Search Results - "INTERLEUKIN-10"

Case Report: Novel IL10RB variant causing very early onset-inflammatory bowel disease.

Authors: Usman Y Ptak CP Cohran VC et al.

Source: Frontiers in immunology [Front Immunol] 2025 Oct 06; Vol. 16, pp. 1655475. Date of Electronic Publication: 2025 Oct 06 (Print Publication: 2025).

Publication Type: Case Reports; Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Inflammatory Bowel Diseases*/genetics , Inflammatory Bowel Diseases*/diagnosis , Inflammatory Bowel Diseases*/therapy , Interleukin-10 Receptor beta Subunit*/genetics , Interleukin-10 Receptor beta Subunit*/chemistry, Humans ; Male ; Infant ; Interleukin-10/metabolism ; Mutation, Missense ; Homozygote ; Genetic Predisposition to Disease ; Age of Onset

Bacterial immunotherapy leveraging IL-10R hysteresis for both phagocytosis evasion and tumor immunity revitalization.

Authors: Chang Z Guo X Li X et al.

Source: Cell [Cell] 2025 Apr 03; Vol. 188 (7), pp. 1842-1857.e20. Date of Electronic Publication: 2025 Mar 03.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

MeSH Terms: Phagocytosis*/immunology , Immunotherapy*/methods , Receptors, Interleukin-10*/metabolism , Receptors, Interleukin-10*/immunology , Neoplasms*/immunology , Neoplasms*/therapy , Salmonella enterica*/immunology, Humans ; Animals ; Interleukin-10/metabolism ; Interleukin-10/immunology ; Tumor Microenvironment/immunology ; Mice ; Neutrophils/immunology ; Mice, Inbred C57BL ; CD8-Positive T-Lymphocytes/immunology ; Cell Line, Tumor ; Female ; Tumor-Associated Macrophages/immunology ; Macrophages/immunology

Successful Use of Anakinra in a Patient with IL-10R Beta Deficiency: A Case Report.

Authors: Dogan S Selen R Ozbay Hosnut F et al.

Source: Pediatric allergy, immunology, and pulmonology [Pediatr Allergy Immunol Pulmonol] 2025 Mar; Vol. 38 (1), pp. 32-35. Date of Electronic Publication: 2025 Feb 14.

Publication Type: Journal Article; Case Reports

Journal Info: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101549629 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2151-3228 (Electronic) Linking ISSN: 2151321X NLM ISO Abbreviation: Pediatr Allergy Immunol Pulmonol Subsets: MEDLINE

MeSH Terms: Interleukin 1 Receptor Antagonist Protein*/therapeutic use , Interleukin-10 Receptor beta Subunit*/deficiency , Interleukin-10 Receptor beta Subunit*/genetics , Inflammatory Bowel Diseases*/therapy , Inflammatory Bowel Diseases*/genetics, Humans ; Male ; Infant ; Hematopoietic Stem Cell Transplantation ; Treatment Outcome ; Interleukin-10

IL-10RA governor the expression of IDO in the instruction of lymphocyte immunity.

Authors: Tai TS Hsu DW Yang YS et al.

Source: British journal of cancer [Br J Cancer] 2025 Jan; Vol. 132 (1), pp. 126-136. Date of Electronic Publication: 2024 Nov 26.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE

MeSH Terms: Indoleamine-Pyrrole 2,3,-Dioxygenase*/genetics , Indoleamine-Pyrrole 2,3,-Dioxygenase*/metabolism , Indoleamine-Pyrrole 2,3,-Dioxygenase*/immunology , Mesenchymal Stem Cells*/immunology , Mesenchymal Stem Cells*/metabolism , Interleukin-10 Receptor alpha Subunit*/genetics , Interleukin-10 Receptor alpha Subunit*/metabolism , Interleukin-10 Receptor alpha Subunit*/immunology , T-Lymphocytes*/immunology, Humans ; Coculture Techniques ; Interleukin-10 ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Interferon-gamma

Upregulation of delta opioid receptor by meningeal interleukin-10 prevents relapsing pain.

Authors: Inyang KE Sim J Clark KB et al.

Source: Brain, behavior, and immunity [Brain Behav Immun] 2025 Jan; Vol. 123, pp. 399-410. Date of Electronic Publication: 2024 Sep 29.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE

MeSH Terms: Interleukin-10*/metabolism , Receptors, Opioid, delta*/metabolism , Meninges*/metabolism , Meninges*/drug effects , Ganglia, Spinal*/metabolism , Up-Regulation*/drug effects, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Recurrence ; Chronic Pain/metabolism ; Macrophages/metabolism ; Macrophages/drug effects ; Sensory Receptor Cells/metabolism ; Sensory Receptor Cells/drug effects ; Receptors, Interleukin-10/metabolism

Foxp3 + Treg-derived IL-10 promotes colorectal cancer-derived lung metastasis.

