Výsledky vyhľadávania - "Hyperalgesia"

Interindividual variations in peak alpha frequency do not predict the magnitude or extent of secondary hyperalgesia induced by high-frequency stimulation.

Autori: Lebrun L Ricci G Courtin AS a ďalší

Zdroj: Journal of neurophysiology [J Neurophysiol] 2025 Dec 01; Vol. 134 (6), pp. 1897-1911. Date of Electronic Publication: 2025 Oct 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Physiological Society Country of Publication: United States NLM ID: 0375404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1598 (Electronic) Linking ISSN: 00223077 NLM ISO Abbreviation: J Neurophysiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hyperalgesia*/physiopathology , Hyperalgesia*/etiology , Alpha Rhythm*/physiology , Central Nervous System Sensitization*/physiology, Humans ; Male ; Female ; Adult ; Young Adult ; Individuality ; Pain Threshold/physiology

Prior adolescent oxycodone exposure enhances pain sensitivity following chronic intermittent ethanol in adult female mice.

Autori: Wilson LL Albrechet-Souza L Ha L a ďalší

Zdroj: Physiology & behavior [Physiol Behav] 2025 Nov 01; Vol. 301, pp. 115067. Date of Electronic Publication: 2025 Aug 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 0151504 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-507X (Electronic) Linking ISSN: 00319384 NLM ISO Abbreviation: Physiol Behav Subsets: MEDLINE

Výrazy zo slovníka MeSH: Oxycodone*/pharmacology , Oxycodone*/administration & dosage , Ethanol*/administration & dosage , Analgesics, Opioid*/pharmacology , Pain Threshold*/drug effects , Hyperalgesia*/chemically induced , Hyperalgesia*/physiopathology , Central Nervous System Depressants*/administration & dosage, Animals ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Sex Characteristics ; Disease Models, Animal ; Pain Measurement ; Hot Temperature

Contribution of thalamo-cortico-limbic circuits to remifentanil-induced hyperalgesia (RIH) and the analgesic effects of electroacupuncture on RIH.

Autori: Cai SQ Tian Y Zhang ZX a ďalší

Zdroj: Brain research bulletin [Brain Res Bull] 2025 Nov; Vol. 232, pp. 111582. Date of Electronic Publication: 2025 Oct 11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2747 (Electronic) Linking ISSN: 03619230 NLM ISO Abbreviation: Brain Res Bull Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hyperalgesia*/chemically induced , Hyperalgesia*/therapy , Hyperalgesia*/physiopathology , Electroacupuncture*/methods , Remifentanil*/pharmacology, Animals ; Male ; Rats ; Rats, Sprague-Dawley ; Thalamus/drug effects ; Thalamus/physiopathology ; Limbic System/drug effects ; Limbic System/physiopathology ; Neural Pathways/drug effects ; Analgesics, Opioid/pharmacology ; Cerebral Cortex/drug effects ; Neurons/drug effects

Kisspeptin-13 induces hyperalgesia and modulates the expression of opioid and glutamate receptors in mice.

Autori: Bodnár É Ibos KE Filkor K a ďalší

Zdroj: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2025 Nov; Vol. 256, pp. 174098. Date of Electronic Publication: 2025 Sep 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 0367050 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5177 (Electronic) Linking ISSN: 00913057 NLM ISO Abbreviation: Pharmacol Biochem Behav Subsets: MEDLINE

Výrazy zo slovníka MeSH: Kisspeptins*/pharmacology , Kisspeptins*/administration & dosage , Hyperalgesia*/chemically induced , Hyperalgesia*/metabolism , Receptors, Opioid*/genetics , Receptors, Opioid*/metabolism , Receptors, Glutamate*/genetics , Receptors, Glutamate*/metabolism, Animals ; Male ; Mice ; Mice, Inbred C57BL

Inflammatory reactivity is unrelated to childhood adversity or provoked modulation of nociception.

