Suchergebnisse - "Heterocyclic compounds"

Fetal Defects in Mice Treated With Integrase Strand Transfer Inhibitors: Comparison of Dolutegravir, Raltegravir, Bictegravir, and Cabotegravir.

Autoren: Mohan H Nguyen J Yee A et al.

Quelle: The Journal of infectious diseases [J Infect Dis] 2025 Oct 15; Vol. 232 (4), pp. 847-858.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE

MeSH-Schlagworte: Heterocyclic Compounds, 3-Ring*/adverse effects , Heterocyclic Compounds, 3-Ring*/administration & dosage , HIV Integrase Inhibitors*/adverse effects , Fetus*/abnormalities , Fetus*/drug effects , Abnormalities, Drug-Induced*, Animals ; Female ; Pyridones/adverse effects ; Pyridones/administration & dosage ; Piperazines ; Pregnancy ; Oxazines ; Raltegravir Potassium/adverse effects ; Raltegravir Potassium/administration & dosage ; Mice ; Mice, Inbred C57BL ; Heterocyclic Compounds, 4 or More Rings/adverse effects ; Heterocyclic Compounds, 4 or More Rings/administration & dosage ; Amides ; Neural Tube Defects/chemically induced ; Diketopiperazines

Bictegravir/emtricitabine/tenofovir alafenamide in clinical practice for people with HIV: final 24-month effectiveness and safety outcomes in key populations in the observational BICSTaR cohort.

Autoren: Trottier B Yang CJ Watanabe D et al.

Quelle: HIV research & clinical practice [HIV Res Clin Pract] 2025 Dec; Vol. 26 (1), pp. 2456890. Date of Electronic Publication: 2025 Feb 12.

Publikationsart: Journal Article; Observational Study

Info zur Zeitschrift: Publisher: Taylor & Francis Group Country of Publication: England NLM ID: 101738312 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2578-7470 (Electronic) Linking ISSN: 25787470 NLM ISO Abbreviation: HIV Res Clin Pract Subsets: MEDLINE

MeSH-Schlagworte: HIV Infections*/drug therapy , HIV Infections*/virology , HIV Infections*/immunology , Emtricitabine*/therapeutic use , Emtricitabine*/adverse effects , Emtricitabine*/administration & dosage , Tenofovir*/therapeutic use , Tenofovir*/analogs & derivatives , Tenofovir*/adverse effects , Tenofovir*/administration & dosage , Anti-HIV Agents*/therapeutic use , Anti-HIV Agents*/adverse effects , Anti-HIV Agents*/administration & dosage , Adenine*/analogs & derivatives , Adenine*/therapeutic use , Adenine*/adverse effects , Heterocyclic Compounds, 4 or More Rings*/therapeutic use , Heterocyclic Compounds, 4 or More Rings*/adverse effects , Heterocyclic Compounds, 4 or More Rings*/administration & dosage, Humans ; Male ; Female ; Adult ; Middle Aged ; Drug Combinations ; Alanine ; HIV-1/drug effects ; Pyridones ; Prospective Studies ; Treatment Outcome ; CD4 Lymphocyte Count ; Piperazines/therapeutic use ; Viral Load/drug effects ; Amides ; Heterocyclic Compounds, 3-Ring

A Robust and Accurate Filter Paper-Based Dried Plasma Spot Method for Bictegravir Monitoring in HIV Therapy.

Autoren: Sathyanarayanan A Arekal RN Somashekara D

Quelle: Rapid communications in mass spectrometry : RCM [Rapid Commun Mass Spectrom] 2025 Nov 15; Vol. 39 (21), pp. e10110.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: John Wiley And Sons Ltd Country of Publication: England NLM ID: 8802365 Publication Model: Print Cited Medium: Internet ISSN: 1097-0231 (Electronic) Linking ISSN: 09514198 NLM ISO Abbreviation: Rapid Commun Mass Spectrom Subsets: MEDLINE

MeSH-Schlagworte: Dried Blood Spot Testing*/methods , Drug Monitoring*/methods , HIV Infections*/drug therapy , HIV Infections*/blood , Heterocyclic Compounds, 4 or More Rings*/blood , Heterocyclic Compounds, 4 or More Rings*/therapeutic use , Anti-HIV Agents*/blood , Anti-HIV Agents*/therapeutic use, Humans ; Tandem Mass Spectrometry/methods ; Limit of Detection ; Reproducibility of Results ; Pyridones ; Chromatography, Liquid/methods ; Paper ; Linear Models ; Pyridazines ; Amides ; Heterocyclic Compounds, 3-Ring ; Piperazines

Real-world Effectiveness and Safety of Bictegravir/Emtricitabine/Tenofovir Alafenamide in Comparison With Other Regimens in People With HIV Starting Therapy With AIDS-Defining Conditions: Results From the CoRIS Cohort-The ACTUAS II Study.

