Suchergebnisse - "Hepatitis D"

Diagnosed Patients With Chronic Hepatitis B and Delta Virus in Italy in 2024: An Estimation From a National Real-World Database.

Autoren: Loglio A Gardini I Conforti M et al.

Quelle: Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2025 Oct; Vol. 45 (10), pp. e70336.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101160857 Publication Model: Print Cited Medium: Internet ISSN: 1478-3231 (Electronic) Linking ISSN: 14783223 NLM ISO Abbreviation: Liver Int Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis B, Chronic*/epidemiology , Hepatitis B, Chronic*/diagnosis , Hepatitis B, Chronic*/economics , Hepatitis D, Chronic*/epidemiology , Hepatitis D, Chronic*/diagnosis, Humans ; Italy/epidemiology ; Male ; Female ; Prevalence ; Middle Aged ; Adult ; Databases, Factual ; Aged ; Young Adult ; Adolescent ; Hepatitis D/epidemiology ; Health Expenditures/statistics & numerical data

Accurate quantification using the new RoboGene HDV RNA Quantification Kit 3.0: A European multicenter study.

Autoren: Stelzl E Berger A Ciesek S et al.

Quelle: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2025 Aug; Vol. 179, pp. 105828. Date of Electronic Publication: 2025 Jun 18.

Publikationsart: Journal Article; Multicenter Study

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9815671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5967 (Electronic) Linking ISSN: 13866532 NLM ISO Abbreviation: J Clin Virol Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis Delta Virus*/isolation & purification , Hepatitis Delta Virus*/genetics , RNA, Viral*/blood , RNA, Viral*/genetics , RNA, Viral*/isolation & purification , Viral Load*/methods , Viral Load*/standards , Reagent Kits, Diagnostic* , Hepatitis D, Chronic*/virology , Hepatitis D, Chronic*/diagnosis, Humans ; Europe ; Sensitivity and Specificity ; Limit of Detection ; Hepatitis D/diagnosis

The diagnostic cascade for patients with hepatitis delta infection in France, 2018-2022: A cross-sectional study.

Autoren: Brichler S Trimoulet P Roque-Afonso AM et al.

Quelle: Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2024 Oct; Vol. 44 (10), pp. 2858-2865. Date of Electronic Publication: 2024 Aug 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101160857 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-3231 (Electronic) Linking ISSN: 14783223 NLM ISO Abbreviation: Liver Int Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis Delta Virus*/genetics , Hepatitis Delta Virus*/isolation & purification , Hepatitis Delta Virus*/immunology , Hepatitis D, Chronic*/diagnosis , Hepatitis D, Chronic*/epidemiology, Humans ; Male ; Female ; Cross-Sectional Studies ; Middle Aged ; Adult ; Retrospective Studies ; France/epidemiology ; Prevalence ; Hepatitis B Surface Antigens/blood ; Mass Screening/methods ; Hepatitis D/diagnosis ; Hepatitis D/epidemiology ; RNA, Viral/blood ; Aged ; Coinfection/diagnosis

[Current status of diagnosis and treatment and progress in drug research and development for hepatitis D].

Autoren: Rao HY Wei L

Quelle: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology [Zhonghua Gan Zang Bing Za Zhi] 2024 Oct 20; Vol. 32 (10), pp. 948-954.

Publikationsart: Journal Article; Review; English Abstract

Info zur Zeitschrift: Publisher: Chongqing yi ke da xue, di 2 lin chuang xue yuan Bing du xing gan yan yan jiu suo Country of Publication: China NLM ID: 9710009 Publication Model: Print Cited Medium: Print ISSN: 1007-3418 (Print) Linking ISSN: 10073418 NLM ISO Abbreviation: Zhonghua Gan Zang Bing Za Zhi Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis Delta Virus* , Antiviral Agents*/therapeutic use , Hepatitis D*/diagnosis , Hepatitis D*/drug therapy , Drug Development*, Humans ; Hepatitis D, Chronic/diagnosis ; Hepatitis D, Chronic/drug therapy

Best practices for screening, testing, diagnosing, and treating patients with hepatitis D (delta) virus based on global expert review and recent guidelines.

