Výsledky vyhľadávania - "Hydroxyurea"

Lower rates of maternal morbidities among pregnant women suffering from sickle cell disease who are exposed to hydroxyurea, a retrospective study from tribal area of Western India.

Autori: Desai G Balar H Dave K a ďalší

Zdroj: Expert review of hematology [Expert Rev Hematol] 2025 Dec; Vol. 18 (12), pp. 1099-1105. Date of Electronic Publication: 2025 Sep 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101485942 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4094 (Electronic) Linking ISSN: 17474094 NLM ISO Abbreviation: Expert Rev Hematol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anemia, Sickle Cell*/complications , Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/ethnology , Pregnancy Complications*/chemically induced , Pregnancy Complications*/epidemiology , Pregnancy Complications*/ethnology , Pregnancy Outcome*/epidemiology , Pregnancy Outcome*/ethnology , Hydroxyurea*/adverse effects , Hydroxyurea*/therapeutic use , Antisickling Agents*/adverse effects , Antisickling Agents*/therapeutic use, Retrospective Studies ; India/epidemiology ; India/ethnology ; Humans ; Female ; Pregnancy ; Young Adult ; Adult ; Case-Control Studies ; Rural Population/statistics & numerical data ; Indigenous Peoples/statistics & numerical data ; Congenital Abnormalities/epidemiology ; Congenital Abnormalities/ethnology ; Congenital Abnormalities/etiology ; Infant, Newborn

Clinical consultation: The pharmacist's role in hydroxyurea management for sickle cell disease.

Autori: Roessner C Uminski K Goodyear D a ďalší

Zdroj: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists [Am J Health Syst Pharm] 2025 Nov 24; Vol. 82 (23), pp. e936-e945.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Oxford University Press Country of Publication: England NLM ID: 9503023 Publication Model: Print Cited Medium: Internet ISSN: 1535-2900 (Electronic) Linking ISSN: 10792082 NLM ISO Abbreviation: Am J Health Syst Pharm Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anemia, Sickle Cell*/drug therapy , Hydroxyurea*/therapeutic use , Hydroxyurea*/administration & dosage , Pharmacists*/organization & administration , Antisickling Agents*/therapeutic use , Antisickling Agents*/administration & dosage , Antisickling Agents*/adverse effects , Professional Role* , Referral and Consultation*, Humans ; Patient Education as Topic/methods

Physiologically based pharmacokinetic modeling of hydroxyurea: Implications for dose adjustment in patients with renal insufficiency.

Autori: Enzama H Cvijic S Kiptoo J a ďalší

Zdroj: Journal of pharmaceutical sciences [J Pharm Sci] 2025 Nov; Vol. 114 (11), pp. 104004. Date of Electronic Publication: 2025 Sep 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hydroxyurea*/pharmacokinetics , Hydroxyurea*/administration & dosage , Models, Biological* , Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/metabolism , Renal Insufficiency*/metabolism , Antisickling Agents*/pharmacokinetics , Antisickling Agents*/administration & dosage, Humans ; Adult ; Area Under Curve ; Computer Simulation ; Male ; Female ; Middle Aged ; Dose-Response Relationship, Drug ; Young Adult

Short-term risks and benefits of hydroxyurea (hydroxycarbamide)-induced transfusion independence in patients with beta-thalassaemia syndromes.

Autori: Sevanthini BR Hegde S Sridhar T a ďalší

Zdroj: British journal of haematology [Br J Haematol] 2025 Nov; Vol. 207 (5), pp. 2196-2199. Date of Electronic Publication: 2025 Aug 29.

Spôsob vydávania: Letter; Journal Article

Informácie o časopise: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hydroxyurea*/therapeutic use , Hydroxyurea*/adverse effects , beta-Thalassemia*/therapy , beta-Thalassemia*/drug therapy , Blood Transfusion* , Antisickling Agents*/therapeutic use, Humans ; Male ; Female ; Adult ; Adolescent ; Young Adult ; Middle Aged ; Child

An observational study of disease management in adult patients with polycythemia vera: results from a large U.S. claims database.

Autori: Kuykendall A Bellamy L Desai L a ďalší

Zdroj: Expert review of hematology [Expert Rev Hematol] 2025 Nov; Vol. 18 (11), pp. 979-986. Date of Electronic Publication: 2025 Jul 27.

Spôsob vydávania: Journal Article; Observational Study

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101485942 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4094 (Electronic) Linking ISSN: 17474094 NLM ISO Abbreviation: Expert Rev Hematol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Polycythemia Vera*/therapy , Polycythemia Vera*/epidemiology , Polycythemia Vera*/diagnosis , Hydroxyurea*/therapeutic use , Hydroxyurea*/administration & dosage, Humans ; Male ; Aged ; Female ; United States/epidemiology ; Middle Aged ; Retrospective Studies ; Databases, Factual ; Adult ; Disease Management ; Aged, 80 and over ; Phlebotomy

3D printed hydroxyurea for pediatric use: toward personalized formulations and reduced exposure risk.

