Suchergebnisse - "Histidine"

Exploring Helicobacter pylori Histidyl tRNA synthetase as a drug target using biophysical and computational approaches.

Autoren: Rajendran V Kanagaraj S

Quelle: Enzyme and microbial technology [Enzyme Microb Technol] 2025 Sep; Vol. 189, pp. 110679. Date of Electronic Publication: 2025 May 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 8003761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0909 (Electronic) Linking ISSN: 01410229 NLM ISO Abbreviation: Enzyme Microb Technol Subsets: MEDLINE

MeSH-Schlagworte: Helicobacter pylori*/enzymology , Helicobacter pylori*/drug effects , Helicobacter pylori*/genetics , Histidine-tRNA Ligase*/antagonists & inhibitors , Histidine-tRNA Ligase*/metabolism , Histidine-tRNA Ligase*/chemistry , Histidine-tRNA Ligase*/genetics , Anti-Bacterial Agents*/pharmacology , Bacterial Proteins*/metabolism , Bacterial Proteins*/chemistry , Bacterial Proteins*/genetics , Bacterial Proteins*/antagonists & inhibitors , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry, Molecular Dynamics Simulation ; Histidine/metabolism ; Catalytic Domain ; Molecular Docking Simulation

Allosteric coupling activation mechanism in histidine kinases.

Autoren: Almada JC Bortolotti A Porrini L et al.

Quelle: Scientific reports [Sci Rep] 2025 Apr 26; Vol. 15 (1), pp. 14682. Date of Electronic Publication: 2025 Apr 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Histidine Kinase*/metabolism , Histidine Kinase*/genetics , Histidine Kinase*/chemistry , Bacillus subtilis*/enzymology , Bacillus subtilis*/genetics , Bacillus subtilis*/metabolism , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Bacterial Proteins*/chemistry, Allosteric Regulation ; Phosphorylation ; Histidine/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Signal Transduction ; Gene Expression Regulation, Bacterial ; Escherichia coli Proteins/metabolism ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/chemistry ; Bacterial Outer Membrane Proteins ; Multienzyme Complexes

Bringing Histidine Phosphorylation into Light: Role of Chemical Tools.

Autoren: Choi S Lee SH Kee JM

Quelle: ACS chemical biology [ACS Chem Biol] 2025 Apr 18; Vol. 20 (4), pp. 778-790. Date of Electronic Publication: 2025 Apr 04.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

MeSH-Schlagworte: Histidine*/analogs & derivatives , Histidine*/metabolism , Histidine*/chemistry, Phosphorylation ; Humans ; Animals ; Protein Processing, Post-Translational ; Histidine Kinase/metabolism ; Proteomics/methods

Characterization of a novel heterozygous variant in the histidyl-tRNA synthetase gene associated with Charcot-Marie-Tooth disease type 2W.

Autoren: Wilhelm SDP Moresco AA Rivero AD et al.

Quelle: IUBMB life [IUBMB Life] 2024 Dec; Vol. 76 (12), pp. 1125-1138. Date of Electronic Publication: 2024 Oct 01.

Publikationsart: Journal Article; Case Reports; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Published for the International Union of Biochemistry and Molecular Biology by Taylor & Francis Country of Publication: England NLM ID: 100888706 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-6551 (Electronic) Linking ISSN: 15216543 NLM ISO Abbreviation: IUBMB Life Subsets: MEDLINE

MeSH-Schlagworte: Charcot-Marie-Tooth Disease*/genetics , Charcot-Marie-Tooth Disease*/pathology , Heterozygote* , Histidine-tRNA Ligase*/genetics , Histidine-tRNA Ligase*/metabolism , Histidine-tRNA Ligase*/chemistry, Female ; Humans ; Male ; Histidine/genetics ; Histidine/metabolism ; Adult

Transfer RNA supplementation rescues HARS deficiency in a humanized yeast model of Charcot-Marie-Tooth disease.

Autoren: Wilhelm SDP Kakadia JH Beharry A et al.

Quelle: Nucleic acids research [Nucleic Acids Res] 2024 Dec 11; Vol. 52 (22), pp. 14043-14060.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

MeSH-Schlagworte: Charcot-Marie-Tooth Disease*/genetics , Charcot-Marie-Tooth Disease*/therapy , Charcot-Marie-Tooth Disease*/metabolism , Saccharomyces cerevisiae*/genetics , RNA, Transfer*/genetics , RNA, Transfer*/metabolism , Histidine-tRNA Ligase*/genetics , Histidine-tRNA Ligase*/metabolism, Humans ; Mutation ; Histidine ; Protein Biosynthesis

Histidine Phosphorylation: Protein Kinases and Phosphatases.

