Výsledky vyhľadávania - "Hydrazines"

Synthesis and antibacterial evaluation of 5-(3-nitrophenyl)-N'-arylisoxazole-3-carbohydrazide derivatives against carbapenem-resistant Acinetobacterbaumannii.

Autori: Bandela R Tupare RR Saxena D a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118154. Date of Electronic Publication: 2025 Sep 13.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemical synthesis , Anti-Bacterial Agents*/chemistry , Acinetobacter baumannii*/drug effects , Carbapenems*/pharmacology , Hydrazines*/pharmacology , Hydrazines*/chemistry , Hydrazines*/chemical synthesis , Isoxazoles*/pharmacology , Isoxazoles*/chemistry , Isoxazoles*/chemical synthesis, Microbial Sensitivity Tests ; Structure-Activity Relationship ; Molecular Structure ; Animals ; Dose-Response Relationship, Drug ; Chlorocebus aethiops ; Vero Cells ; Drug Resistance, Bacterial/drug effects

Design, synthesis and SAR studies of N'-(Ethynylsalicylidene)arenecarbohydrazides as next-generation broad-spectrum antifungal agents.

Autori: Garg A Matos GS Takemura K a ďalší

Zdroj: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Dec 15; Vol. 131, pp. 118406. Date of Electronic Publication: 2025 Sep 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antifungal Agents*/pharmacology , Antifungal Agents*/chemical synthesis , Antifungal Agents*/chemistry , Drug Design* , Hydrazines*/pharmacology , Hydrazines*/chemical synthesis , Hydrazines*/chemistry, Microbial Sensitivity Tests ; Candida albicans/drug effects ; Quantitative Structure-Activity Relationship ; Cryptococcus neoformans/drug effects ; Humans ; Aspergillus fumigatus/drug effects ; Molecular Structure ; Dose-Response Relationship, Drug ; Structure-Activity Relationship ; Caco-2 Cells ; Animals

SINE compounds activate exportin 1 degradation through an allosteric mechanism.

Autori: Wing CE Fung HYJ Kwanten B a ďalší

Zdroj: Nature chemical biology [Nat Chem Biol] 2025 Dec; Vol. 21 (12), pp. 2002-2013. Date of Electronic Publication: 2025 Nov 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Karyopherins*/metabolism , Karyopherins*/chemistry , Karyopherins*/antagonists & inhibitors , Receptors, Cytoplasmic and Nuclear*/metabolism , Receptors, Cytoplasmic and Nuclear*/chemistry , Receptors, Cytoplasmic and Nuclear*/antagonists & inhibitors , Hydrazines*/pharmacology , Hydrazines*/chemistry , Triazoles*/pharmacology , Triazoles*/chemistry, Exportin 1 Protein ; Humans ; Allosteric Regulation/drug effects ; Proteolysis/drug effects ; Active Transport, Cell Nucleus/drug effects ; Cryoelectron Microscopy ; Ubiquitination ; HEK293 Cells

Design, synthesis, and biological evaluation of (E)-3-amino-N'-substituted benzylidene-6-chloropyrazine-2-carbohydrazide derivatives as anti-mycobacterial agents.

Autori: Kumar BVS Bhardwaj P Chaudhari HS a ďalší

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109206. Date of Electronic Publication: 2025 Nov 04.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Mycobacterium tuberculosis*/drug effects , Drug Design* , Antitubercular Agents*/pharmacology , Antitubercular Agents*/chemical synthesis , Antitubercular Agents*/chemistry , Hydrazines*/pharmacology , Hydrazines*/chemistry , Hydrazines*/chemical synthesis , Pyrazines*/pharmacology , Pyrazines*/chemistry , Pyrazines*/chemical synthesis , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemical synthesis , Anti-Bacterial Agents*/chemistry, Microbial Sensitivity Tests ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Molecular Docking Simulation ; Humans

Successful kidney transplantation using eltrombopag in a patient with MYH9-related disease.

Autori: Kato A Shirai Y Kanda S a ďalší

Zdroj: CEN case reports [CEN Case Rep] 2025 Dec; Vol. 14 (6), pp. 833-836. Date of Electronic Publication: 2025 Sep 01.