Autori: Laverdière J Bendicho-Lavilla C Mahrouche L a ďalší

Zdroj: International journal of pharmaceutics [Int J Pharm] 2025 Dec 25; Vol. 686, pp. 126326. Date of Electronic Publication: 2025 Oct 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hydroxyurea*/pharmacokinetics , Hydroxyurea*/administration & dosage , Hydroxyurea*/chemistry , Printing, Three-Dimensional* , Antisickling Agents*/administration & dosage , Antisickling Agents*/pharmacokinetics , Antisickling Agents*/chemistry, Animals ; Humans ; Dogs ; Tablets ; Anemia, Sickle Cell/drug therapy ; Drug Liberation ; Precision Medicine/methods ; Child ; Drug Compounding/methods ; Drug Stability

Synergistic effects of AgNPs and zileuton on PCOS via ferroptosis and inflammation mitigation.

Autori: Eltokhy AK El-Shaer RAA El-Deeb OS a ďalší

Zdroj: Redox report : communications in free radical research [Redox Rep] 2025 Dec; Vol. 30 (1), pp. 2445398. Date of Electronic Publication: 2024 Dec 26.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9511366 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1743-2928 (Electronic) Linking ISSN: 13510002 NLM ISO Abbreviation: Redox Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ferroptosis*/drug effects , Hydroxyurea*/analogs & derivatives , Hydroxyurea*/pharmacology , Polycystic Ovary Syndrome*/drug therapy , Polycystic Ovary Syndrome*/metabolism , Inflammation*/drug therapy , Inflammation*/metabolism, Female ; Animals ; Rats ; Silver ; Metal Nanoparticles/therapeutic use ; Antioxidants/pharmacology

Microsensor Array for the Electrochemical Analysis of Hydroxyurea in Blood Samples of Children Affected by Sickle Cell Anemia.

Autori: Shukla RP Aroosh M Cazelles R a ďalší

Zdroj: Analytical chemistry [Anal Chem] 2025 Nov 11; Vol. 97 (44), pp. 24399-24414. Date of Electronic Publication: 2025 Oct 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hydroxyurea*/blood , Hydroxyurea*/therapeutic use , Anemia, Sickle Cell*/blood , Anemia, Sickle Cell*/drug therapy , Electrochemical Techniques*/instrumentation , Electrochemical Techniques*/methods , Antisickling Agents*/blood , Antisickling Agents*/therapeutic use, Humans ; Child ; Child, Preschool ; Male

Gene polymorphisms predicting response to hydroxyurea treatment in Bahraini patients with sickle cell disease.

Autori: Alshaikh FS Deifalla A Sequeira RP a ďalší

Zdroj: Expert review of hematology [Expert Rev Hematol] 2025 Nov; Vol. 18 (11), pp. 999-1012. Date of Electronic Publication: 2025 Aug 13.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101485942 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4094 (Electronic) Linking ISSN: 17474094 NLM ISO Abbreviation: Expert Rev Hematol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/genetics , Anemia, Sickle Cell*/diagnosis , Hydroxyurea*/therapeutic use , Hydroxyurea*/administration & dosage , Antisickling Agents*/therapeutic use , Polymorphism, Single Nucleotide* , Polymorphism, Genetic*, Humans ; Male ; Female ; Bahrain ; Adult ; Fetal Hemoglobin/genetics ; Adolescent ; Treatment Outcome ; Young Adult ; Gene Frequency ; Middle Aged ; Child

Effectiveness of hydroxyurea (hydroxycarbamide) in a national sickle cell disease programme in Ghana.

Autori: Dwomoh D Abankwah DNY Benneh-Akwasi Kuma AA a ďalší

Zdroj: British journal of haematology [Br J Haematol] 2025 Nov; Vol. 207 (5), pp. 2099-2108. Date of Electronic Publication: 2025 Aug 07.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hydroxyurea*/therapeutic use , Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/epidemiology , Anemia, Sickle Cell*/blood , Antisickling Agents*/therapeutic use, Humans ; Ghana/epidemiology ; Female ; Adult ; Male ; Quality of Life ; Child ; Adolescent ; Middle Aged ; Child, Preschool ; Young Adult

HABIT Efficacy Trial Intervention Improves Elements of General and Disease-Specific Quality of Life in Youth With Sickle Cell Disease.