Autoren: Pérez-Valero I Corona Mata D Camacho Espejo A et al.

Körperschaften: Pérez-Valero I Corona Mata D Camacho Espejo A et al.

Quelle: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2025 Nov 06; Vol. 81 (4), pp. e93-e101.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE

MeSH-Schlagworte: Emtricitabine*/therapeutic use , Emtricitabine*/adverse effects , Tenofovir*/therapeutic use , Tenofovir*/analogs & derivatives , Tenofovir*/adverse effects , Anti-HIV Agents*/therapeutic use , Anti-HIV Agents*/adverse effects , HIV Infections*/drug therapy , Heterocyclic Compounds, 4 or More Rings*/therapeutic use , Heterocyclic Compounds, 4 or More Rings*/adverse effects , Adenine*/analogs & derivatives , Adenine*/therapeutic use , Adenine*/adverse effects, Humans ; Male ; Adult ; Female ; Middle Aged ; Alanine ; Pyridones ; Treatment Outcome ; Viral Load/drug effects ; Cohort Studies ; Piperazines ; CD4 Lymphocyte Count ; Drug Combinations ; Antiretroviral Therapy, Highly Active/methods ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Amides

Clinical Evaluation of Drug-Drug Interactions Between Bictegravir and Strong Inhibitors/Inducers of the CYP3A4, UGT1A1, or P-gp Pathways.

Autoren: Arora P Liu H Ling J et al.

Quelle: Journal of clinical pharmacology [J Clin Pharmacol] 2025 Nov; Vol. 65 (11), pp. 1420-1432. Date of Electronic Publication: 2025 Jun 15.

Publikationsart: Journal Article; Clinical Trial, Phase I

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Glucuronosyltransferase*/antagonists & inhibitors , Glucuronosyltransferase*/metabolism , Heterocyclic Compounds, 4 or More Rings*/pharmacokinetics , Heterocyclic Compounds, 4 or More Rings*/pharmacology , Heterocyclic Compounds, 4 or More Rings*/administration & dosage , Heterocyclic Compounds, 4 or More Rings*/adverse effects , Cytochrome P-450 CYP3A*/metabolism , ATP Binding Cassette Transporter, Subfamily B, Member 1*/antagonists & inhibitors , ATP Binding Cassette Transporter, Subfamily B, Member 1*/metabolism , Cytochrome P-450 CYP3A Inducers*/pharmacology , Cytochrome P-450 CYP3A Inhibitors*/pharmacology , Anti-HIV Agents*/pharmacokinetics, Humans ; Drug Interactions ; Adult ; Male ; Middle Aged ; Female ; Young Adult ; Adolescent ; Amides ; Heterocyclic Compounds, 3-Ring ; Piperazines ; Pyridones

Effectiveness and Safety of Bictegravir/Emtricitabine/Tenofovir Alafenamide in People Living with HIV Aged 50 Years and Older: A Retrospective Analysis of Naïve and Treatment-Experienced Individuals.

Autoren: Trizzino M Pipitò L Di Figlia F et al.

Quelle: Viruses [Viruses] 2025 Oct 31; Vol. 17 (11). Date of Electronic Publication: 2025 Oct 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

MeSH-Schlagworte: HIV Infections*/drug therapy , HIV Infections*/virology , Emtricitabine*/therapeutic use , Emtricitabine*/adverse effects , Emtricitabine*/administration & dosage , Anti-HIV Agents*/therapeutic use , Anti-HIV Agents*/adverse effects , Tenofovir*/therapeutic use , Tenofovir*/analogs & derivatives , Tenofovir*/adverse effects , Heterocyclic Compounds, 4 or More Rings*/therapeutic use , Heterocyclic Compounds, 4 or More Rings*/adverse effects , Adenine*/analogs & derivatives , Adenine*/therapeutic use, Humans ; Middle Aged ; Male ; Retrospective Studies ; Female ; Aged ; HIV-1/drug effects ; Alanine ; Treatment Outcome ; Pyridones ; Viral Load/drug effects ; Piperazines/therapeutic use ; Drug Combinations ; CD4 Lymphocyte Count ; Amides ; Heterocyclic Compounds, 3-Ring

Population pharmacokinetics of bictegravir in real-world people with HIV.