Spôsob vydávania: Journal Article; Case Reports

Informácie o časopise: Publisher: Springer Japan Country of Publication: Japan NLM ID: 101636244 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-4449 (Electronic) Linking ISSN: 21924449 NLM ISO Abbreviation: CEN Case Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Kidney Transplantation*/methods , Benzoates*/therapeutic use , Benzoates*/administration & dosage , Hydrazines*/therapeutic use , Hydrazines*/administration & dosage , Pyrazoles*/therapeutic use , Pyrazoles*/administration & dosage , Thrombocytopenia*/congenital , Thrombocytopenia*/genetics , Thrombocytopenia*/drug therapy , Hearing Loss, Sensorineural*/genetics, Humans ; Female ; Young Adult ; Myosin Heavy Chains/genetics ; Molecular Motor Proteins/genetics ; Living Donors ; Treatment Outcome ; Receptors, Thrombopoietin/agonists ; Platelet Count

SCR Disease Name: MYH9-Related Disorders

Hypomethylating Therapy With or Without Eltrombopag in Elderly Patients With Acute Myeloid Leukemia: Results From the Randomized, Placebo-Controlled Phase 2 DELTA Trial.

Autori: Sockel K Röllig C Mütherig A a ďalší

Zdroj: American journal of hematology [Am J Hematol] 2025 Dec; Vol. 100 (12), pp. 2436-2441. Date of Electronic Publication: 2025 Oct 02.

Spôsob vydávania: Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study; Letter; Journal Article

Informácie o časopise: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 7610369 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-8652 (Electronic) Linking ISSN: 03618609 NLM ISO Abbreviation: Am J Hematol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hydrazines*/administration & dosage , Hydrazines*/therapeutic use , Hydrazines*/adverse effects , Pyrazoles*/administration & dosage , Pyrazoles*/therapeutic use , Pyrazoles*/adverse effects , Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/mortality , Leukemia, Myeloid, Acute*/genetics , Benzoates*/administration & dosage , Benzoates*/therapeutic use , Benzoates*/adverse effects , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Antineoplastic Combined Chemotherapy Protocols*/adverse effects, Humans ; Aged ; Female ; Male ; Aged, 80 and over ; Disease-Free Survival ; Middle Aged ; Azacitidine/administration & dosage ; Azacitidine/analogs & derivatives ; Azacitidine/therapeutic use ; Decitabine/administration & dosage

Design, synthesis, and antiproliferative activity of new 5-ethylsulfonyl-indazole-3-carbohydrazides as dual EGFR/VEGFR-2 kinases inhibitors.

Autori: Al-Wahaibi LH Abou-Zied HA Mahmoud MA a ďalší

Zdroj: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2516075. Date of Electronic Publication: 2025 Jun 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: ErbB Receptors*/antagonists & inhibitors , ErbB Receptors*/metabolism , Vascular Endothelial Growth Factor Receptor-2*/antagonists & inhibitors , Vascular Endothelial Growth Factor Receptor-2*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Drug Design* , Indazoles*/chemistry , Indazoles*/pharmacology , Indazoles*/chemical synthesis , Hydrazines*/pharmacology , Hydrazines*/chemistry , Hydrazines*/chemical synthesis, Humans ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Molecular Structure ; Dose-Response Relationship, Drug ; Molecular Docking Simulation ; Apoptosis/drug effects ; Cell Line, Tumor

Design and synthesis of vanillin-mediated hydrazine derivatives as multi-bioactive drug development.

Autori: Loganathan V Manilal A Akbar I

Zdroj: Future medicinal chemistry [Future Med Chem] 2025 Dec; Vol. 17 (23), pp. 2851-2862. Date of Electronic Publication: 2025 Nov 01.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hydrazines*/chemistry , Hydrazines*/pharmacology , Hydrazines*/chemical synthesis , Benzaldehydes*/chemistry , Benzaldehydes*/pharmacology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemical synthesis , Anti-Bacterial Agents*/chemistry , Drug Design* , Antioxidants*/pharmacology , Antioxidants*/chemical synthesis , Antioxidants*/chemistry , Drug Development* , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry, Microbial Sensitivity Tests ; Molecular Docking Simulation ; Humans ; Structure-Activity Relationship ; Molecular Structure ; Molecular Dynamics Simulation ; Density Functional Theory

Evaluation of quinazolin-4(3H)-one derivatives containing the bioactive acetohydrazide group as fungicidal candidates.