Authors: Shiri AM Fard-Aghaie M Bedke T et al.

Source: Scientific reports [Sci Rep] 2024 Dec 16; Vol. 14 (1), pp. 30483. Date of Electronic Publication: 2024 Dec 16.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Interleukin-10*/metabolism , Interleukin-10*/genetics , Lung Neoplasms*/secondary , Lung Neoplasms*/immunology , Lung Neoplasms*/pathology , Lung Neoplasms*/genetics , T-Lymphocytes, Regulatory*/immunology , T-Lymphocytes, Regulatory*/metabolism , Forkhead Transcription Factors*/metabolism , Forkhead Transcription Factors*/genetics , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/immunology, Animals ; Mice ; Cell Line, Tumor ; Humans ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Interleukin-10/metabolism ; Receptors, Interleukin-10/genetics

Pathobiont-induced suppressive immune imprints thwart T cell vaccine responses.

Authors: Hajam IA Tsai CM Gonzalez C et al.

Source: Nature communications [Nat Commun] 2024 Dec 16; Vol. 15 (1), pp. 10335. Date of Electronic Publication: 2024 Dec 16.

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, N.I.H., Extramural

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Staphylococcus aureus*/immunology , Interleukin-10*/immunology , Interleukin-10*/metabolism , CD4-Positive T-Lymphocytes*/immunology , Interleukin-17*/immunology , Interleukin-17*/metabolism , Staphylococcal Infections*/immunology , Staphylococcal Infections*/prevention & control , Staphylococcal Infections*/microbiology, Animals ; Mice ; Mice, Inbred C57BL ; Staphylococcal Vaccines/immunology ; Interferon-gamma/immunology ; Interferon-gamma/metabolism ; Female ; Humans ; Immune Evasion/immunology ; Vaccination ; Receptors, Interleukin-10/immunology ; Receptors, Interleukin-10/metabolism

Chikungunya virus infection inhibits B16 melanoma-induced immunosuppression of T cells and macrophages mediated by interleukin 10.

Authors: Khamaru S Mukherjee T Tung KS et al.

Source: Microbial pathogenesis [Microb Pathog] 2024 Dec; Vol. 197, pp. 107022. Date of Electronic Publication: 2024 Oct 16.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE

MeSH Terms: Interleukin-10*/metabolism , Macrophages*/immunology , Macrophages*/virology , Chikungunya virus*/immunology , Chikungunya virus*/drug effects , T-Lymphocytes*/immunology , Melanoma, Experimental*/immunology , Chikungunya Fever*/immunology , Chikungunya Fever*/virology, Animals ; Mice ; RAW 264.7 Cells ; STAT3 Transcription Factor/metabolism ; Humans ; Immunosuppression Therapy ; Receptors, Interleukin-10/antagonists & inhibitors ; Immune Tolerance ; Cell Line, Tumor ; Mice, Inbred C57BL

Early introduction of IL-10 weakens BCG revaccination's protection by suppressing CD4 ⁺ Th1 cell responses.

Authors: Lei Q Fu H Yao Z et al.

Source: Journal of translational medicine [J Transl Med] 2024 Dec 04; Vol. 22 (1), pp. 1103. Date of Electronic Publication: 2024 Dec 04.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH Terms: Interleukin-10*/metabolism , Mice, Inbred C57BL* , BCG Vaccine*/immunology , Lung*/immunology , Th1 Cells*/immunology, Animals ; Immunization, Secondary ; Tuberculosis/prevention & control ; Tuberculosis/immunology ; Mycobacterium tuberculosis/immunology ; Female ; CD4-Positive T-Lymphocytes/immunology ; Vaccination ; Mice ; Receptors, Interleukin-10/immunology

Human cytomegalovirus interleukin 10 (cmvIL-10) orchestrates crosstalk between the cellular IL-10 receptor and CXCR4.