Autoren: Ning J Sala M Reina J et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 21; Vol. 25 (14). Date of Electronic Publication: 2024 Jul 21.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Histidine*/metabolism , Histidine*/analogs & derivatives, Humans ; Phosphorylation ; Animals ; Phosphoric Monoester Hydrolases/metabolism ; Protein Processing, Post-Translational ; Protein Kinases/metabolism ; Phosphoprotein Phosphatases/metabolism ; Histidine Kinase/metabolism ; Histidine Kinase/genetics

Chitosan and L-histidine coated biofunctional TiO₂ composite with enhanced ROS-mediated antimicrobial and anticancer efficacy for biomedical applications.

Autoren: Thangavelu I Tadepalli S A AlGhamdi A et al.

Quelle: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Dec; Vol. 398 (12), pp. 17895-17906. Date of Electronic Publication: 2025 Jun 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Titanium*/chemistry , Titanium*/pharmacology , Reactive Oxygen Species*/metabolism , Chitosan*/chemistry , Chitosan*/pharmacology , Histidine*/chemistry , Histidine*/pharmacology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/administration & dosage , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry , Nanocomposites*/chemistry, Humans ; Cell Survival/drug effects ; Animals ; Microbial Sensitivity Tests ; Cell Line, Tumor ; Particle Size ; Mice

Isotopologues of a Metabolic Precursor for Selective N-15 and C-13 Histidine Labeling.

Autoren: Brüschweiler S Hlavac M Kratzwald S et al.

Quelle: Journal of molecular biology [J Mol Biol] 2025 Dec 01; Vol. 437 (23), pp. 169347. Date of Electronic Publication: 2025 Jul 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: Histidine*/chemistry , Histidine*/metabolism , Nitrogen Isotopes*/chemistry , Isotope Labeling*/methods, Carbon Isotopes/chemistry ; Humans ; Proto-Oncogene Proteins p21(ras)/chemistry ; Proto-Oncogene Proteins p21(ras)/metabolism ; Nuclear Magnetic Resonance, Biomolecular ; Magnetic Resonance Spectroscopy

Preparation and safety assessment of BADGE- histidine adduct from epoxy-coated cans.

Autoren: Shi YJ Zhao D Hu CY et al.

Quelle: Food chemistry [Food Chem] 2025 Nov 30; Vol. 493 (Pt 4), pp. 146103. Date of Electronic Publication: 2025 Aug 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Epoxy Compounds*/chemistry , Epoxy Compounds*/toxicity , Histidine*/chemistry , Histidine*/toxicity , Benzhydryl Compounds*/chemistry , Benzhydryl Compounds*/toxicity , Food, Preserved*/analysis, Humans ; Cell Survival/drug effects ; Cell Line ; Food Packaging/instrumentation ; Cell Line, Tumor ; Epoxy Resins/chemistry ; Oxidative Stress/drug effects ; Bisphenol A Compounds

Co-administration of histidine and soy isoflavones induces beige adipogenesis in male rats: depot-specific responses in white adipose tissue.

Autoren: Asahi R Udagawa H Oshiro R et al.

Quelle: Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2025 Nov 25; Vol. 89 (12), pp. 1728-1732.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 9205717 Publication Model: Print Cited Medium: Internet ISSN: 1347-6947 (Electronic) Linking ISSN: 09168451 NLM ISO Abbreviation: Biosci Biotechnol Biochem Subsets: MEDLINE

MeSH-Schlagworte: Adipogenesis*/drug effects , Adipose Tissue, White*/drug effects , Adipose Tissue, White*/metabolism , Adipose Tissue, White*/cytology , Isoflavones*/pharmacology , Isoflavones*/administration & dosage , Histidine*/pharmacology , Histidine*/administration & dosage , Glycine max*/chemistry , Adipocytes, Beige*/drug effects , Adipocytes, Beige*/metabolism , Adipocytes, Beige*/cytology, Animals ; Male ; Uncoupling Protein 1/genetics ; Uncoupling Protein 1/metabolism ; Rats ; Mitochondria/drug effects ; Mitochondria/metabolism ; Lipogenesis/drug effects

Clitoria ternatea flower extract assisted synthesis of Pluronic F127 and L-histidine coated SrO 2 as a multimodality nanocomposite for anti-cancer, anti-oxidant, and antimicrobial activities.

