Výsledky vyhľadávania - "High-throughput screening"

High-Throughput Screening Using the Self-Controlled Tree-Based Scan Statistic to Identify Medications Associated With Hospitalization for Severe Acute Liver Injury.

Autori: Lo Re V 3rd Newcomb CW Carbonari DM a ďalší

Zdroj: Pharmacoepidemiology and drug safety [Pharmacoepidemiol Drug Saf] 2025 Dec; Vol. 34 (12), pp. e70275.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley Country of Publication: England NLM ID: 9208369 Publication Model: Print Cited Medium: Internet ISSN: 1099-1557 (Electronic) Linking ISSN: 10538569 NLM ISO Abbreviation: Pharmacoepidemiol Drug Saf Subsets: MEDLINE

Výrazy zo slovníka MeSH: Chemical and Drug Induced Liver Injury*/epidemiology , Chemical and Drug Induced Liver Injury*/etiology , Chemical and Drug Induced Liver Injury*/diagnosis , Hospitalization*/statistics & numerical data , High-Throughput Screening Assays*/methods , High-Throughput Screening Assays*/statistics & numerical data, Humans ; Male ; Female ; Middle Aged ; Cross-Over Studies ; Aged ; United States/epidemiology ; Severity of Illness Index

Integrating AUROC and SSMD for quality control in high-throughput screening assays.

Autori: Zhang XD; Department of Biostatistics, College of Public Health, University of Kentucky, Lexington KY40536, USA. Electronic address: douglas.zhang@uky.edu.

Zdroj: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2025 Oct; Vol. 36, pp. 100269. Date of Electronic Publication: 2025 Sep 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE

Výrazy zo slovníka MeSH: High-Throughput Screening Assays*/methods , High-Throughput Screening Assays*/standards, Quality Control ; Humans ; ROC Curve ; Drug Discovery/methods ; Reproducibility of Results ; Area Under Curve

Advanced droplet microfluidic platform for high-throughput screening of industrial fungi.

Autori: Yang Q Lu S Wu H a ďalší

Zdroj: Biosensors & bioelectronics [Biosens Bioelectron] 2025 Oct 01; Vol. 285, pp. 117594. Date of Electronic Publication: 2025 May 16.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Elsevier Advanced Technology Country of Publication: England NLM ID: 9001289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4235 (Electronic) Linking ISSN: 09565663 NLM ISO Abbreviation: Biosens Bioelectron Subsets: MEDLINE

Výrazy zo slovníka MeSH: High-Throughput Screening Assays*/instrumentation , High-Throughput Screening Assays*/methods , Fungi*/isolation & purification , Biosensing Techniques*/instrumentation , Biosensing Techniques*/methods , Industrial Microbiology*/instrumentation , Microfluidic Analytical Techniques*/instrumentation , Microfluidic Analytical Techniques*/methods , Lab-On-A-Chip Devices*, Equipment Design ; Single-Cell Analysis/instrumentation

Engineering enhanced signal peptides: A high-throughput computational pipeline for optimizing therapeutic protein production in CHO cells.

Autori: Zhang JH Wang C Wu ZY a ďalší

Zdroj: New biotechnology [N Biotechnol] 2025 Dec 25; Vol. 90, pp. 223-235. Date of Electronic Publication: 2025 Oct 20.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101465345 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-4347 (Electronic) Linking ISSN: 18716784 NLM ISO Abbreviation: N Biotechnol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Protein Sorting Signals*/genetics , Protein Engineering*/methods , Computational Biology*/methods , High-Throughput Screening Assays*, CHO Cells ; Cricetulus ; Animals ; Humans ; Cricetinae ; Serum Albumin, Human/genetics ; Serum Albumin, Human/biosynthesis

Advances and innovations in surface-enhanced Raman scattering detection of microcystins: towards sensitive, rapid, and high-throughput analysis.