Autori: Zhang W Liu J Qi S a ďalší

Zdroj: Pesticide biochemistry and physiology [Pestic Biochem Physiol] 2025 Dec; Vol. 215, pp. 106667. Date of Electronic Publication: 2025 Aug 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 1301573 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9939 (Electronic) Linking ISSN: 00483575 NLM ISO Abbreviation: Pestic Biochem Physiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Fungicides, Industrial*/pharmacology , Fungicides, Industrial*/chemistry , Quinazolinones*/pharmacology , Quinazolinones*/chemistry , Hydrazines*/chemistry , Hydrazines*/pharmacology, Animals ; Microbial Sensitivity Tests ; Rhizoctonia/drug effects ; Ascomycota/drug effects ; Zebrafish ; Fungi/drug effects ; Botrytis

SCR Organism: Rhizoctonia solani; Botrytis cinerea; Sclerotinia sclerotiorum

Synthesis, DFT study, in silico ADMET evaluation, molecular docking, and QSAR analysis of new anti-tuberculosis drugs derived from 2-hydroxybenzohydrazide derivatives.

Autori: Hassanien AE Elsherbiny G Abdelfattah GM a ďalší

Zdroj: Molecular diversity [Mol Divers] 2025 Dec; Vol. 29 (6), pp. 6343-6362. Date of Electronic Publication: 2025 Mar 01.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antitubercular Agents*/chemistry , Antitubercular Agents*/chemical synthesis , Antitubercular Agents*/pharmacology , Antitubercular Agents*/pharmacokinetics , Quantitative Structure-Activity Relationship* , Molecular Docking Simulation* , Hydrazines*/chemistry , Hydrazines*/pharmacology , Hydrazines*/chemical synthesis, Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/enzymology ; Density Functional Theory ; Bacterial Proteins/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/antagonists & inhibitors ; Oxidoreductases/metabolism ; Oxidoreductases/chemistry

Eltrombopag olamine induces apoptosis in human breast adenocarcinoma and hepatocellular carcinoma cells through modulation of multiple apoptotic pathways.

Autori: Kabir SR Asaduzzaman M Shahinuzzaman ADA a ďalší

Zdroj: Scientific reports [Sci Rep] 2025 Nov 27; Vol. 15 (1), pp. 42952. Date of Electronic Publication: 2025 Nov 27.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Apoptosis*/drug effects , Hydrazines*/pharmacology , Hydrazines*/chemistry , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , Breast Neoplasms*/drug therapy , Pyrazoles*/pharmacology , Pyrazoles*/chemistry , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/drug therapy , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/drug therapy , Benzoates*/pharmacology , Benzoates*/chemistry , Antineoplastic Agents*/pharmacology , Adenocarcinoma*/metabolism , Adenocarcinoma*/pathology , Adenocarcinoma*/drug therapy, Humans ; Female ; MCF-7 Cells ; Cell Line, Tumor ; Signal Transduction/drug effects ; Cell Proliferation/drug effects ; HEK293 Cells

Design, Synthesis, and Anti-inflammatory Activity Evaluation for Hydrazide-Based HDAC6 Targeted Protein Degraders.

Autori: Sun S Yue K Liu E a ďalší

Zdroj: Journal of medicinal chemistry [J Med Chem] 2025 Nov 27; Vol. 68 (22), pp. 24519-24545. Date of Electronic Publication: 2025 Nov 11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Histone Deacetylase 6*/metabolism , Histone Deacetylase 6*/antagonists & inhibitors , Drug Design* , Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemical synthesis , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylase Inhibitors*/therapeutic use , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemical synthesis , Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents*/therapeutic use , Hydrazines*/pharmacology , Hydrazines*/chemistry , Hydrazines*/chemical synthesis , Anti-Inflammatory Agents, Non-Steroidal*/pharmacology , Anti-Inflammatory Agents, Non-Steroidal*/chemical synthesis , Anti-Inflammatory Agents, Non-Steroidal*/chemistry, Animals ; Mice ; Humans ; Structure-Activity Relationship ; Colitis/drug therapy ; Colitis/chemically induced ; Mice, Inbred C57BL ; Male ; Proteolysis/drug effects

Eltrombopag for Newly Diagnosed Pediatric Immune Thrombocytopenia Requiring Treatment: The PINES Randomized Clinical Trial.