Autori: Bedwell GJ Mqadi L Kamerman P a ďalší

Zdroj: Pain [Pain] 2025 Nov 01; Vol. 166 (11), pp. e590-e605. Date of Electronic Publication: 2025 May 15.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7508686 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6623 (Electronic) Linking ISSN: 03043959 NLM ISO Abbreviation: Pain Subsets: MEDLINE

Výrazy zo slovníka MeSH: Nociception*/physiology , Hyperalgesia*/immunology , Hyperalgesia*/physiopathology , Adverse Childhood Experiences* , Inflammation*/immunology, Humans ; Adult ; Female ; Male ; Middle Aged ; Young Adult ; Adolescent ; Aged ; Pain Threshold/physiology ; Pain Measurement ; Electric Stimulation/adverse effects ; Lipopolysaccharides

Spinal p38 MAPK/PGC-1α/SIRT3 signaling pathway mediates remifentanil-induced hyperalgesia in rats via ROS release and NR2B activation.

Autori: Feng G Song F Wang A a ďalší

Zdroj: Neurochemistry international [Neurochem Int] 2025 Nov; Vol. 190, pp. 106061. Date of Electronic Publication: 2025 Sep 26.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Pergamon Press Country of Publication: England NLM ID: 8006959 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9754 (Electronic) Linking ISSN: 01970186 NLM ISO Abbreviation: Neurochem Int Subsets: MEDLINE

Výrazy zo slovníka MeSH: Remifentanil*/toxicity , Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha*/metabolism , Hyperalgesia*/chemically induced , Hyperalgesia*/metabolism , p38 Mitogen-Activated Protein Kinases*/metabolism , Receptors, N-Methyl-D-Aspartate*/metabolism , Reactive Oxygen Species*/metabolism , Sirtuin 3*/metabolism , Spinal Cord*/metabolism , Spinal Cord*/drug effects, Animals ; Male ; Rats, Sprague-Dawley ; Rats ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Sirtuins

I expect therefore I avoid? The effects of negative expectancy learning on pain and pain-related avoidance behavior.

Autori: Nadinda PG van Laarhoven AIM Vlaeyen JWS a ďalší

Zdroj: The journal of pain [J Pain] 2025 Oct; Vol. 35, pp. 105506. Date of Electronic Publication: 2025 Jul 21.

Spôsob vydávania: Journal Article; Randomized Controlled Trial

Informácie o časopise: Publisher: Churchill Livingstone Country of Publication: United States NLM ID: 100898657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-8447 (Electronic) Linking ISSN: 15265900 NLM ISO Abbreviation: J Pain Subsets: MEDLINE

Výrazy zo slovníka MeSH: Avoidance Learning*/physiology , Pain*/psychology , Hyperalgesia*/psychology , Hyperalgesia*/physiopathology , Pain Perception*/physiology, Humans ; Male ; Female ; Young Adult ; Adult ; Pain Measurement ; Adolescent ; Pain Threshold/physiology

The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia.

Autori: Pretto KP de Souza Matias L de Oliveira BD a ďalší

Zdroj: Purinergic signalling [Purinergic Signal] 2025 Oct; Vol. 21 (5), pp. 1103-1111. Date of Electronic Publication: 2025 Jul 04.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Springer Country of Publication: Netherlands NLM ID: 101250499 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-9546 (Electronic) Linking ISSN: 15739538 NLM ISO Abbreviation: Purinergic Signal Subsets: MEDLINE

Výrazy zo slovníka MeSH: Endometriosis*/metabolism , Endometriosis*/complications , Receptors, Purinergic P2X3*/metabolism , Hyperalgesia*/metabolism , Hyperalgesia*/etiology, Humans ; Female ; Animals ; Adenosine Triphosphate/metabolism

Cav3.2 channels modulate allodynia but TRP channels are the primary mediators in prenatal valproic acid-induced sensory dysfunction.