Autoren: Ekobena P Briki M Dao K et al.

Körperschaften: Ekobena P Briki M Dao K et al.

Quelle: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2025 Oct 03; Vol. 80 (10), pp. 2782-2789.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

MeSH-Schlagworte: HIV Infections*/drug therapy , Heterocyclic Compounds, 4 or More Rings*/pharmacokinetics , Heterocyclic Compounds, 4 or More Rings*/therapeutic use , HIV Integrase Inhibitors*/pharmacokinetics , HIV Integrase Inhibitors*/therapeutic use , Pyridones*/pharmacokinetics, Humans ; Female ; Middle Aged ; Male ; Adult ; Drug Monitoring ; Switzerland ; Aged ; Amides/pharmacokinetics ; Aged, 80 and over ; Cohort Studies ; Young Adult ; Piperazines/pharmacokinetics ; Heterocyclic Compounds, 3-Ring

AI-driven discovery of antiretroviral drug bictegravir and etravirine as inhibitors against monkeypox and related poxviruses.

Autoren: Wang Y Ünlü A Wang X et al.

Quelle: Communications biology [Commun Biol] 2025 Dec 02; Vol. 8 (1), pp. 1734. Date of Electronic Publication: 2025 Dec 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

MeSH-Schlagworte: Pyridazines*/pharmacology , Pyrimidines*/pharmacology , Antiviral Agents*/pharmacology , Artificial Intelligence* , Drug Discovery*/methods , Monkeypox virus*/drug effects , Anti-Retroviral Agents*/pharmacology , Poxviridae*/drug effects , Heterocyclic Compounds, 4 or More Rings*/pharmacology , Mpox, Monkeypox*/drug therapy , Mpox, Monkeypox*/virology, Humans ; Nitriles/pharmacology ; Pyridones/pharmacology ; Animals ; Amides ; Heterocyclic Compounds, 3-Ring ; Piperazines

Full reservoirs and poor adherence: two cases of symptomatic HIV cerebrospinal fluid escape with tenofovir alafenamide/emtricitabine/bictegravir.

Autoren: Calcagno A Lipani C Rizzello B et al.

Quelle: AIDS (London, England) [AIDS] 2025 Dec 01; Vol. 39 (15), pp. 2250-2253. Date of Electronic Publication: 2025 Aug 11.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8710219 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5571 (Electronic) Linking ISSN: 02699370 NLM ISO Abbreviation: AIDS Subsets: MEDLINE

MeSH-Schlagworte: HIV Infections*/drug therapy , HIV Infections*/virology , HIV Infections*/pathology , Emtricitabine*/therapeutic use , Emtricitabine*/administration & dosage , Tenofovir*/therapeutic use , Tenofovir*/analogs & derivatives , Tenofovir*/administration & dosage , Anti-HIV Agents*/therapeutic use , Anti-HIV Agents*/administration & dosage , Cerebrospinal Fluid*/virology , Heterocyclic Compounds, 4 or More Rings*/therapeutic use , Medication Adherence*, Humans ; Female ; RNA, Viral/cerebrospinal fluid ; RNA, Viral/blood ; Viral Load ; Male ; Adult ; Middle Aged ; Adenine/analogs & derivatives ; Adenine/therapeutic use ; Alanine ; Drug Resistance, Viral ; High-Throughput Nucleotide Sequencing ; Amides ; Heterocyclic Compounds, 3-Ring ; Piperazines ; Pyridones

Noninvasive Evaluation of Trop2 Expression Using ⁶⁴ Cu-NOTA-Trodelvy-F(ab') 2 in Gastric and Pancreatic Cancer.

Autoren: Huang W Chao F Li R et al.

Quelle: Molecular pharmaceutics [Mol Pharm] 2025 Dec 01; Vol. 22 (12), pp. 7630-7640. Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

MeSH-Schlagworte: Stomach Neoplasms*/metabolism , Stomach Neoplasms*/diagnostic imaging , Stomach Neoplasms*/pathology , Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/diagnostic imaging , Pancreatic Neoplasms*/pathology , Antigens, Neoplasm*/metabolism , Cell Adhesion Molecules*/metabolism , Copper Radioisotopes*/chemistry , Heterocyclic Compounds, 1-Ring*/chemistry , Immunoglobulin Fab Fragments*/chemistry, Humans ; Animals ; Mice ; Cell Line, Tumor ; Tissue Distribution ; Positron-Emission Tomography/methods ; Female ; Mice, Nude ; Xenograft Model Antitumor Assays ; Mice, Inbred BALB C ; Heterocyclic Compounds/chemistry

Bictegravir/emtricitabine/tenofovir alafenamide for primary HIV infection: Efficacy, safety and impact on viral reservoir (the BIC-PHI clinical trial).