Autori: Shimano KA Grimes AB Kaicker S a ďalší

Zdroj: JAMA [JAMA] 2025 Nov 25; Vol. 334 (20), pp. 1816-1826.

Spôsob vydávania: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study; Comment

Informácie o časopise: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE

Výrazy zo slovníka MeSH: Benzoates*/administration & dosage , Benzoates*/adverse effects , Hydrazines*/administration & dosage , Hydrazines*/adverse effects , Purpura, Thrombocytopenic, Idiopathic*/blood , Purpura, Thrombocytopenic, Idiopathic*/complications , Purpura, Thrombocytopenic, Idiopathic*/drug therapy , Purpura, Thrombocytopenic, Idiopathic*/psychology , Pyrazoles*/administration & dosage , Pyrazoles*/adverse effects , Receptors, Thrombopoietin*/agonists, Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Administration, Oral ; Glucocorticoids/administration & dosage ; Glucocorticoids/adverse effects ; Hemorrhage/epidemiology ; Hemorrhage/etiology ; Hemorrhage/prevention & control ; Immunoglobulins, Intravenous/administration & dosage ; Immunoglobulins, Intravenous/adverse effects ; Platelet Count ; Prospective Studies ; Quality of Life ; Rho(D) Immune Globulin/administration & dosage ; Rho(D) Immune Globulin/adverse effects ; Treatment Outcome

Novel Triazole-Carbohydrazide hydrazones with dual antioxidant and antibacterial potential.

Autori: Badawy SA Rewish NM Fadda AA a ďalší

Zdroj: Scientific reports [Sci Rep] 2025 Nov 21; Vol. 15 (1), pp. 41456. Date of Electronic Publication: 2025 Nov 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Hydrazones*/chemistry , Hydrazones*/pharmacology , Hydrazones*/chemical synthesis , Antioxidants*/pharmacology , Antioxidants*/chemistry , Antioxidants*/chemical synthesis , Triazoles*/chemistry , Triazoles*/pharmacology , Hydrazines*/chemistry , Hydrazines*/pharmacology, Molecular Docking Simulation ; Microbial Sensitivity Tests ; DNA Gyrase/metabolism ; DNA Gyrase/chemistry

Structural and Mechanistic Insights into Bacterial Hydrazine Biosynthesis.

Autori: Zhao G Huang H Li Y a ďalší

Zdroj: Journal of the American Chemical Society [J Am Chem Soc] 2025 Nov 19; Vol. 147 (46), pp. 42984-42993. Date of Electronic Publication: 2025 Nov 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hydrazines*/metabolism , Hydrazines*/chemistry , Ligases*/chemistry , Ligases*/metabolism, Models, Molecular ; Crystallography, X-Ray ; Molecular Structure

Design, synthesis, radiolabeling, and mechanistic insights of hydrazinyl imidazolones as broad spectrum antitumor agents with potential carbonic anhydrase inhibition: In vitro, in vivo, and in silico studies.

Autori: Husseiny EM Sarg MT Sheta YS a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 15; Vol. 298, pp. 118049. Date of Electronic Publication: 2025 Aug 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/chemical synthesis , Carbonic Anhydrase Inhibitors*/chemistry , Drug Design* , Imidazoles*/pharmacology , Imidazoles*/chemistry , Imidazoles*/chemical synthesis , Carbonic Anhydrases*/metabolism , Hydrazines*/chemistry , Hydrazines*/pharmacology , Hydrazines*/chemical synthesis, Humans ; Animals ; Structure-Activity Relationship ; Mice ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Molecular Structure ; Dose-Response Relationship, Drug ; Cell Line, Tumor ; Molecular Docking Simulation ; Apoptosis/drug effects ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/pathology

Design, synthesis, characterization, biological investigation and docking studies of newly synthesized sulphonyl hydrazide and their derivatives.

