry , Panax*/metabolism , Polysaccharides*/chemistry , Polysaccharides*/metabolism , Polysaccharides*/administration & dosage , Intestinal Absorption*/drug effects , Plant Extracts*/chemistry , Plant Extracts*/metabolism , Plant Extracts*/administration & dosage, Animals ; Male ; Humans ; Biological Availability ; Rats, Sprague-Dawley ; Rats ; Intestinal Mucosa/metabolism

Precipitation as key parameter for early oral drug absorption predictions, Part I: Acquisition of critical data.

Authors: Mayer S Wagner C Lehmann A et al.

Source: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2025 Oct 01; Vol. 213, pp. 107210. Date of Electronic Publication: 2025 Jul 19.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE

MeSH Terms: Intestinal Absorption*, Administration, Oral ; Pharmaceutical Preparations/chemistry ; Pharmaceutical Preparations/metabolism ; Pharmaceutical Preparations/administration & dosage ; Solubility ; Chemical Precipitation ; Humans ; Permeability ; Drug Discovery/methods ; Models, Biological ; Animals

Decoding the mechanism of dietary fatty acids-driven phytosterol esterification promoting intestinal absorption.

Authors: Zhao T Li Z Ji S et al.

Source: Food chemistry [Food Chem] 2025 Dec 25; Vol. 496 (Pt 1), pp. 146525. Date of Electronic Publication: 2025 Oct 03.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH Terms: Phytosterols*/metabolism , Phytosterols*/chemistry , Intestinal Absorption* , Fatty Acids*/metabolism , Fatty Acids*/chemistry , Dietary Fats*/metabolism , Intestinal Mucosa*/metabolism, Esterification ; Humans ; Animals

Capryol® 90 is an efficacious intestinal absorption enhancer for insulin in vivo when combined other excipients.

Authors: McCartney F Caisse P Dumont C et al.

Source: International journal of pharmaceutics [Int J Pharm] 2025 Dec 25; Vol. 686, pp. 126315. Date of Electronic Publication: 2025 Oct 27.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

MeSH Terms: Excipients*/chemistry , Excipients*/administration & dosage , Intestinal Absorption*/drug effects , Insulin*/administration & dosage , Insulin*/pharmacokinetics , Insulin*/chemistry , Decanoic Acids*/chemistry , Decanoic Acids*/administration & dosage , Hypoglycemic Agents*/administration & dosage , Hypoglycemic Agents*/pharmacokinetics , Hypoglycemic Agents*/chemistry, Animals ; Male ; Rats ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/drug effects ; Rats, Sprague-Dawley ; Permeability ; Castor Oil/chemistry ; Polyethylene Glycols/chemistry ; Solubility ; Rats, Wistar

Mechanistic insight into the antidiabetic effects of Ficus hispida fruits: Inhibition of intestinal glucose absorption and pancreatic beta-cell apoptosis.

Authors: Jahan N Siddiquee NH Riva RAK et al.

Source: PloS one [PLoS One] 2025 Dec 01; Vol. 20 (12), pp. e0337465. Date of Electronic Publication: 2025 Dec 01 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH Terms: Apoptosis*/drug effects , Fruit*/chemistry , Ficus*/chemistry , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry , Insulin-Secreting Cells*/drug effects , Insulin-Secreting Cells*/metabolism , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Glucose*/metabolism , Intestinal Absorption*/drug effects, Humans ; Molecular Docking Simulation ; Caspase 3/metabolism ; Caspase 3/chemistry ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Glycoside Hydrolase Inhibitors/pharmacology ; Glycoside Hydrolase Inhibitors/chemistry ; alpha-Glucosidases/metabolism ; Molecular Dynamics Simulation

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter-Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™).

Authors: Chothe PP Whitcher-Johnstone A Karve A et al.

Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2025 Dec; Vol. 118 (6), pp. 1499-1511. Date of Electronic Publication: 2025 Jul 14.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

MeSH Terms: Cytochrome P-450 CYP3A*/metabolism , Cytochrome P-450 CYP3A*/biosynthesis , Models, Biological* , Intestinal Absorption*/physiology , Cytochrome P-450 CYP3A Inducers*/pharmacology , Cytochrome P-450 CYP3A Inducers*/pharmacokinetics, Humans ; Drug Interactions ; Administration, Oral ; Caco-2 Cells ; Pregnane X Receptor/metabolism ; Intestinal Mucosa/metabolism ; Biological Availability ; Pharmaceutical Preparations/metabolism ; Pharmaceutical Preparations/administration & dosage ; Permeability

A Translational Model for In Vivo Intestinal Permeability Assessment in Pigs.

Authors: Van Rymenant E Van Poucke C Van Loo K et al.