Autoren: Ambrosioni J de Lazzari E Sánchez-Palomino S et al.

Körperschaften: Ambrosioni J de Lazzari E Sánchez-Palomino S et al.

Quelle: The Journal of infection [J Infect] 2025 Nov; Vol. 91 (5), pp. 106651. Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article; Multicenter Study

Info zur Zeitschrift: Publisher: W.B. Saunders Country of Publication: England NLM ID: 7908424 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2742 (Electronic) Linking ISSN: 01634453 NLM ISO Abbreviation: J Infect Subsets: MEDLINE

MeSH-Schlagworte: HIV Infections*/drug therapy , HIV Infections*/virology , Emtricitabine*/therapeutic use , Emtricitabine*/adverse effects , Tenofovir*/therapeutic use , Tenofovir*/analogs & derivatives , Anti-HIV Agents*/therapeutic use , Anti-HIV Agents*/adverse effects , Adenine*/analogs & derivatives , Adenine*/therapeutic use , Heterocyclic Compounds, 4 or More Rings*/therapeutic use, Humans ; Male ; Female ; Adult ; Viral Load/drug effects ; Pyridones/therapeutic use ; Alanine ; Piperazines/therapeutic use ; Treatment Outcome ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Drug Combinations ; HIV-1/drug effects ; Middle Aged ; Spain ; Amides

Switch to bictegravir/emtricitabine/tenofovir alafenamide in people living with HIV aged 65 years or older: BICOLDER study - IMEA 057.

Autoren: Lê MP Allavena C Joly V et al.

Körperschaften: Lê MP Allavena C Joly V et al.

Quelle: Journal of infection and public health [J Infect Public Health] 2025 Nov; Vol. 18 (11), pp. 102946. Date of Electronic Publication: 2025 Sep 01.

Publikationsart: Clinical Study; Journal Article; Multicenter Study

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 101487384 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-035X (Electronic) Linking ISSN: 18760341 NLM ISO Abbreviation: J Infect Public Health Subsets: MEDLINE

MeSH-Schlagworte: Adenine*/analogs & derivatives , Adenine*/therapeutic use , Anti-HIV Agents*/therapeutic use , Anti-HIV Agents*/adverse effects , Drug Substitution* , Emtricitabine*/therapeutic use , Emtricitabine*/adverse effects , Heterocyclic Compounds, 4 or More Rings*/therapeutic use , HIV Infections*/drug therapy , Tenofovir*/therapeutic use , Tenofovir*/analogs & derivatives , Tenofovir*/analogs & derivatives, Aged ; Female ; Humans ; Male ; Alanine ; Drug Combinations ; Drug Interactions ; HIV-1/drug effects ; Piperazines ; Prospective Studies ; Pyridones ; RNA, Viral/blood ; Treatment Outcome ; Viral Load ; Amides ; Heterocyclic Compounds, 3-Ring

Dihydroxanthene-Derived Dioxetane Chemiluminophores for Activatable in Vivo Imaging.

Autoren: Liao K Zhang L Jiang J et al.

Quelle: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Oct 20; Vol. 64 (43), pp. e202514236. Date of Electronic Publication: 2025 Sep 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

MeSH-Schlagworte: Xanthenes*/chemistry , Luminescent Agents*/chemistry , Optical Imaging* , Heterocyclic Compounds*/chemistry, Animals ; Mice ; Humans ; Molecular Structure ; Heterocyclic Compounds, 1-Ring

Phenylamine-1,2-Dioxetanes: Promising Class of Chemiluminescent Luminophores for Aqueous Sensing and Bacterial Detection.

Autoren: David M Leirikh T Naama N et al.

Quelle: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Oct; Vol. 64 (44), pp. e202515674. Date of Electronic Publication: 2025 Sep 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

MeSH-Schlagworte: Luminescent Measurements*/methods , Escherichia coli*/isolation & purification , Luminescent Agents*/chemistry , Heterocyclic Compounds*/chemistry, Water/chemistry ; Molecular Structure ; Luminescence ; Heterocyclic Compounds, 1-Ring

Perinatal and Early Infant Outcomes After Bictegravir Exposure in Pregnancy: A Canadian Surveillance Study.