Authors: Satani KH Spencer JV

Source: Virology [Virology] 2025 Nov; Vol. 612, pp. 110693. Date of Electronic Publication: 2025 Sep 12.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0110674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0341 (Electronic) Linking ISSN: 00426822 NLM ISO Abbreviation: Virology Subsets: MEDLINE

MeSH Terms: Cytomegalovirus*/immunology , Cytomegalovirus*/genetics , Cytomegalovirus*/metabolism , Receptors, CXCR4*/metabolism , Receptors, CXCR4*/genetics , Interleukin-10*/metabolism , Interleukin-10*/genetics , Receptors, Interleukin-10*/metabolism , Receptors, Interleukin-10*/genetics , Viral Proteins*/metabolism , Viral Proteins*/genetics , Cytomegalovirus Infections*/virology , Cytomegalovirus Infections*/metabolism , Cytomegalovirus Infections*/genetics , Cytomegalovirus Infections*/immunology, Humans ; Signal Transduction ; Cell Movement ; Cell Proliferation

Chronic stress and the IL-10-mediated immunoregulatory loop in the pathogenesis of periodontitis.

Authors: Skrypnyk M Spahr A Berkovsky S et al.

Source: Clinical science (London, England : 1979) [Clin Sci (Lond)] 2025 Nov 25; Vol. 139 (22).

Publication Type: Journal Article; Review

Journal Info: Publisher: Portland Press on behalf of the Medical Research Society and the Biochemical Society Country of Publication: England NLM ID: 7905731 Publication Model: Print Cited Medium: Internet ISSN: 1470-8736 (Electronic) Linking ISSN: 01435221 NLM ISO Abbreviation: Clin Sci (Lond) Subsets: MEDLINE

MeSH Terms: Interleukin-10*/metabolism , Interleukin-10*/immunology , Stress, Psychological*/immunology , Stress, Psychological*/complications , Stress, Psychological*/metabolism , Stress, Psychological*/physiopathology , Periodontitis*/immunology , Periodontitis*/etiology , Periodontitis*/metabolism , Periodontitis*/physiopathology , Periodontitis*/psychology, Humans ; Hypothalamo-Hypophyseal System/metabolism ; Hypothalamo-Hypophyseal System/immunology ; Hypothalamo-Hypophyseal System/physiopathology ; Pituitary-Adrenal System/metabolism ; Pituitary-Adrenal System/immunology ; Animals

Advances in interleukin-10-based therapies for pulmonary diseases: focus on targeted lung delivery systems.

Authors: Tian W Wang X Zeng J et al.

Source: Frontiers in immunology [Front Immunol] 2025 Nov 12; Vol. 16, pp. 1630990. Date of Electronic Publication: 2025 Nov 12 (Print Publication: 2025).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Interleukin-10*/administration & dosage , Interleukin-10*/therapeutic use , Drug Delivery Systems* , Lung Diseases*/therapy , Lung Diseases*/drug therapy , Lung Diseases*/immunology , Lung Diseases*/metabolism , Lung*/metabolism , Lung*/immunology , Lung*/drug effects, Humans ; Animals

Interleukin 10 enhances endothelial progenitor cell-mediated angiogenesis in extrahepatic portal venous obstruction.

Authors: Zhang JS; Department of General Surgery, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, People's Republic of China. zjs851@163.com.; Department of General Surgery, Capital Institute of Pediatrics, No.2 Yabaolu Rd, Beijing, 100020, China. zjs851@163.com.

Source: Stem cell research & therapy [Stem Cell Res Ther] 2025 Oct 29; Vol. 16 (1), pp. 594. Date of Electronic Publication: 2025 Oct 29.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE

MeSH Terms: Endothelial Progenitor Cells*/metabolism , Endothelial Progenitor Cells*/transplantation , Endothelial Progenitor Cells*/cytology , Interleukin-10*/metabolism , Interleukin-10*/genetics , Portal Vein*/pathology , Portal Vein*/metabolism , Neovascularization, Physiologic*, Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Vascular Endothelial Growth Factor A/metabolism ; Disease Models, Animal ; Angiogenesis

A Novel Surface Plasmon Resonance Imaging (SPRi) Biosensor for the Determination of Bovine Interleukin-10: Development, Validation, and Application in Biological Fluids.

Authors: Pytel A Tobolski D Skup P et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 25; Vol. 26 (21). Date of Electronic Publication: 2025 Oct 25.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH Terms: Surface Plasmon Resonance*/methods , Interleukin-10*/analysis , Interleukin-10*/blood , Biosensing Techniques*/methods, Animals ; Cattle ; Follicular Fluid/chemistry ; Follicular Fluid/metabolism ; Limit of Detection ; Female ; Rabbits

A Phylogenetic Perspective on the Evolutionary Patterns of the Animal Interleukin-10 Signaling System.

Authors: Tang L Zhou Z Wang W et al.

