Suchergebnisse - "Hep G2 Cells"

Comparative analysis of metabolome and transcriptomes to explore the inhibited influence of sonodynamic therapy combined with lonidamine on hepatocellular carcinoma.

Autoren: Tan H Tian H Chen Y et al.

Quelle: Drug delivery [Drug Deliv] 2025 Dec 31; Vol. 32 (1), pp. 2593600. Date of Electronic Publication: 2025 Dec 03.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9417471 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0464 (Electronic) Linking ISSN: 10717544 NLM ISO Abbreviation: Drug Deliv Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/therapy , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/genetics , Liver Neoplasms*/therapy , Liver Neoplasms*/drug therapy , Liver Neoplasms*/metabolism , Liver Neoplasms*/genetics , Metabolome*/drug effects , Indazoles*/pharmacology , Indazoles*/administration & dosage , Transcriptome*/drug effects , Ultrasonic Therapy*/methods, Animals ; Humans ; Mice, Nude ; Mice ; Hep G2 Cells ; Xenograft Model Antitumor Assays ; Mice, Inbred BALB C ; Hematoporphyrins/administration & dosage ; Hematoporphyrins/pharmacology ; Hematoporphyrins/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/administration & dosage ; Combined Modality Therapy ; Nanoparticles/chemistry ; Cell Line, Tumor ; Particle Size ; Male

Structural modification of ferulic acid for manipulating its bitterness inhibition regulation.

Autoren: Sun L Fang Z Zhou J et al.

Quelle: Food chemistry [Food Chem] 2025 Dec 30; Vol. 497, pp. 146994. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Coumaric Acids*/chemistry , Coumaric Acids*/pharmacology , Flavoring Agents*/chemistry , Flavoring Agents*/pharmacology, Humans ; Taste/drug effects ; Molecular Docking Simulation ; Molecular Structure ; Receptors, G-Protein-Coupled/metabolism ; Receptors, G-Protein-Coupled/chemistry ; Receptors, G-Protein-Coupled/genetics ; Structure-Activity Relationship ; Hep G2 Cells

An adeno-associated virus vector-based intracellular peptide delivery system for treating hepatocellular carcinoma with wild-type p53.

Autoren: Qie B Li J Wan M et al.

Quelle: International journal of pharmaceutics [Int J Pharm] 2025 Dec 25; Vol. 686, pp. 126298. Date of Electronic Publication: 2025 Oct 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/therapy , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Tumor Suppressor Protein p53*/metabolism , Tumor Suppressor Protein p53*/genetics , Liver Neoplasms*/therapy , Liver Neoplasms*/genetics , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Dependovirus*/genetics , Genetic Vectors* , Gene Transfer Techniques* , Peptides*/administration & dosage , Peptides*/genetics, Animals ; Humans ; Proto-Oncogene Proteins c-mdm2/metabolism ; Proto-Oncogene Proteins c-mdm2/antagonists & inhibitors ; Proto-Oncogene Proteins c-mdm2/genetics ; Mice, Inbred BALB C ; Mice, Nude ; Cell Line, Tumor ; Mice ; Genetic Therapy/methods ; Xenograft Model Antitumor Assays ; Hep G2 Cells ; Survivin ; Male

Peptide profiling and antioxidant characterization of the simulated gastrointestinal digest of hemp seed proteins.

Autoren: Zhang M Zhang T Chen C et al.

Quelle: Food chemistry [Food Chem] 2025 Dec 25; Vol. 496 (Pt 1), pp. 146658. Date of Electronic Publication: 2025 Oct 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Antioxidants*/chemistry , Antioxidants*/metabolism , Antioxidants*/pharmacology , Seeds*/chemistry , Seeds*/metabolism , Plant Proteins*/chemistry , Plant Proteins*/metabolism , Cannabis*/chemistry , Cannabis*/metabolism , Peptides*/chemistry , Peptides*/metabolism , Peptides*/pharmacology , Gastrointestinal Tract*/metabolism, Humans ; Digestion ; Hep G2 Cells ; Molecular Docking Simulation ; Oxidative Stress/drug effects

Blueberry anthocyanins and their metabolites synergistically alleviated ferroptosis induced by acrylamide in HepG2 cells.

Autoren: Lang Y Gao N Tan H et al.