Autoren: Cornberg M Zoulim F Gish R et al.

Quelle: Antiviral therapy [Antivir Ther] 2025 Oct; Vol. 30 (4), pp. 13596535251349380. Date of Electronic Publication: 2025 Sep 29.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: SAGE Publications Country of Publication: England NLM ID: 9815705 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2040-2058 (Electronic) Linking ISSN: 13596535 NLM ISO Abbreviation: Antivir Ther Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis Delta Virus*/drug effects , Hepatitis Delta Virus*/genetics , Antiviral Agents*/therapeutic use , Hepatitis D*/diagnosis , Hepatitis D*/drug therapy , Hepatitis D*/virology , Hepatitis D, Chronic*/diagnosis , Hepatitis D, Chronic*/drug therapy, Humans ; Mass Screening ; Practice Guidelines as Topic ; Hepatitis B Surface Antigens/blood

Hepatitis D Virus Infection Markedly Increases the Risk of Hepatocellular Carcinoma in Patients With Viral B Cirrhosis.

Autoren: Roulot D Layese R Brichler S et al.

Körperschaften: Roulot D Layese R Brichler S et al.

Quelle: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2025 Oct; Vol. 23 (11), pp. 1943-1953.e2. Date of Electronic Publication: 2024 Oct 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: W.B. Saunders for the American Gastroenterological Association Country of Publication: United States NLM ID: 101160775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-7714 (Electronic) Linking ISSN: 15423565 NLM ISO Abbreviation: Clin Gastroenterol Hepatol Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/epidemiology , Liver Cirrhosis*/complications , Coinfection*/complications , Liver Neoplasms*/epidemiology , Hepatitis D*/complications , Hepatitis B, Chronic*/complications , Hepatitis B*/complications , Hepatitis D, Chronic*/complications, Humans ; Male ; Middle Aged ; Female ; Adult ; Incidence ; France/epidemiology ; Aged ; Risk Assessment

Ubiquitinated hepatitis D antigen-induced CD8 ⁺ T-cell responses inhibit HDV replication in HDV-infected liver organoids.

Autoren: Shen L Tian L Guo Q et al.

Quelle: Antiviral research [Antiviral Res] 2025 Nov; Vol. 243, pp. 106266. Date of Electronic Publication: 2025 Sep 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE

MeSH-Schlagworte: CD8-Positive T-Lymphocytes*/immunology , Hepatitis Delta Virus*/physiology , Hepatitis Delta Virus*/immunology , Organoids*/virology , Organoids*/immunology , Virus Replication* , Hepatitis delta Antigens*/immunology , Hepatitis delta Antigens*/metabolism , Liver*/virology , Liver*/immunology , Hepatitis D*/immunology , Hepatitis D*/virology, Humans ; Dendritic Cells/immunology ; Induced Pluripotent Stem Cells ; Hepatocytes/virology ; Cytokines/metabolism ; Signal Transduction ; Lymphocyte Activation ; Viral Load ; Janus Kinases/metabolism

From Hyperendemic to Low Endemicity: The Effect of Hepatitis B Vaccination on HBV and HDV Prevalence in the Brazilian Amazon.

Autoren: Malheiros AP Gomes-Gouvêa MS Ribeiro LB et al.