Autoren: Wong JMH Balleny R Lee T et al.

Körperschaften: Wong JMH Balleny R Lee T et al.

Quelle: Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2025 Oct 01; Vol. 100 (2), pp. 147-153.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins, Inc Country of Publication: United States NLM ID: 100892005 Publication Model: Print Cited Medium: Internet ISSN: 1944-7884 (Electronic) Linking ISSN: 15254135 NLM ISO Abbreviation: J Acquir Immune Defic Syndr Subsets: MEDLINE

MeSH-Schlagworte: HIV Infections*/drug therapy , HIV Infections*/transmission , Pregnancy Complications, Infectious*/drug therapy , Pyridones*/therapeutic use , Anti-HIV Agents*/therapeutic use , Heterocyclic Compounds, 4 or More Rings*/therapeutic use, Humans ; Female ; Pregnancy ; Canada/epidemiology ; Infant, Newborn ; Adult ; Premature Birth/epidemiology ; Male ; Pregnancy Outcome ; Infectious Disease Transmission, Vertical/prevention & control ; Young Adult ; Infant ; Amides ; Heterocyclic Compounds, 3-Ring ; Piperazines

Maintenance therapy with dolutegravir and lamivudine versus bictegravir, emtricitabine, and tenofovir alafenamide in people with HIV (PASO-DOBLE): 48-week results from a randomised, multicentre, open-label, non-inferiority trial.

Autoren: Ryan P Blanco JL Masia M et al.

Körperschaften: Ryan P Blanco JL Masia M et al.

Quelle: The lancet. HIV [Lancet HIV] 2025 Jul; Vol. 12 (7), pp. e473-e484. Date of Electronic Publication: 2025 Jun 07.

Publikationsart: Journal Article; Multicenter Study; Randomized Controlled Trial; Comparative Study; Equivalence Trial

Info zur Zeitschrift: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101645355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3018 (Electronic) Linking ISSN: 23523018 NLM ISO Abbreviation: Lancet HIV Subsets: MEDLINE

MeSH-Schlagworte: HIV Infections*/drug therapy , HIV Infections*/virology , Heterocyclic Compounds, 3-Ring*/therapeutic use , Heterocyclic Compounds, 3-Ring*/administration & dosage , Lamivudine*/therapeutic use , Lamivudine*/administration & dosage , Anti-HIV Agents*/therapeutic use , Anti-HIV Agents*/administration & dosage, Humans ; Pyridones ; Male ; Female ; Piperazines/therapeutic use ; Adult ; Oxazines ; Emtricitabine/therapeutic use ; Emtricitabine/administration & dosage ; Middle Aged ; Tenofovir/therapeutic use ; Tenofovir/analogs & derivatives ; Tenofovir/administration & dosage ; Heterocyclic Compounds, 4 or More Rings/therapeutic use ; Heterocyclic Compounds, 4 or More Rings/administration & dosage ; HIV-1/drug effects ; Adenine/analogs & derivatives ; Adenine/therapeutic use ; Alanine ; Viral Load/drug effects ; Amides ; Maintenance Chemotherapy/methods ; Spain ; Treatment Outcome ; Drug Therapy, Combination

MMP-9 inhibitor SB-3CT improves neurological outcomes in ischemic stroke mice by modulation of astrocytic lipid metabolism.

Autoren: Du LD Fang C Wang YQ et al.

Quelle: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 Aug; Vol. 46 (8), pp. 2120-2135. Date of Electronic Publication: 2025 Mar 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE

MeSH-Schlagworte: Astrocytes*/drug effects , Astrocytes*/metabolism , Lipid Metabolism*/drug effects , Ischemic Stroke*/drug therapy , Ischemic Stroke*/metabolism , Ischemic Stroke*/pathology , Matrix Metalloproteinase Inhibitors*/pharmacology , Matrix Metalloproteinase Inhibitors*/therapeutic use , Heterocyclic Compounds, 3-Ring*/pharmacology , Heterocyclic Compounds, 3-Ring*/therapeutic use , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use, Animals ; Male ; Mice ; Matrix Metalloproteinase 9/metabolism ; Mice, Inbred C57BL ; Disease Models, Animal ; Infarction, Middle Cerebral Artery/drug therapy ; Heterocyclic Compounds, 1-Ring ; Sulfones

Five-days-on-two-days-off (FOTO) versus daily bictegravir/emtricitabine/tenofovir alafenamide in virologically suppressed people with HIV: a pilot randomized clinical trial.