Quelle: Food chemistry [Food Chem] 2025 Dec 25; Vol. 496 (Pt 2), pp. 146690. Date of Electronic Publication: 2025 Oct 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Blueberry Plants*/chemistry , Blueberry Plants*/metabolism , Anthocyanins*/pharmacology , Anthocyanins*/metabolism , Anthocyanins*/chemistry , Acrylamide*/toxicity , Acrylamide*/adverse effects , Ferroptosis*/drug effects , Plant Extracts*/pharmacology , Plant Extracts*/metabolism , Plant Extracts*/chemistry, Humans ; Hep G2 Cells ; NF-E2-Related Factor 2/metabolism ; NF-E2-Related Factor 2/genetics ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism ; Kelch-Like ECH-Associated Protein 1/metabolism ; Kelch-Like ECH-Associated Protein 1/genetics

Accumulation of succinate in the blood is a potential early indicator of metabolic dysfunction-associated steatotic liver disease (MASLD).

Autoren: Chalifoux O Dagostino C Li M et al.

Quelle: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 220-235. Date of Electronic Publication: 2025 Sep 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH-Schlagworte: Succinic Acid*/blood , Succinic Acid*/metabolism , Fatty Liver*/blood , Fatty Liver*/pathology , Fatty Liver*/diagnosis , Non-alcoholic Fatty Liver Disease*/blood , Non-alcoholic Fatty Liver Disease*/pathology, Animals ; Male ; Mice ; Humans ; Female ; Mice, Inbred C57BL ; Diet, High-Fat/adverse effects ; Biomarkers/blood ; Hep G2 Cells ; Fructose/metabolism ; Disease Models, Animal ; Hydrogen Peroxide/metabolism ; Mitochondria/metabolism ; Mitochondria/pathology ; Taurochenodeoxycholic Acid

Supercritical fluid extraction and micro-encapsulation of Saussurea costus roots for next gen functional foods: antioxidant potential, surface morphology and anti-diabetic potential.

Autoren: Mushtaq M Amin QA Wani TA et al.

Quelle: Food chemistry [Food Chem] 2025 Dec 15; Vol. 495 (Pt 1), pp. 146290. Date of Electronic Publication: 2025 Sep 07.

Publikationsart: Journal Article; Evaluation Study

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Plant Extracts*/isolation & purification , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Antioxidants*/isolation & purification , Antioxidants*/chemistry , Antioxidants*/pharmacology , Hypoglycemic Agents*/isolation & purification , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/pharmacology , Functional Food*/analysis , Saussurea*/chemistry , Plant Roots*/chemistry , Chromatography, Supercritical Fluid*/methods, Humans ; Hep G2 Cells ; alpha-Amylases/antagonists & inhibitors ; alpha-Amylases/metabolism ; Drug Compounding/methods

Hypoglycemic potential of American ginseng saponins: inhibition of α-amylase and improvement of insulin resistance.

Autoren: Liang L Guo Y Yao X et al.

Quelle: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2025 Dec 15; Vol. 1267, pp. 124813. Date of Electronic Publication: 2025 Oct 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-376X (Electronic) Linking ISSN: 15700232 NLM ISO Abbreviation: J Chromatogr B Analyt Technol Biomed Life Sci Subsets: MEDLINE

MeSH-Schlagworte: Insulin Resistance* , Panax*/chemistry , alpha-Amylases*/antagonists & inhibitors , alpha-Amylases*/metabolism , Saponins*/pharmacology , Saponins*/chemistry , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry, Humans ; Hep G2 Cells ; Molecular Docking Simulation ; Chromatography, High Pressure Liquid ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Ginsenosides/pharmacology ; Ginsenosides/chemistry

Raman spectral analyses to investigate the physiological and metabolic development of a 3D hepatocellular carcinoma model.

Autoren: Rizzo MG Corsaro C Marrara S et al.

Quelle: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2025 Dec 15; Vol. 343, pp. 126564. Date of Electronic Publication: 2025 Jun 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 9602533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3557 (Electronic) Linking ISSN: 13861425 NLM ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/genetics , Spectrum Analysis, Raman*/methods , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics, Humans ; Hep G2 Cells ; Cell Proliferation ; Spheroids, Cellular/metabolism ; Spheroids, Cellular/pathology ; Tumor Microenvironment ; Gene Expression Regulation, Neoplastic ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics

Modulating glucose homeostasis via expression of PPAR-γ TF: Pharmacological insights into quinolone-based hydrazones.