Quelle: Pathogens (Basel, Switzerland) [Pathogens] 2025 Oct 25; Vol. 14 (11). Date of Electronic Publication: 2025 Oct 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Internet ISSN: 2076-0817 (Electronic) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis B*/epidemiology , Hepatitis B*/prevention & control , Hepatitis B*/immunology , Hepatitis D*/epidemiology , Hepatitis D*/prevention & control , Hepatitis D*/virology , Hepatitis D*/immunology , Hepatitis B Vaccines*/administration & dosage , Hepatitis B Vaccines*/immunology , Endemic Diseases*, Humans ; Brazil/epidemiology ; Adult ; Male ; Female ; Prevalence ; Middle Aged ; Adolescent ; Cross-Sectional Studies ; Hepatitis Delta Virus/immunology ; Young Adult ; Vaccination ; Child ; Hepatitis B virus/immunology ; Child, Preschool ; Aged ; Hepatitis B Surface Antigens/blood ; Infant ; Coinfection/epidemiology ; Coinfection/virology ; Rural Population

Detection of hepatitis delta virus RNA in cervical swab and seminal plasma of chronic hepatitis delta patients.

Autoren: Enkhjargal S Lhagva-Ochir O Purvee A et al.

Quelle: Sexually transmitted infections [Sex Transm Infect] 2025 Oct 16; Vol. 101 (7), pp. 461-466. Date of Electronic Publication: 2025 Oct 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 9805554 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-3263 (Electronic) Linking ISSN: 13684973 NLM ISO Abbreviation: Sex Transm Infect Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis Delta Virus*/isolation & purification , Hepatitis Delta Virus*/genetics , RNA, Viral*/isolation & purification , RNA, Viral*/analysis , RNA, Viral*/blood , Semen*/virology , Hepatitis D, Chronic*/virology , Hepatitis D, Chronic*/transmission , Cervix Uteri*/virology, Humans ; Female ; Adult ; Middle Aged ; Male ; Young Adult ; Coinfection/virology ; Hepatitis B, Chronic/virology ; Hepatitis B Surface Antigens/blood

Prevalence of hepatitis D virus in chronic hepatitis B patients: findings from Poland.

Autoren: Zarębska-Michaluk D Brzdęk M Dobrowolska K et al.

Quelle: Advances in medical sciences [Adv Med Sci] 2025 Oct; Vol. 70 (2), pp. 277-283. Date of Electronic Publication: 2025 Jul 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101276222 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1898-4002 (Electronic) Linking ISSN: 18961126 NLM ISO Abbreviation: Adv Med Sci Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis B, Chronic*/epidemiology , Hepatitis B, Chronic*/virology , Hepatitis B, Chronic*/drug therapy , Hepatitis B, Chronic*/complications , Hepatitis Delta Virus*/isolation & purification , Hepatitis D*/epidemiology , Hepatitis D*/virology, Humans ; Male ; Female ; Poland/epidemiology ; Middle Aged ; Prevalence ; Adult ; Aged ; Antiviral Agents/therapeutic use ; Coinfection/epidemiology ; Hepatitis B virus ; Young Adult

High Prevalence of Cirrhosis or Hepatocellular Carcinoma at Hepatitis Delta Infection Diagnosis Reflects Alarming Delays in Testing.

Autoren: Wong RJ Yang Z Lim J et al.

Quelle: Journal of viral hepatitis [J Viral Hepat] 2025 Oct; Vol. 32 (10), pp. e70086.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9435672 Publication Model: Print Cited Medium: Internet ISSN: 1365-2893 (Electronic) Linking ISSN: 13520504 NLM ISO Abbreviation: J Viral Hepat Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/epidemiology , Liver Neoplasms*/epidemiology , Liver Cirrhosis*/epidemiology , Hepatitis B, Chronic*/complications , Hepatitis D, Chronic*/complications , Hepatitis D, Chronic*/diagnosis , Hepatitis D*/complications , Hepatitis D*/diagnosis , Delayed Diagnosis*, Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Prevalence ; United States/epidemiology ; Aged ; Adult ; Veterans ; Hepatitis Delta Virus ; Coinfection

Hepatitis Delta Virus Testing and Prevalence Among Chronic Hepatitis B Patients Across Three U.S. Safety-net Health Systems.

Autoren: Wong RJ Jain MK Niu B et al.

Quelle: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2025 Oct; Vol. 23 (11), pp. 1954-1963. Date of Electronic Publication: 2024 Oct 24.