Autori: Antunes FTT Gandini MA Huang S a ďalší

Zdroj: Neuroscience [Neuroscience] 2025 Dec 05; Vol. 590, pp. 95-103. Date of Electronic Publication: 2025 Nov 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hyperalgesia*/metabolism , Hyperalgesia*/chemically induced , Hyperalgesia*/physiopathology , Calcium Channels, T-Type*/metabolism , Calcium Channels, T-Type*/genetics , Calcium Channels, T-Type*/deficiency , Prenatal Exposure Delayed Effects*/metabolism , Prenatal Exposure Delayed Effects*/physiopathology , Valproic Acid*/toxicity , Transient Receptor Potential Channels*/metabolism, Animals ; Female ; Male ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/metabolism ; Pregnancy ; Mice, Inbred C57BL ; Mice, Knockout ; Mice ; Disease Models, Animal ; TRPM Cation Channels/metabolism

Leishmania amazonensis infection induces IL1β-dependent hyperalgesia, while dampening mechanical allodynia in C57BL/6 mice.

Autori: Perez GG de Lima EV Antonio LS a ďalší

Zdroj: Virulence [Virulence] 2025 Dec; Vol. 16 (1), pp. 2581346. Date of Electronic Publication: 2025 Oct 31.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

Výrazy zo slovníka MeSH: Interleukin-1beta*/genetics , Interleukin-1beta*/metabolism , Interleukin-1beta*/immunology , Hyperalgesia*/parasitology , Hyperalgesia*/immunology , Leishmaniasis, Cutaneous*/immunology , Leishmaniasis, Cutaneous*/parasitology , Leishmaniasis, Cutaneous*/pathology , Leishmania mexicana*/immunology, Animals ; Mice, Inbred C57BL ; Mice ; Disease Models, Animal ; Ganglia, Spinal/pathology ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism ; Nociception ; Male ; Female

Chronic alcohol drinking delays recovery from capsaicin- and nerve injury-induced hypersensitivity in mice.

Autori: Schorn R Riedl M Stone LS a ďalší

Zdroj: Alcohol (Fayetteville, N.Y.) [Alcohol] 2025 Dec; Vol. 129, pp. 123-133. Date of Electronic Publication: 2025 Oct 04.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8502311 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6823 (Electronic) Linking ISSN: 07418329 NLM ISO Abbreviation: Alcohol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Capsaicin*/toxicity , Ethanol*/administration & dosage , Alcohol Drinking*/adverse effects , Hyperalgesia*/chemically induced , Hyperalgesia*/physiopathology , Recovery of Function*/drug effects, Animals ; Male ; Mice ; Female ; Mice, Inbred C57BL ; Sciatic Nerve/injuries ; Pain Threshold/drug effects

Complement factor D (adipsin) mediates pressure-pain hypersensitivity post destabilization of medial meniscus injury.

Autori: Tjandra PM Andoko BA Kim JA a ďalší

Zdroj: Arthritis research & therapy [Arthritis Res Ther] 2025 Nov 26; Vol. 27 (1), pp. 221. Date of Electronic Publication: 2025 Nov 26.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101154438 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-6362 (Electronic) Linking ISSN: 14786354 NLM ISO Abbreviation: Arthritis Res Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hyperalgesia*/metabolism , Hyperalgesia*/etiology , Tibial Meniscus Injuries*/metabolism , Tibial Meniscus Injuries*/complications , Complement Factor D*/metabolism , Complement Factor D*/genetics , Complement Factor D*/deficiency, Animals ; Male ; Female ; Mice ; Mice, Knockout ; Mice, Inbred C57BL ; Pressure

Acute sleep deprivation induces hyperalgesia through P2X4-mediated microglial activation in mice.

Autori: Huang S Cheng W Lai P a ďalší

Zdroj: European journal of medical research [Eur J Med Res] 2025 Nov 11; Vol. 30 (1), pp. 1106. Date of Electronic Publication: 2025 Nov 11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 9517857 Publication Model: Electronic Cited Medium: Internet ISSN: 2047-783X (Electronic) Linking ISSN: 09492321 NLM ISO Abbreviation: Eur J Med Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Microglia*/metabolism , Microglia*/drug effects , Sleep Deprivation*/complications , Sleep Deprivation*/metabolism , Hyperalgesia*/etiology , Hyperalgesia*/metabolism , Receptors, Purinergic P2X4*/metabolism, Animals ; Mice ; Male ; Cytokines/metabolism ; Mice, Inbred C57BL

MDFIC2 is a PIEZO channel modulator that can alleviate mechanical allodynia associated with neuropathic pain.