Source: Genes [Genes (Basel)] 2025 Oct 22; Vol. 16 (11). Date of Electronic Publication: 2025 Oct 22.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE

MeSH Terms: Phylogeny* , Interleukin-10*/genetics , Interleukin-10*/metabolism , Signal Transduction* , Evolution, Molecular* , Receptors, Interleukin-10*/genetics , Receptors, Interleukin-10*/metabolism, Animals ; Humans

Mechanisms of Interleukin-10-Mediated Immunosuppression in Viral Infections.

Authors: Guo Z He Q Zhang Y et al.

Source: Pathogens (Basel, Switzerland) [Pathogens] 2025 Oct 01; Vol. 14 (10). Date of Electronic Publication: 2025 Oct 01.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Internet ISSN: 2076-0817 (Electronic) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: MEDLINE

MeSH Terms: Interleukin-10*/immunology , Interleukin-10*/metabolism , Virus Diseases*/immunology , Immune Tolerance*, Humans ; Animals ; Immunity, Innate ; Adaptive Immunity ; T-Lymphocytes/immunology

Interleukin-10 deficiency suppresses colorectal cancer metastasis by enriching gut Parabacteroides distasonis.

Authors: Yu J Feng L Luo Z et al.

Source: Journal of advanced research [J Adv Res] 2025 Oct; Vol. 76, pp. 467-479. Date of Electronic Publication: 2024 Nov 19.

Publication Type: Journal Article

Journal Info: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE

MeSH Terms: Interleukin-10*/deficiency , Interleukin-10*/metabolism , Interleukin-10*/blood , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/microbiology , Colorectal Neoplasms*/metabolism , Gastrointestinal Microbiome*, Animals ; Mice ; Humans ; Fecal Microbiota Transplantation ; Neoplasm Metastasis ; Male ; Female ; Cell Line, Tumor

Evaluation of PD-1 and interleukin-10-receptor expression by T lymphocytes in malignant and benign pleural effusions.

Authors: Mosleh B Hammer B El-Gazzar A et al.

Source: Clinical and experimental medicine [Clin Exp Med] 2024 Sep 26; Vol. 24 (1), pp. 228. Date of Electronic Publication: 2024 Sep 26.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100973405 Publication Model: Electronic Cited Medium: Internet ISSN: 1591-9528 (Electronic) Linking ISSN: 15918890 NLM ISO Abbreviation: Clin Exp Med Subsets: MEDLINE

MeSH Terms: Interleukin-10*/metabolism , Pleural Effusion*/immunology , Pleural Effusion*/metabolism , Pleural Effusion, Malignant*/immunology , Pleural Effusion, Malignant*/pathology , Pleural Effusion, Malignant*/metabolism , Programmed Cell Death 1 Receptor*/metabolism, Aged ; Female ; Humans ; Male ; Middle Aged ; Flow Cytometry ; Prospective Studies ; Receptors, Interleukin-10/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism

MAB_0676c-induced enhanced IL-10 production inhibits the autophagic flux via the MTOR/RUBCN pathway.

Authors: Kim DH Woo K Park HS et al.

Source: Virulence [Virulence] 2025 Dec; Vol. 16 (1), pp. 2529493. Date of Electronic Publication: 2025 Jul 10.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

MeSH Terms: Interleukin-10*/metabolism , Interleukin-10*/biosynthesis , Autophagy*/drug effects , TOR Serine-Threonine Kinases*/metabolism , Mycobacterium abscessus*/immunology , Mycobacterium abscessus*/pathogenicity , Mycobacterium abscessus*/genetics , Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism , Bacterial Proteins*/immunology, Humans ; Signal Transduction ; Macrophages/microbiology ; Macrophages/immunology ; Immunity, Innate ; Mycobacterium Infections, Nontuberculous/microbiology ; Mycobacterium Infections, Nontuberculous/immunology

Human gut commensal Alistipes timonensis modulates the host lipidome and delivers anti-inflammatory outer membrane vesicles to suppress colitis in an Il10 -deficient mouse model.

Authors: Older EA Mitchell MK Campbell A et al.

Source: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2517380. Date of Electronic Publication: 2025 Jun 11.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

MeSH Terms: Interleukin-10*/deficiency , Interleukin-10*/genetics , Gastrointestinal Microbiome* , Colitis*/microbiology , Colitis*/immunology , Clostridiales*/physiology , Anti-Inflammatory Agents*/pharmacology, Animals ; Mice ; Disease Models, Animal ; Humans ; Mice, Inbred C57BL ; Macrophages/immunology ; Macrophages/drug effects ; Mice, Knockout ; Lipidomics ; Male