Autoren: Pravin NJ Kavalapure RS Gharge S et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118168. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: PPAR gamma*/metabolism , PPAR gamma*/genetics , Homeostasis*/drug effects , Quinolones*/chemistry , Quinolones*/pharmacology , Quinolones*/chemical synthesis , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Experimental*/metabolism , Diabetes Mellitus, Experimental*/chemically induced , Hydrazones*/pharmacology , Hydrazones*/chemistry , Hydrazones*/chemical synthesis , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/chemical synthesis , Glucose*/metabolism, Animals ; Humans ; Rats ; Structure-Activity Relationship ; Molecular Structure ; Male ; Molecular Docking Simulation ; Hep G2 Cells ; Dose-Response Relationship, Drug ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism

Colorimetric and fluorimetric detection of Fe(III) using a novel chromenylium-cyanine near-infrared fluorescence probe: Photophysical properties, DFT studies and cell imaging.

Autoren: Luo P Chen H Cheng X et al.

Quelle: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2025 Dec 15; Vol. 343, pp. 126593. Date of Electronic Publication: 2025 Jun 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 9602533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3557 (Electronic) Linking ISSN: 13861425 NLM ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Subsets: MEDLINE

MeSH-Schlagworte: Fluorescent Dyes*/chemistry , Density Functional Theory* , Colorimetry*/methods , Fluorometry*/methods , Ferric Compounds*/analysis , Iron*/analysis, Humans ; Animals ; Mice ; Hep G2 Cells ; MCF-7 Cells ; Spectroscopy, Fourier Transform Infrared ; Spectrometry, Fluorescence ; Optical Imaging/methods

Imidazole-based highly selective and sensitive carbonate anions chemosensor: Design, synthesis, characterization, DFT, and biological screening.

Autoren: Pramanik C Jana A Bera P et al.

Quelle: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2025 Dec 15; Vol. 343, pp. 126563. Date of Electronic Publication: 2025 Jun 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 9602533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3557 (Electronic) Linking ISSN: 13861425 NLM ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Subsets: MEDLINE

MeSH-Schlagworte: Imidazoles*/chemistry , Imidazoles*/chemical synthesis , Carbonates*/analysis , Carbonates*/chemistry , Density Functional Theory* , Fluorescent Dyes*/chemistry , Fluorescent Dyes*/chemical synthesis, Humans ; Anions/analysis ; Hep G2 Cells ; Spectrometry, Fluorescence ; Limit of Detection

Molecular insights into the formation of polymeric nanoassemblies of the anticancer peptide PEN-FFW.

Autoren: Wang T Lazareva PA Malinovskaya J et al.

Quelle: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Dec 10; Vol. 388 (Pt 2), pp. 114364. Date of Electronic Publication: 2025 Oct 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH-Schlagworte: Nanoparticle Drug Delivery System*/chemical synthesis , Peptides*/administration & dosage , Peptides*/chemistry , Peptides*/pharmacokinetics , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacokinetics, Hep G2 Cells ; Drug Screening Assays, Antitumor ; Humans ; Female ; Animals ; Mice ; Mice, Inbred BALB C ; Excipients/chemistry ; Models, Molecular

Understanding the early onset of intracellular lipid accumulation induced by oleic and palmitic acids in HepG2 cells.

Autoren: Esther Jebarani Elangovan Rihana Habeeb Rakuman Vellaichamy A

Quelle: Cellular and molecular biology (Noisy-le-Grand, France) [Cell Mol Biol (Noisy-le-grand)] 2025 Dec 06; Vol. 71 (11), pp. 68-73. Date of Electronic Publication: 2025 Dec 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: C.M.B. Association Country of Publication: France NLM ID: 9216789 Publication Model: Electronic Cited Medium: Internet ISSN: 1165-158X (Electronic) Linking ISSN: 01455680 NLM ISO Abbreviation: Cell Mol Biol (Noisy-le-grand) Subsets: MEDLINE

MeSH-Schlagworte: Oleic Acid*/pharmacology , Lipid Metabolism*/drug effects , Lipid Metabolism*/genetics , Palmitic Acid*/pharmacology, Humans ; Hep G2 Cells ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Lipid Droplets/metabolism ; Lipid Droplets/drug effects

Dual defects in HBsAg antigenicity and secretion caused by the C138R mutation in the S gene trigger occult hepatitis B virus infection.

Autoren: Hong X Chen X Zhang P et al.

Quelle: Journal of translational medicine [J Transl Med] 2025 Dec 05; Vol. 23 (1), pp. 1379. Date of Electronic Publication: 2025 Dec 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH-Schlagworte: Hepatitis B Surface Antigens*/genetics , Hepatitis B Surface Antigens*/immunology , Hepatitis B Surface Antigens*/metabolism , Hepatitis B Surface Antigens*/chemistry , Hepatitis B*/virology , Hepatitis B*/immunology , Hepatitis B*/genetics , Hepatitis B virus*/genetics , Hepatitis B virus*/immunology , Mutation*/genetics, Animals ; Humans ; Mice ; Protein Multimerization ; Hep G2 Cells ; Female

FBP1 promotes ABCG2-mediated uric acid excretion through activation of the PI3K/AKT/CREB signaling pathway.