Autori: Smaldone A Manwani D Aygun B a ďalší

Zdroj: Pediatric blood & cancer [Pediatr Blood Cancer] 2025 Nov; Vol. 72 (11), pp. e31990. Date of Electronic Publication: 2025 Aug 26.

Spôsob vydávania: Journal Article; Randomized Controlled Trial; Multicenter Study

Informácie o časopise: Publisher: John Wiley Country of Publication: United States NLM ID: 101186624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-5017 (Electronic) Linking ISSN: 15455009 NLM ISO Abbreviation: Pediatr Blood Cancer Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/psychology , Quality of Life* , Hydroxyurea*/therapeutic use , Antisickling Agents*/therapeutic use , Medication Adherence*, Humans ; Adolescent ; Male ; Female ; Child ; Prospective Studies ; Follow-Up Studies ; Prognosis

Ropeginterferon alfa-2b in hydroxyurea-intolerant or hydroxyurea-refractory essential thrombocythaemia (SURPASS ET): a multicentre, open-label, randomised, active-controlled, phase 3 study.

Autori: Mesa R Gill H Zhang L a ďalší

Korporácia: Mesa R Gill H Zhang L a ďalší

Zdroj: The Lancet. Haematology [Lancet Haematol] 2025 Nov; Vol. 12 (11), pp. e862-e875.

Spôsob vydávania: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study

Informácie o časopise: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101643584 Publication Model: Print Cited Medium: Internet ISSN: 2352-3026 (Electronic) Linking ISSN: 23523026 NLM ISO Abbreviation: Lancet Haematol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Thrombocythemia, Essential*/drug therapy , Hydroxyurea*/therapeutic use , Hydroxyurea*/adverse effects , Hydroxyurea*/pharmacology , Interferon alpha-2*/therapeutic use , Interferon alpha-2*/adverse effects , Polyethylene Glycols*/therapeutic use , Polyethylene Glycols*/adverse effects , Interferon-alpha*/therapeutic use, Humans ; Female ; Male ; Middle Aged ; Recombinant Proteins/therapeutic use ; Recombinant Proteins/adverse effects ; Aged ; Adult ; Quinazolines/therapeutic use ; Drug Resistance ; Treatment Outcome

Association of depression and hydroxyurea use with neuropathic pain in hemoglobinopathies.

Autori: Demiray DY Oktay G

Zdroj: Scientific reports [Sci Rep] 2025 Oct 13; Vol. 15 (1), pp. 35750. Date of Electronic Publication: 2025 Oct 13.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hydroxyurea*/adverse effects , Hydroxyurea*/therapeutic use , Neuralgia*/etiology , Depression*/etiology , Depression*/complications , Anemia, Sickle Cell*/complications , Anemia, Sickle Cell*/drug therapy , beta-Thalassemia*/complications , beta-Thalassemia*/drug therapy , Hemoglobinopathies*/complications , Hemoglobinopathies*/drug therapy, Humans ; Adult ; Male ; Female ; Middle Aged ; Young Adult

The Protective Effect of Fetal Hemoglobin on Retinal Damage in Sickle Cell Disease Patients: A Correlation With Optical Coherence Tomography, Hematologic Parameters, and Hydroxyurea Treatment.

Autori: Jin J Ploysangam P Hendricks DH a ďalší

Zdroj: Pediatric blood & cancer [Pediatr Blood Cancer] 2025 Oct; Vol. 72 (10), pp. e31951. Date of Electronic Publication: 2025 Aug 01.

Spôsob vydávania: Journal Article; Observational Study

Informácie o časopise: Publisher: John Wiley Country of Publication: United States NLM ID: 101186624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-5017 (Electronic) Linking ISSN: 15455009 NLM ISO Abbreviation: Pediatr Blood Cancer Subsets: MEDLINE

Výrazy zo slovníka MeSH: Fetal Hemoglobin*/metabolism , Hydroxyurea*/therapeutic use , Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/blood , Anemia, Sickle Cell*/complications , Anemia, Sickle Cell*/pathology , Tomography, Optical Coherence* , Retinal Diseases*/etiology , Retinal Diseases*/blood , Retinal Diseases*/prevention & control , Retinal Diseases*/pathology , Antisickling Agents*/therapeutic use , Retina*/pathology , Retina*/drug effects, Humans ; Child ; Female ; Male ; Prospective Studies ; Adolescent ; Child, Preschool ; Follow-Up Studies ; Infant ; Prognosis

Optimizing the right time to start sickle cell therapies.