Autoren: Sharma A Ballal S Sharma D et al.

Quelle: Bioprocess and biosystems engineering [Bioprocess Biosyst Eng] 2025 Nov; Vol. 48 (11), pp. 1801-1816. Date of Electronic Publication: 2025 Jul 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101088505 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-7605 (Electronic) Linking ISSN: 16157591 NLM ISO Abbreviation: Bioprocess Biosyst Eng Subsets: MEDLINE

MeSH-Schlagworte: Antioxidants*/pharmacology , Antioxidants*/chemistry , Antioxidants*/chemical synthesis , Poloxamer*/chemistry , Poloxamer*/pharmacology , Nanocomposites*/chemistry , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Histidine*/chemistry , Histidine*/pharmacology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Flowers*/chemistry , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry, Humans ; Hep G2 Cells ; Liver Neoplasms/drug therapy ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry

Evaluation of HER2 Targeted Poly(Ethylene Glycol)-Poly(L-histidine) Copolymer Micelles in Breast Cancer Models.

Autoren: Valsala Kumari R Pandya AD Pettersen SJ et al.

Quelle: Macromolecular bioscience [Macromol Biosci] 2025 Nov; Vol. 25 (11), pp. e00047. Date of Electronic Publication: 2025 Jul 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101135941 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1616-5195 (Electronic) Linking ISSN: 16165187 NLM ISO Abbreviation: Macromol Biosci Subsets: MEDLINE

MeSH-Schlagworte: Micelles* , Receptor, ErbB-2*/metabolism , Polyethylene Glycols*/chemistry , Polyethylene Glycols*/pharmacology , Histidine*/chemistry , Histidine*/pharmacology , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism, Humans ; Female ; Doxorubicin/pharmacology ; Doxorubicin/chemistry ; Trastuzumab/pharmacology ; Trastuzumab/chemistry ; Animals ; Cell Line, Tumor ; Mice ; Cell Proliferation/drug effects ; Xenograft Model Antitumor Assays

Conformational dynamics of a histidine molecular switch in a cation/proton antiporter.

Autoren: Pecorilla C Altmeyer A Haapanen O et al.

Quelle: Biochimica et biophysica acta. Bioenergetics [Biochim Biophys Acta Bioenerg] 2025 Nov 01; Vol. 1866 (4), pp. 149563. Date of Electronic Publication: 2025 Jun 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731706 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2650 (Electronic) Linking ISSN: 00052728 NLM ISO Abbreviation: Biochim Biophys Acta Bioenerg Subsets: MEDLINE

MeSH-Schlagworte: Histidine*/chemistry , Histidine*/metabolism , Histidine*/genetics , Sodium-Hydrogen Exchangers*/chemistry , Sodium-Hydrogen Exchangers*/metabolism , Sodium-Hydrogen Exchangers*/genetics , Bacterial Proteins*/chemistry , Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism, Molecular Dynamics Simulation ; Protein Conformation ; Protons ; Mutagenesis, Site-Directed ; Hydrogen Bonding

Role of Extracellular Histidine Residues for the Function and pH Sensitivity of Human Organic Anion Transporting Polypeptide 1B3.

Autoren: Han W Liu H Liang T et al.

Quelle: Proteins [Proteins] 2025 Oct; Vol. 93 (10), pp. 1876-1885. Date of Electronic Publication: 2025 Jun 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8700181 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0134 (Electronic) Linking ISSN: 08873585 NLM ISO Abbreviation: Proteins Subsets: MEDLINE

MeSH-Schlagworte: Histidine*/chemistry , Histidine*/metabolism , Histidine*/genetics , Solute Carrier Organic Anion Transporter Family Member 1B3*/chemistry , Solute Carrier Organic Anion Transporter Family Member 1B3*/metabolism , Solute Carrier Organic Anion Transporter Family Member 1B3*/genetics, Humans ; Hydrogen-Ion Concentration ; Bicarbonates/metabolism ; Bicarbonates/chemistry ; Hydrogen Bonding ; Protein Binding ; Binding Sites ; Models, Molecular ; HEK293 Cells ; Mutation ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Recombinant Proteins/genetics ; Biological Transport

Structures of two LarA-like nickel-pincer nucleotide cofactor-utilizing enzymes with a single catalytic histidine residue.

