Suchergebnisse - "Hydro-Lyases"

The very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase Phs1 regulates ATP levels and virulence in Cryptococcus neoformans.

Autoren: Ma Y Pan K Xu B et al.

Quelle: BMC microbiology [BMC Microbiol] 2025 Nov 26; Vol. 25 (1), pp. 781. Date of Electronic Publication: 2025 Nov 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 100966981 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2180 (Electronic) Linking ISSN: 14712180 NLM ISO Abbreviation: BMC Microbiol Subsets: MEDLINE

MeSH-Schlagworte: Cryptococcus neoformans*/pathogenicity , Cryptococcus neoformans*/genetics , Cryptococcus neoformans*/enzymology , Cryptococcus neoformans*/metabolism , Adenosine Triphosphate*/metabolism , Fungal Proteins*/genetics , Fungal Proteins*/metabolism , Hydro-Lyases*/metabolism , Hydro-Lyases*/genetics , Enoyl-CoA Hydratase*/metabolism , Enoyl-CoA Hydratase*/genetics, Virulence ; Animals ; Mice ; Cryptococcosis/microbiology ; Gene Expression Regulation, Fungal ; Melanins/metabolism ; Melanins/biosynthesis ; Gene Deletion ; Cell Wall/metabolism ; Female ; Disease Models, Animal

The novel GlcNAc 6-phosphate dehydratase NagS governs a metabolic checkpoint that controls nutrient signaling in Streptomyces.

Autoren: Li C Urem M Kotsogianni I et al.

Quelle: PLoS biology [PLoS Biol] 2025 Nov 25; Vol. 23 (11), pp. e3003514. Date of Electronic Publication: 2025 Nov 25 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

MeSH-Schlagworte: Streptomyces*/metabolism , Streptomyces*/enzymology , Streptomyces*/genetics , Hydro-Lyases*/metabolism , Hydro-Lyases*/genetics , Hydro-Lyases*/chemistry , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Bacterial Proteins*/chemistry , Nutrients*/metabolism, Signal Transduction ; Acetylglucosamine/metabolism

Discovery of Cycloheptanone-Pyrrole Derivatives with α-Hydroxycarboxylate Fragments as Novel Dihydroxy Acid Dehydratase-Targeting Herbicides.

Autoren: Xu H Hu Y Wei M et al.

Quelle: Journal of agricultural and food chemistry [J Agric Food Chem] 2025 Nov 12; Vol. 73 (45), pp. 28662-28669. Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Herbicides*/chemistry , Herbicides*/pharmacology , Pyrroles*/chemistry , Pyrroles*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Hydro-Lyases*/antagonists & inhibitors , Hydro-Lyases*/chemistry , Hydro-Lyases*/metabolism , Plant Proteins*/antagonists & inhibitors , Plant Proteins*/chemistry , Plant Proteins*/metabolism , Plant Proteins*/genetics, Amaranthus/drug effects ; Amaranthus/enzymology ; Amaranthus/growth & development ; Arabidopsis/drug effects ; Arabidopsis/growth & development ; Arabidopsis/enzymology ; Plant Weeds/drug effects ; Plant Weeds/enzymology ; Plant Weeds/growth & development ; Germination/drug effects ; Molecular Structure ; Structure-Activity Relationship ; Setaria Plant/drug effects ; Setaria Plant/growth & development ; Setaria Plant/enzymology

Cloning and characterization of a new oleate hydratase from Acinetobacter ursingii for asymmetric hydration of unactivated alkenes.

Autoren: Deng X Wan Y Li Y et al.

Quelle: Biotechnology letters [Biotechnol Lett] 2025 Nov 04; Vol. 47 (6), pp. 124. Date of Electronic Publication: 2025 Nov 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 8008051 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6776 (Electronic) Linking ISSN: 01415492 NLM ISO Abbreviation: Biotechnol Lett Subsets: MEDLINE

MeSH-Schlagworte: Alkenes*/metabolism , Alkenes*/chemistry , Acinetobacter*/enzymology , Acinetobacter*/genetics , Hydro-Lyases*/metabolism , Hydro-Lyases*/genetics , Hydro-Lyases*/chemistry , Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism , Bacterial Proteins*/chemistry, Cloning, Molecular ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Oleic Acid/metabolism ; Substrate Specificity ; Recombinant Proteins/metabolism ; Recombinant Proteins/genetics

Crystal structure of dihydrodipicolinate synthase from Mycobacterium tuberculosis in complex with pyruvate and insights into allosteric regulation.