Autori: Habib AM Li S Zhang C a ďalší

Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 11; Vol. 122 (45), pp. e2512426122. Date of Electronic Publication: 2025 Nov 07.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Výrazy zo slovníka MeSH: Neuralgia*/metabolism , Neuralgia*/genetics , Neuralgia*/therapy , Hyperalgesia*/metabolism , Hyperalgesia*/genetics , Hyperalgesia*/therapy , Ion Channels*/metabolism , Ion Channels*/genetics, Animals ; Mice ; Male ; Disease Models, Animal ; Mice, Inbred C57BL ; Humans ; Mechanotransduction, Cellular ; HEK293 Cells ; Sensory Receptor Cells/metabolism

Redox and Bioenergetic Modulation by Acacetin Attenuated Neuropathic Allodynia in Mice with Diet-induced Diabetes.

Autori: Fan Y Zhou W Zhu Z a ďalší

Zdroj: Molecular neurobiology [Mol Neurobiol] 2025 Nov 07; Vol. 63 (1), pp. 7. Date of Electronic Publication: 2025 Nov 07.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hyperalgesia*/drug therapy , Hyperalgesia*/complications , Hyperalgesia*/metabolism , Energy Metabolism*/drug effects , Neuralgia*/drug therapy , Neuralgia*/metabolism , Neuralgia*/complications , Flavones*/pharmacology , Flavones*/therapeutic use , Diet, High-Fat*/adverse effects , Diabetes Mellitus, Experimental*/complications , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Experimental*/metabolism, Animals ; Male ; Mice, Inbred C57BL ; Oxidation-Reduction/drug effects ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/pathology ; Ganglia, Spinal/metabolism ; Mice ; Diabetic Neuropathies/drug therapy ; Oxidative Stress/drug effects ; Sciatic Nerve/drug effects ; Sciatic Nerve/physiopathology ; Mitochondria/metabolism ; Mitochondria/drug effects ; Blood Glucose/metabolism

Activation of the zona incerta GABAergic circuit for the treatment of pain hypersensitivity in Parkinson's disease mice model.

Autori: Cui J Qian J Shi Y a ďalší

Zdroj: The journal of headache and pain [J Headache Pain] 2025 Nov 07; Vol. 26 (1), pp. 244. Date of Electronic Publication: 2025 Nov 07.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 100940562 Publication Model: Electronic Cited Medium: Internet ISSN: 1129-2377 (Electronic) Linking ISSN: 11292369 NLM ISO Abbreviation: J Headache Pain Subsets: MEDLINE

Výrazy zo slovníka MeSH: GABAergic Neurons*/physiology , Zona Incerta*/physiopathology , Hyperalgesia*/physiopathology , Hyperalgesia*/therapy , Hyperalgesia*/etiology , Parkinson Disease*/complications , Parkinson Disease*/physiopathology, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Disease Models, Animal ; Oxidopamine ; Ventral Tegmental Area/physiopathology ; Mice, Transgenic

Corticosteroid-dependent increased expression of CGRP and its receptor subunits within the rodent trigeminal ganglion does not prompt cephalic allodynia.

Autori: Pistolesi A Tuniz S Lapucci A a ďalší

Zdroj: Cephalalgia : an international journal of headache [Cephalalgia] 2025 Nov; Vol. 45 (11), pp. 3331024251367043. Date of Electronic Publication: 2025 Nov 27.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Sage Country of Publication: England NLM ID: 8200710 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2982 (Electronic) Linking ISSN: 03331024 NLM ISO Abbreviation: Cephalalgia Subsets: MEDLINE

Výrazy zo slovníka MeSH: Calcitonin Gene-Related Peptide*/biosynthesis , Calcitonin Gene-Related Peptide*/metabolism , Trigeminal Ganglion*/metabolism , Trigeminal Ganglion*/drug effects , Dexamethasone*/pharmacology , Hyperalgesia*/metabolism , Hyperalgesia*/chemically induced , Calcitonin Receptor-Like Protein*/metabolism , Calcitonin Receptor-Like Protein*/biosynthesis , Receptors, Calcitonin Gene-Related Peptide*/biosynthesis , Adrenal Cortex Hormones*/pharmacology, Animals ; Rats ; Humans ; Mice ; Male ; Receptor Activity-Modifying Protein 1/metabolism ; Receptor Activity-Modifying Protein 1/biosynthesis ; Betamethasone/pharmacology ; Rats, Sprague-Dawley ; Mice, Inbred C57BL

(2R,6R)-hydroxynorketamine reverses mechanical and thermal pain hypersensitivity produced by the chemotherapeutic agent oxaliplatin in rats.