Autori: Han Y Wen R Liu J a ďalší

Zdroj: Food chemistry [Food Chem] 2025 Dec 25; Vol. 496 (Pt 2), pp. 146824. Date of Electronic Publication: 2025 Oct 25.

Spôsob vydávania: Journal Article; Review; Evaluation Study

Informácie o časopise: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Microcystins*/analysis , Microcystins*/chemistry , Spectrum Analysis, Raman*/methods , Spectrum Analysis, Raman*/instrumentation , High-Throughput Screening Assays*/methods , High-Throughput Screening Assays*/instrumentation, Humans ; Cyanobacteria/chemistry

High-Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15-Specific Protease mUSP18.

Autori: Kooij R Pol V Gan J a ďalší

Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Dec 01; Vol. 64 (49), pp. e202510941. Date of Electronic Publication: 2025 Oct 07.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

Výrazy zo slovníka MeSH: High-Throughput Screening Assays* , Ubiquitins*/metabolism , Ubiquitins*/antagonists & inhibitors , Small Molecule Libraries*/chemistry , Small Molecule Libraries*/chemical synthesis , Small Molecule Libraries*/pharmacology , Protease Inhibitors*/chemistry , Protease Inhibitors*/chemical synthesis , Protease Inhibitors*/pharmacology , Cytokines*/metabolism , Cytokines*/antagonists & inhibitors, Humans

High-throughput cytokine detection platform for evaluation of chemical induced microglial activation.

Autori: Yang S Carstens KE Ipaye I a ďalší

Zdroj: SLAS technology [SLAS Technol] 2025 Dec; Vol. 35, pp. 100347. Date of Electronic Publication: 2025 Sep 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697564 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-6311 (Electronic) Linking ISSN: 24726303 NLM ISO Abbreviation: SLAS Technol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Microglia*/drug effects , Microglia*/metabolism , Cytokines*/analysis , Cytokines*/metabolism , High-Throughput Screening Assays*/methods, Humans ; Lipopolysaccharides/pharmacology ; Induced Pluripotent Stem Cells/drug effects ; Cell Line ; Tumor Necrosis Factor-alpha

Integrating computational simulation and high-throughput screening for the development of robust ultra-high concentration formulation of IgG1 antibody.

Autori: Lyu C Lu S Yin Y a ďalší

Zdroj: MAbs [MAbs] 2025 Dec; Vol. 17 (1), pp. 2577159. Date of Electronic Publication: 2025 Nov 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antibodies, Monoclonal*/chemistry , High-Throughput Screening Assays*/methods , Immunoglobulin G*/chemistry , Computer Simulation* , Drug Compounding*/methods, Viscosity ; Humans ; Chemistry, Pharmaceutical/methods ; Protein Stability ; Drug Stability ; Excipients/chemistry

Microplate-in-a-Box: thermophysical exploration of cold storage high-throughput microplate designs for enhanced rate control in cryopreservation.

Autori: Guerreiro BM Lima JC Silva JC a ďalší

Zdroj: Cryobiology [Cryobiology] 2025 Dec; Vol. 121, pp. 105298. Date of Electronic Publication: 2025 Sep 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0006252 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2392 (Electronic) Linking ISSN: 00112240 NLM ISO Abbreviation: Cryobiology Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cryopreservation*/instrumentation , Cryopreservation*/methods , High-Throughput Screening Assays*/instrumentation , High-Throughput Screening Assays*/methods, Cryoprotective Agents/pharmacology ; Cold Temperature ; Animals ; Cell Survival/drug effects ; Humans ; Freezing ; Ice

HI-CeFSpot: High-throughput Immune Cell FluoroSpot assay.