Autoren: Rosa LVS Blaszczyk B Blundell T et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 330 (Pt 1), pp. 147950. Date of Electronic Publication: 2025 Sep 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/enzymology , Hydro-Lyases*/chemistry , Hydro-Lyases*/metabolism , Pyruvic Acid*/metabolism , Pyruvic Acid*/chemistry , Bacterial Proteins*/chemistry , Bacterial Proteins*/metabolism, Allosteric Regulation ; Crystallography, X-Ray ; Models, Molecular ; Catalytic Domain ; Protein Binding ; Protein Conformation

Conversion of a Heme-Dependent Dehydratase to a Piperazate Synthase Reveals the Role of the Heme Propionate Group in N-N Bond-Formation.

Autoren: Higgins MA Mirotadze N Shi X et al.

Quelle: Journal of the American Chemical Society [J Am Chem Soc] 2025 Oct 29; Vol. 147 (43), pp. 39160-39168. Date of Electronic Publication: 2025 Oct 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

MeSH-Schlagworte: Heme*/metabolism , Heme*/chemistry , Hydro-Lyases*/metabolism , Hydro-Lyases*/chemistry , Hydro-Lyases*/genetics , Propionates*/chemistry , Propionates*/metabolism , Nitrogen*/chemistry , Nitrogen*/metabolism, Models, Molecular ; Mutagenesis, Site-Directed ; Crystallography, X-Ray

Combining Reactive Quantum-Mechanical Molecular-Dynamics Simulations with Mutagenesis, Crystallography, and Enzyme Kinetics to Reveal Plausible Steps of Isocyanide Hydratase Catalysis.

Autoren: Corrigan Grove RA Moxley MA Negre CFA et al.

Quelle: Journal of chemical information and modeling [J Chem Inf Model] 2025 Oct 27; Vol. 65 (20), pp. 11079-11093. Date of Electronic Publication: 2025 Oct 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-960X (Electronic) Linking ISSN: 15499596 NLM ISO Abbreviation: J Chem Inf Model Subsets: MEDLINE

MeSH-Schlagworte: Molecular Dynamics Simulation* , Quantum Theory* , Hydro-Lyases*/metabolism , Hydro-Lyases*/chemistry , Hydro-Lyases*/genetics , Biocatalysis* , Mutagenesis*, Kinetics ; Crystallography, X-Ray ; Catalytic Domain ; Cyanides/metabolism

Large protein-like leader peptides engage differently with RiPP halogenases and lanthionine synthetases.

Autoren: Vidya F Luo Y Wu H et al.

Quelle: Nature communications [Nat Commun] 2025 Oct 20; Vol. 16 (1), pp. 9273. Date of Electronic Publication: 2025 Oct 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Protein Processing, Post-Translational* , Bacterial Proteins*/metabolism , Bacterial Proteins*/chemistry , Bacterial Proteins*/genetics , Peptides*/metabolism , Peptides*/chemistry , Peptides*/genetics , Hydro-Lyases*/metabolism , Hydro-Lyases*/chemistry , Hydro-Lyases*/genetics , Ligases*/metabolism, Protein Binding ; Models, Molecular ; Amino Acid Sequence ; Alanine/analogs & derivatives ; Alanine/metabolism ; Ribosomes/metabolism ; Sulfides/metabolism

Identification of dehydrogenase, hydratase, and aldolase responsible for the propionyl residue removal in degradation of cholic acid C-17 side chain in Comamonas testosteroni TA441.

Autoren: Horinouchi M; Surface and Interface Science Laboratory, RIKEN, Wako, Saitama, Japan.

Quelle: Microbiology spectrum [Microbiol Spectr] 2025 Oct 07; Vol. 13 (10), pp. e0030825. Date of Electronic Publication: 2025 Sep 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE

MeSH-Schlagworte: Comamonas testosteroni*/enzymology , Comamonas testosteroni*/genetics , Comamonas testosteroni*/metabolism , Oxidoreductases*/metabolism , Oxidoreductases*/genetics , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Bacterial Proteins*/chemistry , Fructose-Bisphosphate Aldolase*/metabolism , Fructose-Bisphosphate Aldolase*/genetics , Cholic Acid*/metabolism , Cholic Acid*/chemistry , Hydro-Lyases*/metabolism , Hydro-Lyases*/genetics

Mutation of the GDP-Fucose Biosynthesis Gene gmds Increases Hair Cell Number and Neuromast Regenerative Capacity in Zebrafish.