Autoren: Bai Q Wang C Li J et al.

Quelle: Scientific reports [Sci Rep] 2025 Dec 05; Vol. 15 (1), pp. 43228. Date of Electronic Publication: 2025 Dec 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Uric Acid*/metabolism , ATP Binding Cassette Transporter, Subfamily G, Member 2*/metabolism , ATP Binding Cassette Transporter, Subfamily G, Member 2*/genetics , Signal Transduction* , Proto-Oncogene Proteins c-akt*/metabolism , Fructose-Bisphosphatase*/metabolism , Fructose-Bisphosphatase*/genetics , Neoplasm Proteins*/metabolism , Neoplasm Proteins*/genetics , Phosphatidylinositol 3-Kinases*/metabolism, Humans ; Hyperuricemia/metabolism ; Hyperuricemia/genetics ; Caco-2 Cells ; Hep G2 Cells

Ultrasoft hydrogel immune millirobot with multimodal locomotion.

Autoren: Zheng Z Demir SO Wu A et al.

Quelle: Science advances [Sci Adv] 2025 Dec 05; Vol. 11 (49), pp. eadw9133. Date of Electronic Publication: 2025 Dec 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

MeSH-Schlagworte: Hydrogels*/chemistry , Immunotherapy*/methods , Magnetite Nanoparticles*/chemistry, Animals ; Humans ; Mice ; Robotics ; Hep G2 Cells ; Mice, Nude ; Xenograft Model Antitumor Assays ; Killer Cells, Natural/immunology ; Neoplasms/therapy ; Neoplasms/immunology

Ciclopirox, a broad-spectrum antifungal drug, moonlights as a pyroptosis agonist to drive hepatocellular carcinoma cell death.

Autoren: Yuan H Xia C Zhang J et al.

Quelle: European journal of pharmacology [Eur J Pharmacol] 2025 Dec 05; Vol. 1008, pp. 178358. Date of Electronic Publication: 2025 Nov 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Pyroptosis*/drug effects , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/drug therapy , Carcinoma, Hepatocellular*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/drug therapy , Liver Neoplasms*/metabolism , Ciclopirox*/pharmacology , Ciclopirox*/therapeutic use , Antifungal Agents*/pharmacology , Antifungal Agents*/therapeutic use , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use, Humans ; Animals ; Reactive Oxygen Species/metabolism ; Mice ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Cell Movement/drug effects ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Mice, Nude ; Hep G2 Cells ; Male ; Cell Cycle Checkpoints/drug effects

Autophagy regulates MK-2206-induced LDL receptor expression and cholesterol efflux pathways.

Autoren: Sundvold H Strøm TB

Quelle: PloS one [PLoS One] 2025 Dec 04; Vol. 20 (12), pp. e0338076. Date of Electronic Publication: 2025 Dec 04 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH-Schlagworte: Autophagy*/drug effects , Autophagy*/genetics , Receptors, LDL*/metabolism , Receptors, LDL*/genetics , Cholesterol*/metabolism , Heterocyclic Compounds, 3-Ring*/pharmacology, Humans ; Hep G2 Cells ; ATP Binding Cassette Transporter 1/metabolism ; ATP Binding Cassette Transporter 1/genetics ; Autophagy-Related Protein 5/genetics ; Autophagy-Related Protein 7/genetics ; Hepatocytes/metabolism ; Hepatocytes/drug effects ; Sterol Regulatory Element Binding Protein 2/metabolism ; Sterol Regulatory Element Binding Protein 2/genetics ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt/metabolism

Biointerface Behavior of Layered Double Hydroxides: Dispersibility and Toxicity Assessment Using Experimental and Computational Models.

Autoren: Singh AV Sharma A Kumar MS et al.

Quelle: Langmuir : the ACS journal of surfaces and colloids [Langmuir] 2025 Dec 02; Vol. 41 (47), pp. 32158-32176. Date of Electronic Publication: 2025 Nov 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9882736 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5827 (Electronic) Linking ISSN: 07437463 NLM ISO Abbreviation: Langmuir Subsets: MEDLINE

MeSH-Schlagworte: Hydroxides*/chemistry , Hydroxides*/toxicity, Humans ; Hep G2 Cells ; Cell Survival/drug effects ; Reactive Oxygen Species/metabolism ; HL-60 Cells ; Membrane Potential, Mitochondrial/drug effects ; Apoptosis/drug effects