Autori: Jethmalani Y Sutton MS Carroll R a ďalší

Zdroj: Methods (San Diego, Calif.) [Methods] 2025 Dec; Vol. 244, pp. 210-218. Date of Electronic Publication: 2025 Oct 09.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 9426302 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9130 (Electronic) Linking ISSN: 10462023 NLM ISO Abbreviation: Methods Subsets: MEDLINE

Výrazy zo slovníka MeSH: High-Throughput Screening Assays*/methods , High-Throughput Screening Assays*/instrumentation , Enzyme-Linked Immunospot Assay*/methods , Enzyme-Linked Immunospot Assay*/instrumentation, Animals ; Interferon-gamma/immunology ; Interferon-gamma/metabolism ; T-Lymphocytes/immunology ; B-Lymphocytes/immunology ; Humans

ZEMs: Zebrafish embedding molds for high-throughput imaging of zebrafish embryos and larvae.

Autori: Sim Y Lee E Jeong J

Zdroj: Methods (San Diego, Calif.) [Methods] 2025 Dec; Vol. 244, pp. 157-167. Date of Electronic Publication: 2025 Oct 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 9426302 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9130 (Electronic) Linking ISSN: 10462023 NLM ISO Abbreviation: Methods Subsets: MEDLINE

Výrazy zo slovníka MeSH: Zebrafish*/embryology , Zebrafish*/growth & development , Embryo, Nonmammalian*/diagnostic imaging , High-Throughput Screening Assays*/methods , High-Throughput Screening Assays*/instrumentation, Animals ; Larva/growth & development

Discovery of aldolase A inhibitors via high-throughput screening assay based on an enzymatic coupling reaction.

Autori: Xiong Q Qian R Huang Q a ďalší

Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Dec 01; Vol. 128, pp. 130332. Date of Electronic Publication: 2025 Jul 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Výrazy zo slovníka MeSH: High-Throughput Screening Assays* , Fructose-Bisphosphate Aldolase*/antagonists & inhibitors , Fructose-Bisphosphate Aldolase*/metabolism , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemical synthesis , Drug Discovery*, Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Kinetics

Neurofibromatosis Type 1 and the Search for Effective Tumor Therapies Using High-Throughput Drug Screening.

Autori: Bouley SJ Housden BE Walker JA

Zdroj: Current oncology (Toronto, Ont.) [Curr Oncol] 2025 Nov 20; Vol. 32 (11). Date of Electronic Publication: 2025 Nov 20.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 9502503 Publication Model: Electronic Cited Medium: Internet ISSN: 1718-7729 (Electronic) Linking ISSN: 11980052 NLM ISO Abbreviation: Curr Oncol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Neurofibromatosis 1*/drug therapy , Neurofibromatosis 1*/genetics , High-Throughput Screening Assays*/methods , Antineoplastic Agents*/therapeutic use, Humans ; Neurofibromin 1/genetics

An engineered cysteine sensor optimized for high-throughput screening identifies regulators of intracellular thiol levels.

Autori: Abrams RPM Donahue RG Ma J a ďalší

Zdroj: Cell chemical biology [Cell Chem Biol] 2025 Nov 20; Vol. 32 (11), pp. 1381-1396.e8. Date of Electronic Publication: 2025 Nov 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cysteine*/analysis , Cysteine*/metabolism , High-Throughput Screening Assays* , Sulfhydryl Compounds*/metabolism , Sulfhydryl Compounds*/analysis , Fluorescent Dyes*/chemistry, Humans

PPARγ-responsive luciferase reporter system for high-throughput screening of chemical toxins with potential pulmonary fibrosis effects.

Autori: Lin X Yang Y Sun Y a ďalší

Zdroj: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2025 Nov 15; Vol. 307, pp. 119433. Date of Electronic Publication: 2025 Nov 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

Výrazy zo slovníka MeSH: PPAR gamma*/metabolism , PPAR gamma*/genetics , High-Throughput Screening Assays*/methods , Pulmonary Fibrosis*/chemically induced , Luciferases*/genetics , Luciferases*/metabolism, Humans ; Genes, Reporter ; Molecular Docking Simulation

Magnetic microsphere based droplet microarray for high-throughput screening of multiple chemical residues in milk.