Autoren: Ameen MT Fowler G French CR

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 07; Vol. 26 (19). Date of Electronic Publication: 2025 Oct 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Zebrafish*/genetics , Mutation* , Hair Cells, Auditory*/metabolism , Hair Cells, Auditory*/physiology , Hair Cells, Auditory*/cytology , Hair Cells, Auditory*/drug effects , Regeneration*/genetics , Guanosine Diphosphate Fucose*/biosynthesis , Hydro-Lyases*/genetics , Hydro-Lyases*/metabolism , Zebrafish Proteins*/genetics , Zebrafish Proteins*/metabolism, Animals ; Receptors, Notch/metabolism ; Signal Transduction

Cooperative Enhancement of Aldoxime Dehydratase Stability through Whole-Cell Immobilization and Flow Reactor Integration.

Autoren: Nespoli L Donzella S Bigliardi M et al.

Quelle: Chembiochem : a European journal of chemical biology [Chembiochem] 2025 Oct 03; Vol. 26 (19), pp. e202500618. Date of Electronic Publication: 2025 Sep 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

MeSH-Schlagworte: Hydro-Lyases*/metabolism , Hydro-Lyases*/chemistry , Hydro-Lyases*/genetics , Pseudomonas putida*/enzymology, Enzyme Stability ; Oximes/metabolism ; Oximes/chemistry ; Nitriles/metabolism ; Nitriles/chemistry ; Bioreactors ; Benzaldehydes/metabolism ; Benzaldehydes/chemistry ; Biocatalysis

Pseudouridine synthase 1-targeted therapy activates antiviral immunity to boost cancer immunotherapy.

Autoren: Wang F Tong Y Guo W et al.

Quelle: Cell reports [Cell Rep] 2025 Sep 23; Vol. 44 (9), pp. 116233. Date of Electronic Publication: 2025 Sep 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH-Schlagworte: Immunotherapy*/methods , Hydro-Lyases*/metabolism , Hydro-Lyases*/antagonists & inhibitors , Hydro-Lyases*/genetics , Liver Neoplasms*/immunology , Liver Neoplasms*/therapy , Liver Neoplasms*/pathology, Animals ; Mice ; Humans ; Cell Line, Tumor ; RNA, Double-Stranded/metabolism ; Mice, Inbred C57BL ; Intramolecular Transferases

Extending the Peptide/Protein Interaction Paradigm to a Protein/Protein Engagement Model in RiPP Biosynthesis.

Autoren: Wakeel MA Corbin EA McShan AC et al.

Quelle: ACS chemical biology [ACS Chem Biol] 2025 Sep 19; Vol. 20 (9), pp. 2069-2074. Date of Electronic Publication: 2025 Aug 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

MeSH-Schlagworte: Hydro-Lyases*/metabolism , Hydro-Lyases*/chemistry , Peptides*/metabolism , Peptides*/chemistry, Protein Binding ; Models, Molecular ; Protein Processing, Post-Translational

A Thermostable Fatty Acid Hydratase from Marinitoga Piezophila with Low Temperature Optimum and Broad Product Scope.

Autoren: Johnsen NK Marcher DMW Nielsen MB et al.

Quelle: Chembiochem : a European journal of chemical biology [Chembiochem] 2025 Sep 15; Vol. 26 (17), pp. e202500081. Date of Electronic Publication: 2025 Aug 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

MeSH-Schlagworte: Temperature* , Hydro-Lyases*/metabolism , Hydro-Lyases*/chemistry , Hydro-Lyases*/genetics , Fatty Acids*/metabolism , Fatty Acids*/chemistry , Bacterial Proteins*/metabolism , Bacterial Proteins*/chemistry , Bacterial Proteins*/genetics, Enzyme Stability ; Substrate Specificity ; Kinetics ; Hydrogen-Ion Concentration

Improved Substrate Specificity of Fatty Acid Hydratases Enables Efficient and Selective Linoleic Acid Isolation.

Autoren: Lu D Jin S Wu Q et al.

Quelle: Journal of agricultural and food chemistry [J Agric Food Chem] 2025 Sep 10; Vol. 73 (36), pp. 22645-22658. Date of Electronic Publication: 2025 Aug 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Linoleic Acid*/isolation & purification , Linoleic Acid*/chemistry , Linoleic Acid*/metabolism , Bacterial Proteins*/chemistry , Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism , Hydro-Lyases*/chemistry , Hydro-Lyases*/genetics , Hydro-Lyases*/metabolism , Bifidobacterium*/enzymology , Bifidobacterium*/genetics , Bifidobacterium*/chemistry, Substrate Specificity ; Kinetics ; Oleic Acid/chemistry ; Oleic Acid/metabolism ; Biocatalysis

Pseudouridine Synthase 7 in Cancer: Functions, Mechanisms, and Therapeutic Potential.