Publikationsart: Journal Article; Multicenter Study; Observational Study

Info zur Zeitschrift: Publisher: W.B. Saunders for the American Gastroenterological Association Country of Publication: United States NLM ID: 101160775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-7714 (Electronic) Linking ISSN: 15423565 NLM ISO Abbreviation: Clin Gastroenterol Hepatol Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis B, Chronic*/epidemiology , Hepatitis B, Chronic*/complications , Hepatitis D*/epidemiology , Hepatitis D*/diagnosis , Hepatitis Delta Virus*/isolation & purification , Safety-net Providers*, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Prevalence ; Retrospective Studies ; Risk Factors ; United States/epidemiology

Comparison of diagnostic performances of HDV-RNA quantification assays used in clinical practice: Results from a national quality control multicenter study.

Autoren: Salpini R Piermatteo L Caviglia GP et al.

Körperschaften: Salpini R Piermatteo L Caviglia GP et al.

Quelle: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2025 Oct; Vol. 180, pp. 105850. Date of Electronic Publication: 2025 Aug 06.

Publikationsart: Journal Article; Multicenter Study; Comparative Study

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9815671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5967 (Electronic) Linking ISSN: 13866532 NLM ISO Abbreviation: J Clin Virol Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis Delta Virus*/genetics , Hepatitis Delta Virus*/isolation & purification , RNA, Viral*/blood , RNA, Viral*/genetics , Hepatitis D*/diagnosis , Hepatitis D*/virology , Viral Load*/methods , Viral Load*/standards , Molecular Diagnostic Techniques*/methods , Molecular Diagnostic Techniques*/standards, Humans ; Sensitivity and Specificity ; Quality Control ; Reproducibility of Results

Advances in hepatitis delta research: emerging insights and future directions.

Autoren: Degasperi E Anolli MP Lampertico P

Quelle: Sexually transmitted infections [Sex Transm Infect] 2024 Jul 26; Vol. 100 (5), pp. 310-317. Date of Electronic Publication: 2024 Jul 26.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 9805554 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-3263 (Electronic) Linking ISSN: 13684973 NLM ISO Abbreviation: Sex Transm Infect Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis Delta Virus*/drug effects , Antiviral Agents*/therapeutic use , Hepatitis D, Chronic*/drug therapy, Humans ; Hepatitis D/drug therapy ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/virology ; Hepatitis B virus/drug effects

Bulevirtide Monotherapy or in Combination for Chronic Hepatitis Delta: 2025 Update.

Autoren: Lampertico P Anolli MP Steppich K et al.

Quelle: Journal of viral hepatitis [J Viral Hepat] 2025 Dec; Vol. 32 (12), pp. e70056.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9435672 Publication Model: Print Cited Medium: Internet ISSN: 1365-2893 (Electronic) Linking ISSN: 13520504 NLM ISO Abbreviation: J Viral Hepat Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis D, Chronic*/drug therapy , Hepatitis D, Chronic*/epidemiology , Hepatitis D, Chronic*/virology , Antiviral Agents*/therapeutic use , Antiviral Agents*/administration & dosage , Peptide Fragments*/therapeutic use , Peptides*/therapeutic use, Humans ; Hepatitis Delta Virus/drug effects ; Drug Therapy, Combination ; Treatment Outcome ; Hepatitis B Surface Antigens/blood ; Viral Load ; Nucleic Acids ; Polymers

Large spatial variation of intrahepatic HDV RNA levels without association with HBV core or S RNA levels in HDV cirrhosis patients.

Autoren: Rydell GE Strömberg LG Ringlander J et al.