Autoren: Gatreddi S Subramanian S Sui D et al.

Quelle: Protein science : a publication of the Protein Society [Protein Sci] 2025 Dec; Vol. 34 (12), pp. e70362.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

MeSH-Schlagworte: Histidine*/chemistry , Histidine*/metabolism , Nickel*/chemistry , Nickel*/metabolism , Nucleotides*/chemistry , Nucleotides*/metabolism, Catalytic Domain ; Models, Molecular ; Cryoelectron Microscopy

Premature termination codon mutations in osmosensor-like histidine kinase FgOs1 endow Fusarium graminearum with fludioxonil resistance.

Autoren: He Y Li Z He Z et al.

Quelle: Pesticide biochemistry and physiology [Pestic Biochem Physiol] 2025 Dec; Vol. 215, pp. 106633. Date of Electronic Publication: 2025 Aug 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 1301573 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9939 (Electronic) Linking ISSN: 00483575 NLM ISO Abbreviation: Pestic Biochem Physiol Subsets: MEDLINE

MeSH-Schlagworte: Fusarium*/drug effects , Fusarium*/genetics , Fusarium*/enzymology , Dioxoles*/pharmacology , Pyrroles*/pharmacology , Fungicides, Industrial*/pharmacology , Drug Resistance, Fungal*/genetics , Histidine Kinase*/genetics , Histidine Kinase*/metabolism , Fungal Proteins*/genetics , Fungal Proteins*/metabolism , Codon, Nonsense*/genetics

SCR Organism: Fusarium graminearum

Alteration of alanine-327 in LXRα to LXRβ-type histidine deteriorates its subtype-selective activation by riccardin C.

Autoren: Tamehiro N Shigemoto-Mogami Y Cui H et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 3), pp. 117304. Date of Electronic Publication: 2025 Sep 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Liver X Receptors*/genetics , Liver X Receptors*/metabolism , Liver X Receptors*/agonists , Histidine*/genetics , Histidine*/metabolism , Alanine*/genetics , Alanine*/metabolism, Animals ; Mice ; Humans ; Male ; Mice, Inbred C57BL ; HEK293 Cells ; ATP Binding Cassette Transporter 1/genetics ; ATP Binding Cassette Transporter 1/metabolism ; Liver/metabolism ; Liver/drug effects

Cu/Zn/histidine supramolecular assemblies with optimized Cu catalytic sites as an alternative of superoxide dismutase.

Autoren: Jin H Zhu X Zhang M et al.

Quelle: Nature communications [Nat Commun] 2025 Nov 18; Vol. 16 (1), pp. 10075. Date of Electronic Publication: 2025 Nov 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Histidine*/chemistry , Histidine*/metabolism , Copper*/chemistry , Copper*/metabolism , Superoxide Dismutase*/metabolism , Superoxide Dismutase*/chemistry , Zinc*/chemistry , Zinc*/metabolism, Catalytic Domain ; Animals ; Mice ; Oxidative Stress/drug effects ; Macrophages/metabolism ; Macrophages/drug effects ; Catalysis ; Reactive Oxygen Species/metabolism ; Male ; Humans

5-Thiohistidine N-Acetyltransferase from Proteiniphilum Saccharofermentans.

Autoren: Liao C Lim D Suryatin Alim G et al.

Quelle: Chembiochem : a European journal of chemical biology [Chembiochem] 2025 Nov 17; Vol. 26 (22), pp. e202400439. Date of Electronic Publication: 2025 Oct 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

MeSH-Schlagworte: Histidine*/analogs & derivatives , Histidine*/metabolism , Histidine*/chemistry , Acetyltransferases*/metabolism , Acetyltransferases*/chemistry , Acetyltransferases*/genetics

Investigating the conformational landscape of human histidine-rich glycoprotein using amide HDX-MS.

Autoren: Hierons SJ Lin B Fritzen R et al.

Quelle: The Biochemical journal [Biochem J] 2025 Nov 17; Vol. 482 (22).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

MeSH-Schlagworte: Histidine-Rich Glycoprotein*/chemistry, Hydrogen Deuterium Exchange-Mass Spectrometry ; Protein Folding ; Protein Structure, Secondary ; Circular Dichroism ; Glycosylation ; Protein Domains