Autoren: Yang Q Boyer TG Al-Hendy A

Quelle: Cells [Cells] 2025 Sep 04; Vol. 14 (17). Date of Electronic Publication: 2025 Sep 04.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/genetics , Neoplasms*/enzymology , Neoplasms*/therapy , Neoplasms*/pathology , Intramolecular Transferases*/metabolism , Hydro-Lyases*/metabolism , Hydro-Lyases*/genetics, Humans ; Animals ; Gene Expression Regulation, Neoplastic ; Pseudouridine/metabolism

Regioselective Hydration of Terpenes with Cofactor-Independent Carotenoid 1,2-Hydratase.

Autoren: Horz P Härterich N Schneider A et al.

Quelle: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Sep 01; Vol. 64 (36), pp. e202505942. Date of Electronic Publication: 2025 Jul 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

MeSH-Schlagworte: Terpenes*/chemistry , Terpenes*/metabolism , Carotenoids*/metabolism , Carotenoids*/chemistry , Hydro-Lyases*/metabolism , Hydro-Lyases*/chemistry , Hydro-Lyases*/genetics, Stereoisomerism ; Biocatalysis ; Water/chemistry ; Water/metabolism ; Molecular Structure

Crystal structure and molecular dynamics simulation of Mycobacterium tuberculosis MaoC-like dehydratase HtdX provide insights into substrate binding and membrane interactions.

Autoren: Biswas R Bhattacharje G Singh BK et al.

Quelle: Biochimica et biophysica acta. Proteins and proteomics [Biochim Biophys Acta Proteins Proteom] 2025 Sep 01; Vol. 1873 (5), pp. 141082. Date of Electronic Publication: 2025 Jun 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1454 (Electronic) Linking ISSN: 15709639 NLM ISO Abbreviation: Biochim Biophys Acta Proteins Proteom Subsets: MEDLINE

MeSH-Schlagworte: Mycobacterium tuberculosis*/enzymology , Mycobacterium tuberculosis*/genetics , Bacterial Proteins*/chemistry , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Hydro-Lyases*/chemistry , Hydro-Lyases*/metabolism , Hydro-Lyases*/genetics, Molecular Dynamics Simulation ; Crystallography, X-Ray ; Substrate Specificity ; Protein Binding ; Mutagenesis, Site-Directed

Catalytic Versatility of FnsA: Substrate-dependent Activity of KR and DH Domains in Naringenin Biosynthesis.

Autoren: Zhang H Zhang A Wen Y et al.

Quelle: Journal of agricultural and food chemistry [J Agric Food Chem] 2025 Aug 20; Vol. 73 (33), pp. 20810-20817. Date of Electronic Publication: 2025 Aug 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Flavanones*/biosynthesis , Fungal Proteins*/metabolism , Fungal Proteins*/genetics , Fungal Proteins*/chemistry , Hydro-Lyases*/metabolism , Hydro-Lyases*/genetics , Hydro-Lyases*/chemistry, Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae/enzymology ; Substrate Specificity ; Phylogeny ; Protein Domains ; Biocatalysis ; Fermentation ; Parabens/metabolism

HACD3 promotes malignant progression of NSCLC by suppressing the MKK7/MAPK10 signaling axis.

Autoren: Wang X Liang H Du Q et al.

Quelle: BMC cancer [BMC Cancer] 2025 Aug 15; Vol. 25 (1), pp. 1317. Date of Electronic Publication: 2025 Aug 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/genetics , Carcinoma, Non-Small-Cell Lung*/metabolism , Lung Neoplasms*/pathology , Lung Neoplasms*/genetics , Lung Neoplasms*/metabolism , MAP Kinase Kinase 7*/metabolism , Hydro-Lyases*/metabolism , Hydro-Lyases*/genetics, Humans ; Animals ; Mice ; Cell Proliferation ; Disease Progression ; Cell Line, Tumor ; Cell Movement ; Signal Transduction ; MAP Kinase Signaling System ; Mice, Knockout ; Gene Expression Regulation, Neoplastic ; Apoptosis ; Female