Autori: Martin OY Jacob SA

Zdroj: Hematology. American Society of Hematology. Education Program [Hematology Am Soc Hematol Educ Program] 2025 Dec 05; Vol. 2025 (1), pp. 577-584.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 100890099 Publication Model: Print Cited Medium: Internet ISSN: 1520-4383 (Electronic) Linking ISSN: 15204383 NLM ISO Abbreviation: Hematology Am Soc Hematol Educ Program Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anemia, Sickle Cell*/therapy , Anemia, Sickle Cell*/genetics , Hydroxyurea*/therapeutic use , Genetic Therapy* , Hematopoietic Stem Cell Transplantation*, Humans ; Antibodies, Monoclonal, Humanized/therapeutic use ; Glutamine/therapeutic use ; Benzaldehydes ; Pyrazines ; Pyrazoles

Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation.

Autori: Sánchez-Molina A Bernal M Posligua-García JD a ďalší

Zdroj: PLoS biology [PLoS Biol] 2025 Nov 19; Vol. 23 (11), pp. e3003493. Date of Electronic Publication: 2025 Nov 19 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hydroxyurea*/pharmacology , Endoplasmic Reticulum*/metabolism , Endoplasmic Reticulum*/drug effects , Oxidative Stress*/drug effects , Schizosaccharomyces*/metabolism , Schizosaccharomyces*/drug effects , Cytoplasm*/metabolism , Cytoplasm*/drug effects , Protein Aggregates*/drug effects, Schizosaccharomyces pombe Proteins/metabolism ; Protein Folding/drug effects ; Heat-Shock Proteins/metabolism ; Oxidation-Reduction ; Diamide/pharmacology

Changes in haematological indices among children with sickle cell disease on hydroxyurea treatment for at least 1 year: A cohort study.

Autori: Emuli S Tegu C Oguttu F a ďalší

Zdroj: PloS one [PLoS One] 2025 Nov 03; Vol. 20 (11), pp. e0335617. Date of Electronic Publication: 2025 Nov 03 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hydroxyurea*/therapeutic use , Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/blood , Antisickling Agents*/therapeutic use, Humans ; Male ; Female ; Child ; Child, Preschool ; Cohort Studies ; Adolescent ; Uganda ; Hemoglobins/analysis ; Erythrocyte Indices/drug effects

Hydroxyurea for Children with Sickle Cell Disease: A Practical Guide for Pediatric Clinicians.

Autori: Coyne F Strouse JJ

Zdroj: Pediatric clinics of North America [Pediatr Clin North Am] 2026 Feb; Vol. 73 (1), pp. 29-41. Date of Electronic Publication: 2025 Sep 30.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0401126 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8240 (Electronic) Linking ISSN: 00313955 NLM ISO Abbreviation: Pediatr Clin North Am Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hydroxyurea*/therapeutic use , Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/complications , Antisickling Agents*/therapeutic use, Humans ; Child ; Practice Guidelines as Topic

Safety of Hydroxyurea in Pregnancy: A Systematic Review of the Literature.

Autori: Al Sulaimani R Zitoun N Alothman H a ďalší

Zdroj: Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC [J Obstet Gynaecol Can] 2025 Jul; Vol. 47 (7), pp. 102924. Date of Electronic Publication: 2025 May 15.

Spôsob vydávania: Journal Article; Systematic Review

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101126664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2665-9867 (Electronic) Linking ISSN: 17012163 NLM ISO Abbreviation: J Obstet Gynaecol Can Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hydroxyurea*/adverse effects , Hydroxyurea*/administration & dosage , Pregnancy Complications, Hematologic*/drug therapy , Antisickling Agents*/adverse effects, Humans ; Pregnancy ; Female ; Anemia, Sickle Cell/drug therapy ; Pregnancy Outcome ; Adult ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy

The Indian experience with hydroxyurea in sickle cell disease: A 25-year systematic review.

Autori: Jain D Sarvaiya D Mehta S a ďalší

Zdroj: The Indian journal of medical research [Indian J Med Res] 2025 Jul; Vol. 162 (1), pp. 28-43.

Spôsob vydávania: Journal Article; Systematic Review

Informácie o časopise: Publisher: Scientific Scholar Country of Publication: United States NLM ID: 0374701 Publication Model: Print Cited Medium: Internet ISSN: 0971-5916 (Print) Linking ISSN: 09715916 NLM ISO Abbreviation: Indian J Med Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anemia, Sickle Cell*/drug therapy , Anemia, Sickle Cell*/epidemiology , Anemia, Sickle Cell*/genetics , Anemia, Sickle Cell*/pathology , Hydroxyurea*/therapeutic use , Hydroxyurea*/adverse effects , Antisickling Agents*/therapeutic use, Humans ; India/epidemiology ; Fetal Hemoglobin/genetics ; Acute Chest Syndrome/drug therapy ; Acute Chest Syndrome/epidemiology