Autoren: Sun HY Lin YT Chang WC et al.

Quelle: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2025 Aug 01; Vol. 80 (8), pp. 2179-2186.

Publikationsart: Journal Article; Randomized Controlled Trial; Comparative Study

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

MeSH-Schlagworte: HIV Infections*/drug therapy , HIV Infections*/virology , Emtricitabine*/administration & dosage , Emtricitabine*/therapeutic use , Anti-HIV Agents*/administration & dosage , Anti-HIV Agents*/therapeutic use , Heterocyclic Compounds, 4 or More Rings*/administration & dosage , Heterocyclic Compounds, 4 or More Rings*/therapeutic use , Tenofovir*/analogs & derivatives , Tenofovir*/administration & dosage , Tenofovir*/therapeutic use , Adenine*/analogs & derivatives , Adenine*/administration & dosage , Adenine*/therapeutic use, Humans ; Adult ; Male ; Female ; Middle Aged ; Pilot Projects ; Viral Load/drug effects ; Pyridones ; Piperazines ; Treatment Outcome ; Alanine ; HIV-1/drug effects ; Heterocyclic Compounds, 3-Ring ; RNA, Viral/blood ; Amides ; Carbamates ; Drug Combinations ; Young Adult

Bictegravir-emtrictabine-tenofovir alafenamide in combination with oxcarbazepine in a person living with HIV and viral load suppression.

Autoren: Pecora Fulco P Gray M

Quelle: International journal of STD & AIDS [Int J STD AIDS] 2025 Jul; Vol. 36 (8), pp. 664-666. Date of Electronic Publication: 2025 Apr 15.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Sage Country of Publication: England NLM ID: 9007917 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1758-1052 (Electronic) Linking ISSN: 09564624 NLM ISO Abbreviation: Int J STD AIDS Subsets: MEDLINE

MeSH-Schlagworte: Adenine*/analogs & derivatives , Adenine*/therapeutic use , Adenine*/administration & dosage , Anti-HIV Agents*/therapeutic use , Anti-HIV Agents*/administration & dosage , Carbamazepine*/analogs & derivatives , Carbamazepine*/therapeutic use , Carbamazepine*/administration & dosage , Heterocyclic Compounds, 4 or More Rings*/therapeutic use , Heterocyclic Compounds, 4 or More Rings*/administration & dosage , HIV Infections*/drug therapy , HIV Infections*/virology , Tenofovir*/analogs & derivatives , Tenofovir*/therapeutic use , Tenofovir*/administration & dosage , Tenofovir*/analogs & derivatives, Humans ; Alanine ; Amides ; Drug Therapy, Combination ; Emtricitabine/therapeutic use ; Oxcarbazepine/therapeutic use ; Piperazines ; Pyridones ; Treatment Outcome ; Viral Load/drug effects ; Heterocyclic Compounds, 3-Ring

Rapid start with bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) as initial treatment in people with human immunodeficiency virus-1 (HIV-1): A systematic literature review of clinical and patient-reported outcomes.

Autoren: Ghosn J Chow J Gandhi M et al.

Quelle: HIV medicine [HIV Med] 2025 Sep; Vol. 26 (9), pp. 1375-1394. Date of Electronic Publication: 2025 Jun 26.

Publikationsart: Journal Article; Systematic Review

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 100897392 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-1293 (Electronic) Linking ISSN: 14642662 NLM ISO Abbreviation: HIV Med Subsets: MEDLINE

MeSH-Schlagworte: HIV Infections*/drug therapy , HIV Infections*/virology , Emtricitabine*/therapeutic use , Emtricitabine*/administration & dosage , Tenofovir*/therapeutic use , Tenofovir*/analogs & derivatives , Tenofovir*/administration & dosage , Anti-HIV Agents*/therapeutic use , Anti-HIV Agents*/administration & dosage , Heterocyclic Compounds, 4 or More Rings*/therapeutic use , Adenine*/therapeutic use , Adenine*/analogs & derivatives, Humans ; HIV-1/drug effects ; Patient Reported Outcome Measures ; Pyridones/therapeutic use ; Drug Combinations ; Alanine ; Piperazines/therapeutic use ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Treatment Outcome ; Viral Load ; Amides