Autori: Liu C Zhai P Luo P a ďalší

Zdroj: Food chemistry [Food Chem] 2025 Nov 15; Vol. 492 (Pt 2), pp. 145509. Date of Electronic Publication: 2025 Jul 09.

Spôsob vydávania: Journal Article; Evaluation Study

Informácie o časopise: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Milk*/chemistry , Food Contamination*/analysis , Microarray Analysis*/instrumentation , Microarray Analysis*/methods , High-Throughput Screening Assays*/methods , High-Throughput Screening Assays*/instrumentation , Drug Residues*/analysis, Animals ; Microspheres ; Cattle ; Aflatoxin M1/analysis ; Ciprofloxacin/analysis ; Sulfamethoxazole/analysis ; Limit of Detection

High-throughput screening and meta-analysis for lead compounds in antimalarial drug discovery.

Autori: Van Truong N Na SW Park JH a ďalší

Zdroj: Malaria journal [Malar J] 2025 Nov 06; Vol. 24 (1), pp. 378. Date of Electronic Publication: 2025 Nov 06.

Spôsob vydávania: Journal Article; Meta-Analysis

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE

Výrazy zo slovníka MeSH: Antimalarials*/pharmacology , Antimalarials*/isolation & purification , Antimalarials*/adverse effects , Plasmodium berghei*/drug effects , High-Throughput Screening Assays*/methods , Plasmodium falciparum*/drug effects , Drug Discovery*/methods , Malaria*/drug therapy , Malaria*/parasitology, Animals ; Mice ; Inhibitory Concentration 50 ; Disease Models, Animal ; Drug Evaluation, Preclinical/methods ; Female

Ultrahigh-throughput screening of heterogeneous vancomycin-intermediate Staphylococcus aureus based on fluorescence-activated droplet sorting.

Autori: Cheng X Wang Z Liu Y a ďalší

Zdroj: BMC medicine [BMC Med] 2025 Nov 03; Vol. 23 (1), pp. 599. Date of Electronic Publication: 2025 Nov 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Vancomycin*/pharmacology , High-Throughput Screening Assays*/methods , Staphylococcus aureus*/drug effects , Staphylococcus aureus*/isolation & purification , Anti-Bacterial Agents*/pharmacology, Microbial Sensitivity Tests/methods ; Humans ; Staphylococcal Infections/microbiology ; Staphylococcal Infections/drug therapy ; Microfluidics

A High-Throughput Microbial Viability Assay to Evaluate Lyoprotectants for Live Biotherapeutic Products.

Autori: Cui H Feng JT Kumari S a ďalší

Zdroj: Molecular pharmaceutics [Mol Pharm] 2025 Nov 03; Vol. 22 (11), pp. 6623-6635. Date of Electronic Publication: 2025 Oct 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

Výrazy zo slovníka MeSH: High-Throughput Screening Assays*/methods , Microbial Viability*/drug effects , Excipients*/chemistry , Excipients*/pharmacology , Biological Products*/chemistry , Biological Products*/pharmacology, Freeze Drying/methods ; Trehalose/chemistry ; Humans ; Sucrose/chemistry

High-throughput in vivo screening platform for rapid discovery of adult mosquitocides: Design, validation and automation for scalable vector control.

Autori: McComic SE Shumate JR Peña J a ďalší

Zdroj: Pesticide biochemistry and physiology [Pestic Biochem Physiol] 2025 Nov; Vol. 214, pp. 106619. Date of Electronic Publication: 2025 Aug 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 1301573 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9939 (Electronic) Linking ISSN: 00483575 NLM ISO Abbreviation: Pestic Biochem Physiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Insecticides*/pharmacology , High-Throughput Screening Assays*/methods , Mosquito Control*/methods , Culicidae*/drug effects, Animals ; Mosquito Vectors/drug effects ; Automation