Source: The Journal of nutrition [J Nutr] 2025 Dec; Vol. 155 (12), pp. 4433-4445. Date of Electronic Publication: 2025 Sep 20.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0404243 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1541-6100 (Electronic) Linking ISSN: 00223166 NLM ISO Abbreviation: J Nutr Subsets: MEDLINE

MeSH Terms: Intestinal Mucosa*/metabolism , Intestinal Mucosa*/drug effects , Intestines*/drug effects , Intestinal Absorption*/drug effects, Animals ; Permeability ; Swine ; Feces/chemistry ; Indomethacin/pharmacology ; Sucrose/analogs & derivatives ; Sucrose/urine ; Dextran Sulfate ; Male ; Female ; Biomarkers ; Translational Research, Biomedical ; Intestinal Barrier Function

Structure-activity relationship and antioxidant properties of walnut peptides with high intestinal absorption capacity.

Authors: Li J Fang L Liu C et al.

Source: Food & function [Food Funct] 2025 Nov 24; Vol. 16 (23), pp. 9063-9079. Date of Electronic Publication: 2025 Nov 24.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Electronic Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE

MeSH Terms: Juglans*/chemistry , Antioxidants*/chemistry , Antioxidants*/pharmacology , Antioxidants*/metabolism , Peptides*/chemistry , Peptides*/pharmacology , Peptides*/metabolism , Intestinal Absorption* , Plant Proteins*/chemistry , Plant Proteins*/pharmacology, Animals ; Rats ; PC12 Cells ; Oxidative Stress/drug effects ; Structure-Activity Relationship ; Molecular Docking Simulation ; Nuts/chemistry

Green tea prepared via the daily infusion method prevents non-alcoholic fatty liver disease by targeting intestinal lipid absorption, hepatic lipid metabolism and gut microbiota composition.

Authors: Orita T Chogahara S Sakao K et al.

Source: Food & function [Food Funct] 2025 Nov 24; Vol. 16 (23), pp. 8991-9005. Date of Electronic Publication: 2025 Nov 24.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Electronic Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE

MeSH Terms: Non-alcoholic Fatty Liver Disease*/prevention & control , Non-alcoholic Fatty Liver Disease*/metabolism , Non-alcoholic Fatty Liver Disease*/microbiology , Gastrointestinal Microbiome*/drug effects , Tea*/chemistry , Lipid Metabolism*/drug effects , Liver*/metabolism , Liver*/drug effects , Plant Extracts*/pharmacology , Plant Extracts*/administration & dosage , Intestinal Absorption*/drug effects, Animals ; Mice ; Humans ; Male ; Mice, Inbred C57BL ; Disease Models, Animal ; Camellia sinensis/chemistry ; Catechin/analogs & derivatives ; Catechin/pharmacology

Anthocyanin-sulfated polysaccharide-ovalbumin nanocomplex: Intestinal absorption mechanism and intracellular antioxidant activity in Caco-2 cells.

Authors: Dong R Wang Y McClements DJ et al.

Source: Food chemistry [Food Chem] 2025 Nov 15; Vol. 492 (Pt 2), pp. 145472. Date of Electronic Publication: 2025 Jul 07.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH Terms: Antioxidants*/chemistry , Antioxidants*/metabolism , Antioxidants*/pharmacology , Intestinal Absorption*/drug effects , Anthocyanins*/chemistry , Anthocyanins*/metabolism , Anthocyanins*/pharmacology , Ovalbumin*/chemistry , Ovalbumin*/metabolism , Polysaccharides*/chemistry , Polysaccharides*/metabolism, Caco-2 Cells ; Humans ; Intestinal Mucosa/metabolism

Genome edited intestine liver on a chip system for integrated intestinal hepatic drug absorption and metabolism evaluation.

Authors: Negoro R Deguchi S Yamazaki D et al.

Source: Scientific reports [Sci Rep] 2025 Nov 04; Vol. 15 (1), pp. 38609. Date of Electronic Publication: 2025 Nov 04.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Liver*/metabolism , Intestinal Absorption* , Lab-On-A-Chip Devices*, Humans ; Caco-2 Cells ; Cytochrome P-450 CYP3A/metabolism ; Cytochrome P-450 CYP3A/genetics ; Hep G2 Cells ; Hepatocytes/metabolism ; Intestinal Mucosa/metabolism

Dexamethasone enhances intestinal glucose absorption and TMPRSS2 expression with implications for hyperglycaemia and infection risk.

Authors: Visvanathan R Houghton MJ Barber E et al.