Quelle: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2025 Dec; Vol. 181, pp. 105871. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9815671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5967 (Electronic) Linking ISSN: 13866532 NLM ISO Abbreviation: J Clin Virol Subsets: MEDLINE

MeSH-Schlagworte: RNA, Viral*/analysis , RNA, Viral*/blood , RNA, Viral*/genetics , Hepatitis Delta Virus*/genetics , Hepatitis Delta Virus*/isolation & purification , Liver Cirrhosis*/virology , Liver*/virology , Hepatitis D*/virology , Hepatitis D*/complications , Hepatitis B Surface Antigens*/blood , Hepatitis B Surface Antigens*/genetics , Hepatitis B virus*/genetics , Hepatitis B Core Antigens*/genetics, Humans ; Male ; Female ; Middle Aged ; Adult ; Viral Load ; Aged

TIGIT expression on natural killer cell subsets is an early indicator of alleviating liver inflammation following bulevirtide treatment in chronic hepatitis D.

Autoren: Chen PC Deterding K Engelskircher SA et al.

Quelle: Hepatology (Baltimore, Md.) [Hepatology] 2025 Dec 01; Vol. 82 (6), pp. 1565-1581. Date of Electronic Publication: 2025 Jan 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE

MeSH-Schlagworte: Killer Cells, Natural*/immunology , Killer Cells, Natural*/metabolism , Killer Cells, Natural*/drug effects , Hepatitis D, Chronic*/drug therapy , Hepatitis D, Chronic*/immunology , Receptors, Immunologic*/metabolism , Antiviral Agents*/therapeutic use, Humans ; Male ; Female ; Middle Aged ; Adult ; Longitudinal Studies ; Hepatitis Delta Virus ; Liver/pathology

Evaluation of HDV stability under different biological sample collection and storage conditions: implications for molecular diagnosis.

Autoren: Queiroz JADS Arruda MB Roca TP et al.

Quelle: Virology journal [Virol J] 2025 Nov 21; Vol. 22 (1), pp. 383. Date of Electronic Publication: 2025 Nov 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101231645 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-422X (Electronic) Linking ISSN: 1743422X NLM ISO Abbreviation: Virol J Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis Delta Virus*/genetics , Hepatitis Delta Virus*/isolation & purification , Hepatitis Delta Virus*/physiology , Specimen Handling*/methods , Hepatitis D*/diagnosis , Hepatitis D*/virology , Microbial Viability*, Humans ; Temperature ; RNA, Viral/genetics ; Brazil ; Molecular Diagnostic Techniques/methods ; Time Factors ; Real-Time Polymerase Chain Reaction

Cost-Effectiveness of One-time Universal Testing for Hepatitis D Among Adults With Chronic Hepatitis B in the United States.

Autoren: Toy M Hutton D Teshale E et al.

Quelle: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2025 Nov 06; Vol. 81 (4), pp. e211-e217.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis B, Chronic*/complications , Hepatitis B, Chronic*/drug therapy , Hepatitis D, Chronic*/diagnosis , Hepatitis D, Chronic*/drug therapy , Hepatitis D, Chronic*/economics, Humans ; Cost-Benefit Analysis ; United States/epidemiology ; Adult ; Hepatitis B Surface Antigens/blood ; Antiviral Agents/therapeutic use ; Antiviral Agents/economics ; Markov Chains ; Hepatitis Delta Virus/immunology ; Male ; Female ; Middle Aged ; Quality-Adjusted Life Years ; RNA, Viral/blood

Therapies and Pipeline for Hepatitis B and Hepatitis D.

Autoren: Lee J Shah N Kukreja R et al.

Quelle: Clinics in liver disease [Clin Liver Dis] 2025 Nov; Vol. 29 (4), pp. 627-640.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Health Sciences Division Country of Publication: United States NLM ID: 9710002 Publication Model: Print Cited Medium: Internet ISSN: 1557-8224 (Electronic) Linking ISSN: 10893261 NLM ISO Abbreviation: Clin Liver Dis Subsets: MEDLINE

MeSH-Schlagworte: Antiviral Agents*/therapeutic use , Hepatitis B*/drug therapy , Hepatitis D*/drug therapy , Hepatitis B, Chronic*/drug therapy, Humans ; Hepatitis B virus/drug effects ; Guanine/analogs & derivatives ; Guanine/therapeutic use ; Gene Editing ; Tenofovir/therapeutic use