Autori: Campanile M Castell K Pampalone JO a ďalší

Zdroj: Journal of pharmacological sciences [J Pharmacol Sci] 2025 Nov; Vol. 159 (3), pp. 184-190. Date of Electronic Publication: 2025 Aug 20.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Japanese Pharmacological Society Country of Publication: Japan NLM ID: 101167001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1347-8648 (Electronic) Linking ISSN: 13478613 NLM ISO Abbreviation: J Pharmacol Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ketamine*/analogs & derivatives , Ketamine*/pharmacology , Ketamine*/therapeutic use , Ketamine*/administration & dosage , Hyperalgesia*/drug therapy , Hyperalgesia*/chemically induced , Antineoplastic Agents*/adverse effects , Organoplatinum Compounds*/adverse effects , Neuralgia*/chemically induced , Neuralgia*/drug therapy , Analgesics*/therapeutic use , Analgesics*/pharmacology , Peripheral Nervous System Diseases*/chemically induced , Peripheral Nervous System Diseases*/drug therapy, Animals ; Oxaliplatin ; Male ; Disease Models, Animal ; Duloxetine Hydrochloride ; Hot Temperature ; Rats, Sprague-Dawley ; Rats

C-176 reduces inflammation-induced pain by blocking the cGAS-STING pathway in microglia.

Autori: Yang SM Li YB Si HX a ďalší

Zdroj: The International journal of neuroscience [Int J Neurosci] 2025 Nov; Vol. 135 (11), pp. 1193-1207. Date of Electronic Publication: 2024 May 13.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 0270707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1563-5279 (Electronic) Linking ISSN: 00207454 NLM ISO Abbreviation: Int J Neurosci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Microglia*/drug effects , Microglia*/metabolism , Nucleotidyltransferases*/metabolism , Nucleotidyltransferases*/antagonists & inhibitors , Membrane Proteins*/metabolism , Membrane Proteins*/antagonists & inhibitors , Inflammation*/complications , Inflammation*/metabolism , Inflammation*/chemically induced , Signal Transduction*/drug effects , Pain*/metabolism , Pain*/drug therapy , Pain*/etiology , Hyperalgesia*/drug therapy , Hyperalgesia*/metabolism, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Disease Models, Animal

Evaluating the efficacy of neurokinin-1 (substance P) receptor antagonist CP-99994 on facial grimacing and allodynia in mice postsurgery: a comparative study with known analgesics.

Autori: McCoy ES Ryan DF Park SK a ďalší

Zdroj: Pain [Pain] 2025 Nov 01; Vol. 166 (11), pp. 2550-2562. Date of Electronic Publication: 2025 Jul 15.

Spôsob vydávania: Journal Article; Comparative Study

Informácie o časopise: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7508686 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6623 (Electronic) Linking ISSN: 03043959 NLM ISO Abbreviation: Pain Subsets: MEDLINE

Výrazy zo slovníka MeSH: Neurokinin-1 Receptor Antagonists*/therapeutic use , Neurokinin-1 Receptor Antagonists*/pharmacology , Analgesics*/therapeutic use , Analgesics*/pharmacology , Hyperalgesia*/drug therapy , Hyperalgesia*/etiology , Piperidines*/therapeutic use , Pain, Postoperative*/drug therapy , Facial Expression*, Animals ; Mice ; Male ; Carbazoles/therapeutic use ; Carbazoles/pharmacology ; Disease Models, Animal ; Pain Measurement ; Buprenorphine/therapeutic use ; Buprenorphine/pharmacology ; Dose-Response Relationship, Drug