Source: Scientific reports [Sci Rep] 2025 Nov 03; Vol. 15 (1), pp. 38329. Date of Electronic Publication: 2025 Nov 03.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Dexamethasone*/pharmacology , Dexamethasone*/adverse effects , Glucose*/metabolism , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics , Hyperglycemia*/metabolism , Hyperglycemia*/chemically induced , Intestinal Absorption*/drug effects, Humans ; Animals ; Caco-2 Cells ; Mice ; Sodium-Glucose Transporter 1/metabolism ; Sodium-Glucose Transporter 1/genetics ; COVID-19/metabolism ; COVID-19/virology ; Angiotensin-Converting Enzyme 2/metabolism ; Angiotensin-Converting Enzyme 2/genetics ; SARS-CoV-2 ; Glucose Transporter Type 2/metabolism ; Glucose Transporter Type 2/genetics ; COVID-19 Drug Treatment ; Male

Flax Lignans modulate the digestion and absorption of α-linolenic acid in sunflower phospholipid-stabilized nanoemulsions: In vitro digestion simulation and in vivo studies in mice.

Authors: Wang L Yu X Cheng C et al.

Source: Food research international (Ottawa, Ont.) [Food Res Int] 2025 Nov; Vol. 220, pp. 117049. Date of Electronic Publication: 2025 Jul 26.

Publication Type: Journal Article

Journal Info: Publisher: Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science Country of Publication: Canada NLM ID: 9210143 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7145 (Electronic) Linking ISSN: 09639969 NLM ISO Abbreviation: Food Res Int Subsets: MEDLINE

MeSH Terms: alpha-Linolenic Acid*/pharmacokinetics , alpha-Linolenic Acid*/metabolism , alpha-Linolenic Acid*/blood , Lignans*/pharmacology , Lignans*/chemistry , Flax*/chemistry , Digestion*/drug effects , Phospholipids*/chemistry , Intestinal Absorption*/drug effects , Helianthus*/chemistry, Emulsions ; Animals ; Mice ; Male ; Biological Availability

Effects of yeast protein on the promotion of intestinal calcium absorption (in vivo/in vitro) and bone formation (in vivo) in rats fed by normal and low-calcium diets.

Authors: Liang Y Cheng Q Chen Z et al.

Source: Food research international (Ottawa, Ont.) [Food Res Int] 2025 Nov; Vol. 220, pp. 117179. Date of Electronic Publication: 2025 Jul 31.

Publication Type: Journal Article

Journal Info: Publisher: Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science Country of Publication: Canada NLM ID: 9210143 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7145 (Electronic) Linking ISSN: 09639969 NLM ISO Abbreviation: Food Res Int Subsets: MEDLINE

MeSH Terms: Intestinal Absorption*/drug effects , Calcium, Dietary*/administration & dosage , Calcium, Dietary*/metabolism , Osteogenesis*/drug effects , Calcium*/metabolism , Calcium*/deficiency, Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Alkaline Phosphatase/blood ; Bone and Bones/metabolism

Modulation of Jejunal Glucose Absorption as a Central Mechanism in the Antidiabetic Action of Myrtle Berry Seeds Aqueous Extract.

Authors: Hajaji S Jabri MA Arrari F et al.

Source: Neurogastroenterology and motility [Neurogastroenterol Motil] 2025 Nov; Vol. 37 (11), pp. e70154. Date of Electronic Publication: 2025 Sep 12.

Publication Type: Journal Article

Journal Info: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9432572 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2982 (Electronic) Linking ISSN: 13501925 NLM ISO Abbreviation: Neurogastroenterol Motil Subsets: MEDLINE

MeSH Terms: Plant Extracts*/pharmacology , Hypoglycemic Agents*/pharmacology , Jejunum*/metabolism , Jejunum*/drug effects , Glucose*/metabolism , Intestinal Absorption*/drug effects , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Experimental*/metabolism , Syzygium*, Animals ; Mice ; Male ; Rats ; Seeds ; Rats, Wistar ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Fruit

Study on the intestinal metabolism and absorption of polysaccharides from Dendrobium officinale.

Authors: Wu Z He Z Dou P et al.

Source: International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 331 (Pt 2), pp. 148390. Date of Electronic Publication: 2025 Oct 17.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH Terms: Dendrobium*/chemistry , Polysaccharides*/metabolism , Polysaccharides*/chemistry , Polysaccharides*/pharmacokinetics , Polysaccharides*/pharmacology , Intestinal Absorption* , Intestinal Mucosa*/metabolism , Intestines*/microbiology, Gastrointestinal Microbiome/drug effects ; Animals ; Male ; Bacteroides/metabolism ; Bacteroides/genetics

Oral absorption mechanisms of Astragalus polysaccharides and potential as an excipient to increase the absorption of flavonoids.

Authors: Wu X Xu Y Zhu D et al.

Source: International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 330 (Pt 2), pp. 147977. Date of Electronic Publication: 2025 Sep 29.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH Terms: Polysaccharides*/chemistry , Polysaccharides*/pharmacokinetics , Polysaccharides*/administration & dosage , Polysaccharides*/pharmacology , Astragalus Plant*/chemistry , Flavonoids*/chemistry , Flavonoids*/pharmacokinetics , Intestinal Absorption*/drug effects , Excipients*/chemistry , Excipients*/pharmacology, Animals ; Administration, Oral ; Male ; Humans ; Rats ; Biological Transport