Autori: Rahman M Zafar R Jan MS a ďalší

Zdroj: Scientific reports [Sci Rep] 2025 Nov 11; Vol. 15 (1), pp. 39527. Date of Electronic Publication: 2025 Nov 11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Drug Design* , Anti-Inflammatory Agents, Non-Steroidal*/pharmacology , Anti-Inflammatory Agents, Non-Steroidal*/chemical synthesis , Anti-Inflammatory Agents, Non-Steroidal*/chemistry , Hydrazines*/chemical synthesis , Hydrazines*/pharmacology , Hydrazines*/chemistry, Molecular Docking Simulation ; Animals ; Humans ; Edema/drug therapy ; Edema/chemically induced ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2/chemistry ; Arachidonate 5-Lipoxygenase/metabolism ; Arachidonate 5-Lipoxygenase/chemistry ; Cyclooxygenase 2 Inhibitors/pharmacology ; Cyclooxygenase 2 Inhibitors/chemical synthesis ; Cyclooxygenase 2 Inhibitors/chemistry ; Rats ; Lipoxygenase Inhibitors/pharmacology ; Lipoxygenase Inhibitors/chemical synthesis ; Lipoxygenase Inhibitors/chemistry ; Male ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/chemistry ; Mice

Discovery of novel hydrazinyl thiazole derivatives as potent anticancer agents by inhibiting eIF4E/eIF4G interactions.

Autori: Yao B Zhang C Ye Z a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 05; Vol. 297, pp. 117911. Date of Electronic Publication: 2025 Jun 26.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Thiazoles*/pharmacology , Thiazoles*/chemistry , Thiazoles*/chemical synthesis , Eukaryotic Initiation Factor-4E*/metabolism , Eukaryotic Initiation Factor-4E*/antagonists & inhibitors , Eukaryotic Initiation Factor-4G*/metabolism , Eukaryotic Initiation Factor-4G*/antagonists & inhibitors , Drug Discovery* , Hydrazines*/chemistry , Hydrazines*/pharmacology , Hydrazines*/chemical synthesis, Humans ; Animals ; Cell Proliferation/drug effects ; Mice ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Mice, Nude ; Molecular Structure ; Apoptosis/drug effects ; Dose-Response Relationship, Drug ; Molecular Docking Simulation ; Cell Line, Tumor ; Mice, Inbred BALB C ; Protein Binding/drug effects

Targeting Mitochondrial Oxidative Stress by Calcium/Copper/Elesclomol Tri-Overloaded Nanocages for Osteosarcoma Immunotherapy via Immunogenic Cell Death.

Autori: Jiang G Zhang F Wu Z a ďalší

Zdroj: ACS nano [ACS Nano] 2025 Nov 04; Vol. 19 (43), pp. 37600-37616. Date of Electronic Publication: 2025 Oct 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE

Výrazy zo slovníka MeSH: Oxidative Stress*/drug effects , Copper*/chemistry , Copper*/pharmacology , Immunotherapy* , Immunogenic Cell Death*/drug effects , Mitochondria*/drug effects , Mitochondria*/metabolism , Osteosarcoma*/pathology , Osteosarcoma*/therapy , Osteosarcoma*/immunology , Osteosarcoma*/drug therapy , Calcium*/chemistry , Calcium*/pharmacology , Hydrazines*/chemistry , Hydrazines*/pharmacology, Humans ; Animals ; Mice ; Cell Line, Tumor

Synthesis, and Computational Insights Into Quinoline Hydrazide Derivatives as Potential Antimicrobial Agents.

Autori: Patel AJ Patel VC Patel DS a ďalší

Zdroj: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2025 Nov; Vol. 39 (11), pp. e70614.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print Cited Medium: Internet ISSN: 1099-0461 (Electronic) Linking ISSN: 10956670 NLM ISO Abbreviation: J Biochem Mol Toxicol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Quinolines*/chemistry , Quinolines*/pharmacology , Quinolines*/chemical synthesis , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemical synthesis , Anti-Bacterial Agents*/chemistry , Anti-Infective Agents*/chemical synthesis , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry , Hydrazines*/pharmacology , Hydrazines*/chemical synthesis , Hydrazines*/chemistry, Molecular Docking Simulation ; Microbial Sensitivity Tests ; Molecular Dynamics Simulation ; DNA Gyrase/chemistry ; DNA Gyrase/metabolism ; Bacillus subtilis/drug effects